UniProtKB - Q01201 (RELB_HUMAN)
Protein
Transcription factor RelB
Gene
RELB
Organism
Homo sapiens (Human)
Status
Functioni
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (PubMed:26385063).5 Publications
Caution
Was originally thought to inhibit the transcriptional activity of nuclear factor NF-kappa-B.1 Publication
GO - Molecular functioni
- chromatin binding Source: GO_Central
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- identical protein binding Source: Ensembl
- protein kinase binding Source: UniProtKB
- RNA polymerase II distal enhancer sequence-specific DNA binding Source: UniProtKB
- RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central
- transcription corepressor activity Source: ProtInc
GO - Biological processi
- antigen processing and presentation Source: Ensembl
- cellular response to osmotic stress Source: Ensembl
- circadian regulation of gene expression Source: UniProtKB
- I-kappaB kinase/NF-kappaB signaling Source: GO_Central
- inflammatory response Source: GO_Central
- lymphocyte differentiation Source: UniProtKB
- myeloid dendritic cell differentiation Source: Ensembl
- negative regulation of interferon-beta production Source: CACAO
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- NIK/NF-kappaB signaling Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- response to cytokine Source: GO_Central
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
- T-helper 1 cell differentiation Source: Ensembl
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5621575 CD209 (DC-SIGN) signaling R-HSA-5676590 NIK-->noncanonical NF-kB signaling |
SIGNORi | Q01201 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor RelBAlternative name(s): I-Rel |
Gene namesi | Name:RELB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9956 RELB |
MIMi | 604758 gene |
neXtProti | NX_Q01201 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytoskeleton
- centrosome 1 Publication
Note: Colocalizes with NEK6 in the centrosome.
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: CACAO
Other locations
- protein-containing complex Source: UniProtKB
- transcriptional repressor complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Involvement in diseasei
Immunodeficiency 53 (IMD53)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive primary immunodeficiency apparent from early infancy and resulting in recurrent infections, severe autoimmune skin disease rheumatoid arthritis, and failure to thrive. Immunologic workup shows increased CD4+/CD8+ ratio, impaired T-cell proliferative response to multiple antigen, T-cell developmental and functional defects, and impaired ability to produce specific immunoglobulins.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079201 | 397 – 579 | Missing in IMD53. 1 PublicationAdd BLAST | 183 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 5971 |
MalaCardsi | RELB |
MIMi | 617585 phenotype |
OpenTargetsi | ENSG00000104856 |
PharmGKBi | PA34322 |
Miscellaneous databases
Pharosi | Q01201 |
Polymorphism and mutation databases
BioMutai | RELB |
DMDMi | 92090634 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000205173 | 1 – 579 | Transcription factor RelBAdd BLAST | 579 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 16 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 37 | PhosphoserineCombined sources | 1 | |
Modified residuei | 573 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation.By similarity
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q01201 |
jPOSTi | Q01201 |
MassIVEi | Q01201 |
MaxQBi | Q01201 |
PaxDbi | Q01201 |
PeptideAtlasi | Q01201 |
PRIDEi | Q01201 |
ProteomicsDBi | 57938 |
PTM databases
iPTMneti | Q01201 |
PhosphoSitePlusi | Q01201 |
Expressioni
Inductioni
Up-regulated by mitogens and NUPR1.1 Publication
Gene expression databases
Bgeei | ENSG00000104856 Expressed in 120 organ(s), highest expression level in adrenal gland |
ExpressionAtlasi | Q01201 baseline and differential |
Genevisiblei | Q01201 HS |
Organism-specific databases
HPAi | CAB007753 HPA040506 |
Interactioni
Subunit structurei
Component of the NF-kappa-B RelB-p50 complex.
Component of the NF-kappa-B RelB-p52 complex. Self-associates; the interaction seems to be transient and may prevent degradation allowing for heterodimer formation with p50 or p52.
Interacts with NFKB1/p50, NFKB2/p52 and NFKB2/p100.
Interacts with NFKBID.
Interacts with ARNTL/BMAL1 and the interaction is enhanced in the presence of CLOCK (By similarity).
By similarityBinary interactionsi
GO - Molecular functioni
- identical protein binding Source: Ensembl
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 111903, 61 interactors |
CORUMi | Q01201 |
DIPi | DIP-27531N |
IntActi | Q01201, 43 interactors |
MINTi | Q01201 |
STRINGi | 9606.ENSP00000221452 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 125 – 440 | RHDPROSITE-ProRule annotationAdd BLAST | 316 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 40 – 68 | Leucine-zipperAdd BLAST | 29 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 433 – 438 | Nuclear localization signalSequence analysis | 6 |
Domaini
Both N- and C-terminal domains are required for transcriptional activation.
