SRSF2

Functionⁱ

Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.2 Publications

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
transcription corepressor activity
Source: UniProtKB
Non-traceable author statementⁱ
- 15652350

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA 3'-end processing Source: Reactome
mRNA cis splicing, via spliceosome
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mRNA export from nucleus Source: Reactome
mRNA processing
Source: ProtInc
Traceable author statementⁱ
- 8530103
mRNA splicing, via spliceosome Source: Reactome
regulation of alternative mRNA splicing, via spliceosome
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA export from nucleus Source: Reactome
RNA splicing
Source: ProtInc
Traceable author statementⁱ
- 8530103

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72165 mRNA Splicing - Minor Pathway R-HSA-72187 mRNA 3'-end processing
SIGNORⁱ	Q01130

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/arginine-rich splicing factor 2 Alternative name(s): Protein PR264 Splicing component, 35 kDa Splicing factor SC35 Short name: SC-35 Splicing factor, arginine/serine-rich 2
Gene namesⁱ	Name:SRSF2 Synonyms:SFRS2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000161547.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10783 SRSF2
MIMⁱ	600813 gene
neXtProtⁱ	NX_Q01130

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6427
Open Targets More...OpenTargetsⁱ	ENSG00000161547
PharmGKBⁱ	PA35699

Polymorphism and mutation databases

BioMutaⁱ	SRSF2
DMDMⁱ	60416437

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000081918	2 – 221	Serine/arginine-rich splicing factor 2Add BLAST		220

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources1 Publication	1
Modified residueⁱ	2	PhosphoserineCombined sources	1
Modified residueⁱ	22	PhosphothreonineCombined sources	1
Modified residueⁱ	25	PhosphothreonineCombined sources	1
Modified residueⁱ	26	PhosphoserineCombined sources	1
Modified residueⁱ	52	N6-acetyllysine1 Publication	1
Modified residueⁱ	189	PhosphoserineCombined sources	1
Modified residueⁱ	191	PhosphoserineCombined sources	1
Modified residueⁱ	204	PhosphoserineCombined sources	1
Modified residueⁱ	206	PhosphoserineCombined sources	1
Modified residueⁱ	208	PhosphoserineCombined sources	1
Modified residueⁱ	212	PhosphoserineCombined sources	1
Modified residueⁱ	220	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by SRPK2 and this causes its redistribution from the nuclear speckle to nucleoplasm and controls cell fate decision in response to cisplatin treatment. KAT5/TIP60 inhibits its phosphorylation by preventing SRPK2 nuclear translocation.2 Publications

Acetylation on Lys-52 by KAT5/TIP60 promotes its proteasomal degradation. This effect is counterbalanced by HDAC6, which positively controls SRSF2 protein level by deacetylating it and preventing its proteasomal degradation.2 Publications

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q01130
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q01130
PaxDbⁱ	Q01130
PeptideAtlas More...PeptideAtlasⁱ	Q01130
PRIDEⁱ	Q01130
ProteomicsDBⁱ	57922
TopDownProteomicsⁱ	Q01130-1 [Q01130-1]

PTM databases

iPTMnetⁱ	Q01130
PhosphoSitePlusⁱ	Q01130
SwissPalmⁱ	Q01130

Expressionⁱ

Inductionⁱ

Accumulates in a hypoacetylated/phosphorylated form in response to cisplatin treatment.

Gene expression databases

Bgeeⁱ	ENSG00000161547 Expressed in 236 organ(s), highest expression level in female gonad
CleanExⁱ	HS_SFRS2
ExpressionAtlasⁱ	Q01130 baseline and differential
Genevisibleⁱ	Q01130 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA049905

HPAⁱ

HPA049905

Interactionⁱ

Subunit structureⁱ

Interacts with BRDT (By similarity). In vitro, self-associates and binds SRSF1/SFRS1 (ASF/SF2), SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with CCNL1 and CCNL2. Interacts with SCAF11. Interacts with ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus).By similarity8 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CIR1	Q86X95	4	EBI-627047,EBI-627102
KAT5	Q92993	3	EBI-627047,EBI-399080
SNRNP70	P08621	2	EBI-627047,EBI-1049228
U2AF1	Q01081	3	EBI-627047,EBI-632461

