UniProtKB - Q01082 (SPTB2_HUMAN)
Spectrin beta chain, non-erythrocytic 1
SPTBN1
Functioni
GO - Molecular functioni
- actin binding Source: ProtInc
- ankyrin binding Source: BHF-UCL
- cadherin binding Source: BHF-UCL
- calmodulin binding Source: UniProtKB-KW
- GTPase binding Source: UniProtKB
- phospholipid binding Source: InterPro
- RNA binding Source: UniProtKB
- structural constituent of cytoskeleton Source: BHF-UCL
GO - Biological processi
- actin filament capping Source: UniProtKB-KW
- axon guidance Source: Reactome
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
- Golgi to plasma membrane protein transport Source: BHF-UCL
- MAPK cascade Source: Reactome
- membrane assembly Source: BHF-UCL
- mitotic cytokinesis Source: BHF-UCL
- plasma membrane organization Source: BHF-UCL
- positive regulation of interleukin-2 production Source: UniProtKB
- positive regulation of protein localization to plasma membrane Source: UniProtKB
- protein localization to plasma membrane Source: BHF-UCL
- regulation of protein localization to plasma membrane Source: UniProtKB
Keywordsi
Molecular function | Actin capping, Actin-binding, Calmodulin-binding |
Enzyme and pathway databases
PathwayCommonsi | Q01082 |
Reactomei | R-HSA-373753, Nephrin family interactions R-HSA-375165, NCAM signaling for neurite out-growth R-HSA-445095, Interaction between L1 and Ankyrins R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6807878, COPI-mediated anterograde transport R-HSA-9703465, Signaling by FLT3 fusion proteins |
SignaLinki | Q01082 |
SIGNORi | Q01082 |
Names & Taxonomyi
Protein namesi | Recommended name: Spectrin beta chain, non-erythrocytic 1Alternative name(s): Beta-II spectrin Fodrin beta chain Spectrin, non-erythroid beta chain 1 |
Gene namesi | Name:SPTBN1 Synonyms:SPTB2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11275, SPTBN1 |
MIMi | 182790, gene |
neXtProti | NX_Q01082 |
VEuPathDBi | HostDB:ENSG00000115306.15 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Other locations
- M line By similarity
Note: Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes.By similarity
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Cytoskeleton
- spectrin Source: ProtInc
- spectrin-associated cytoskeleton Source: BHF-UCL
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleolus Source: HGNC-UCL
Plasma Membrane
- axolemma Source: BHF-UCL
Other locations
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoskeleton, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 6711 |
OpenTargetsi | ENSG00000115306 |
PharmGKBi | PA36104 |
Miscellaneous databases
Pharosi | Q01082, Tbio |
Chemistry databases
DrugBanki | DB03401, 1D-myo-inositol 1,4,5-trisphosphate DB01373, Calcium |
Genetic variation databases
BioMutai | SPTBN1 |
DMDMi | 116242799 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000073461 | 2 – 2364 | Spectrin beta chain, non-erythrocytic 1Add BLAST | 2363 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylthreonineCombined sources | 1 | ||
Modified residuei | 36 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 90 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 228 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 817 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 825 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 903 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1057 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1076 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1079 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1237 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1388 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1447 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1557 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1805 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 1815 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 1913 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 1989 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 2102 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 2128 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 2138 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 2147 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 2148 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 2159 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 2160 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 2161 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 2164 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 2165 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 2169 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 2171 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 2172 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 2184 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 2187 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 2195 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 2314 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 2319 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 2320 | PhosphothreonineCombined sources | 1 | ||
Glycosylationi | 2324 | O-linked (GlcNAc) serineBy similarity | 1 | ||
Modified residuei | 2328 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 2340 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 2341 | PhosphoserineCombined sources | 1 | ||
Isoform 2 (identifier: Q01082-3) | |||||
Modified residuei | 14 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Glycoprotein, PhosphoproteinProteomic databases
CPTACi | CPTAC-590 |
EPDi | Q01082 |
jPOSTi | Q01082 |
MassIVEi | Q01082 |
MaxQBi | Q01082 |
PaxDbi | Q01082 |
PeptideAtlasi | Q01082 |
PRIDEi | Q01082 |
ProteomicsDBi | 57910 [Q01082-1] 57911 [Q01082-2] 57912 [Q01082-3] |
PTM databases
GlyGeni | Q01082, 4 sites, 1 O-linked glycan (4 sites) |
iPTMneti | Q01082 |
MetOSitei | Q01082 |
PhosphoSitePlusi | Q01082 |
SwissPalmi | Q01082 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000115306, Expressed in forebrain and 264 other tissues |
ExpressionAtlasi | Q01082, baseline and differential |
Genevisiblei | Q01082, HS |
Organism-specific databases
HPAi | ENSG00000115306, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with CAMSAP1 (PubMed:24117850).
