UniProtKB - Q01130 (SRSF2_HUMAN)
Serine/arginine-rich splicing factor 2
SRSF2
Functioni
GO - Molecular functioni
- pre-mRNA binding Source: Ensembl
- protein kinase C binding Source: Ensembl
- RNA binding Source: UniProtKB
- transcription corepressor activity Source: UniProtKB
GO - Biological processi
- mitotic cell cycle Source: Ensembl
- mRNA 3'-end processing Source: Reactome
- mRNA cis splicing, via spliceosome Source: GO_Central
- mRNA export from nucleus Source: Reactome
- mRNA processing Source: ProtInc
- mRNA splicing, via spliceosome Source: Reactome
- regulation of alternative mRNA splicing, via spliceosome Source: GO_Central
- response to vitamin E Source: Ensembl
- RNA export from nucleus Source: Reactome
- RNA splicing Source: ProtInc
Keywordsi
Molecular function | RNA-binding |
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
PathwayCommonsi | Q01130 |
Reactomei | R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72165, mRNA Splicing - Minor Pathway R-HSA-72187, mRNA 3'-end processing R-HSA-73856, RNA Polymerase II Transcription Termination |
SIGNORi | Q01130 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/arginine-rich splicing factor 2Alternative name(s): Protein PR264 Splicing component, 35 kDa Splicing factor SC35 Short name: SC-35 Splicing factor, arginine/serine-rich 2 |
Gene namesi | Name:SRSF2 Synonyms:SFRS2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000161547.14 |
HGNCi | HGNC:10783, SRSF2 |
MIMi | 600813, gene |
neXtProti | NX_Q01130 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
- nucleoplasm 1 Publication
- Nucleus speckle 1 Publication
Note: Phosphorylation by SRPK2 provokes its redistribution from the nuclear specke to nucleoplasm.
Cytosol
- cytosol Source: HPA
Nucleus
- interchromatin granule Source: Ensembl
- nuclear speck Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- spliceosomal complex Source: Ensembl
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6427 |
MalaCardsi | SRSF2 |
OpenTargetsi | ENSG00000161547 |
Orphaneti | 98850, Aggressive systemic mastocytosis 98823, Chronic myelomonocytic leukemia 98849, Systemic mastocytosis with associated hematologic neoplasm |
PharmGKBi | PA35699 |
Miscellaneous databases
Pharosi | Q01130, Tbio |
Polymorphism and mutation databases
BioMutai | SRSF2 |
DMDMi | 60416437 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000081918 | 2 – 221 | Serine/arginine-rich splicing factor 2Add BLAST | 220 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources1 Publication | 1 | |
Modified residuei | 2 | PhosphoserineCombined sources | 1 | |
Modified residuei | 22 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 25 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 26 | PhosphoserineCombined sources | 1 | |
Modified residuei | 52 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 189 | PhosphoserineCombined sources | 1 | |
Modified residuei | 191 | PhosphoserineCombined sources | 1 | |
Modified residuei | 204 | PhosphoserineCombined sources | 1 | |
Modified residuei | 206 | PhosphoserineCombined sources | 1 | |
Modified residuei | 208 | PhosphoserineCombined sources | 1 | |
Modified residuei | 212 | PhosphoserineCombined sources | 1 | |
Modified residuei | 220 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q01130 |
jPOSTi | Q01130 |
MassIVEi | Q01130 |
MaxQBi | Q01130 |
PaxDbi | Q01130 |
PeptideAtlasi | Q01130 |
PRIDEi | Q01130 |
ProteomicsDBi | 38281 57922 [Q01130-1] |
TopDownProteomicsi | Q01130-1 [Q01130-1] |
PTM databases
iPTMneti | Q01130 |
MetOSitei | Q01130 |
PhosphoSitePlusi | Q01130 |
SwissPalmi | Q01130 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000161547, Expressed in female gonad and 248 other tissues |
ExpressionAtlasi | Q01130, baseline and differential |
Genevisiblei | Q01130, HS |
Organism-specific databases
HPAi | ENSG00000161547, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with BRDT (By similarity). In vitro, self-associates and binds SRSF1/SFRS1 (ASF/SF2), SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12.
Interacts with CCNL1 and CCNL2.
Interacts with SCAF11.
Interacts with ZRSR2/U2AF1-RS2.
Interacts with CCDC55 (via C-terminus).
