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Protein

Interleukin-9 receptor

Gene

Il9r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is a receptor for interleukin-9.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-8985947 Interleukin-9 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-9 receptor
Short name:
IL-9 receptor
Short name:
IL-9R
Alternative name(s):
CD_antigen: CD129
Gene namesi
Name:Il9r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96564 Il9r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini38 – 270ExtracellularSequence analysisAdd BLAST233
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 468CytoplasmicSequence analysisAdd BLAST177

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
ChainiPRO_000001091238 – 468Interleukin-9 receptorAdd BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ01114
PRIDEiQ01114

PTM databases

PhosphoSitePlusiQ01114

Expressioni

Gene expression databases

BgeeiENSMUSG00000020279
CleanExiMM_IL9R
ExpressionAtlasiQ01114 baseline and differential
GenevisibleiQ01114 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119557

Structurei

3D structure databases

ProteinModelPortaliQ01114
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini148 – 256Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST109

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi244 – 248WSXWS motif5
Motifi301 – 309Box 1 motif9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi44 – 47Poly-Gly4
Compositional biasi419 – 422Poly-Pro4

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZ2W Eukaryota
ENOG41116AC LUCA
GeneTreeiENSGT00510000049125
HOVERGENiHBG005032
InParanoidiQ01114
KOiK05073

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003531 Hempt_rcpt_S_F1_CS
IPR013783 Ig-like_fold
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS01355 HEMATOPO_REC_S_F1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q01114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGRCIAEG WTLERVAVKQ VSWFLIYSWV CSGVCRGVSV PEQGGGGQKA
60 70 80 90 100
GAFTCLSNSI YRIDCHWSAP ELGQESRAWL LFTSNQVTEI KHKCTFWDSM
110 120 130 140 150
CTLVLPKEEV FLPFDNFTIT LHRCIMGQEQ VSLVDSQYLP RRHIKLDPPS
160 170 180 190 200
DLQSNVSSGR CVLTWGINLA LEPLITSLSY ELAFKRQEEA WEARHKDRIV
210 220 230 240 250
GVTWLILEAV ELNPGSIYEA RLRVQMTLES YEDKTEGEYY KSHWSEWSQP
260 270 280 290 300
VSFPSPQRRQ GLLVPRWQWS ASILVVVPIF LLLTGFVHLL FKLSPRLKRI
310 320 330 340 350
FYQNIPSPEA FFHPLYSVYH GDFQSWTGAR RAGPQARQNG VSTSSAGSES
360 370 380 390 400
SIWEAVATLT YSPACPVQFA CLKWEATAPG FPGLPGSEHV LPAGCLELEG
410 420 430 440 450
QPSAYLPQED WAPLGSARPP PPDSDSGSSD YCMLDCCEEC HLSAFPGHTE
460
SPELTLAQPV ALPVSSRA
Length:468
Mass (Da):52,261
Last modified:April 1, 1993 - v1
Checksum:iBBE7179FD72E29A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84746 mRNA Translation: AAA37871.1
CCDSiCCDS24517.1
PIRiA45268
RefSeqiNP_032400.1, NM_008374.2
UniGeneiMm.384

Genome annotation databases

EnsembliENSMUST00000145401; ENSMUSP00000118204; ENSMUSG00000020279
GeneIDi16199
KEGGimmu:16199
UCSCiuc007iix.2 mouse

Similar proteinsi

Entry informationi

Entry nameiIL9R_MOUSE
AccessioniPrimary (citable) accession number: Q01114
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 20, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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