UniProtKB - Q01231 (CXA5_MOUSE)
Protein
Gap junction alpha-5 protein
Gene
Gja5
Organism
Mus musculus (Mouse)
Status
Functioni
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
GO - Molecular functioni
- connexin binding Source: MGI
- disordered domain specific binding Source: MGI
- gap junction channel activity Source: MGI
- gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling Source: MGI
- gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling Source: MGI
- gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling Source: MGI
- gap junction channel activity involved in cardiac conduction electrical coupling Source: MGI
- gap junction hemi-channel activity Source: MGI
GO - Biological processi
- angiogenesis Source: Ensembl
- artery morphogenesis Source: BHF-UCL
- atrial cardiac muscle cell to AV node cell communication by electrical coupling Source: BHF-UCL
- atrial septum development Source: MGI
- atrial septum morphogenesis Source: MGI
- atrial ventricular junction remodeling Source: MGI
- AV node cell to bundle of His cell communication Source: MGI
- AV node cell to bundle of His cell communication by electrical coupling Source: BHF-UCL
- blood vessel development Source: MGI
- bundle of His cell to Purkinje myocyte communication by electrical coupling Source: MGI
- cardiac conduction Source: MGI
- cardiac conduction system development Source: MGI
- cell-cell signaling Source: GO_Central
- cell communication by chemical coupling Source: MGI
- cell communication by electrical coupling Source: MGI
- cell communication by electrical coupling involved in cardiac conduction Source: MGI
- cell communication involved in cardiac conduction Source: MGI
- embryonic heart tube development Source: MGI
- embryonic limb morphogenesis Source: MGI
- endothelium development Source: Ensembl
- foramen ovale closure Source: MGI
- gap junction assembly Source: MGI
- mitral valve development Source: MGI
- negative regulation of blood pressure Source: MGI
- negative regulation of glomerular filtration Source: MGI
- outflow tract morphogenesis Source: MGI
- positive regulation of blood vessel diameter Source: MGI
- positive regulation of cell communication by chemical coupling Source: MGI
- positive regulation of vasoconstriction Source: MGI
- potassium ion transport Source: MGI
- pulmonary valve formation Source: MGI
- regulation of atrial cardiac muscle cell action potential Source: MGI
- regulation of atrial cardiac muscle cell membrane depolarization Source: MGI
- regulation of AV node cell action potential Source: BHF-UCL
- regulation of blood vessel diameter Source: MGI
- regulation of bundle of His cell action potential Source: BHF-UCL
- regulation of cardiac muscle contraction Source: MGI
- regulation of cell communication by electrical coupling Source: MGI
- regulation of heart rate by cardiac conduction Source: MGI
- regulation of membrane depolarization during cardiac muscle cell action potential Source: MGI
- regulation of Purkinje myocyte action potential Source: MGI
- regulation of renin secretion into blood stream Source: MGI
- regulation of systemic arterial blood pressure Source: MGI
- regulation of ventricular cardiac muscle cell membrane depolarization Source: MGI
- regulation of ventricular cardiac muscle cell membrane repolarization Source: MGI
- renal system process involved in regulation of systemic arterial blood pressure Source: MGI
- SA node cell action potential Source: MGI
- septum primum development Source: MGI
- skeletal system development Source: MGI
- vasomotion Source: MGI
- ventricular cardiac muscle cell action potential Source: MGI
- ventricular septum development Source: MGI
- ventricular septum morphogenesis Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-190861, Gap junction assembly |
Names & Taxonomyi
Protein namesi | Recommended name: Gap junction alpha-5 proteinAlternative name(s): Connexin-40 Short name: Cx40 |
Gene namesi | Name:Gja5 Synonyms:Cxn-40 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95716, Gja5 |
Subcellular locationi
Plasma membrane
Other locations
Plasma Membrane
- connexin complex Source: MGI
- integral component of plasma membrane Source: MGI
Other locations
- cell projection Source: MGI
- gap junction Source: MGI
- intercalated disc Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 19 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 20 – 40 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 41 – 76 | ExtracellularSequence analysisAdd BLAST | 36 | |
Transmembranei | 77 – 97 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 98 – 164 | CytoplasmicSequence analysisAdd BLAST | 67 | |
Transmembranei | 165 – 185 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 186 – 205 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 206 – 226 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 227 – 358 | CytoplasmicSequence analysisAdd BLAST | 132 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Gap junction, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000057820 | 1 – 358 | Gap junction alpha-5 proteinAdd BLAST | 358 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 353 | PhosphoserineBy similarity | 1 | |
Modified residuei | 357 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q01231 |
PaxDbi | Q01231 |
PRIDEi | Q01231 |
PTM databases
iPTMneti | Q01231 |
PhosphoSitePlusi | Q01231 |
Expressioni
Tissue specificityi
Kidney, heart and skin, but most abundant in lung.
Gene expression databases
Bgeei | ENSMUSG00000057123, Expressed in cardiac atrium and 100 other tissues |
Genevisiblei | Q01231, MM |
Interactioni
Subunit structurei
A connexon is composed of a hexamer of connexins.
