UniProtKB - Q01101 (INSM1_HUMAN)

BLAST

>sp|Q01101|INSM1_HUMAN Insulinoma-associated protein 1 OS=Homo sapiens OX=9606 GN=INSM1 PE=1 SV=1
MPRGFLVKRSKKSTPVSYRVRGGEDGDRALLLSPSCGGARAEPPAPSPVPGPLPPPPPAE
RAHAALAAALACAPGPQPPPQGPRAAHFGNPEAAHPAPLYSPTRPVSREHEKHKYFERSF
NLGSPVSAESFPTPAALLGGGGGGGASGAGGGGTCGGDPLLFAPAELKMGTAFSAGAEAA
RGPGPGPPLPPAAALRPPGKRPPPPTAAEPPAKAVKAPGAKKPKAIRKLHFEDEVTTSPV
LGLKIKEGPVEAPRGRAGGAARPLGEFICQLCKEEYADPFALAQHKCSRIVRVEYRCPEC
AKVFSCPANLASHRRWHKPRPAPAAARAPEPEAAARAEAREAPGGGSDRDTPSPGGVSES
GSEDGLYECHHCAKKFRRQAYLRKHLLAHHQALQAKGAPLAPPAEDLLALYPGPDEKAPQ
EAAGDGEGAGVLGLSASAECHLCPVCGESFASKGAQERHLRLLHAAQVFPCKYCPATFYS
SPGLTRHINKCHPSENRQVILLQVPVRPAC

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History
Entry version 156 (07 Nov 2018)
Sequence version 1 (01 Jun 1994)
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Protein

Insulinoma-associated protein 1

Gene

INSM1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation.5 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	267 – 287	C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	295 – 317	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	367 – 389	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	441 – 464	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	469 – 492	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

chromatin DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16569215
- 18417529
cyclin binding
Source: UniProtKB
Inferred from physical interactionⁱ
DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
histone deacetylase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16569215
- 18417529
metal ion binding Source: UniProtKB-KW
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 16569215
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11842116
- 18417529

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adrenal chromaffin cell differentiation Source: UniProtKB
cell cycle Source: UniProtKB-KW
endocrine pancreas development Source: Reactome
negative regulation of cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 19124461
negative regulation of protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 19124461
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
noradrenergic neuron development Source: UniProtKB
norepinephrine biosynthetic process Source: UniProtKB
pancreatic A cell differentiation Source: UniProtKB
positive regulation of cell cycle arrest
Source: UniProtKB
Inferred from direct assayⁱ
- 19124461
positive regulation of cell differentiation Source: UniProtKB
positive regulation of cell migration Source: Ensembl
positive regulation of neural precursor cell proliferation Source: UniProtKB
regulation of gene expression Source: UniProtKB
regulation of protein complex assembly
Source: UniProtKB
Inferred from direct assayⁱ
- 19124461
sympathetic ganglion development Source: UniProtKB
transdifferentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 16511571
type B pancreatic cell development Source: Ensembl
type B pancreatic cell differentiation Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding, Repressor
Biological process	Cell cycle, Differentiation, Neurogenesis, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
SignaLinkⁱ	Q01101
SIGNORⁱ	Q01101

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Insulinoma-associated protein 1 Alternative name(s): Zinc finger protein IA-1
Gene namesⁱ	Name:INSM1 Synonyms:IA1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000173404.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6090 INSM1
MIMⁱ	600010 gene
neXtProtⁱ	NX_Q01101

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	43 – 58	PPAPS…PPPPP → LLALSLVLGLLLLLLL: Inhibits weakly translational repression activity. Inhibits interaction with CCND1 and cell cycle arrest. 1 PublicationAdd BLAST		16

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3642
Open Targets More...OpenTargetsⁱ	ENSG00000173404
PharmGKBⁱ	PA29897

Polymorphism and mutation databases

BioMutaⁱ	INSM1
DMDMⁱ	547700

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047268	1 – 510	Insulinoma-associated protein 1Add BLAST		510

Proteomic databases

EPDⁱ	Q01101
PaxDbⁱ	Q01101
PeptideAtlas More...PeptideAtlasⁱ	Q01101
PRIDEⁱ	Q01101
ProteomicsDBⁱ	57916

