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Protein

CD83 antigen

Gene

CD83

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.

GO - Biological processi

Enzyme and pathway databases

SIGNORiQ01151

Names & Taxonomyi

Protein namesi
Recommended name:
CD83 antigen
Short name:
hCD83
Alternative name(s):
B-cell activation protein
Cell surface protein HB15
CD_antigen: CD83
Gene namesi
Name:CD83
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112149.9
HGNCiHGNC:1703 CD83
MIMi604534 gene
neXtProtiNX_Q01151

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 144ExtracellularSequence analysisAdd BLAST125
Transmembranei145 – 166HelicalSequence analysisAdd BLAST22
Topological domaini167 – 205CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9308
OpenTargetsiENSG00000112149
PharmGKBiPA26241

Polymorphism and mutation databases

BioMutaiCD83
DMDMi232223

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001465720 – 205CD83 antigenAdd BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 107PROSITE-ProRule annotation
Glycosylationi79N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ01151
PaxDbiQ01151
PeptideAtlasiQ01151
PRIDEiQ01151
ProteomicsDBi57923

PTM databases

iPTMnetiQ01151
PhosphoSitePlusiQ01151
SwissPalmiQ01151

Expressioni

Tissue specificityi

Expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells.

Gene expression databases

BgeeiENSG00000112149 Expressed in 226 organ(s), highest expression level in adrenal tissue
CleanExiHS_CD83
ExpressionAtlasiQ01151 baseline and differential
GenevisibleiQ01151 HS

Organism-specific databases

HPAiCAB002509
HPA041454

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi114721, 51 interactors
IntActiQ01151, 4 interactors
STRINGi9606.ENSP00000368450

Structurei

Secondary structure

1205
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ01151
SMRiQ01151
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 114Ig-like V-typeAdd BLAST95

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKX7 Eukaryota
ENOG410ZACF LUCA
GeneTreeiENSGT00390000007302
HOGENOMiHOG000057288
HOVERGENiHBG005291
InParanoidiQ01151
KOiK06510
OMAiAPWDPQV
OrthoDBiEOG091G0OEV
PhylomeDBiQ01151
TreeFamiTF337861

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q01151-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRGLQLLLL SCAYSLAPAT PEVKVACSED VDLPCTAPWD PQVPYTVSWV
60 70 80 90 100
KLLEGGEERM ETPQEDHLRG QHYHQKGQNG SFDAPNERPY SLKIRNTTSC
110 120 130 140 150
NSGTYRCTLQ DPDGQRNLSG KVILRVTGCP AQRKEETFKK YRAEIVLLLA
160 170 180 190 200
LVIFYLTLII FTCKFARLQS IFPDFSKAGM ERAFLPVTSP NKHLGLVTPH

KTELV
Length:205
Mass (Da):23,042
Last modified:April 1, 1993 - v1
Checksum:i1D77133595F2B852
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WX61A0A087WX61_HUMAN
CD83 antigen
CD83
146Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033609182R → Q. Corresponds to variant dbSNP:rs2230193Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11697 mRNA Translation: CAA77755.1
S53354 mRNA Translation: AAB25085.1
CR457019 mRNA Translation: CAG33300.1
AL133259 Genomic DNA No translation available.
AL022396 Genomic DNA No translation available.
BC030830 mRNA Translation: AAH30830.1
CCDSiCCDS4532.1
PIRiA48929
RefSeqiNP_001035370.1, NM_001040280.1
NP_001238830.1, NM_001251901.1
NP_004224.1, NM_004233.3
UniGeneiHs.595133

Genome annotation databases

EnsembliENST00000379153; ENSP00000368450; ENSG00000112149
GeneIDi9308
KEGGihsa:9308
UCSCiuc003nbi.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

CD83 antigen

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11697 mRNA Translation: CAA77755.1
S53354 mRNA Translation: AAB25085.1
CR457019 mRNA Translation: CAG33300.1
AL133259 Genomic DNA No translation available.
AL022396 Genomic DNA No translation available.
BC030830 mRNA Translation: AAH30830.1
CCDSiCCDS4532.1
PIRiA48929
RefSeqiNP_001035370.1, NM_001040280.1
NP_001238830.1, NM_001251901.1
NP_004224.1, NM_004233.3
UniGeneiHs.595133

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MIXX-ray1.70A20-131[»]
5MJ0X-ray3.20A/B20-131[»]
5MJ1X-ray1.80A20-131[»]
5MJ2X-ray1.98A20-131[»]
ProteinModelPortaliQ01151
SMRiQ01151
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114721, 51 interactors
IntActiQ01151, 4 interactors
STRINGi9606.ENSP00000368450

PTM databases

iPTMnetiQ01151
PhosphoSitePlusiQ01151
SwissPalmiQ01151

Polymorphism and mutation databases

BioMutaiCD83
DMDMi232223

Proteomic databases

MaxQBiQ01151
PaxDbiQ01151
PeptideAtlasiQ01151
PRIDEiQ01151
ProteomicsDBi57923

Protocols and materials databases

DNASUi9308
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379153; ENSP00000368450; ENSG00000112149
GeneIDi9308
KEGGihsa:9308
UCSCiuc003nbi.4 human

Organism-specific databases

CTDi9308
DisGeNETi9308
EuPathDBiHostDB:ENSG00000112149.9
GeneCardsiCD83
HGNCiHGNC:1703 CD83
HPAiCAB002509
HPA041454
MIMi604534 gene
neXtProtiNX_Q01151
OpenTargetsiENSG00000112149
PharmGKBiPA26241
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKX7 Eukaryota
ENOG410ZACF LUCA
GeneTreeiENSGT00390000007302
HOGENOMiHOG000057288
HOVERGENiHBG005291
InParanoidiQ01151
KOiK06510
OMAiAPWDPQV
OrthoDBiEOG091G0OEV
PhylomeDBiQ01151
TreeFamiTF337861

Enzyme and pathway databases

SIGNORiQ01151

Miscellaneous databases

ChiTaRSiCD83 human
GeneWikiiCD83
GenomeRNAii9308
PROiPR:Q01151
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112149 Expressed in 226 organ(s), highest expression level in adrenal tissue
CleanExiHS_CD83
ExpressionAtlasiQ01151 baseline and differential
GenevisibleiQ01151 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD83_HUMAN
AccessioniPrimary (citable) accession number: Q01151
Secondary accession number(s): Q5THX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 7, 2018
This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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