GO - Molecular functioni
- connexin binding Source: MGI
- disordered domain specific binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000088264 |
Miscellaneous databases
RNActi | Q01231, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QW11, Eukaryota |
GeneTreei | ENSGT01000000214463 |
HOGENOMi | CLU_037388_0_0_1 |
InParanoidi | Q01231 |
OMAi | LYVCKAW |
OrthoDBi | 992551at2759 |
TreeFami | TF329606 |
Family and domain databases
DisProti | DP00646 |
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR002264, Connexin40 IPR034634, Connexin_C IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf IPR031862, Cx40_C |
PANTHERi | PTHR11984, PTHR11984, 1 hit PTHR11984:SF13, PTHR11984:SF13, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit PF16791, Connexin40_C, 1 hit |
PRINTSi | PR00206, CONNEXIN PR01135, CONNEXINA5 |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
SUPFAMi | SSF118220, SSF118220, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q01231-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDWSFLGEF LEEVHKHSTV IGKVWLTVLF IFRMLVLGTA AESSWGDEQA
60 70 80 90 100
DFRCDTIQPG CQNVCYDQAF PISHIRYWVL QIIFVSTPSL VYMGHAMHTV
110 120 130 140 150
RMQEKQKLRD AEKAKEAHRT GAYEYPVAEK AELSCWKEVD GKIVLQGTLL
160 170 180 190 200
NTYVCTILIR TTMEVAFIVG QYLLYGIFLD TLHVCRRSPC PHPVNCYVSR
210 220 230 240 250
PTEKNVFIVF MMAVAGLSLF LSLAELYHLG WKKIRQRFGK SRQGVDKHQL
260 270 280 290 300
PGPPTSLVQS LTPPPDFNQC LKNSSGEKFF SDFSNNMGSR KNPDALATGE
310 320 330 340 350
VPNQEQIPGE GFIHMHYSQK PEYASGASAG HRLPQGYHSD KRRLSKASSK
ARSDDLSV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8CAG8 | Q8CAG8_MOUSE | Gap junction protein | Gja5 | 368 | Annotation score: | ||
Q6TPI9 | Q6TPI9_MOUSE | Connexin-40 | Gja5 | 81 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X61675 Genomic DNA Translation: CAA43850.1 BC053054 mRNA Translation: AAH53054.1 |
CCDSi | CCDS17652.1 |
PIRi | S23111 |
RefSeqi | NP_001258557.1, NM_001271628.1 NP_032147.1, NM_008121.3 |
Genome annotation databases
Ensembli | ENSMUST00000072600; ENSMUSP00000088264; ENSMUSG00000057123 |
GeneIDi | 14613 |
KEGGi | mmu:14613 |
UCSCi | uc008qoo.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X61675 Genomic DNA Translation: CAA43850.1 BC053054 mRNA Translation: AAH53054.1 |
CCDSi | CCDS17652.1 |
PIRi | S23111 |
RefSeqi | NP_001258557.1, NM_001271628.1 NP_032147.1, NM_008121.3 |
3D structure databases
SMRi | Q01231 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000088264 |
PTM databases
iPTMneti | Q01231 |
PhosphoSitePlusi | Q01231 |
Proteomic databases
MaxQBi | Q01231 |
PaxDbi | Q01231 |
PRIDEi | Q01231 |
Protocols and materials databases
Antibodypediai | 72405, 287 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000072600; ENSMUSP00000088264; ENSMUSG00000057123 |
GeneIDi | 14613 |
KEGGi | mmu:14613 |
UCSCi | uc008qoo.2, mouse |
Organism-specific databases
CTDi | 2702 |
MGIi | MGI:95716, Gja5 |
Phylogenomic databases
eggNOGi | ENOG502QW11, Eukaryota |
GeneTreei | ENSGT01000000214463 |
HOGENOMi | CLU_037388_0_0_1 |
InParanoidi | Q01231 |
OMAi | LYVCKAW |
OrthoDBi | 992551at2759 |
TreeFami | TF329606 |
Enzyme and pathway databases
Reactomei | R-MMU-190861, Gap junction assembly |
Miscellaneous databases
BioGRID-ORCSi | 14613, 2 hits in 18 CRISPR screens |
ChiTaRSi | Gja5, mouse |
PROi | PR:Q01231 |
RNActi | Q01231, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000057123, Expressed in cardiac atrium and 100 other tissues |
Genevisiblei | Q01231, MM |
Family and domain databases
DisProti | DP00646 |
Gene3Di | 1.20.1440.80, 1 hit |
InterProi | View protein in InterPro IPR000500, Connexin IPR002264, Connexin40 IPR034634, Connexin_C IPR019570, Connexin_CCC IPR017990, Connexin_CS IPR013092, Connexin_N IPR038359, Connexin_N_sf IPR031862, Cx40_C |
PANTHERi | PTHR11984, PTHR11984, 1 hit PTHR11984:SF13, PTHR11984:SF13, 1 hit |
Pfami | View protein in Pfam PF00029, Connexin, 1 hit PF16791, Connexin40_C, 1 hit |
PRINTSi | PR00206, CONNEXIN PR01135, CONNEXINA5 |
SMARTi | View protein in SMART SM00037, CNX, 1 hit SM01089, Connexin_CCC, 1 hit |
SUPFAMi | SSF118220, SSF118220, 1 hit |
PROSITEi | View protein in PROSITE PS00407, CONNEXINS_1, 1 hit PS00408, CONNEXINS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXA5_MOUSE | |
Accessioni | Q01231Primary (citable) accession number: Q01231 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families