PTM databases

iPTMnetⁱ	Q01101
PhosphoSitePlusⁱ	Q01101

Expressionⁱ

Tissue specificityⁱ

Expressed in pancreatic duct cells. Expressed in several tumor cell lines of neuroendocrine origin including pheochromocytoma, medullary thyroid carcinoma, insulinoma, medulloblastoma, retinoblastoma, pheochromacytoma, medullary thyroid carcinoma and small cell lung carcinoma.2 Publications

Inductionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000173404 Expressed in 92 organ(s), highest expression level in brain
CleanExⁱ	HS_INSM1
Genevisibleⁱ	Q01101 HS

Interactionⁱ

Subunit structureⁱ

Interacts (via the SNAG domain) with HDAC1. Interacts (via the SNAG domain) with HDAC2. Interacts (via the SNAG domain) with KDM1A. Interacts (via the SNAG domain) with RCOR1. Interacts with SORBS1 (By similarity). Interacts (via the N-terminal region) with CCND1 (via cyclin N-terminal domain); the interaction competes with the binding of CCND1 to CDK4 during cell cycle progression and increases its transcriptional repressor activity. Interacts with HDAC3; the interaction increases its transcriptional repressor activity. Interacts with HDAC1.By similarity4 Publications

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109853, 5 interactors
IntActⁱ	Q01101, 10 interactors
STRINGⁱ	9606.ENSP00000312631

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	3 – 5	Combined sources	3
Beta strandⁱ	449 – 452	Combined sources	4
Helixⁱ	453 – 461	Combined sources	9
Beta strandⁱ	466 – 470	Combined sources	5
Beta strandⁱ	477 – 480	Combined sources	4
Helixⁱ	481 – 489	Combined sources	9

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP01023
ProteinModelPortalⁱ	Q01101
SMRⁱ	Q01101
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 20	SNAG domainBy similarityAdd BLAST		20
Regionⁱ	43 – 58	Necessary for interaction with CCND1Add BLAST		16

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	1 – 250	Ala/Gly/Pro-richAdd BLAST		250

Domainⁱ

The C-terminal region is necessary for NEUROD1 promoter DNA-binding and transcriptional repressor activity.

Sequence similaritiesⁱ

Belongs to the INSM1 family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	267 – 287	C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	295 – 317	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	367 – 389	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	441 – 464	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	469 – 492	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3993 Eukaryota ENOG4111MVC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000064190
HOGENOMⁱ	HOG000113079
HOVERGENⁱ	HBG052137
InParanoidⁱ	Q01101
OMAⁱ	APAELKM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BI3
PhylomeDBⁱ	Q01101
TreeFamⁱ	TF320538

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q01101-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPRGFLVKRS KKSTPVSYRV RGGEDGDRAL LLSPSCGGAR AEPPAPSPVP 
        60         70         80         90        100
GPLPPPPPAE RAHAALAAAL ACAPGPQPPP QGPRAAHFGN PEAAHPAPLY 
       110        120        130        140        150
SPTRPVSREH EKHKYFERSF NLGSPVSAES FPTPAALLGG GGGGGASGAG 
       160        170        180        190        200
GGGTCGGDPL LFAPAELKMG TAFSAGAEAA RGPGPGPPLP PAAALRPPGK 
       210        220        230        240        250
RPPPPTAAEP PAKAVKAPGA KKPKAIRKLH FEDEVTTSPV LGLKIKEGPV 
       260        270        280        290        300
EAPRGRAGGA ARPLGEFICQ LCKEEYADPF ALAQHKCSRI VRVEYRCPEC 
       310        320        330        340        350
AKVFSCPANL ASHRRWHKPR PAPAAARAPE PEAAARAEAR EAPGGGSDRD 
       360        370        380        390        400
TPSPGGVSES GSEDGLYECH HCAKKFRRQA YLRKHLLAHH QALQAKGAPL 
       410        420        430        440        450
APPAEDLLAL YPGPDEKAPQ EAAGDGEGAG VLGLSASAEC HLCPVCGESF 
       460        470        480        490        500
ASKGAQERHL RLLHAAQVFP CKYCPATFYS SPGLTRHINK CHPSENRQVI 
       510
LLQVPVRPAC

Length:510

Mass (Da):52,923

Last modified:June 1, 1994 - v1

Checksum:ⁱ22D4E97696397365

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M93119 mRNA Translation: AAA58680.1 AL161658 Genomic DNA No translation available. U07172 Genomic DNA Translation: AAA20938.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13143.1
PIRⁱ	A42750
NCBI Reference Sequences More...RefSeqⁱ	NP_002187.1, NM_002196.2
UniGeneⁱ	Hs.89584

Genome annotation databases

Ensemblⁱ	ENST00000310227; ENSP00000312631; ENSG00000173404
GeneIDⁱ	3642
KEGGⁱ	hsa:3642
UCSC genome browser More...UCSCⁱ	uc002wrx.4 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q01101	Insulinoma-associated protein 1		MOUSE		521	UniRef90_Q63ZV0
Insulinoma-associated protein 1		BOVIN		522
LOW QUALITY PROTEIN: insulinoma-associated protein 1		DELLE		524
insulinoma-associated protein 1		MESAU		517
insulinoma-associated protein 1		TURTR		516
+37

Protein	Similar proteins		Species	Score	Length	Source
Q01101	Insulinoma-associated protein 1		MOUSE		521	UniRef50_Q63ZV0
Insulinoma-associated protein 1		BOVIN		522
LOW QUALITY PROTEIN: insulinoma-associated protein 1		DELLE		524
insulinoma-associated protein 1		MESAU		517
insulinoma-associated protein 1		TURTR		516
+55

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M93119 mRNA Translation: AAA58680.1 AL161658 Genomic DNA No translation available. U07172 Genomic DNA Translation: AAA20938.1
CCDSⁱ	CCDS13143.1
PIRⁱ	A42750
RefSeqⁱ	NP_002187.1, NM_002196.2
UniGeneⁱ	Hs.89584

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2LV2	NMR	-	A	424-497	[»]
	3ZMS	X-ray	2.96	C	2-510	[»]
DisProtⁱ	DP01023
ProteinModelPortalⁱ	Q01101
SMRⁱ	Q01101
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109853, 5 interactors
IntActⁱ	Q01101, 10 interactors
STRINGⁱ	9606.ENSP00000312631

PTM databases

iPTMnetⁱ	Q01101
PhosphoSitePlusⁱ	Q01101

Polymorphism and mutation databases

BioMutaⁱ	INSM1
DMDMⁱ	547700

Proteomic databases

EPDⁱ	Q01101
PaxDbⁱ	Q01101
PeptideAtlasⁱ	Q01101
PRIDEⁱ	Q01101
ProteomicsDBⁱ	57916

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000310227; ENSP00000312631; ENSG00000173404
GeneIDⁱ	3642
KEGGⁱ	hsa:3642
UCSCⁱ	uc002wrx.4 human

Organism-specific databases

CTDⁱ	3642
DisGeNETⁱ	3642
EuPathDBⁱ	HostDB:ENSG00000173404.4
GeneCardsⁱ	INSM1
HGNCⁱ	HGNC:6090 INSM1
MIMⁱ	600010 gene
neXtProtⁱ	NX_Q01101
OpenTargetsⁱ	ENSG00000173404
PharmGKBⁱ	PA29897
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3993 Eukaryota ENOG4111MVC LUCA
GeneTreeⁱ	ENSGT00530000064190
HOGENOMⁱ	HOG000113079
HOVERGENⁱ	HBG052137
InParanoidⁱ	Q01101
OMAⁱ	APAELKM
OrthoDBⁱ	EOG091G0BI3
PhylomeDBⁱ	Q01101
TreeFamⁱ	TF320538

Enzyme and pathway databases

Reactomeⁱ	R-HSA-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
SignaLinkⁱ	Q01101
SIGNORⁱ	Q01101

Miscellaneous databases

GeneWikiⁱ	INSM1
GenomeRNAiⁱ	3642
Protein Ontology More...PROⁱ	PR:Q01101
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000173404 Expressed in 92 organ(s), highest expression level in brain
CleanExⁱ	HS_INSM1
Genevisibleⁱ	Q01101 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	INSM1_HUMAN
Accessionⁱ	Q01101Primary (citable) accession number: Q01101
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	June 1, 1994
	Last modified:	November 7, 2018
	This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Supporting data

UniProtKB - Q01101 (INSM1_HUMAN)

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Insulinoma-associated protein 1

INSM1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