RELB

Functionⁱ

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063).5 Publications

Caution

Was originally thought to inhibit the transcriptional activity of nuclear factor NF-kappa-B.1 Publication

GO - Molecular functionⁱ

chromatin binding Source: GO_Central
DNA binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 8188306
identical protein binding Source: Ensembl
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20873783
RNA polymerase II distal enhancer sequence-specific DNA binding Source: UniProtKB
RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcription corepressor activity
Source: ProtInc
Traceable author statementⁱ
- 1577270

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antigen processing and presentation Source: Ensembl
cellular response to osmotic stress Source: Ensembl
circadian regulation of gene expression Source: UniProtKB
I-kappaB kinase/NF-kappaB signaling Source: GO_Central
inflammatory response Source: GO_Central
innate immune response Source: GO_Central
lymphocyte differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26385063
myeloid dendritic cell differentiation Source: Ensembl
negative regulation of interferon-beta production
Source: CACAO
Inferred from mutant phenotypeⁱ
- 22065573
negative regulation of transcription by RNA polymerase II Source: GO_Central
NIK/NF-kappaB signaling Source: GO_Central
positive regulation of transcription by RNA polymerase II Source: GO_Central
response to cytokine Source: GO_Central
stimulatory C-type lectin receptor signaling pathway Source: Reactome
T-helper 1 cell differentiation Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Biological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5621575 CD209 (DC-SIGN) signaling R-HSA-5676590 NIK-->noncanonical NF-kB signaling
SIGNORⁱ	Q01201

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor RelB Alternative name(s): I-Rel
Gene namesⁱ	Name:RELB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000104856.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9956 RELB
MIMⁱ	604758 gene
neXtProtⁱ	NX_Q01201

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Immunodeficiency 53 (IMD53)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive primary immunodeficiency apparent from early infancy and resulting in recurrent infections, severe autoimmune skin disease rheumatoid arthritis, and failure to thrive. Immunologic workup shows increased CD4+/CD8+ ratio, impaired T-cell proliferative response to multiple antigen, T-cell developmental and functional defects, and impaired ability to produce specific immunoglobulins.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_079201	397 – 579	Missing in IMD53. 1 PublicationAdd BLAST		183

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5971
MalaCards human disease database More...MalaCardsⁱ	RELB
MIMⁱ	617585 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000104856
PharmGKBⁱ	PA34322

Polymorphism and mutation databases

BioMutaⁱ	RELB
DMDMⁱ	92090634

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000205173	1 – 579	Transcription factor RelBAdd BLAST		579

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	16	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	37	PhosphoserineCombined sources	1
Modified residueⁱ	573	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation.By similarity

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q01201
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q01201
PaxDbⁱ	Q01201
PeptideAtlas More...PeptideAtlasⁱ	Q01201
PRIDEⁱ	Q01201
ProteomicsDBⁱ	57938

PTM databases

iPTMnetⁱ	Q01201
PhosphoSitePlusⁱ	Q01201

Expressionⁱ

Inductionⁱ

Up-regulated by mitogens and NUPR1.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000104856
CleanExⁱ	HS_RELB
ExpressionAtlasⁱ	Q01201 baseline and differential
Genevisibleⁱ	Q01201 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB007753 HPA040506

HPAⁱ

CAB007753
HPA040506

Interactionⁱ

Subunit structureⁱ

Component of the NF-kappa-B RelB-p50 complex. Component of the NF-kappa-B RelB-p52 complex. Self-associates; the interaction seems to be transient and may prevent degradation allowing for heterodimer formation with p50 or p52. Interacts with NFKB1/p50, NFKB2/p52 and NFKB2/p100. Interacts with NFKBID. Interacts with ARNTL/BMAL1 and the interaction is enhanced in the presence of CLOCK (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
COMMD1	Q8N668	2	EBI-357837,EBI-1550112
GSK3B	P49841	4	EBI-357837,EBI-373586
NFKB1	P19838	3	EBI-357837,EBI-300010
NFKB2	D3DR86	2	EBI-357837,EBI-307345
NFKB2	Q00653	2	EBI-357837,EBI-307326
RELA	Q04206	2	EBI-357837,EBI-73886

Show more details

GO - Molecular functionⁱ

identical protein binding Source: Ensembl
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20873783

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111903, 52 interactors
CORUMⁱ	Q01201
Database of interacting proteins More...DIPⁱ	DIP-27531N
IntActⁱ	Q01201, 81 interactors
Molecular INTeraction database More...MINTⁱ	Q01201
STRINGⁱ	9606.ENSP00000221452

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q01201
SMRⁱ	Q01201
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	125 – 440	RHDPROSITE-ProRule annotationAdd BLAST		316

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	40 – 68	Leucine-zipperAdd BLAST		29

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	433 – 438	Nuclear localization signalSequence analysis		6

Domainⁱ

Both N- and C-terminal domains are required for transcriptional activation.

