UniProtKB - Q01101 (INSM1_HUMAN)
Insulinoma-associated protein 1
INSM1
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 267 – 287 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 295 – 317 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 367 – 389 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 441 – 464 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 469 – 492 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- chromatin DNA binding Source: UniProtKB
- cyclin binding Source: UniProtKB
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- histone deacetylase binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- adrenal chromaffin cell differentiation Source: UniProtKB
- cell cycle Source: UniProtKB-KW
- endocrine pancreas development Source: Reactome
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of protein phosphorylation Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- neuron differentiation Source: GO_Central
- noradrenergic neuron development Source: UniProtKB
- norepinephrine biosynthetic process Source: UniProtKB
- pancreatic A cell differentiation Source: UniProtKB
- positive regulation of cell cycle arrest Source: UniProtKB
- positive regulation of cell differentiation Source: UniProtKB
- positive regulation of cell migration Source: Ensembl
- positive regulation of neural precursor cell proliferation Source: UniProtKB
- regulation of cell cycle process Source: GO_Central
- regulation of gene expression Source: UniProtKB
- regulation of protein-containing complex assembly Source: UniProtKB
- sympathetic ganglion development Source: UniProtKB
- transdifferentiation Source: UniProtKB
- type B pancreatic cell development Source: Ensembl
- type B pancreatic cell differentiation Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, DNA-binding, Repressor |
Biological process | Cell cycle, Differentiation, Neurogenesis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q01101 |
Reactomei | R-HSA-210746, Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells |
SignaLinki | Q01101 |
SIGNORi | Q01101 |
Names & Taxonomyi
Protein namesi | Recommended name: Insulinoma-associated protein 1Alternative name(s): Zinc finger protein IA-1 |
Gene namesi | Name:INSM1 Synonyms:IA1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6090, INSM1 |
MIMi | 600010, gene |
neXtProti | NX_Q01101 |
VEuPathDBi | HostDB:ENSG00000173404.4 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- transcription repressor complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 43 – 58 | PPAPS…PPPPP → LLALSLVLGLLLLLLL: Inhibits weakly translational repression activity. Inhibits interaction with CCND1 and cell cycle arrest. 1 PublicationAdd BLAST | 16 |
Organism-specific databases
DisGeNETi | 3642 |
OpenTargetsi | ENSG00000173404 |
PharmGKBi | PA29897 |
Miscellaneous databases
Pharosi | Q01101, Tbio |
Genetic variation databases
BioMutai | INSM1 |
DMDMi | 547700 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047268 | 1 – 510 | Insulinoma-associated protein 1Add BLAST | 510 |
Proteomic databases
EPDi | Q01101 |
jPOSTi | Q01101 |
MassIVEi | Q01101 |
PaxDbi | Q01101 |
PeptideAtlasi | Q01101 |
PRIDEi | Q01101 |
ProteomicsDBi | 57916 |
PTM databases
iPTMneti | Q01101 |
PhosphoSitePlusi | Q01101 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000173404, Expressed in subventricular zone (outer) (primate) and 102 other tissues |
Genevisiblei | Q01101, HS |
Organism-specific databases
HPAi | ENSG00000173404, Tissue enhanced (adrenal gland, brain, pituitary gland) |
Interactioni
Subunit structurei
Interacts (via the SNAG domain) with HDAC1 (PubMed:16569215).
Interacts (via the SNAG domain) with HDAC2 (By similarity).
Interacts (via the SNAG domain) with KDM1A (PubMed:23721412).
Interacts (via the SNAG domain) with RCOR1.
Interacts with SORBS1 (By similarity).
Interacts (via the N-terminal region) with CCND1 (via cyclin N-terminal domain); the interaction competes with the binding of CCND1 to CDK4 during cell cycle progression and increases its transcriptional repressor activity (PubMed:16569215, PubMed:18417529, PubMed:19124461).
Interacts with HDAC3; the interaction increases its transcriptional repressor activity (PubMed:16569215, PubMed:18417529).