Phylogenomic databases
eggNOGi | ENOG410IFBK Eukaryota ENOG410ZMME LUCA |
GeneTreei | ENSGT00940000160230 |
HOGENOMi | HOG000148598 |
InParanoidi | Q01201 |
KOi | K09253 |
OMAi | LDDSFAY |
OrthoDBi | 916931at2759 |
PhylomeDBi | Q01201 |
TreeFami | TF325632 |
Family and domain databases
CDDi | cd01177 IPT_NFkappaB, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR013783 Ig-like_fold IPR014756 Ig_E-set IPR002909 IPT_dom IPR033926 IPT_NFkappaB IPR000451 NFkB/Dor IPR008967 p53-like_TF_DNA-bd IPR030496 RelB IPR032399 RelB_leu_zip IPR032400 RelB_transact IPR030492 RHD_CS IPR032397 RHD_dimer IPR011539 RHD_DNA_bind_dom IPR037059 RHD_DNA_bind_dom_sf |
PANTHERi | PTHR24169 PTHR24169, 1 hit PTHR24169:SF18 PTHR24169:SF18, 1 hit |
Pfami | View protein in Pfam PF16180 RelB_leu_zip, 1 hit PF16181 RelB_transactiv, 1 hit PF16179 RHD_dimer, 1 hit PF00554 RHD_DNA_bind, 1 hit |
PRINTSi | PR00057 NFKBTNSCPFCT |
SMARTi | View protein in SMART SM00429 IPT, 1 hit |
SUPFAMi | SSF49417 SSF49417, 1 hit SSF81296 SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS01204 REL_1, 1 hit PS50254 REL_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q01201-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRSGPASGP SVPTGRAMPS RRVARPPAAP ELGALGSPDL SSLSLAVSRS
60 70 80 90 100
TDELEIIDEY IKENGFGLDG GQPGPGEGLP RLVSRGAASL STVTLGPVAP
110 120 130 140 150
PATPPPWGCP LGRLVSPAPG PGPQPHLVIT EQPKQRGMRF RYECEGRSAG
160 170 180 190 200
SILGESSTEA SKTLPAIELR DCGGLREVEV TACLVWKDWP HRVHPHSLVG
210 220 230 240 250
KDCTDGICRV RLRPHVSPRH SFNNLGIQCV RKKEIEAAIE RKIQLGIDPY
260 270 280 290 300
NAGSLKNHQE VDMNVVRICF QASYRDQQGQ MRRMDPVLSE PVYDKKSTNT
310 320 330 340 350
SELRICRINK ESGPCTGGEE LYLLCDKVQK EDISVVFSRA SWEGRADFSQ
360 370 380 390 400
ADVHRQIAIV FKTPPYEDLE IVEPVTVNVF LQRLTDGVCS EPLPFTYLPR
410 420 430 440 450
DHDSYGVDKK RKRGMPDVLG ELNSSDPHGI ESKRRKKKPA ILDHFLPNHG
460 470 480 490 500
SGPFLPPSAL LPDPDFFSGT VSLPGLEPPG GPDLLDDGFA YDPTAPTLFT
510 520 530 540 550
MLDLLPPAPP HASAVVCSGG AGAVVGETPG PEPLTLDSYQ APGPGDGGTA
560 570
SLVGSNMFPN HYREAAFGGG LLSPGPEAT
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6R992 | D6R992_HUMAN | Transcription factor RelB | RELB hCG_22137 | 576 | Annotation score: | ||
K7ERX9 | K7ERX9_HUMAN | Transcription factor RelB | RELB | 142 | Annotation score: | ||
D6RIV7 | D6RIV7_HUMAN | Transcription factor RelB | RELB | 58 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 139 | R → P in AAA36127 (PubMed:1577270).Curated | 1 | |
Sequence conflicti | 411 | R → A in AAA36127 (PubMed:1577270).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051782 | 396 | T → M. Corresponds to variant dbSNP:rs2230682Ensembl. | 1 | |
Natural variantiVAR_079201 | 397 – 579 | Missing in IMD53. 1 PublicationAdd BLAST | 183 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M83221 mRNA Translation: AAA36127.1 AF043463 AF043462 Genomic DNA Translation: AAC82346.1 DQ314887 Genomic DNA Translation: ABC40746.1 BC028013 mRNA Translation: AAH28013.1 |
CCDSi | CCDS46110.1 |
PIRi | A42617 |
RefSeqi | NP_006500.2, NM_006509.3 |
Genome annotation databases
Ensembli | ENST00000221452; ENSP00000221452; ENSG00000104856 ENST00000625761; ENSP00000485826; ENSG00000104856 |
GeneIDi | 5971 |
KEGGi | hsa:5971 |
