Gap junction alpha-5 protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• connexin binding Source: MGI
• disordered domain specific binding Source: MGI
• gap junction channel activity Source: MGI
• gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling Source: MGI
• gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling Source: MGI
• gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling Source: MGI
• gap junction channel activity involved in cardiac conduction electrical coupling Source: MGI
• gap junction hemi-channel activity Source: MGI

GO - Biological processⁱ

• angiogenesis Source: Ensembl
• artery morphogenesis Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 20530546
• atrial cardiac muscle cell to AV node cell communication by electrical coupling Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 10515563
• atrial septum development Source: MGI
• atrial septum morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 10969038
• atrial ventricular junction remodeling Source: MGIInferred from mutant phenotypeⁱ
  • 10969038
• AV node cell to bundle of His cell communication Source: MGIInferred from mutant phenotypeⁱ
  • 10515563
• AV node cell to bundle of His cell communication by electrical coupling Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 10515563
• blood vessel development Source: MGIInferred from mutant phenotypeⁱ
  • 12435353
• bundle of His cell to Purkinje myocyte communication by electrical coupling Source: MGI
• cardiac conduction Source: MGIInferred from mutant phenotypeⁱ
  • 10515563
  • 10969038
  • 18599871
  • 9501069
  • 9501070
• cardiac conduction system development Source: MGIInferred from mutant phenotypeⁱ
  • 18599871
  • 22203979
• cell communication by chemical coupling Source: MGI
• cell communication by electrical coupling Source: MGI
• cell communication by electrical coupling involved in cardiac conduction Source: MGIInferred from mutant phenotypeⁱ
  • 11046183
• cell communication involved in cardiac conduction Source: MGIInferred from mutant phenotypeⁱ
  • 10747000
• embryonic heart tube development Source: MGIInferred from mutant phenotypeⁱ
  • 14732399
  • 22203979
• embryonic limb morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 15923624
• endothelium development Source: Ensembl
• foramen ovale closure Source: MGIInferred from mutant phenotypeⁱ
  • 10969038
• gap junction assembly Source: MGI
• mitral valve development Source: MGI
• negative regulation of blood pressure Source: MGI
• negative regulation of glomerular filtration Source: MGI
• outflow tract morphogenesis Source: MGI
• positive regulation of blood vessel diameter Source: MGI
• positive regulation of cell communication by chemical coupling Source: MGI
• positive regulation of vasoconstriction Source: MGI
• potassium ion transport Source: MGI
• protein complex oligomerization Source: MGI
• pulmonary valve formation Source: MGI
• regulation of atrial cardiac muscle cell action potential Source: MGI
• regulation of atrial cardiac muscle cell membrane depolarization Source: MGIInferred from mutant phenotypeⁱ
  • 10515563
  • 10969038
  • 9501070
• regulation of AV node cell action potential Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 10515563
• regulation of blood vessel diameter Source: MGIInferred from mutant phenotypeⁱ
  • 10747000
• regulation of bundle of His cell action potential Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 10515563
• regulation of cardiac muscle contraction Source: MGI
• regulation of heart rate by cardiac conduction Source: MGIInferred from mutant phenotypeⁱ
  • 11046183
• regulation of membrane depolarization during cardiac muscle cell action potential Source: MGIInferred from mutant phenotypeⁱ
  • 9501070
• regulation of Purkinje myocyte action potential Source: MGI
• regulation of renin secretion into blood stream Source: MGIInferred from mutant phenotypeⁱ
  • 17255527
• regulation of systemic arterial blood pressure Source: MGIInferred from mutant phenotypeⁱ
  • 10747000
• regulation of ventricular cardiac muscle cell membrane depolarization Source: MGIInferred from mutant phenotypeⁱ
  • 10515563
  • 9501070
• regulation of ventricular cardiac muscle cell membrane repolarization Source: MGIInferred from mutant phenotypeⁱ
  • 10969038
• renal system process involved in regulation of systemic arterial blood pressure Source: MGIInferred from mutant phenotypeⁱ
  • 17255527
• SA node cell action potential Source: MGIInferred from mutant phenotypeⁱ
  • 11046183
• septum primum development Source: MGIInferred from mutant phenotypeⁱ
  • 10969038
• skeletal system development Source: MGIInferred from mutant phenotypeⁱ
  • 15923624
• vasomotion Source: MGI
• ventricular cardiac muscle cell action potential Source: MGIInferred from mutant phenotypeⁱ
  • 9501070
• ventricular septum development Source: MGI
• ventricular septum morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 10969038

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• connexin binding Source: MGI
• disordered domain specific binding Source: MGI

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MGDWSFLGEF LEEVHKHSTV IGKVWLTVLF IFRMLVLGTA AESSWGDEQA 
        60         70         80         90        100
DFRCDTIQPG CQNVCYDQAF PISHIRYWVL QIIFVSTPSL VYMGHAMHTV 
       110        120        130        140        150
RMQEKQKLRD AEKAKEAHRT GAYEYPVAEK AELSCWKEVD GKIVLQGTLL 
       160        170        180        190        200
NTYVCTILIR TTMEVAFIVG QYLLYGIFLD TLHVCRRSPC PHPVNCYVSR 
       210        220        230        240        250
PTEKNVFIVF MMAVAGLSLF LSLAELYHLG WKKIRQRFGK SRQGVDKHQL 
       260        270        280        290        300
PGPPTSLVQS LTPPPDFNQC LKNSSGEKFF SDFSNNMGSR KNPDALATGE 
       310        320        330        340        350
VPNQEQIPGE GFIHMHYSQK PEYASGASAG HRLPQGYHSD KRRLSKASSK 

ARSDDLSV                                               

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot