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Protein

Gap junction alpha-5 protein

Gene

Gja5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-5 protein
Alternative name(s):
Connexin-40
Short name:
Cx40
Gene namesi
Name:Gja5
Synonyms:Cxn-40
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:95716 Gja5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 76ExtracellularSequence analysisAdd BLAST36
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 164CytoplasmicSequence analysisAdd BLAST67
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 205ExtracellularSequence analysisAdd BLAST20
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 358CytoplasmicSequence analysisAdd BLAST132

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578201 – 358Gap junction alpha-5 proteinAdd BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei353PhosphoserineBy similarity1
Modified residuei357PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ01231
PaxDbiQ01231
PRIDEiQ01231

PTM databases

iPTMnetiQ01231
PhosphoSitePlusiQ01231

Expressioni

Tissue specificityi

Kidney, heart and skin, but most abundant in lung.

Gene expression databases

BgeeiENSMUSG00000057123 Expressed in 59 organ(s), highest expression level in cardiac atrium
CleanExiMM_GJA5
ExpressionAtlasiQ01231 baseline and differential
GenevisibleiQ01231 MM

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088264

Structurei

3D structure databases

DisProtiDP00646
ProteinModelPortaliQ01231
SMRiQ01231
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF3Z Eukaryota
ENOG410ZC96 LUCA
GeneTreeiENSGT00910000143998
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiQ01231
KOiK07614
OMAiECQLPGP
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002264 Connexin40
IPR034634 Connexin_C
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
IPR031862 Cx40_C
PANTHERiPTHR11984 PTHR11984, 1 hit
PTHR11984:SF13 PTHR11984:SF13, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PF16791 Connexin40_C, 1 hit
PRINTSiPR00206 CONNEXIN
PR01135 CONNEXINA5
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
SUPFAMiSSF118220 SSF118220, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q01231-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDWSFLGEF LEEVHKHSTV IGKVWLTVLF IFRMLVLGTA AESSWGDEQA
60 70 80 90 100
DFRCDTIQPG CQNVCYDQAF PISHIRYWVL QIIFVSTPSL VYMGHAMHTV
110 120 130 140 150
RMQEKQKLRD AEKAKEAHRT GAYEYPVAEK AELSCWKEVD GKIVLQGTLL
160 170 180 190 200
NTYVCTILIR TTMEVAFIVG QYLLYGIFLD TLHVCRRSPC PHPVNCYVSR
210 220 230 240 250
PTEKNVFIVF MMAVAGLSLF LSLAELYHLG WKKIRQRFGK SRQGVDKHQL
260 270 280 290 300
PGPPTSLVQS LTPPPDFNQC LKNSSGEKFF SDFSNNMGSR KNPDALATGE
310 320 330 340 350
VPNQEQIPGE GFIHMHYSQK PEYASGASAG HRLPQGYHSD KRRLSKASSK

ARSDDLSV
Length:358
Mass (Da):40,413
Last modified:January 23, 2007 - v2
Checksum:iC5418F657142896A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8CAG8Q8CAG8_MOUSE
Gap junction protein
Gja5
368Annotation score:
Q6TPI9Q6TPI9_MOUSE
Connexin 40
Gja5
81Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61675 Genomic DNA Translation: CAA43850.1
BC053054 mRNA Translation: AAH53054.1
CCDSiCCDS17652.1
PIRiS23111
RefSeqiNP_001258557.1, NM_001271628.1
NP_032147.1, NM_008121.3
UniGeneiMm.281816

Genome annotation databases

EnsembliENSMUST00000072600; ENSMUSP00000088264; ENSMUSG00000057123
GeneIDi14613
KEGGimmu:14613
UCSCiuc008qoo.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61675 Genomic DNA Translation: CAA43850.1
BC053054 mRNA Translation: AAH53054.1
CCDSiCCDS17652.1
PIRiS23111
RefSeqiNP_001258557.1, NM_001271628.1
NP_032147.1, NM_008121.3
UniGeneiMm.281816

3D structure databases

DisProtiDP00646
ProteinModelPortaliQ01231
SMRiQ01231
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088264

PTM databases

iPTMnetiQ01231
PhosphoSitePlusiQ01231

Proteomic databases

MaxQBiQ01231
PaxDbiQ01231
PRIDEiQ01231

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072600; ENSMUSP00000088264; ENSMUSG00000057123
GeneIDi14613
KEGGimmu:14613
UCSCiuc008qoo.2 mouse

Organism-specific databases

CTDi2702
MGIiMGI:95716 Gja5

Phylogenomic databases

eggNOGiENOG410IF3Z Eukaryota
ENOG410ZC96 LUCA
GeneTreeiENSGT00910000143998
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiQ01231
KOiK07614
OMAiECQLPGP
TreeFamiTF329606

Enzyme and pathway databases

ReactomeiR-MMU-190861 Gap junction assembly

Miscellaneous databases

PROiPR:Q01231
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057123 Expressed in 59 organ(s), highest expression level in cardiac atrium
CleanExiMM_GJA5
ExpressionAtlasiQ01231 baseline and differential
GenevisibleiQ01231 MM

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002264 Connexin40
IPR034634 Connexin_C
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
IPR031862 Cx40_C
PANTHERiPTHR11984 PTHR11984, 1 hit
PTHR11984:SF13 PTHR11984:SF13, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PF16791 Connexin40_C, 1 hit
PRINTSiPR00206 CONNEXIN
PR01135 CONNEXINA5
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
SUPFAMiSSF118220 SSF118220, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXA5_MOUSE
AccessioniPrimary (citable) accession number: Q01231
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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