UCSCi | uc060zvi.1 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M83221 mRNA Translation: AAA36127.1 AF043463 AF043462 Genomic DNA Translation: AAC82346.1 DQ314887 Genomic DNA Translation: ABC40746.1 BC028013 mRNA Translation: AAH28013.1 |
CCDSi | CCDS46110.1 |
PIRi | A42617 |
RefSeqi | NP_006500.2, NM_006509.3 |
3D structure databases
SMRi | Q01201 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 111903, 61 interactors |
CORUMi | Q01201 |
DIPi | DIP-27531N |
IntActi | Q01201, 43 interactors |
MINTi | Q01201 |
STRINGi | 9606.ENSP00000221452 |
PTM databases
iPTMneti | Q01201 |
PhosphoSitePlusi | Q01201 |
Polymorphism and mutation databases
BioMutai | RELB |
DMDMi | 92090634 |
Proteomic databases
EPDi | Q01201 |
jPOSTi | Q01201 |
MassIVEi | Q01201 |
MaxQBi | Q01201 |
PaxDbi | Q01201 |
PeptideAtlasi | Q01201 |
PRIDEi | Q01201 |
ProteomicsDBi | 57938 |
Protocols and materials databases
DNASUi | 5971 |
Genome annotation databases
Ensembli | ENST00000221452; ENSP00000221452; ENSG00000104856 ENST00000625761; ENSP00000485826; ENSG00000104856 |
GeneIDi | 5971 |
KEGGi | hsa:5971 |
UCSCi | uc060zvi.1 human |
Organism-specific databases
CTDi | 5971 |
DisGeNETi | 5971 |
GeneCardsi | RELB |
HGNCi | HGNC:9956 RELB |
HPAi | CAB007753 HPA040506 |
MalaCardsi | RELB |
MIMi | 604758 gene 617585 phenotype |
neXtProti | NX_Q01201 |
OpenTargetsi | ENSG00000104856 |
PharmGKBi | PA34322 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IFBK Eukaryota ENOG410ZMME LUCA |
GeneTreei | ENSGT00940000160230 |
HOGENOMi | HOG000148598 |
InParanoidi | Q01201 |
KOi | K09253 |
OMAi | LDDSFAY |
OrthoDBi | 916931at2759 |
PhylomeDBi | Q01201 |
TreeFami | TF325632 |
Enzyme and pathway databases
Reactomei | R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5621575 CD209 (DC-SIGN) signaling R-HSA-5676590 NIK-->noncanonical NF-kB signaling |
SIGNORi | Q01201 |
Miscellaneous databases
ChiTaRSi | RELB human |
GeneWikii | RELB |
GenomeRNAii | 5971 |
Pharosi | Q01201 |
PROi | PR:Q01201 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104856 Expressed in 120 organ(s), highest expression level in adrenal gland |
ExpressionAtlasi | Q01201 baseline and differential |
Genevisiblei | Q01201 HS |
Family and domain databases
CDDi | cd01177 IPT_NFkappaB, 1 hit |
Gene3Di | 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR013783 Ig-like_fold IPR014756 Ig_E-set IPR002909 IPT_dom IPR033926 IPT_NFkappaB IPR000451 NFkB/Dor IPR008967 p53-like_TF_DNA-bd IPR030496 RelB IPR032399 RelB_leu_zip IPR032400 RelB_transact IPR030492 RHD_CS IPR032397 RHD_dimer IPR011539 RHD_DNA_bind_dom IPR037059 RHD_DNA_bind_dom_sf |
PANTHERi | PTHR24169 PTHR24169, 1 hit PTHR24169:SF18 PTHR24169:SF18, 1 hit |
Pfami | View protein in Pfam PF16180 RelB_leu_zip, 1 hit PF16181 RelB_transactiv, 1 hit PF16179 RHD_dimer, 1 hit PF00554 RHD_DNA_bind, 1 hit |
PRINTSi | PR00057 NFKBTNSCPFCT |
SMARTi | View protein in SMART SM00429 IPT, 1 hit |
SUPFAMi | SSF49417 SSF49417, 1 hit SSF81296 SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS01204 REL_1, 1 hit PS50254 REL_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RELB_HUMAN | |
Accessioni | Q01201Primary (citable) accession number: Q01201 Secondary accession number(s): Q6GTX7, Q9UEI7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | April 4, 2006 | |
Last modified: | October 16, 2019 | |
This is version 190 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot