Cyclic AMP-responsive element-binding protein 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• arrestin family protein binding Source: MGI
• cAMP response element binding Source: ARUK-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Inducible interleukin 32 (IL-32) exerts extensive antiviral function via selective stimulation of interferon lambda1 (IFN-lambda1)."
    Li Y., Xie J., Xu X., Liu L., Wan Y., Liu Y., Zhu C., Zhu Y.
    J Biol Chem 288:20927-20941(2013) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: MGIInferred from direct assayⁱ
  • "Secalonic acid D alters the expression and phosphorylation of the transcription factors and their binding to cAMP response element in developing murine secondary palate."
    Umesh H., Ganesh B., Reddy C.S.
    J Craniofac Genet Dev Biol 20:173-182(2000) [PubMed] [Europe PMC] [Abstract]
  • "CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism."
    Merluzzi S., Moretti M., Altamura S., Zwollo P., Sigvardsson M., Vitale G., Pucillo C.
    J Biol Chem 279:1777-1786(2004) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: ARUK-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress."
    Kim T.S., Kawaguchi M., Suzuki M., Jung C.G., Asai K., Shibamoto Y., Lavin M.F., Khanna K.K., Miura Y.
    Dis Model Mech 3:752-762(2010) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: MGIInferred from direct assayⁱ
  • "Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite."
    Gong P., Stewart D., Hu B., Vinson C., Alam J.
    Arch Biochem Biophys 405:265-274(2002) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
• double-stranded DNA binding Source: MGI
• enzyme binding Source: MGI
• histone acetyltransferase binding Source: MGI
• Hsp70 protein binding Source: MGI
• identical protein binding Source: MGI
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
• RNA polymerase II-specific DNA-binding transcription factor binding Source: MGI
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators."
    Bai Z., Chai X.R., Yoon M.J., Kim H.J., Lo K.A., Zhang Z.C., Xu D., Siang D.T.C., Walet A.C.E., Xu S.H., Chia S.Y., Chen P., Yang H., Ghosh S., Sun L.
    PLoS Biol 15:e2002176-e2002176(2017) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "A twist code determines the onset of osteoblast differentiation."
    Bialek P., Kern B., Yang X., Schrock M., Sosic D., Hong N., Wu H., Yu K., Ornitz D.M., Olson E.N., Justice M.J., Karsenty G.
    Dev Cell 6:423-435(2004) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: MGI
• transcription cis-regulatory region binding Source: MGI
• transcription coactivator binding Source: MGI

GO - Biological processⁱ

• axonogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB."
    Lonze B.E., Riccio A., Cohen S., Ginty D.D.
    Neuron 34:371-385(2002) [PubMed] [Europe PMC] [Abstract]
• cellular response to growth factor stimulus Source: BHF-UCLInferred from direct assayⁱ
  • "A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons."
    Riccio A., Alvania R.S., Lonze B.E., Ramanan N., Kim T., Huang Y., Dawson T.M., Snyder S.H., Ginty D.D.
    Mol Cell 21:283-294(2006) [PubMed] [Europe PMC] [Abstract]
• cellular response to hepatocyte growth factor stimulus Source: MGIInferred from direct assayⁱ
  • "Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases."
    Coudriet G.M., He J., Trucco M., Mars W.M., Piganelli J.D.
    PLoS One 5:e15384-e15384(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to leukemia inhibitory factor Source: MGI <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells."
    Tarantino C., Paolella G., Cozzuto L., Minopoli G., Pastore L., Parisi S., Russo T.
    FASEB J 24:3255-3263(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to retinoic acid Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress."
    Kim T.S., Kawaguchi M., Suzuki M., Jung C.G., Asai K., Shibamoto Y., Lavin M.F., Khanna K.K., Miura Y.
    Dis Model Mech 3:752-762(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to zinc ion Source: MGIInferred from direct assayⁱ
  • "Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12)."
    Chowanadisai W., Graham D.M., Keen C.L., Rucker R.B., Messerli M.A.
    Proc Natl Acad Sci U S A 110:9903-9908(2013) [PubMed] [Europe PMC] [Abstract]
• chemotaxis to arachidonic acid Source: MGI
• circadian rhythm Source: UniProtKBInferred from direct assayⁱ
  • Ref.7