Protein-protein interaction databases

BioGridⁱ	112325, 134 interactors
CORUMⁱ	Q01130
Database of interacting proteins More...DIPⁱ	DIP-33836N
IntActⁱ	Q01130, 61 interactors
Molecular INTeraction database More...MINTⁱ	Q01130
STRINGⁱ	9606.ENSP00000353089

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	10 – 12	Combined sources	3
Beta strandⁱ	15 – 20	Combined sources	6
Helixⁱ	27 – 37	Combined sources	11
Beta strandⁱ	40 – 44	Combined sources	5
Beta strandⁱ	49 – 53	Combined sources	5
Beta strandⁱ	57 – 64	Combined sources	8
Helixⁱ	65 – 74	Combined sources	10
Beta strandⁱ	79 – 84	Combined sources	6
Beta strandⁱ	86 – 90	Combined sources	5
Beta strandⁱ	91 – 94	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q01130
SMRⁱ	Q01130
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q01130

EvolutionaryTraceⁱ

Q01130

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	14 – 92	RRMPROSITE-ProRule annotationAdd BLAST		79

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	111 – 116	Gly-rich (hinge region)		6
Compositional biasⁱ	117 – 221	Arg/Ser-rich (RS domain)Add BLAST		105

Sequence similaritiesⁱ

Belongs to the splicing factor SR family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4207 Eukaryota ENOG4111NJ8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00700000104403
HOVERGENⁱ	HBG107480
InParanoidⁱ	Q01130
KEGG Orthology (KO) More...KOⁱ	K12891
OMAⁱ	GRPPDSM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G13K0
TreeFamⁱ	TF106262

Family and domain databases

Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR003954 RRM_dom_euk IPR034893 SRSF2-like
PANTHERⁱ	PTHR23147:SF16 PTHR23147:SF16, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit SM00361 RRM_1, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q01130-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYGRPPPDV EGMTSLKVDN LTYRTSPDTL RRVFEKYGRV GDVYIPRDRY 
        60         70         80         90        100
TKESRGFAFV RFHDKRDAED AMDAMDGAVL DGRELRVQMA RYGRPPDSHH 
       110        120        130        140        150
SRRGPPPRRY GGGGYGRRSR SPRRRRRSRS RSRSRSRSRS RSRYSRSKSR 
       160        170        180        190        200
SRTRSRSRST SKSRSARRSK SKSSSVSRSR SRSRSRSRSR SPPPVSKRES 
       210        220 
KSRSRSKSPP KSPEEEGAVS S

Length:221

Mass (Da):25,476

Last modified:January 23, 2007 - v4

Checksum:ⁱ68121AC4D35714FA

GO

Isoform 2 (identifier: Q01130-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
108-119: Missing.

« Hide

        10         20         30         40         50
MSYGRPPPDV EGMTSLKVDN LTYRTSPDTL RRVFEKYGRV GDVYIPRDRY 
        60         70         80         90        100
TKESRGFAFV RFHDKRDAED AMDAMDGAVL DGRELRVQMA RYGRPPDSHH 
       110        120        130        140        150
SRRGPPPRSP RRRRRSRSRS RSRSRSRSRS RYSRSKSRSR TRSRSRSTSK 
       160        170        180        190        200
SRSARRSKSK SSSVSRSRSR SRSRSRSRSP PPVSKRESKS RSRSKSPPKS 

PEEEGAVSS

Note: No experimental confirmation available.

Show »

Length:209

Mass (Da):24,153

Checksum:ⁱE1229752981E5304

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3KP15	J3KP15_HUMAN	Serine/arginine-rich-splicing facto... Serine/arginine-rich-splicing factor 2	SRSF2	133	Annotation score:
J3QL05	J3QL05_HUMAN	Serine/arginine-rich-splicing facto... Serine/arginine-rich-splicing factor 2	SRSF2	130	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	38	G → R in AAA60306 (PubMed:1373910).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056153	108 – 119	Missing in isoform 2. 1 PublicationAdd BLAST		12

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M90104 mRNA Translation: AAA60306.1 X62447 mRNA Translation: CAA44307.1 X75755 Genomic DNA Translation: CAA53383.1 BT007250 mRNA Translation: AAP35914.1 AK124792 mRNA Translation: BAG54097.1 AK297813 mRNA Translation: BAG60151.1 AC005837 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89439.1 CH471099 Genomic DNA Translation: EAW89448.1 BC000339 mRNA Translation: AAH00339.1 BC001303 mRNA Translation: AAH01303.1 BC070086 mRNA Translation: AAH70086.1 L03693 Genomic DNA Translation: AAA60162.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11749.1 [Q01130-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001182356.1, NM_001195427.1 [Q01130-1] NP_003007.2, NM_003016.4 [Q01130-1] XP_016880431.1, XM_017024942.1 [Q01130-1]
UniGeneⁱ	Hs.584801

Genome annotation databases

Ensemblⁱ	ENST00000359995; ENSP00000353089; ENSG00000161547 [Q01130-1] ENST00000392485; ENSP00000376276; ENSG00000161547 [Q01130-1] ENST00000452355; ENSP00000391278; ENSG00000161547 [Q01130-1] ENST00000508921; ENSP00000441780; ENSG00000161547 [Q01130-2] ENST00000585202; ENSP00000462425; ENSG00000161547 [Q01130-1]
GeneIDⁱ	6427
KEGGⁱ	hsa:6427
UCSC genome browser More...UCSCⁱ	uc002jsv.4 human [Q01130-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q01130	Serine/arginine-rich splicing factor 2		BOVIN		221	UniRef100_Q01130
Serine/arginine-rich splicing factor 2		MOUSE		221
Serine/arginine-rich splicing factor 2		RAT		221
Splicing factor, arginine/serine-rich 2, isoform CRA_d		HUMAN		209
Serine/arginine-rich splicing factor 2 (Fragment)		CANLF		167
+39
Q01130-2	Uncharacterized protein		MACMU		209	UniRef100_F7DBT5
serine/arginine-rich splicing factor 2 isoform X2		ERIEU		209
SRSF2 isoform 9		PONAB		209
SRSF2 isoform 9		PANTR		209
serine/arginine-rich splicing factor 2 isoform X2		LIPVE		209

Protein	Similar proteins		Species	Score	Length	Source
Q01130	Serine/arginine-rich splicing factor 2		BOVIN		221	UniRef90_Q01130
Serine/arginine-rich splicing factor 2		MOUSE		221
Serine/arginine-rich splicing factor 2		RAT		221
Splicing factor, arginine/serine-rich 2, isoform CRA_d		HUMAN		209
Serine/arginine-rich splicing factor 2 (Fragment)		CANLF		167
+40
Q01130-2	Serine/arginine-rich splicing factor 2		PIG		221	UniRef90_Q06A98
Serine/arginine-rich splicing factor 2		CHICK		221
Serine/arginine-rich splicing factor 2		PANTR		221
Uncharacterized protein		MONDO		253
Uncharacterized protein (Fragment)		MICSU		227
+67

Protein	Similar proteins		Species	Score	Length	Source
Q01130	Serine/arginine-rich splicing factor 2		BOVIN		221	UniRef50_Q01130
Serine/arginine-rich splicing factor 2		MOUSE		221
Serine/arginine-rich splicing factor 2		RAT		221
Serine/arginine-rich splicing factor 2		PANTR		221
Serine/arginine-rich splicing factor 2		PIG		221
+125

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M90104 mRNA Translation: AAA60306.1 X62447 mRNA Translation: CAA44307.1 X75755 Genomic DNA Translation: CAA53383.1 BT007250 mRNA Translation: AAP35914.1 AK124792 mRNA Translation: BAG54097.1 AK297813 mRNA Translation: BAG60151.1 AC005837 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89439.1 CH471099 Genomic DNA Translation: EAW89448.1 BC000339 mRNA Translation: AAH00339.1 BC001303 mRNA Translation: AAH01303.1 BC070086 mRNA Translation: AAH70086.1 L03693 Genomic DNA Translation: AAA60162.1
CCDSⁱ	CCDS11749.1 [Q01130-1]
RefSeqⁱ	NP_001182356.1, NM_001195427.1 [Q01130-1] NP_003007.2, NM_003016.4 [Q01130-1] XP_016880431.1, XM_017024942.1 [Q01130-1]
UniGeneⁱ	Hs.584801