By similarity8 PublicationsBinary interactionsi
Hide detailsQ01130
With | #Exp. | IntAct |
---|---|---|
CIR1 [Q86X95] | 4 | EBI-627047,EBI-627102 |
KAT5 [Q92993] | 3 | EBI-627047,EBI-399080 |
SNRNP70 [P08621] | 2 | EBI-627047,EBI-1049228 |
U2AF1 [Q01081] | 3 | EBI-627047,EBI-632461 |
GO - Molecular functioni
- protein kinase C binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 112325, 165 interactors |
CORUMi | Q01130 |
DIPi | DIP-33836N |
IntActi | Q01130, 77 interactors |
MINTi | Q01130 |
STRINGi | 9606.ENSP00000376276 |
Miscellaneous databases
RNActi | Q01130, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q01130 |
SMRi | Q01130 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q01130 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 92 | RRMPROSITE-ProRule annotationAdd BLAST | 79 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 111 – 116 | Gly-rich (hinge region) | 6 | |
Compositional biasi | 117 – 221 | Arg/Ser-rich (RS domain)Add BLAST | 105 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4207, Eukaryota |
GeneTreei | ENSGT00940000154883 |
HOGENOMi | CLU_012062_10_3_1 |
InParanoidi | Q01130 |
OMAi | GRPPDSM |
TreeFami | TF106262 |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR003954, RRM_dom_euk IPR034893, SRSF2-like |
PANTHERi | PTHR23147:SF119, PTHR23147:SF119, 1 hit |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit SM00361, RRM_1, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSYGRPPPDV EGMTSLKVDN LTYRTSPDTL RRVFEKYGRV GDVYIPRDRY
60 70 80 90 100
TKESRGFAFV RFHDKRDAED AMDAMDGAVL DGRELRVQMA RYGRPPDSHH
110 120 130 140 150
SRRGPPPRRY GGGGYGRRSR SPRRRRRSRS RSRSRSRSRS RSRYSRSKSR
160 170 180 190 200
SRTRSRSRST SKSRSARRSK SKSSSVSRSR SRSRSRSRSR SPPPVSKRES
210 220
KSRSRSKSPP KSPEEEGAVS S
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KP15 | J3KP15_HUMAN | Serine/arginine-rich splicing facto... | SRSF2 | 133 | Annotation score: | ||
J3QL05 | J3QL05_HUMAN | Serine/arginine-rich splicing facto... | SRSF2 | 130 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 38 | G → R in AAA60306 (PubMed:1373910).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056153 | 108 – 119 | Missing in isoform 2. 1 PublicationAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M90104 mRNA Translation: AAA60306.1 X62447 mRNA Translation: CAA44307.1 X75755 Genomic DNA Translation: CAA53383.1 BT007250 mRNA Translation: AAP35914.1 AK124792 mRNA Translation: BAG54097.1 AK297813 mRNA Translation: BAG60151.1 AC005837 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89439.1 CH471099 Genomic DNA Translation: EAW89448.1 BC000339 mRNA Translation: AAH00339.1 BC001303 mRNA Translation: AAH01303.1 BC070086 mRNA Translation: AAH70086.1 L03693 Genomic DNA Translation: AAA60162.1 |
CCDSi | CCDS11749.1 [Q01130-1] |
RefSeqi | NP_001182356.1, NM_001195427.1 [Q01130-1] NP_003007.2, NM_003016.4 [Q01130-1] XP_016880431.1, XM_017024942.1 [Q01130-1] |
Genome annotation databases
Ensembli | ENST00000359995; ENSP00000353089; ENSG00000161547 [Q01130-1] ENST00000392485; ENSP00000376276; ENSG00000161547 [Q01130-1] ENST00000452355; ENSP00000391278; ENSG00000161547 [Q01130-1] ENST00000508921; ENSP00000441780; ENSG00000161547 [Q01130-2] ENST00000585202; ENSP00000462425; ENSG00000161547 [Q01130-1] |
GeneIDi | 6427 |
KEGGi | hsa:6427 |
UCSCi | uc002jsv.4, human [Q01130-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M90104 mRNA Translation: AAA60306.1 X62447 mRNA Translation: CAA44307.1 X75755 Genomic DNA Translation: CAA53383.1 BT007250 mRNA Translation: AAP35914.1 AK124792 mRNA Translation: BAG54097.1 AK297813 mRNA Translation: BAG60151.1 AC005837 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89439.1 CH471099 Genomic DNA Translation: EAW89448.1 BC000339 mRNA Translation: AAH00339.1 BC001303 mRNA Translation: AAH01303.1 BC070086 mRNA Translation: AAH70086.1 L03693 Genomic DNA Translation: AAA60162.1 |
