We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - Q01269 (PHEC_PSEAE)
Protein
Cyclohexadienyl dehydratase
Gene
pheC
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Functioni
Forms alternative pathway for phenylalanine biosynthesis. Can catalyze two reactions: prephenate dehydratase and arogenate dehydratase. May have a role in chemotaxis or transport.
Catalytic activityi
: L-phenylalanine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-phenylalanine from L-arogenate. This subpathway is part of the pathway L-phenylalanine biosynthesis, which is itself part of Amino-acid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-phenylalanine from L-arogenate, the pathway L-phenylalanine biosynthesis and in Amino-acid biosynthesis.
Pathwayi: L-phenylalanine biosynthesis
This protein is involved in step 1 of the subpathway that synthesizes phenylpyruvate from prephenate. This subpathway is part of the pathway L-phenylalanine biosynthesis, which is itself part of Amino-acid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes phenylpyruvate from prephenate, the pathway L-phenylalanine biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 179 | Important for catalysis | 1 |
GO - Molecular functioni
- arogenate dehydratase activity Source: UniProtKB-EC
- prephenate dehydratase activity Source: UniProtKB-EC
GO - Biological processi
- L-phenylalanine biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Lyase, Multifunctional enzyme |
Biological process | Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Phenylalanine biosynthesis |
Enzyme and pathway databases
BRENDAi | 4.2.1.91, 5087 |
SABIO-RKi | Q01269 |
UniPathwayi | UPA00121;UER00344 UPA00121;UER00345 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pheC Ordered Locus Names:PA3475 |
Organismi | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Taxonomic identifieri | 208964 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › |
Proteomesi |
|
Organism-specific databases
PseudoCAPi | PA3475 |
Subcellular locationi
Other locations
- Periplasm 1 Publication
Other locations
- periplasmic space Source: UniProtKB-SubCell
Keywords - Cellular componenti
PeriplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | 1 PublicationAdd BLAST | 25 | |
ChainiPRO_0000031773 | 26 – 268 | Cyclohexadienyl dehydrataseAdd BLAST | 243 |
Proteomic databases
PaxDbi | Q01269 |
Interactioni
Subunit structurei
Homodimer.
CuratedProtein-protein interaction databases
STRINGi | 287.DR97_4446 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q01269 |
SMRi | Q01269 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q01269 |
Family & Domainsi
Sequence similaritiesi
Belongs to the bacterial solute-binding protein 3 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
HOGENOMi | CLU_019602_9_0_6 |
InParanoidi | Q01269 |
OMAi | MQYGEKA |
PhylomeDBi | Q01269 |
Family and domain databases
CDDi | cd01069, PBP2_PheC, 1 hit |
InterProi | View protein in InterPro IPR037298, PheC_PBP2 IPR018313, SBP_3_CS IPR001638, Solute-binding_3/MltF_N |
Pfami | View protein in Pfam PF00497, SBP_bac_3, 1 hit |
SMARTi | View protein in SMART SM00062, PBPb, 1 hit |
PROSITEi | View protein in PROSITE PS01039, SBP_BACTERIAL_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q01269-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPKSFRHLVQ ALACLALLAS ASLQAQESRL DRILESGVLR VATTGDYKPF
60 70 80 90 100
SYRTEEGGYA GFDVDMAQRL AESLGAKLVV VPTSWPNLMR DFADDRFDIA
110 120 130 140 150
MSGISINLER QRQAYFSIPY LRDGKTPITL CSEEARFQTL EQIDQPGVTA
160 170 180 190 200
IVNPGGTNEK FARANLKKAR ILVHPDNVTI FQQIVDGKAD LMMTDAIEAR
210 220 230 240 250
LQSRLHPELC AVHPQQPFDF AEKAYLLPRD EAFKRYVDQW LHIAEQSGLL
260
RQRMEHWLEY RWPTAHGK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 42 | A → T in AAC08596 (PubMed:1733946).Curated | 1 | |
Sequence conflicti | 115 | Y → H in AAC08596 (PubMed:1733946).Curated | 1 | |
Sequence conflicti | 123 – 124 | DG → NS in AAC08596 (PubMed:1733946).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF054868 Genomic DNA Translation: AAC08596.1 AE004091 Genomic DNA Translation: AAG06863.1 |
PIRi | B42325 H83211 |
RefSeqi | NP_252165.1, NC_002516.2 WP_003092003.1, NZ_QZGE01000039.1 |
Genome annotation databases
EnsemblBacteriai | AAG06863; AAG06863; PA3475 |
GeneIDi | 878976 |
KEGGi | pae:PA3475 |
PATRICi | fig|208964.12.peg.3638 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF054868 Genomic DNA Translation: AAC08596.1 AE004091 Genomic DNA Translation: AAG06863.1 |
PIRi | B42325 H83211 |
RefSeqi | NP_252165.1, NC_002516.2 WP_003092003.1, NZ_QZGE01000039.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3KBR | X-ray | 1.66 | A | 26-261 | [»] | |
5HPQ | X-ray | 2.05 | A | 26-268 | [»] | |
AlphaFoldDBi | Q01269 | |||||
SMRi | Q01269 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 287.DR97_4446 |
Proteomic databases
PaxDbi | Q01269 |
Protocols and materials databases
DNASUi | 878976 |
Genome annotation databases
EnsemblBacteriai | AAG06863; AAG06863; PA3475 |
GeneIDi | 878976 |
KEGGi | pae:PA3475 |
PATRICi | fig|208964.12.peg.3638 |
Organism-specific databases
PseudoCAPi | PA3475 |
Phylogenomic databases
HOGENOMi | CLU_019602_9_0_6 |
InParanoidi | Q01269 |
OMAi | MQYGEKA |
PhylomeDBi | Q01269 |
Enzyme and pathway databases
UniPathwayi | UPA00121;UER00344 UPA00121;UER00345 |
BRENDAi | 4.2.1.91, 5087 |
SABIO-RKi | Q01269 |
Miscellaneous databases
EvolutionaryTracei | Q01269 |
Family and domain databases
CDDi | cd01069, PBP2_PheC, 1 hit |
InterProi | View protein in InterPro IPR037298, PheC_PBP2 IPR018313, SBP_3_CS IPR001638, Solute-binding_3/MltF_N |
Pfami | View protein in Pfam PF00497, SBP_bac_3, 1 hit |
SMARTi | View protein in SMART SM00062, PBPb, 1 hit |
PROSITEi | View protein in PROSITE PS01039, SBP_BACTERIAL_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PHEC_PSEAE | |
Accessioni | Q01269Primary (citable) accession number: Q01269 Secondary accession number(s): Q9HYD3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | January 11, 2001 | |
Last modified: | May 25, 2022 | |
This is version 132 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families