By similarity4 PublicationsGO - Molecular functioni
- cyclin binding Source: UniProtKB
- histone deacetylase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109853, 7 interactors |
IntActi | Q01101, 5 interactors |
STRINGi | 9606.ENSP00000312631 |
Miscellaneous databases
RNActi | Q01101, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q01101 |
SMRi | Q01101 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | SNAG domainBy similarityAdd BLAST | 20 | |
Regioni | 2 – 7 | Required and sufficient for interaction with KDM1A1 Publication | 6 | |
Regioni | 43 – 58 | Necessary for interaction with CCND1Add BLAST | 16 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 250 | Ala/Gly/Pro-richAdd BLAST | 250 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 267 – 287 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 295 – 317 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 367 – 389 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 441 – 464 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 469 – 492 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG3993, Eukaryota |
GeneTreei | ENSGT00940000162552 |
HOGENOMi | CLU_033476_1_0_1 |
InParanoidi | Q01101 |
OMAi | REHEKHK |
OrthoDBi | 1306883at2759 |
PhylomeDBi | Q01101 |
TreeFami | TF320538 |
Family and domain databases
DisProti | DP01023 |
IDEALi | IID00415 |
InterProi | View protein in InterPro IPR042972, INSM1/2 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR15065, PTHR15065, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MPRGFLVKRS KKSTPVSYRV RGGEDGDRAL LLSPSCGGAR AEPPAPSPVP
60 70 80 90 100
GPLPPPPPAE RAHAALAAAL ACAPGPQPPP QGPRAAHFGN PEAAHPAPLY
110 120 130 140 150
SPTRPVSREH EKHKYFERSF NLGSPVSAES FPTPAALLGG GGGGGASGAG
160 170 180 190 200
GGGTCGGDPL LFAPAELKMG TAFSAGAEAA RGPGPGPPLP PAAALRPPGK
210 220 230 240 250
RPPPPTAAEP PAKAVKAPGA KKPKAIRKLH FEDEVTTSPV LGLKIKEGPV
260 270 280 290 300
EAPRGRAGGA ARPLGEFICQ LCKEEYADPF ALAQHKCSRI VRVEYRCPEC
310 320 330 340 350
AKVFSCPANL ASHRRWHKPR PAPAAARAPE PEAAARAEAR EAPGGGSDRD
360 370 380 390 400
TPSPGGVSES GSEDGLYECH HCAKKFRRQA YLRKHLLAHH QALQAKGAPL
410 420 430 440 450
APPAEDLLAL YPGPDEKAPQ EAAGDGEGAG VLGLSASAEC HLCPVCGESF
460 470 480 490 500
ASKGAQERHL RLLHAAQVFP CKYCPATFYS SPGLTRHINK CHPSENRQVI
510
LLQVPVRPAC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M93119 mRNA Translation: AAA58680.1 AL161658 Genomic DNA No translation available. U07172 Genomic DNA Translation: AAA20938.1 |
CCDSi | CCDS13143.1 |
PIRi | A42750 |
RefSeqi | NP_002187.1, NM_002196.2 |
Genome annotation databases
Ensembli | ENST00000310227; ENSP00000312631; ENSG00000173404 |
GeneIDi | 3642 |
KEGGi | hsa:3642 |
UCSCi | uc002wrx.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M93119 mRNA Translation: AAA58680.1 AL161658 Genomic DNA No translation available. U07172 Genomic DNA Translation: AAA20938.1 |
CCDSi | CCDS13143.1 |
PIRi | A42750 |
RefSeqi | NP_002187.1, NM_002196.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2LV2 | NMR | - | A | 424-497 | [»] | |
3ZMS | X-ray | 2.96 | C | 2-9 | [»] | |
BMRBi | Q01101 | |||||
SMRi | Q01101 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109853, 7 interactors |
IntActi | Q01101, 5 interactors |
STRINGi | 9606.ENSP00000312631 |
PTM databases
iPTMneti | Q01101 |
PhosphoSitePlusi | Q01101 |
Genetic variation databases
BioMutai | INSM1 |
DMDMi | 547700 |
Proteomic databases
EPDi | Q01101 |
jPOSTi | Q01101 |
MassIVEi | Q01101 |
PaxDbi | Q01101 |
PeptideAtlasi | Q01101 |
PRIDEi | Q01101 |
ProteomicsDBi | 57916 |
Protocols and materials databases
Antibodypediai | 9637, 82 antibodies |
Genome annotation databases
Ensembli | ENST00000310227; ENSP00000312631; ENSG00000173404 |
GeneIDi | 3642 |
KEGGi | hsa:3642 |
UCSCi | uc002wrx.4, human |
Organism-specific databases
CTDi | 3642 |
DisGeNETi | 3642 |
GeneCardsi | INSM1 |
HGNCi | HGNC:6090, INSM1 |
HPAi | ENSG00000173404, Tissue enhanced (adrenal gland, brain, pituitary gland) |
MIMi | 600010, gene |
neXtProti | NX_Q01101 |
OpenTargetsi | ENSG00000173404 |
PharmGKBi | PA29897 |
VEuPathDBi | HostDB:ENSG00000173404.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3993, Eukaryota |
GeneTreei | ENSGT00940000162552 |
HOGENOMi | CLU_033476_1_0_1 |
InParanoidi | Q01101 |
OMAi | REHEKHK |
OrthoDBi | 1306883at2759 |
PhylomeDBi | Q01101 |
TreeFami | TF320538 |
Enzyme and pathway databases
PathwayCommonsi | Q01101 |
Reactomei | R-HSA-210746, Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells |
SignaLinki | Q01101 |
SIGNORi | Q01101 |
Miscellaneous databases
BioGRID-ORCSi | 3642, 5 hits in 1005 CRISPR screens |
GeneWikii | INSM1 |
GenomeRNAii | 3642 |
Pharosi | Q01101, Tbio |
PROi | PR:Q01101 |
RNActi | Q01101, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000173404, Expressed in subventricular zone (outer) (primate) and 102 other tissues |
Genevisiblei | Q01101, HS |
Family and domain databases
DisProti | DP01023 |
IDEALi | IID00415 |
InterProi | View protein in InterPro IPR042972, INSM1/2 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR15065, PTHR15065, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | INSM1_HUMAN | |
Accessioni | Q01101Primary (citable) accession number: Q01101 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | April 7, 2021 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families