CCDSi | CCDS11749.1 [Q01130-1] |
RefSeqi | NP_001182356.1, NM_001195427.1 [Q01130-1] NP_003007.2, NM_003016.4 [Q01130-1] XP_016880431.1, XM_017024942.1 [Q01130-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2KN4 | NMR | - | A | 9-101 | [»] | |
2LEA | NMR | - | A | 1-101 | [»] | |
2LEB | NMR | - | A | 1-101 | [»] | |
2LEC | NMR | - | A | 1-101 | [»] | |
BMRBi | Q01130 | |||||
SMRi | Q01130 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112325, 165 interactors |
CORUMi | Q01130 |
DIPi | DIP-33836N |
IntActi | Q01130, 77 interactors |
MINTi | Q01130 |
STRINGi | 9606.ENSP00000376276 |
PTM databases
iPTMneti | Q01130 |
MetOSitei | Q01130 |
PhosphoSitePlusi | Q01130 |
SwissPalmi | Q01130 |
Polymorphism and mutation databases
BioMutai | SRSF2 |
DMDMi | 60416437 |
Proteomic databases
EPDi | Q01130 |
jPOSTi | Q01130 |
MassIVEi | Q01130 |
MaxQBi | Q01130 |
PaxDbi | Q01130 |
PeptideAtlasi | Q01130 |
PRIDEi | Q01130 |
ProteomicsDBi | 38281 57922 [Q01130-1] |
TopDownProteomicsi | Q01130-1 [Q01130-1] |
Protocols and materials databases
Antibodypediai | 19705, 133 antibodies |
DNASUi | 6427 |
Genome annotation databases
Ensembli | ENST00000359995; ENSP00000353089; ENSG00000161547 [Q01130-1] ENST00000392485; ENSP00000376276; ENSG00000161547 [Q01130-1] ENST00000452355; ENSP00000391278; ENSG00000161547 [Q01130-1] ENST00000508921; ENSP00000441780; ENSG00000161547 [Q01130-2] ENST00000585202; ENSP00000462425; ENSG00000161547 [Q01130-1] |
GeneIDi | 6427 |
KEGGi | hsa:6427 |
UCSCi | uc002jsv.4, human [Q01130-1] |
Organism-specific databases
CTDi | 6427 |
DisGeNETi | 6427 |
EuPathDBi | HostDB:ENSG00000161547.14 |
GeneCardsi | SRSF2 |
HGNCi | HGNC:10783, SRSF2 |
HPAi | ENSG00000161547, Low tissue specificity |
MalaCardsi | SRSF2 |
MIMi | 600813, gene |
neXtProti | NX_Q01130 |
OpenTargetsi | ENSG00000161547 |
Orphaneti | 98850, Aggressive systemic mastocytosis 98823, Chronic myelomonocytic leukemia 98849, Systemic mastocytosis with associated hematologic neoplasm |
PharmGKBi | PA35699 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4207, Eukaryota |
GeneTreei | ENSGT00940000154883 |
HOGENOMi | CLU_012062_10_3_1 |
InParanoidi | Q01130 |
OMAi | GRPPDSM |
TreeFami | TF106262 |
Enzyme and pathway databases
PathwayCommonsi | Q01130 |
Reactomei | R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72165, mRNA Splicing - Minor Pathway R-HSA-72187, mRNA 3'-end processing R-HSA-73856, RNA Polymerase II Transcription Termination |
SIGNORi | Q01130 |
Miscellaneous databases
BioGRID-ORCSi | 6427, 767 hits in 852 CRISPR screens |
ChiTaRSi | SRSF2, human |
EvolutionaryTracei | Q01130 |
GeneWikii | SFRS2 |
GenomeRNAii | 6427 |
Pharosi | Q01130, Tbio |
PROi | PR:Q01130 |
RNActi | Q01130, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000161547, Expressed in female gonad and 248 other tissues |
ExpressionAtlasi | Q01130, baseline and differential |
Genevisiblei | Q01130, HS |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR003954, RRM_dom_euk IPR034893, SRSF2-like |
PANTHERi | PTHR23147:SF119, PTHR23147:SF119, 1 hit |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit SM00361, RRM_1, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SRSF2_HUMAN | |
Accessioni | Q01130Primary (citable) accession number: Q01130 Secondary accession number(s): B3KWD5, B4DN89, H0YG49 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 236 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM