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Protein

37S ribosomal protein S23, mitochondrial

Gene

RSM23

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. mS29 binds GTP and is probably an active GTPase. GTP hydrolysis may be linked to subunit association (PubMed:25609543, PubMed:28154081). mS29 also has an extraribosomal function, being required for maintenance of mitochondrial DNA (PubMed:11017876).2 Publications1 Publication

Miscellaneous

Present with 1300 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi150 – 157GTPBy similarity8

GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30625-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
37S ribosomal protein S23, mitochondrial
Alternative name(s):
DAP-3
Mitochondrial small ribosomal subunit protein mS291 Publication
Gene namesi
Name:RSM23
Ordered Locus Names:YGL129C
ORF Names:G2856
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL129C
SGDiS000003097 RSM23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 14MitochondrionSequence analysisAdd BLAST14
ChainiPRO_000020274315 – 45037S ribosomal protein S23, mitochondrialAdd BLAST436

Proteomic databases

MaxQBiQ01163
PaxDbiQ01163
PRIDEiQ01163

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33122, 34 interactors
ComplexPortaliCPX-1603 37S mitochondrial small ribosomal subunit
DIPiDIP-5302N
IntActiQ01163, 19 interactors
MINTiQ01163
STRINGi4932.YGL129C

Structurei

3D structure databases

ProteinModelPortaliQ01163
SMRiQ01163
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000142042
InParanoidiQ01163
KOiK17408
OMAiMEYWGAS
OrthoDBiEOG092C274Q

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR019368 Ribosomal_S23/S29_mit
IPR017082 Ribosomal_S23_mit_fun
PANTHERiPTHR12810 PTHR12810, 1 hit
PfamiView protein in Pfam
PF10236 DAP3, 1 hit
PIRSFiPIRSF036996 RSM23, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRMSTSRFI GQRLFTTARS LQAAKPAPKG KTQGFSKKSS SVSSYSSAKR
60 70 80 90 100
VTPGSLYKNW TNTTHTAQLQ QTAVPLALPI FNFDDISKTL NKVVSYSNKQ
110 120 130 140 150
YKSLHHLGSF KKSQFNELFQ KPVCLVREDA TNSFLKKLVS HPVKKFIITG
160 170 180 190 200
EPGVGKTVLL SQAHAYAVDS KQIIINISYP ELFLNGRNDF SYDDDLKLFI
210 220 230 240 250
QPMYLKKLIR KILKANDPAL LKSIELSKDY KFSNANPKNA SVKPFVTLNK
260 270 280 290 300
TKNTVLDLLS VMTHPHNRGK LMKAIIDELS VQSKVPIMFT VDNFSKVLTT
310 320 330 340 350
AYSAYRNTEN KQIYSLDLQM GKLMMDIISG ETKFANGESS TILAISGVDR
360 370 380 390 400
TNKTLPVALG KIPVDPYVTR YHYEPKFVEL LQKGNVTEFE VPKLNKQEVN
410 420 430 440 450
ELIDYYKQSN VLLDKDITGK KWENLIDEKY FLSGNGNPRE LLKSLVLSHR
Length:450
Mass (Da):50,867
Last modified:September 21, 2011 - v3
Checksum:iDCE220C14D020AE2
GO

Sequence cautioni

The sequence CAA60702 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA96838 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10263 Genomic DNA Translation: BAA01104.1
X87252 Genomic DNA Translation: CAA60702.1 Different initiation.
Z72651 Genomic DNA Translation: CAA96838.1 Different initiation.
BK006941 Genomic DNA Translation: DAA07980.2
PIRiS64140
RefSeqiNP_011386.2, NM_001180994.2

Genome annotation databases

EnsemblFungiiYGL129C; YGL129C; YGL129C
GeneIDi852748
KEGGisce:YGL129C

Similar proteinsi

Entry informationi

Entry nameiRT23_YEAST
AccessioniPrimary (citable) accession number: Q01163
Secondary accession number(s): D6VU19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: September 21, 2011
Last modified: July 18, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

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