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Entry version 137 (29 Sep 2021)
Sequence version 3 (04 Dec 2007)
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Protein

Chitin synthase 4

Gene

chs-4

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chitin synthase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell wall biogenesis/degradation

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.1.16, 26170

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT2, Glycosyltransferase Family 2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chitin synthase 4 (EC:2.4.1.16)
Alternative name(s):
Chitin-UDP acetyl-glucosaminyl transferase 4
Class-IV chitin synthase 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:chs-4
ORF Names:NCU09324
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri367110 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001805 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 1, Linkage Group I, Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:NCU09324

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 212CytoplasmicCuratedAdd BLAST212
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 244ExtracellularCuratedAdd BLAST11
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 514CytoplasmicCuratedAdd BLAST249
Transmembranei515 – 535HelicalSequence analysisAdd BLAST21
Topological domaini536 – 1065ExtracellularCuratedAdd BLAST530
Transmembranei1066 – 1086HelicalSequence analysisAdd BLAST21
Topological domaini1087 – 1092CytoplasmicCurated6
Transmembranei1093 – 1113HelicalSequence analysisAdd BLAST21
Topological domaini1114 – 1116ExtracellularCurated3
Transmembranei1117 – 1137HelicalSequence analysisAdd BLAST21
Topological domaini1138 – 1235CytoplasmicCuratedAdd BLAST98

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001937041 – 1235Chitin synthase 4Add BLAST1235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi639N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1034N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q01285

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 203DisorderedSequence analysisAdd BLAST203
Regioni545 – 592DisorderedSequence analysisAdd BLAST48
Regioni645 – 670DisorderedSequence analysisAdd BLAST26
Regioni1201 – 1235DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi47 – 64Polar residuesSequence analysisAdd BLAST18
Compositional biasi69 – 83Pro residuesSequence analysisAdd BLAST15
Compositional biasi91 – 111Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi143 – 200Basic and acidic residuesSequence analysisAdd BLAST58
Compositional biasi548 – 565Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1201 – 1219Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002572_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q01285

Identification of Orthologs from Complete Genome Data

More...
OMAi
FPLAHTM

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.550.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004835, Chitin_synth
IPR029044, Nucleotide-diphossugar_trans

The PANTHER Classification System

More...
PANTHERi
PTHR22914, PTHR22914, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53448, SSF53448, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q01285-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLPRRPGPS PPHEEPRRYR QSGSRRSRPP PADVETGYAP MAGERPSQQQ
60 70 80 90 100
RVPSISSFPE TLPSPNPNVE RDPLAPTPEP AHPSGIPQRK RSLIRPERNR
110 120 130 140 150
IGKDHPNYHY RKHAANMNTL PSSTGHDPIY EDLEGATDDV SGTGSRNDDD
160 170 180 190 200
VSEESPPRRK HSTKMQVIET EKSGDERRRR RKSDTTKHGK IVKASKGKRE
210 220 230 240 250
KSGGLPTPSF WNIYCGFVTF WCPGFVLKCF GMPEMAQQRA WREKMGLISI
260 270 280 290 300
ILLIMGFVGF ITFGFTQVVC GKPPLRLRIN EVGSGYMIFH GSAYDLTKSH
310 320 330 340 350
HPPAEGIPRR PDGLGANVIY DLPQHYGGQD GSFLFQNVNG KCKGLITKQE
360 370 380 390 400
NSDVPSDKSG NLAWYFPCNT FNQDGSSKPN TTIPYYLGYA CHTTANARDS
410 420 430 440 450
FYLGLKSSAD VYFTWDDIKN SSRNLVVYSG HVLDLDLLHW FNDTQVTYPA
460 470 480 490 500
RFKELRDKNT AGNQAIRGRD ITHAFQSSKD KQIAECFEEI IKVGSVDTET
510 520 530 540 550
VGCIASKVVL YVSLVLILAV VLARFVLALI FQWFISKTYA AAKTSQTSDQ
560 570 580 590 600
RKRNRQIEDW TEDIYRAPPR LPGEVGSSVA GSSDRQSKRS SAFLPTHSRF
610 620 630 640 650
STVYGNERGN RKPGLPTTMA SQNAAGQLLH PGTIYGQGNE SRSSFLKSDA
660 670 680 690 700
YGSSSSPADG PGPAGFIHEA VVPQPPSDWM PFGFPLAHTI CLVTAYSEGE
710 720 730 740 750
MGVRTTLDSI AMTDYPNSHK VILVICDGII KGHGEEHSTP DIILGMMKDH
760 770 780 790 800
TIHPDDVEPF SYVAVATGSK RHNMAKVYTG FYDYGTNSAI PLEKQQRVPM
810 820 830 840 850
MMVVKCGTPA EASKSKPGNR GKRDSQIILM SFLQKVMFDE RMTELEYEMF
860 870 880 890 900
NGLWKITGIS PDFYEIVLMV DADTKVFPDS LTHMISAMVK DPEIMGLCGE
910 920 930 940 950
TKIANKRASW VSAIQVFEYF VSHHLAKAFE SVFGGVTCLP GCFCMYRIKA
960 970 980 990 1000
PKGAQNYWVP ILANPDVVEH YSENVVDTLH KKNLLLLGED RYLSTLMLRT
1010 1020 1030 1040 1050
FPKRKQVFVP QAVCKTTVPD EFMVLLSQRR RWINSTIHNL MELVLVRDLC
1060 1070 1080 1090 1100
GTFCFSMQFI VGIELIGTLV LPAAIAFTFY VVIISIINSP PQIIPLVLLG
1110 1120 1130 1140 1150
LILGLPAILV VVTAHSWSYI IWMFIYLLSL PVWNFVLPTY AFWKFDDFSW
1160 1170 1180 1190 1200
GDTRKTAGEK SSKGGHGEAE GEFDSSMITM KRWAEFERDR RVRSTYWAGS
1210 1220 1230
RDNVISGVGG SNGWGSSQPR GHEQGRHFDD YFSDA
Length:1,235
Mass (Da):137,990
Last modified:December 4, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF275C6603FB8CDD4
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB03563 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti480D → Y in AAB03563 (PubMed:8628221).Curated1
Sequence conflicti563D → E in AAB03563 (PubMed:8628221).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U25097 Genomic DNA Translation: AAB03563.1 Different initiation.
CM002236 Genomic DNA Translation: ESA44002.1
CM002236 Genomic DNA Translation: ESA44003.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S61886

NCBI Reference Sequences

More...
RefSeqi
XP_011393274.1, XM_011394972.1
XP_011393275.1, XM_011394973.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
ESA44002; ESA44002; NCU09324
ESA44003; ESA44003; NCU09324

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3880177

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ncr:NCU09324

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25097 Genomic DNA Translation: AAB03563.1 Different initiation.
CM002236 Genomic DNA Translation: ESA44002.1
CM002236 Genomic DNA Translation: ESA44003.1
PIRiS61886
RefSeqiXP_011393274.1, XM_011394972.1
XP_011393275.1, XM_011394973.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

CAZyiGT2, Glycosyltransferase Family 2

Proteomic databases

PRIDEiQ01285

Genome annotation databases

EnsemblFungiiESA44002; ESA44002; NCU09324
ESA44003; ESA44003; NCU09324
GeneIDi3880177
KEGGincr:NCU09324

Organism-specific databases

VEuPathDBiFungiDB:NCU09324

Phylogenomic databases

HOGENOMiCLU_002572_1_0_1
InParanoidiQ01285
OMAiFPLAHTM

Enzyme and pathway databases

BRENDAi2.4.1.16, 26170

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR004835, Chitin_synth
IPR029044, Nucleotide-diphossugar_trans
PANTHERiPTHR22914, PTHR22914, 1 hit
SUPFAMiSSF53448, SSF53448, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHS4_NEUCR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01285
Secondary accession number(s): Q7RVJ8, V5IPD9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 4, 2007
Last modified: September 29, 2021
This is version 137 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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