Phylogenomic databases

eggNOGⁱ	ENOG410IFBK Eukaryota ENOG410ZMME LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00500000044765
HOGENOMⁱ	HOG000148598
HOVERGENⁱ	HBG017021
InParanoidⁱ	Q01201
KEGG Orthology (KO) More...KOⁱ	K09253
OMAⁱ	DFFSGTV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08JD
PhylomeDBⁱ	Q01201
TreeFamⁱ	TF325632

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01177 IPT_NFkappaB, 1 hit
Gene3Dⁱ	2.60.40.10, 1 hit 2.60.40.340, 1 hit
InterProⁱ	View protein in InterPro IPR013783 Ig-like_fold IPR014756 Ig_E-set IPR002909 IPT_dom IPR033926 IPT_NFkappaB IPR000451 NFkB/Dor IPR008967 p53-like_TF_DNA-bd IPR030496 RelB IPR032399 RelB_leu_zip IPR032400 RelB_transact IPR030492 RHD_CS IPR032397 RHD_dimer IPR011539 RHD_DNA_bind_dom IPR037059 RHD_DNA_bind_dom_sf
PANTHERⁱ	PTHR24169 PTHR24169, 1 hit PTHR24169:SF18 PTHR24169:SF18, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16180 RelB_leu_zip, 1 hit PF16181 RelB_transactiv, 1 hit PF16179 RHD_dimer, 1 hit PF00554 RHD_DNA_bind, 1 hit
PRINTSⁱ	PR00057 NFKBTNSCPFCT
SMARTⁱ	View protein in SMART SM00429 IPT, 1 hit
SUPFAMⁱ	SSF49417 SSF49417, 1 hit SSF81296 SSF81296, 1 hit
PROSITEⁱ	View protein in PROSITE PS01204 REL_1, 1 hit PS50254 REL_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q01201-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLRSGPASGP SVPTGRAMPS RRVARPPAAP ELGALGSPDL SSLSLAVSRS 
        60         70         80         90        100
TDELEIIDEY IKENGFGLDG GQPGPGEGLP RLVSRGAASL STVTLGPVAP 
       110        120        130        140        150
PATPPPWGCP LGRLVSPAPG PGPQPHLVIT EQPKQRGMRF RYECEGRSAG 
       160        170        180        190        200
SILGESSTEA SKTLPAIELR DCGGLREVEV TACLVWKDWP HRVHPHSLVG 
       210        220        230        240        250
KDCTDGICRV RLRPHVSPRH SFNNLGIQCV RKKEIEAAIE RKIQLGIDPY 
       260        270        280        290        300
NAGSLKNHQE VDMNVVRICF QASYRDQQGQ MRRMDPVLSE PVYDKKSTNT 
       310        320        330        340        350
SELRICRINK ESGPCTGGEE LYLLCDKVQK EDISVVFSRA SWEGRADFSQ 
       360        370        380        390        400
ADVHRQIAIV FKTPPYEDLE IVEPVTVNVF LQRLTDGVCS EPLPFTYLPR 
       410        420        430        440        450
DHDSYGVDKK RKRGMPDVLG ELNSSDPHGI ESKRRKKKPA ILDHFLPNHG 
       460        470        480        490        500
SGPFLPPSAL LPDPDFFSGT VSLPGLEPPG GPDLLDDGFA YDPTAPTLFT 
       510        520        530        540        550
MLDLLPPAPP HASAVVCSGG AGAVVGETPG PEPLTLDSYQ APGPGDGGTA 
       560        570 
SLVGSNMFPN HYREAAFGGG LLSPGPEAT

Length:579

Mass (Da):62,134

Last modified:April 4, 2006 - v2

Checksum:ⁱC2C61C2C8640513E

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	139	R → P in AAA36127 (PubMed:1577270).Curated		1
Sequence conflictⁱ	411	R → A in AAA36127 (PubMed:1577270).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051782	396	T → M. Corresponds to variant dbSNP:rs2230682Ensembl.		1
Natural variantⁱVAR_079201	397 – 579	Missing in IMD53. 1 PublicationAdd BLAST		183

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M83221 mRNA Translation: AAA36127.1 AF043463 AF043462 Genomic DNA Translation: AAC82346.1 DQ314887 Genomic DNA Translation: ABC40746.1 BC028013 mRNA Translation: AAH28013.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS46110.1
PIRⁱ	A42617
NCBI Reference Sequences More...RefSeqⁱ	NP_006500.2, NM_006509.3
UniGeneⁱ	Hs.654402

Genome annotation databases

Ensemblⁱ	ENST00000221452; ENSP00000221452; ENSG00000104856 ENST00000625761; ENSP00000485826; ENSG00000104856
GeneIDⁱ	5971
KEGGⁱ	hsa:5971
UCSC genome browser More...UCSCⁱ	uc060zvi.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q01201	UPI000C2FABA9		FELCA		664
UPI000CEF78F3		PONAB		591
UPI00046B7AB9		EPTFU		579
RELB isoform 1		PANTR		579
UPI0006C9D43A		PANPA		442
+95