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2KN4	NMR	-	A	9-101	[»]
	2LEA	NMR	-	A	1-101	[»]
	2LEB	NMR	-	A	1-101	[»]
	2LEC	NMR	-	A	1-101	[»]
ProteinModelPortalⁱ	Q01130
SMRⁱ	Q01130
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112325, 134 interactors
CORUMⁱ	Q01130
DIPⁱ	DIP-33836N
IntActⁱ	Q01130, 61 interactors
MINTⁱ	Q01130
STRINGⁱ	9606.ENSP00000353089

PTM databases

iPTMnetⁱ	Q01130
PhosphoSitePlusⁱ	Q01130
SwissPalmⁱ	Q01130

Polymorphism and mutation databases

BioMutaⁱ	SRSF2
DMDMⁱ	60416437

Proteomic databases

EPDⁱ	Q01130
MaxQBⁱ	Q01130
PaxDbⁱ	Q01130
PeptideAtlasⁱ	Q01130
PRIDEⁱ	Q01130
ProteomicsDBⁱ	57922
TopDownProteomicsⁱ	Q01130-1 [Q01130-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6427
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000359995; ENSP00000353089; ENSG00000161547 [Q01130-1] ENST00000392485; ENSP00000376276; ENSG00000161547 [Q01130-1] ENST00000452355; ENSP00000391278; ENSG00000161547 [Q01130-1] ENST00000508921; ENSP00000441780; ENSG00000161547 [Q01130-2] ENST00000585202; ENSP00000462425; ENSG00000161547 [Q01130-1]
GeneIDⁱ	6427
KEGGⁱ	hsa:6427
UCSCⁱ	uc002jsv.4 human [Q01130-1]

Organism-specific databases

CTDⁱ	6427
DisGeNETⁱ	6427
EuPathDBⁱ	HostDB:ENSG00000161547.14
GeneCardsⁱ	SRSF2
HGNCⁱ	HGNC:10783 SRSF2
HPAⁱ	HPA049905
MIMⁱ	600813 gene
neXtProtⁱ	NX_Q01130
OpenTargetsⁱ	ENSG00000161547
PharmGKBⁱ	PA35699
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4207 Eukaryota ENOG4111NJ8 LUCA
GeneTreeⁱ	ENSGT00700000104403
HOVERGENⁱ	HBG107480
InParanoidⁱ	Q01130
KOⁱ	K12891
OMAⁱ	GRPPDSM
OrthoDBⁱ	EOG091G13K0
TreeFamⁱ	TF106262

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72165 mRNA Splicing - Minor Pathway R-HSA-72187 mRNA 3'-end processing
SIGNORⁱ	Q01130

Miscellaneous databases

ChiTaRSⁱ	SRSF2 human
EvolutionaryTraceⁱ	Q01130
GeneWikiⁱ	SFRS2
GenomeRNAiⁱ	6427
Protein Ontology More...PROⁱ	PR:Q01130
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000161547 Expressed in 236 organ(s), highest expression level in female gonad
CleanExⁱ	HS_SFRS2
ExpressionAtlasⁱ	Q01130 baseline and differential
Genevisibleⁱ	Q01130 HS

Family and domain databases

Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR003954 RRM_dom_euk IPR034893 SRSF2-like
PANTHERⁱ	PTHR23147:SF16 PTHR23147:SF16, 1 hit
Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit SM00361 RRM_1, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SRSF2_HUMAN
Accessionⁱ	Q01130Primary (citable) accession number: Q01130 Secondary accession number(s): B3KWD5, B4DN89, H0YG49
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 218 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q01130 (SRSF2_HUMAN)

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Serine/arginine-rich splicing factor 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