    "Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis."
    Zhang E.E., Liu Y., Dentin R., Pongsawakul P.Y., Liu A.C., Hirota T., Nusinow D.A., Sun X., Landais S., Kodama Y., Brenner D.A., Montminy M., Kay S.A.
    Nat. Med. 16:1152-1156(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: PHOSPHORYLATION.
• lactation Source: MGIInferred from mutant phenotypeⁱ
  • "Hypothalamic 3',5'-cyclic adenosine monophosphate response element-binding protein loss causes anterior pituitary hypoplasia and dwarfism in mice."
    Mantamadiotis T., Kretz O., Ridder S., Bleckmann S.C., Bock D., Grone H.J., Malaterre J., Dworkin S., Ramsay R.G., Schutz G.
    Mol Endocrinol 20:204-211(2006) [PubMed] [Europe PMC] [Abstract]
• lung epithelium development Source: MGIInferred from mutant phenotypeⁱ
  • "cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development."
    Bird A.D., Flecknoe S.J., Tan K.H., Olsson P.F., Antony N., Mantamadiotis T., Mollard R., Hooper S.B., Cole T.J.
    PLoS One 6:e17843-e17843(2011) [PubMed] [Europe PMC] [Abstract]
• lung saccule development Source: MGIInferred from mutant phenotypeⁱ
  • "cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development."
    Bird A.D., Flecknoe S.J., Tan K.H., Olsson P.F., Antony N., Mantamadiotis T., Mollard R., Hooper S.B., Cole T.J.
    PLoS One 6:e17843-e17843(2011) [PubMed] [Europe PMC] [Abstract]
• mammary gland development Source: MGIInferred from mutant phenotypeⁱ
  • "Hypothalamic 3',5'-cyclic adenosine monophosphate response element-binding protein loss causes anterior pituitary hypoplasia and dwarfism in mice."
    Mantamadiotis T., Kretz O., Ridder S., Bleckmann S.C., Bock D., Grone H.J., Malaterre J., Dworkin S., Ramsay R.G., Schutz G.
    Mol Endocrinol 20:204-211(2006) [PubMed] [Europe PMC] [Abstract]
• memory Source: MGIInferred from mutant phenotypeⁱ
  • "Increasing CRTC1 function in the dentate gyrus during memory formation or reactivation increases memory strength without compromising memory quality."
    Sekeres M.J., Mercaldo V., Richards B., Sargin D., Mahadevan V., Woodin M.A., Frankland P.W., Josselyn S.A.
    J Neurosci 32:17857-17868(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: MGI
• negative regulation of neuron death Source: MGI
• negative regulation of transcription by competitive promoter binding Source: MGI
• pituitary gland development Source: MGIInferred from mutant phenotypeⁱ
  • "Hypothalamic 3',5'-cyclic adenosine monophosphate response element-binding protein loss causes anterior pituitary hypoplasia and dwarfism in mice."
    Mantamadiotis T., Kretz O., Ridder S., Bleckmann S.C., Bock D., Grone H.J., Malaterre J., Dworkin S., Ramsay R.G., Schutz G.
    Mol Endocrinol 20:204-211(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process Source: MGI
• positive regulation of cardiac muscle tissue development Source: MGIInferred from mutant phenotypeⁱ
  • "Neuregulin-1beta induces embryonic stem cell cardiomyogenesis via ErbB3/ErbB2 receptors."
    Hao J., Galindo C.L., Tran T.L., Sawyer D.B.
    Biochem J 458:335-341(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fat cell differentiation Source: UniProtKB <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • Ref.8

    "CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes."
    Ma X., Zhang H., Yuan L., Jing H., Thacker P., Li D.
    Biochem. J. 439:27-38(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN ADIPOCYTE DIFFERENTIATION, INTERACTION WITH CREBL2, SUBCELLULAR LOCATION.
• positive regulation of hormone secretion Source: MGIInferred from mutant phenotypeⁱ
  • "Hypothalamic 3',5'-cyclic adenosine monophosphate response element-binding protein loss causes anterior pituitary hypoplasia and dwarfism in mice."
    Mantamadiotis T., Kretz O., Ridder S., Bleckmann S.C., Bock D., Grone H.J., Malaterre J., Dworkin S., Ramsay R.G., Schutz G.
    Mol Endocrinol 20:204-211(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of lipid biosynthetic process Source: UniProtKBInferred from genetic interactionⁱ
  • Ref.8

    "CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes."
    Ma X., Zhang H., Yuan L., Jing H., Thacker P., Li D.
    Biochem. J. 439:27-38(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN ADIPOCYTE DIFFERENTIATION, INTERACTION WITH CREBL2, SUBCELLULAR LOCATION.
• positive regulation of long-term synaptic potentiation Source: MGI
• positive regulation of multicellular organism growth Source: MGIInferred from mutant phenotypeⁱ
  • "Hypothalamic 3',5'-cyclic adenosine monophosphate response element-binding protein loss causes anterior pituitary hypoplasia and dwarfism in mice."
    Mantamadiotis T., Kretz O., Ridder S., Bleckmann S.C., Bock D., Grone H.J., Malaterre J., Dworkin S., Ramsay R.G., Schutz G.
    Mol Endocrinol 20:204-211(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of osteoclast differentiation Source: MGIInferred from direct assayⁱ
  • "Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation."
    Kim H., Kim T., Jeong B.C., Cho I.T., Han D., Takegahara N., Negishi-Koga T., Takayanagi H., Lee J.H., Sul J.Y., Prasad V., Lee S.H., Choi Y.
    Cell Metab. 17:249-260(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of RNA polymerase II transcription preinitiation complex assembly Source: MGI
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from genetic interactionⁱ
  • Ref.8

    "CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes."
    Ma X., Zhang H., Yuan L., Jing H., Thacker P., Li D.
    Biochem. J. 439:27-38(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN ADIPOCYTE DIFFERENTIATION, INTERACTION WITH CREBL2, SUBCELLULAR LOCATION.
• positive regulation of transcription by RNA polymerase II Source: UniProtKBInferred from direct assayⁱ
  • Ref.7

    "Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis."
    Zhang E.E., Liu Y., Dentin R., Pongsawakul P.Y., Liu A.C., Hirota T., Nusinow D.A., Sun X., Landais S., Kodama Y., Brenner D.A., Montminy M., Kay S.A.
    Nat. Med. 16:1152-1156(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: PHOSPHORYLATION.
• positive regulation of transforming growth factor beta3 production Source: MGI
• protein phosphorylation Source: MGIInferred from sequence orthologyⁱ
  • "CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas."
    Ji L., Mochon E., Arcinas M., Boxer L.M.
    J Biol Chem 271:22687-22691(1996) [PubMed] [Europe PMC] [Abstract]
• protein stabilization Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.8

    "CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes."
    Ma X., Zhang H., Yuan L., Jing H., Thacker P., Li D.
    Biochem. J. 439:27-38(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN ADIPOCYTE DIFFERENTIATION, INTERACTION WITH CREBL2, SUBCELLULAR LOCATION.
• regulation of apoptotic process Source: MGI
• regulation of cell size Source: MGIInferred from genetic interactionⁱ
  • "Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development."
    Sordella R., Classon M., Hu K.Q., Matheson S.F., Brouns M.R., Fine B., Zhang L., Takami H., Yamada Y., Settleman J.
    Dev Cell 2:553-565(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of circadian rhythm Source: MGI
• regulation of fibroblast proliferation Source: MGI
• regulation of glial cell proliferation Source: MGI
• regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • "Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite."
    Gong P., Stewart D., Hu B., Vinson C., Alam J.
    Arch Biochem Biophys 405:265-274(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: ComplexPortalInferred from direct assayⁱ
  • "Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements."
    Luo S., Baumeister P., Yang S., Abcouwer S.F., Lee A.S.
    J Biol Chem 278:37375-37385(2003) [PubMed] [Europe PMC] [Abstract]
• response to glucagon Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.7

    "Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis."
    Zhang E.E., Liu Y., Dentin R., Pongsawakul P.Y., Liu A.C., Hirota T., Nusinow D.A., Sun X., Landais S., Kodama Y., Brenner D.A., Montminy M., Kay S.A.
    Nat. Med. 16:1152-1156(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: PHOSPHORYLATION.
• response to organic substance Source: MGIInferred from sequence orthologyⁱ
  • "CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas."
    Ji L., Mochon E., Arcinas M., Boxer L.M.
    J Biol Chem 271:22687-22691(1996) [PubMed] [Europe PMC] [Abstract]
• response to xenobiotic stimulus Source: MGIInferred from direct assayⁱ
  • "Valproic acid-induced changes in gene expression during neurulation in a mouse model."
    Wlodarczyk B.C., Craig J.C., Bennett G.D., Calvin J.A., Finnell R.H.
    Teratology 54:284-297(1996) [PubMed] [Europe PMC] [Abstract]
• secretory granule organization Source: MGIInferred from mutant phenotypeⁱ
  • "cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development."
    Bird A.D., Flecknoe S.J., Tan K.H., Olsson P.F., Antony N., Mantamadiotis T., Mollard R., Hooper S.B., Cole T.J.
    PLoS One 6:e17843-e17843(2011) [PubMed] [Europe PMC] [Abstract]
• transcription by RNA polymerase II Source: MGI
• transforming growth factor beta receptor signaling pathway Source: MGI
• type I pneumocyte differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development."
    Bird A.D., Flecknoe S.J., Tan K.H., Olsson P.F., Antony N., Mantamadiotis T., Mollard R., Hooper S.B., Cole T.J.
    PLoS One 6:e17843-e17843(2011) [PubMed] [Europe PMC] [Abstract]
• visual learning Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• arrestin family protein binding Source: MGI
• enzyme binding Source: MGI
• histone acetyltransferase binding Source: MGI
• Hsp70 protein binding Source: MGI
• identical protein binding Source: MGI
• RNA polymerase II-specific DNA-binding transcription factor binding Source: MGI
• transcription coactivator binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MTMESGADNQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA 
        60         70         80         90        100
PTVTLVQLPN GQTVQVHGVI QAAQPSVIQS PQVQTVQIST IAESEDSQES 
       110        120        130        140        150
VDSVTDSQKR REILSRRPSY RKILNDLSSD APGVPRIEEE KSEEETSAPA 
       160        170        180        190        200
ITTVTVPTPI YQTSSGQYIA ITQGGAIQLA NNGTDGVQGL QTLTMTNAAA 
       210        220        230        240        250
TQPGTTILQY AQTTDGQQIL VPSNQVVVQA ASGDVQTYQI RTAPTSTIAP 
       260        270        280        290        300
GVVMASSPAL PTQPAEEAAR KREVRLMKNR EAARECRRKK KEYVKCLENR 
       310        320 
VAVLENQNKT LIEELKALKD LYCHKSD                          

        10         20         30         40         50
MTMESGADNQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA 
        60         70         80         90        100
PTVTLVQLPN GQTVQVHGVI QAAQPSVIQS PQVQTVQSSC KDLKRLFSGT 
       110        120        130        140        150
QISTIAESED SQESVDSVTD SQKRREILSR RPSYRKILND LSSDAPGVPR 
       160        170        180        190        200
IEEEKSEEET SAPAITTVTV PTPIYQTSSG QYIAITQGGA IQLANNGTDG 
       210        220        230        240        250
VQGLQTLTMT NAAATQPGTT ILQYAQTTDG QQILVPSNQV VVQAASGDVQ 
       260        270        280        290        300
TYQIRTAPTS TIAPGVVMAS SPALPTQPAE EAARKREVRL MKNREAAREC 
       310        320        330        340 
RRKKKEYVKC LENRVAVLEN QNKTLIEELK ALKDLYCHKS D          

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families