Protein	Similar proteins		Species	Score	Length
Q01201	Transcription factor RelB	)	MOUSE		558
UPI0004E47CB5		RAT		559
UPI00038BBED4		MICOH		559
UPI000B4FB793		MERUN		558
UPI000A30B21E		MUSPA		558
+134

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M83221 mRNA Translation: AAA36127.1 AF043463 AF043462 Genomic DNA Translation: AAC82346.1 DQ314887 Genomic DNA Translation: ABC40746.1 BC028013 mRNA Translation: AAH28013.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS46110.1
PIRⁱ	A42617
NCBI Reference Sequences More...RefSeqⁱ	NP_006500.2, NM_006509.3
UniGeneⁱ	Hs.654402

3D structure databases

ProteinModelPortalⁱ	Q01201
SMRⁱ	Q01201
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111903, 52 interactors
CORUMⁱ	Q01201
Database of interacting proteins More...DIPⁱ	DIP-27531N
IntActⁱ	Q01201, 81 interactors
Molecular INTeraction database More...MINTⁱ	Q01201
STRINGⁱ	9606.ENSP00000221452

PTM databases

iPTMnetⁱ	Q01201
PhosphoSitePlusⁱ	Q01201

Polymorphism and mutation databases

BioMutaⁱ	RELB
DMDMⁱ	92090634

Proteomic databases

EPDⁱ	Q01201
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q01201
PaxDbⁱ	Q01201
PeptideAtlas More...PeptideAtlasⁱ	Q01201
PRIDEⁱ	Q01201
ProteomicsDBⁱ	57938

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5971
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000221452; ENSP00000221452; ENSG00000104856 ENST00000625761; ENSP00000485826; ENSG00000104856
GeneIDⁱ	5971
KEGGⁱ	hsa:5971
UCSC genome browser More...UCSCⁱ	uc060zvi.1 human

Organism-specific databases

CTDⁱ	5971
DisGeNET More...DisGeNETⁱ	5971
EuPathDBⁱ	HostDB:ENSG00000104856.13
GeneCardsⁱ	RELB
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9956 RELB
Human Protein Atlas More...HPAⁱ	CAB007753 HPA040506
MalaCards human disease database More...MalaCardsⁱ	RELB
MIMⁱ	604758 gene 617585 phenotype
neXtProtⁱ	NX_Q01201
Open Targets More...OpenTargetsⁱ	ENSG00000104856
PharmGKBⁱ	PA34322
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFBK Eukaryota ENOG410ZMME LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00500000044765
HOGENOMⁱ	HOG000148598
HOVERGENⁱ	HBG017021
InParanoidⁱ	Q01201
KEGG Orthology (KO) More...KOⁱ	K09253
OMAⁱ	DFFSGTV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08JD
PhylomeDBⁱ	Q01201
TreeFamⁱ	TF325632

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5621575 CD209 (DC-SIGN) signaling R-HSA-5676590 NIK-->noncanonical NF-kB signaling
SIGNORⁱ	Q01201

Miscellaneous databases

ChiTaRSⁱ	RELB human
GeneWikiⁱ	RELB
GenomeRNAiⁱ	5971
Protein Ontology More...PROⁱ	PR:Q01201
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000104856
CleanExⁱ	HS_RELB
ExpressionAtlasⁱ	Q01201 baseline and differential
Genevisibleⁱ	Q01201 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01177 IPT_NFkappaB, 1 hit
Gene3Dⁱ	2.60.40.10, 1 hit 2.60.40.340, 1 hit
InterProⁱ	View protein in InterPro IPR013783 Ig-like_fold IPR014756 Ig_E-set IPR002909 IPT_dom IPR033926 IPT_NFkappaB IPR000451 NFkB/Dor IPR008967 p53-like_TF_DNA-bd IPR030496 RelB IPR032399 RelB_leu_zip IPR032400 RelB_transact IPR030492 RHD_CS IPR032397 RHD_dimer IPR011539 RHD_DNA_bind_dom IPR037059 RHD_DNA_bind_dom_sf
PANTHERⁱ	PTHR24169 PTHR24169, 1 hit PTHR24169:SF18 PTHR24169:SF18, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16180 RelB_leu_zip, 1 hit PF16181 RelB_transactiv, 1 hit PF16179 RHD_dimer, 1 hit PF00554 RHD_DNA_bind, 1 hit
PRINTSⁱ	PR00057 NFKBTNSCPFCT
SMARTⁱ	View protein in SMART SM00429 IPT, 1 hit
SUPFAMⁱ	SSF49417 SSF49417, 1 hit SSF81296 SSF81296, 1 hit
PROSITEⁱ	View protein in PROSITE PS01204 REL_1, 1 hit PS50254 REL_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RELB_HUMAN
Accessionⁱ	Q01201Primary (citable) accession number: Q01201 Secondary accession number(s): Q6GTX7, Q9UEI7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
	Last sequence update:	April 4, 2006
	Last modified:	July 18, 2018
	This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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UniRef

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Supporting data

UniProtKB - Q01201 (RELB_HUMAN)

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Transcription factor RelB

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Nucleus

Cytoskeleton

Cytosol

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