UniProtKB - Q01098 (NMDE3_MOUSE)
Glutamate receptor ionotropic, NMDA 2C
Grin2c
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 511 | GlutamateBy similarity | 1 | |
Binding sitei | 516 | GlutamateBy similarity | 1 | |
Sitei | 612 | Functional determinant of NMDA receptorsBy similarity | 1 | |
Binding sitei | 729 | GlutamateBy similarity | 1 |
GO - Molecular functioni
- cation channel activity Source: MGI
- glutamate-gated calcium ion channel activity Source: UniProtKB
- ionotropic glutamate receptor activity Source: MGI
- ligand-gated ion channel activity Source: GO_Central
- NMDA glutamate receptor activity Source: MGI
- PDZ domain binding Source: MGI
- protein N-terminus binding Source: MGI
- signaling receptor activity Source: GO_Central
- transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Source: SynGO
GO - Biological processi
- calcium ion transmembrane import into cytosol Source: UniProtKB
- directional locomotion Source: MGI
- excitatory postsynaptic potential Source: MGI
- long-term synaptic potentiation Source: GO_Central
- negative regulation of protein catabolic process Source: MGI
- neuromuscular process controlling balance Source: MGI
- protein localization to postsynaptic membrane Source: MGI
- regulation of membrane potential Source: MGI
- response to wounding Source: MGI
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Ligand | Calcium, Magnesium |
Enzyme and pathway databases
Reactomei | R-MMU-438066, Unblocking of NMDA receptors, glutamate binding and activation R-MMU-8849932, Synaptic adhesion-like molecules R-MMU-9609736, Assembly and cell surface presentation of NMDA receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamate receptor ionotropic, NMDA 2CShort name: GluN2C Alternative name(s): Glutamate [NMDA] receptor subunit epsilon-31 Publication N-methyl D-aspartate receptor subtype 2C Short name: NMDAR2C Short name: NR2C1 Publication |
Gene namesi | Name:Grin2c |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95822, Grin2c |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Curated
- postsynaptic cell membrane ; Multi-pass membrane protein
Plasma Membrane
- integral component of plasma membrane Source: MGI
- NMDA selective glutamate receptor complex Source: MGI
- plasma membrane Source: GO_Central
- postsynaptic density membrane Source: GO_Central
Other locations
- glutamatergic synapse Source: SynGO
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 554 | ExtracellularBy similarityAdd BLAST | 535 | |
Transmembranei | 555 – 573 | HelicalBy similarityAdd BLAST | 19 | |
Topological domaini | 574 – 600 | CytoplasmicBy similarityAdd BLAST | 27 | |
Intramembranei | 601 – 620 | Discontinuously helicalBy similarityAdd BLAST | 20 | |
Topological domaini | 621 – 627 | CytoplasmicBy similarity | 7 | |
Transmembranei | 628 – 643 | HelicalBy similarityAdd BLAST | 16 | |
Topological domaini | 644 – 814 | ExtracellularBy similarityAdd BLAST | 171 | |
Transmembranei | 815 – 834 | HelicalBy similarityAdd BLAST | 20 | |
Topological domaini | 835 – 1239 | CytoplasmicBy similarityAdd BLAST | 405 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Disruption phenotypei
Chemistry databases
ChEMBLi | CHEMBL3832634 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000011581 | 20 – 1239 | Glutamate receptor ionotropic, NMDA 2CAdd BLAST | 1220 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 70 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 73 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 82 ↔ 317 | By similarity | ||
Glycosylationi | 337 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 426 ↔ 453 | By similarity | ||
Disulfide bondi | 433 ↔ 454 | By similarity | ||
Glycosylationi | 438 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 539 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 685 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 743 ↔ 798 | By similarity | ||
Modified residuei | 875 | PhosphoserineCombined sources | 1 | |
Modified residuei | 881 | PhosphoserineCombined sources | 1 | |
Modified residuei | 912 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q01098 |
PRIDEi | Q01098 |
PTM databases
GlyConnecti | 2352, 1 N-Linked glycan (1 site) |
GlyGeni | Q01098, 4 sites |
iPTMneti | Q01098 |
PhosphoSitePlusi | Q01098 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000020734, Expressed in cerebellar cortex and 120 other tissues |
ExpressionAtlasi | Q01098, baseline and differential |
Genevisiblei | Q01098, MM |
Interactioni
Subunit structurei
Heterotetramer. Forms heterotetrameric channels composed of two zeta subunits (GRIN1), and two epsilon subunits (GRIN2A, GRIN2B, GRIN2C or GRIN2D) (in vitro) (PubMed:1377365). Can also form heterotetrameric channels that contain at least one zeta subunit (GRIN1), at least one epsilon subunit, plus GRIN3A or GRIN3B (By similarity). In vivo, the subunit composition may depend on the expression levels of the different subunits (Probable).
Interacts with PDZ domains of PATJ and DLG4 (By similarity).
Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (By similarity).
By similarityCurated1 PublicationGO - Molecular functioni
- PDZ domain binding Source: MGI
- protein N-terminus binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 200070, 6 interactors |
ComplexPortali | CPX-292, NMDA receptor complex, GluN1-GluN2C |
IntActi | Q01098, 1 interactor |
MINTi | Q01098 |
STRINGi | 10090.ENSMUSP00000102164 |
Miscellaneous databases
RNActi | Q01098, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 509 – 511 | Glutamate bindingBy similarity | 3 | |
Regioni | 601 – 620 | Pore-formingBy similarityAdd BLAST | 20 | |
Regioni | 687 – 688 | Glutamate bindingBy similarity | 2 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1237 – 1239 | PDZ-binding | 3 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1053, Eukaryota |
GeneTreei | ENSGT00940000156964 |
HOGENOMi | CLU_002039_1_0_1 |
InParanoidi | Q01098 |
OMAi | ATWGNDR |
OrthoDBi | 188544at2759 |
PhylomeDBi | Q01098 |
TreeFami | TF314731 |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR019594, Glu/Gly-bd IPR001508, Iono_rcpt_met IPR001320, Iontro_rcpt IPR018884, NMDAR2_C IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF00060, Lig_chan, 1 hit PF10613, Lig_chan-Glu_bd, 1 hit PF10565, NMDAR2_C, 1 hit |
PRINTSi | PR00177, NMDARECEPTOR |
SMARTi | View protein in SMART SM00918, Lig_chan-Glu_bd, 1 hit SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MGGALGPALL LTSLLGAWAG LGAGQGEQAV TVAVVFGSSG PLQAQARTRL
60 70 80 90 100
TPQNFLDLPL EIQPLTIGVN NTNPSSILTQ ICGLLGAARV HGIVFEDNVD
110 120 130 140 150
TEAVAQLLDF VSSQTHVPIL SISGGSAVVL TPKEPGSAFL QLGVSLEQQL
160 170 180 190 200
QVLFKVLEEY DWSAFAVITS LHPGHALFLE GVRAVADASY LSWRLLDVLT
210 220 230 240 250
LELGPGGPRA RTQRLLRQVD APVLVAYCSR EEAEVLFAEA AQAGLVGPGH
260 270 280 290 300
VWLVPNLALG STDAPPAAFP VGLISVVTES WRLSLRQKVR DGVAILALGA
310 320 330 340 350
HSYRRQYGTL PAPAGDCRSH PGPVSPAREA FYRHLLNVTW EGRDFSFSPG
360 370 380 390 400
GYLVQPTMVV IALNRHRLWE MVGRWDHGVL YMKYPVWPRY STSLQPVVDS
410 420 430 440 450
RHLTVATLEE RPFVIVESPD PGTGGCVPNT VPCRRQSNHT FSSGDITPYT
460 470 480 490 500
KLCCKGFCID ILKKLAKVVK FSYDLYLVTN GKHGKRVRGV WNGMIGEVYY
510 520 530 540 550
KRADMAIGSL TINEERSEII DFSVPFVETG ISVMVARSNG TVSPSAFLEP
560 570 580 590 600
YSPAVWVMMF VMCLTVVAIT VFMFEYFSPV SYNQNLTKGK KSGGPSFTIG
610 620 630 640 650
KSVWLLWALV FNNSVPIENP RGTTSKIMVL VWAFFAVIFL ASYTANLAAF
660 670 680 690 700
MIQEQYIDTV SGLSDKKFQR PQDQYPPFRF GTVPNGSTER NIRSNYRDMH
710 720 730 740 750
THMVKFNQRS VEDALTSLKM GKLDAFIYDA AVLNYMAGKD EGCKLVTIGS
760 770 780 790 800
GKVFATTGYG IAMQKDSHWK RAIDLALLQF LGDGETQKLE TVWLSGICHN
810 820 830 840 850
EKNEVMSSKL DIDNMAGVFY MLLVAMGLAL LVFAWEHLVY WKLRHSVPSS
860 870 880 890 900
SQLDFLLAFS RGIYSCFNGV QSLPSPARPP SPDLTAGSAQ ANVLKMLQAA
910 920 930 940 950
RDMVSTADVS GSLDRATRTI ENWGNNRRAP APTTSGPRSC TPGPPGQPSP
960 970 980 990 1000
SGWRPPGGGR TPLARRAPQP PARPATCAGS PQPDVSRASC RHAWDARWPV
1010 1020 1030 1040 1050
RVGHQGSHLS ASERRALPER SLLHAHCHYS SFPRAERSGR PFLPLFPEPP
1060 1070 1080 1090 1100
EPDDLPLLGP EQLARREALL RAAWARGPRP RHASLPSSVA EAFTRSNPLP
1110 1120 1130 1140 1150
ARCTGHACAC PCPQSRPSCR HVAQTQSLRL PSYREACVEG VPAGVAATWQ
1160 1170 1180 1190 1200
PRQHVCLHTH THLPFCWGTV CRHPPPCSSH SPWLIGTWEP PSHRGRTLGL
1210 1220 1230
GTGYRDSGVL EEVSREACGT QGFPRSCTWR RISSLESEV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D10694 mRNA Translation: BAA01536.1 |
CCDSi | CCDS25624.1 |
PIRi | I49705 |
RefSeqi | NP_034480.2, NM_010350.2 |
Genome annotation databases
Ensembli | ENSMUST00000003351; ENSMUSP00000003351; ENSMUSG00000020734 ENSMUST00000106554; ENSMUSP00000102164; ENSMUSG00000020734 |
GeneIDi | 14813 |
KEGGi | mmu:14813 |
UCSCi | uc007mgx.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D10694 mRNA Translation: BAA01536.1 |
CCDSi | CCDS25624.1 |
PIRi | I49705 |
RefSeqi | NP_034480.2, NM_010350.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 200070, 6 interactors |
ComplexPortali | CPX-292, NMDA receptor complex, GluN1-GluN2C |
IntActi | Q01098, 1 interactor |
MINTi | Q01098 |
STRINGi | 10090.ENSMUSP00000102164 |
Chemistry databases
ChEMBLi | CHEMBL3832634 |
PTM databases
GlyConnecti | 2352, 1 N-Linked glycan (1 site) |
GlyGeni | Q01098, 4 sites |
iPTMneti | Q01098 |
PhosphoSitePlusi | Q01098 |
Proteomic databases
PaxDbi | Q01098 |
PRIDEi | Q01098 |
Protocols and materials databases
ABCDi | Q01098, 3 sequenced antibodies |
Antibodypediai | 19474, 269 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000003351; ENSMUSP00000003351; ENSMUSG00000020734 ENSMUST00000106554; ENSMUSP00000102164; ENSMUSG00000020734 |
GeneIDi | 14813 |
KEGGi | mmu:14813 |
UCSCi | uc007mgx.1, mouse |
Organism-specific databases
CTDi | 2905 |
MGIi | MGI:95822, Grin2c |
Phylogenomic databases
eggNOGi | KOG1053, Eukaryota |
GeneTreei | ENSGT00940000156964 |
HOGENOMi | CLU_002039_1_0_1 |
InParanoidi | Q01098 |
OMAi | ATWGNDR |
OrthoDBi | 188544at2759 |
PhylomeDBi | Q01098 |
TreeFami | TF314731 |
Enzyme and pathway databases
Reactomei | R-MMU-438066, Unblocking of NMDA receptors, glutamate binding and activation R-MMU-8849932, Synaptic adhesion-like molecules R-MMU-9609736, Assembly and cell surface presentation of NMDA receptors |
Miscellaneous databases
BioGRID-ORCSi | 14813, 2 hits in 17 CRISPR screens |
PROi | PR:Q01098 |
RNActi | Q01098, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020734, Expressed in cerebellar cortex and 120 other tissues |
ExpressionAtlasi | Q01098, baseline and differential |
Genevisiblei | Q01098, MM |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR019594, Glu/Gly-bd IPR001508, Iono_rcpt_met IPR001320, Iontro_rcpt IPR018884, NMDAR2_C IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF00060, Lig_chan, 1 hit PF10613, Lig_chan-Glu_bd, 1 hit PF10565, NMDAR2_C, 1 hit |
PRINTSi | PR00177, NMDARECEPTOR |
SMARTi | View protein in SMART SM00918, Lig_chan-Glu_bd, 1 hit SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NMDE3_MOUSE | |
Accessioni | Q01098Primary (citable) accession number: Q01098 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | February 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 183 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families