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UniProtKB - Q01220 (A52_VACCW)
Protein
Protein A52
Gene
VACWR178
Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Functioni
Bcl-2-like protein which targets host toll-like receptor signaling complexes to suppress innate immune response. Interacts with host TRAF6 to activate p38 and subsequently induce the expression of several cytokines such as IL-10. Associates also with host IRAK2 to inhibit NF-kappa-B signaling.
1 PublicationGO - Biological processi
- suppression by virus of host innate immune response Source: UniProtKB-KW
- suppression by virus of host NF-kappaB cascade Source: UniProtKB-KW
- suppression by virus of host TRAF activity Source: UniProtKB-KW
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Protein A52 |
Gene namesi | Ordered Locus Names:VACWR178 ORF Names:A52R |
Organismi | Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) |
Taxonomic identifieri | 10254 [NCBI] |
Taxonomic lineagei | Viruses › Varidnaviria › Bamfordvirae › Nucleocytoviricota › Pokkesviricetes › Chitovirales › Poxviridae › Chordopoxvirinae › Orthopoxvirus › Vaccinia virus |
Virus hosti | Bos taurus (Bovine) [TaxID: 9913] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000099350 | 1 – 190 | Protein A52Add BLAST | 190 |
Interactioni
Subunit structurei
Interacts with host TRAF6 and IRAK2.
1 PublicationBinary interactionsi
Q01220
With | #Exp. | IntAct |
---|---|---|
TRAF6 [Q9Y4K3] from Homo sapiens. | 2 | EBI-3863691,EBI-359276 |
Protein-protein interaction databases
IntActi | Q01220, 21 interactors |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q01220 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q01220 |
Family & Domainsi
Sequence similaritiesi
Belongs to the orthopoxvirus A52R protein family.Curated
Family and domain databases
Gene3Di | 1.10.437.20, 1 hit |
InterProi | View protein in InterPro IPR022819, Poxvirus_Bcl-2-like IPR043018, Poxvirus_sf |
Pfami | View protein in Pfam PF06227, Poxvirus, 1 hit |
i Sequence
Sequence statusi: Complete.
Q01220-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDIKIDISIS GDKFTVTTRR ENEERKKYLP LQKEKTTDVI KPDYLEYDDL
60 70 80 90 100
LDRDEMFTIL EEYFMYRGLL GLRIKYGRLF NEIKKFDNDA EEQFGTIEEL
110 120 130 140 150
KQKLRLNSEE GADNFIDYIK VQKQDIVKLT VYDCISMIGL CACVVDVWRN
160 170 180 190
EKLFSRWKYC LRAIKLFIND HMLDKIKSIL QNRLVYVEMS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D11079 Genomic DNA Translation: BAA01826.1 AY243312 Genomic DNA Translation: AAO89457.1 |
PIRi | JQ1790 |
RefSeqi | YP_233060.1, NC_006998.1 |
Genome annotation databases
GeneIDi | 3707707 |
KEGGi | vg:3707707 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D11079 Genomic DNA Translation: BAA01826.1 AY243312 Genomic DNA Translation: AAO89457.1 |
PIRi | JQ1790 |
RefSeqi | YP_233060.1, NC_006998.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2VVW | X-ray | 1.90 | A/B | 37-190 | [»] | |
2VVX | X-ray | 2.75 | A/B | 37-190 | [»] | |
SMRi | Q01220 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | Q01220, 21 interactors |
Protocols and materials databases
DNASUi | 3707707 |
Genome annotation databases
GeneIDi | 3707707 |
KEGGi | vg:3707707 |
Miscellaneous databases
EvolutionaryTracei | Q01220 |
Family and domain databases
Gene3Di | 1.10.437.20, 1 hit |
InterProi | View protein in InterPro IPR022819, Poxvirus_Bcl-2-like IPR043018, Poxvirus_sf |
Pfami | View protein in Pfam PF06227, Poxvirus, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A52_VACCW | |
Accessioni | Q01220Primary (citable) accession number: Q01220 Secondary accession number(s): Q76ZM6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | February 23, 2022 | |
This is version 71 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families