Interacts with ANK2 (PubMed:15262991).
Interacts with CPNE4 (via VWFA domain) (By similarity). Like erythrocyte spectrin, the spectrin-like proteins are capable to form dimers which can further associate to tetramers (By similarity). Isoform Short cannot bind to the axonal protein fodaxin.
By similarity2 PublicationsBinary interactionsi
Hide detailsQ01082
GO - Molecular functioni
- actin binding Source: ProtInc
- ankyrin binding Source: BHF-UCL
- cadherin binding Source: BHF-UCL
- calmodulin binding Source: UniProtKB-KW
- GTPase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112589, 215 interactors |
DIPi | DIP-33182N |
ELMi | Q01082 |
IntActi | Q01082, 108 interactors |
MINTi | Q01082 |
STRINGi | 9606.ENSP00000349259 |
Miscellaneous databases
RNActi | Q01082, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q01082 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q01082 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 54 – 158 | Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST | 105 | |
Domaini | 173 – 278 | Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST | 106 | |
Repeati | 303 – 411 | Spectrin 1Sequence analysisAdd BLAST | 109 | |
Repeati | 423 – 525 | Spectrin 2Sequence analysisAdd BLAST | 103 | |
Repeati | 530 – 636 | Spectrin 3Sequence analysisAdd BLAST | 107 | |
Repeati | 639 – 742 | Spectrin 4Sequence analysisAdd BLAST | 104 | |
Repeati | 745 – 847 | Spectrin 5Sequence analysisAdd BLAST | 103 | |
Repeati | 850 – 952 | Spectrin 6Sequence analysisAdd BLAST | 103 | |
Repeati | 957 – 1060 | Spectrin 7Sequence analysisAdd BLAST | 104 | |
Repeati | 1063 – 1166 | Spectrin 8Sequence analysisAdd BLAST | 104 | |
Repeati | 1170 – 1258 | Spectrin 9Sequence analysisAdd BLAST | 89 | |
Repeati | 1276 – 1376 | Spectrin 10Sequence analysisAdd BLAST | 101 | |
Repeati | 1381 – 1482 | Spectrin 11Sequence analysisAdd BLAST | 102 | |
Repeati | 1486 – 1590 | Spectrin 12Sequence analysisAdd BLAST | 105 | |
Repeati | 1592 – 1696 | Spectrin 13Sequence analysisAdd BLAST | 105 | |
Repeati | 1698 – 1801 | Spectrin 14Sequence analysisAdd BLAST | 104 | |
Repeati | 1805 – 1907 | Spectrin 15Sequence analysisAdd BLAST | 103 | |
Repeati | 1914 – 2014 | Spectrin 16Sequence analysisAdd BLAST | 101 | |
Repeati | 2018 – 2097 | Spectrin 17Sequence analysisAdd BLAST | 80 | |
Domaini | 2197 – 2307 | PHPROSITE-ProRule annotationAdd BLAST | 111 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 275 | Actin-bindingAdd BLAST | 274 | |
Regioni | 1563 – 2093 | Interaction with ANK21 PublicationAdd BLAST | 531 | |
Regioni | 2149 – 2177 | Mediates interaction with CAMSAP11 PublicationAdd BLAST | 29 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0517, Eukaryota |
GeneTreei | ENSGT00940000154864 |
HOGENOMi | CLU_000146_0_0_1 |
InParanoidi | Q01082 |
PhylomeDBi | Q01082 |
TreeFami | TF313446 |
Family and domain databases
CDDi | cd00014, CH, 2 hits |
Gene3Di | 1.10.418.10, 2 hits 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR001589, Actinin_actin-bd_CS IPR001715, CH-domain IPR036872, CH_dom_sf IPR011993, PH-like_dom_sf IPR041681, PH_9 IPR001605, PH_dom-spectrin-type IPR001849, PH_domain IPR018159, Spectrin/alpha-actinin IPR016343, Spectrin_bsu IPR002017, Spectrin_repeat |
Pfami | View protein in Pfam PF00307, CH, 2 hits PF15410, PH_9, 1 hit PF00435, Spectrin, 17 hits |
PIRSFi | PIRSF002297, Spectrin_beta_subunit, 1 hit |
PRINTSi | PR00683, SPECTRINPH |
SMARTi | View protein in SMART SM00033, CH, 2 hits SM00233, PH, 1 hit SM00150, SPEC, 17 hits |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS00019, ACTININ_1, 1 hit PS00020, ACTININ_2, 1 hit PS50021, CH, 2 hits PS50003, PH_DOMAIN, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTTTVATDYD NIEIQQQYSD VNNRWDVDDW DNENSSARLF ERSRIKALAD
60 70 80 90 100
EREAVQKKTF TKWVNSHLAR VSCRITDLYT DLRDGRMLIK LLEVLSGERL
110 120 130 140 150
PKPTKGRMRI HCLENVDKAL QFLKEQRVHL ENMGSHDIVD GNHRLTLGLI
160 170 180 190 200
WTIILRFQIQ DISVETEDNK EKKSAKDALL LWCQMKTAGY PNVNIHNFTT
210 220 230 240 250
SWRDGMAFNA LIHKHRPDLI DFDKLKKSNA HYNLQNAFNL AEQHLGLTKL
260 270 280 290 300
LDPEDISVDH PDEKSIITYV VTYYHYFSKM KALAVEGKRI GKVLDNAIET
310 320 330 340 350
EKMIEKYESL ASDLLEWIEQ TIIILNNRKF ANSLVGVQQQ LQAFNTYRTV
360 370 380 390 400
EKPPKFTEKG NLEVLLFTIQ SKMRANNQKV YMPREGKLIS DINKAWERLE
410 420 430 440 450
KAEHERELAL RNELIRQEKL EQLARRFDRK AAMRETWLSE NQRLVSQDNF
460 470 480 490 500
GFDLPAVEAA TKKHEAIETD IAAYEERVQA VVAVARELEA ENYHDIKRIT
510 520 530 540 550
ARKDNVIRLW EYLLELLRAR RQRLEMNLGL QKIFQEMLYI MDWMDEMKVL
560 570 580 590 600
VLSQDYGKHL LGVEDLLQKH TLVEADIGIQ AERVRGVNAS AQKFATDGEG
610 620 630 640 650
YKPCDPQVIR DRVAHMEFCY QELCQLAAER RARLEESRRL WKFFWEMAEE
660 670 680 690 700
EGWIREKEKI LSSDDYGKDL TSVMRLLSKH RAFEDEMSGR SGHFEQAIKE
710 720 730 740 750
GEDMIAEEHF GSEKIRERII YIREQWANLE QLSAIRKKRL EEASLLHQFQ
760 770 780 790 800
ADADDIDAWM LDILKIVSSS DVGHDEYSTQ SLVKKHKDVA EEIANYRPTL
810 820 830 840 850
DTLHEQASAL PQEHAESPDV RGRLSGIEER YKEVAELTRL RKQALQDTLA
860 870 880 890 900
LYKMFSEADA CELWIDEKEQ WLNNMQIPEK LEDLEVIQHR FESLEPEMNN
910 920 930 940 950
QASRVAVVNQ IARQLMHSGH PSEKEIKAQQ DKLNTRWSQF RELVDRKKDA
960 970 980 990 1000
LLSALSIQNY HLECNETKSW IREKTKVIES TQDLGNDLAG VMALQRKLTG
1010 1020 1030 1040 1050
MERDLVAIEA KLSDLQKEAE KLESEHPDQA QAILSRLAEI SDVWEEMKTT
1060 1070 1080 1090 1100
LKNREASLGE ASKLQQFLRD LDDFQSWLSR TQTAIASEDM PNTLTEAEKL
1110 1120 1130 1140 1150
LTQHENIKNE IDNYEEDYQK MRDMGEMVTQ GQTDAQYMFL RQRLQALDTG
1160 1170 1180 1190 1200
WNELHKMWEN RQNLLSQSHA YQQFLRDTKQ AEAFLNNQEY VLAHTEMPTT
1210 1220 1230 1240 1250
LEGAEAAIKK QEDFMTTMDA NEEKINAVVE TGRRLVSDGN INSDRIQEKV
1260 1270 1280 1290 1300
DSIDDRHRKN RETASELLMR LKDNRDLQKF LQDCQELSLW INEKMLTAQD
1310 1320 1330 1340 1350
MSYDEARNLH SKWLKHQAFM AELASNKEWL DKIEKEGMQL ISEKPETEAV
1360 1370 1380 1390 1400
VKEKLTGLHK MWEVLESTTQ TKAQRLFDAN KAELFTQSCA DLDKWLHGLE
1410 1420 1430 1440 1450
SQIQSDDYGK DLTSVNILLK KQQMLENQME VRKKEIEELQ SQAQALSQEG
1460 1470 1480 1490 1500
KSTDEVDSKR LTVQTKFMEL LEPLNERKHN LLASKEIHQF NRDVEDEILW
1510 1520 1530 1540 1550
VGERMPLATS TDHGHNLQTV QLLIKKNQTL QKEIQGHQPR IDDIFERSQN
1560 1570 1580 1590 1600
IVTDSSSLSA EAIRQRLADL KQLWGLLIEE TEKRHRRLEE AHRAQQYYFD
1610 1620 1630 1640 1650
AAEAEAWMSE QELYMMSEEK AKDEQSAVSM LKKHQILEQA VEDYAETVHQ
1660 1670 1680 1690 1700
LSKTSRALVA DSHPESERIS MRQSKVDKLY AGLKDLAEER RGKLDERHRL
1710 1720 1730 1740 1750
FQLNREVDDL EQWIAEREVV AGSHELGQDY EHVTMLQERF REFARDTGNI
1760 1770 1780 1790 1800
GQERVDTVNH LADELINSGH SDAATIAEWK DGLNEAWADL LELIDTRTQI
1810 1820 1830 1840 1850
LAASYELHKF YHDAKEIFGR IQDKHKKLPE ELGRDQNTVE TLQRMHTTFE
1860 1870 1880 1890 1900
HDIQALGTQV RQLQEDAARL QAAYAGDKAD DIQKRENEVL EAWKSLLDAC
1910 1920 1930 1940 1950
ESRRVRLVDT GDKFRFFSMV RDLMLWMEDV IRQIEAQEKP RDVSSVELLM
1960 1970 1980 1990 2000
NNHQGIKAEI DARNDSFTTC IELGKSLLAR KHYASEEIKE KLLQLTEKRK
2010 2020 2030 2040 2050
EMIDKWEDRW EWLRLILEVH QFSRDASVAE AWLLGQEPYL SSREIGQSVD
2060 2070 2080 2090 2100
EVEKLIKRHE AFEKSAATWD ERFSALERLT TLELLEVRRQ QEEEERKRRP
2110 2120 2130 2140 2150
PSPEPSTKVS EEAESQQQWD TSKGEQVSQN GLPAEQGSPR MAETVDTSEM
2160 2170 2180 2190 2200
VNGATEQRTS SKESSPIPSP TSDRKAKTAL PAQSAATLPA RTQETPSAQM
2210 2220 2230 2240 2250
EGFLNRKHEW EAHNKKASSR SWHNVYCVIN NQEMGFYKDA KTAASGIPYH
2260 2270 2280 2290 2300
SEVPVSLKEA VCEVALDYKK KKHVFKLRLN DGNEYLFQAK DDEEMNTWIQ
2310 2320 2330 2340 2350
AISSAISSDK HEVSASTQST PASSRAQTLP TSVVTITSES SPGKREKDKE
2360
KDKEKRFSLF GKKK
The sequence of this isoform differs from the canonical sequence as follows:
2141-2168: MAETVDTSEMVNGATEQRTSSKESSPIP → VSYRSQTYQNYKNFNSRRTASDQPWSGL
2169-2364: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WUZ3 | A0A087WUZ3_HUMAN | Spectrin beta chain | SPTBN1 | 2,366 | Annotation score: | ||
F8W6C1 | F8W6C1_HUMAN | Spectrin beta chain, non-erythrocyt... | SPTBN1 | 690 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 583 | R → W in BAD92985 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032641 | 1411 | D → H2 PublicationsCorresponds to variant dbSNP:rs1052790Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_026054 | 1 – 49 | MTTTV…IKALA → MELQRTSSISGPLSPAYTGQ VPYNYNQLEGRFKQLQ in isoform 2. 2 PublicationsAdd BLAST | 49 | |
Alternative sequenceiVSP_026055 | 2141 – 2225 | MAETV…SWHNV → VSYRSQTYQNYKNFNSRRTA SDQPWSGL in isoform 2. 2 PublicationsAdd BLAST | 85 | |
Alternative sequenceiVSP_000720 | 2141 – 2168 | MAETV…SSPIP → VSYRSQTYQNYKNFNSRRTA SDQPWSGL in isoform Short. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_000721 | 2169 – 2364 | Missing in isoform Short. 1 PublicationAdd BLAST | 196 | |
Alternative sequenceiVSP_026056 | 2226 – 2364 | Missing in isoform 2. 2 PublicationsAdd BLAST | 139 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M96803 mRNA Translation: AAA60580.1 AF327441 mRNA Translation: AAO15362.1 AB209748 mRNA Translation: BAD92985.1 Different initiation. AC093110 Genomic DNA Translation: AAY24229.1 AC092839 Genomic DNA No translation available. CH471053 Genomic DNA Translation: EAX00147.1 BC137282 mRNA Translation: AAI37283.1 BC137283 mRNA Translation: AAI37284.1 S65762 mRNA Translation: AAB28324.1 AJ005694 mRNA Translation: CAA06678.1 AJ238723 Genomic DNA Translation: CAB91088.1 |
CCDSi | CCDS33198.1 [Q01082-1] CCDS33199.1 [Q01082-3] |
PIRi | A44159 A47213 |
RefSeqi | NP_003119.2, NM_003128.2 [Q01082-1] NP_842565.2, NM_178313.2 [Q01082-3] XP_005264574.1, XM_005264517.2 [Q01082-1] XP_006712150.1, XM_006712087.2 [Q01082-1] XP_016860268.1, XM_017004779.1 [Q01082-1] XP_016860269.1, XM_017004780.1 [Q01082-1] XP_016860270.1, XM_017004781.1 [Q01082-1] |
Genome annotation databases
Ensembli | ENST00000333896; ENSP00000334156; ENSG00000115306 [Q01082-3] ENST00000356805; ENSP00000349259; ENSG00000115306 [Q01082-1] |
GeneIDi | 6711 |
KEGGi | hsa:6711 |
UCSCi | uc002rxu.4, human [Q01082-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M96803 mRNA Translation: AAA60580.1 AF327441 mRNA Translation: AAO15362.1 AB209748 mRNA Translation: BAD92985.1 Different initiation. AC093110 Genomic DNA Translation: AAY24229.1 AC092839 Genomic DNA No translation available. CH471053 Genomic DNA Translation: EAX00147.1 BC137282 mRNA Translation: AAI37283.1 BC137283 mRNA Translation: AAI37284.1 S65762 mRNA Translation: AAB28324.1 AJ005694 mRNA Translation: CAA06678.1 AJ238723 Genomic DNA Translation: CAB91088.1 |
CCDSi | CCDS33198.1 [Q01082-1] CCDS33199.1 [Q01082-3] |
PIRi | A44159 A47213 |
RefSeqi | NP_003119.2, NM_003128.2 [Q01082-1] NP_842565.2, NM_178313.2 [Q01082-3] XP_005264574.1, XM_005264517.2 [Q01082-1] XP_006712150.1, XM_006712087.2 [Q01082-1] XP_016860268.1, XM_017004779.1 [Q01082-1] XP_016860269.1, XM_017004780.1 [Q01082-1] XP_016860270.1, XM_017004781.1 [Q01082-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AA2 | X-ray | 2.00 | A | 173-280 | [»] | |
1BKR | X-ray | 1.10 | A | 172-280 | [»] | |
3EDV | X-ray | 1.95 | A/B | 1697-2015 | [»] | |
SMRi | Q01082 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112589, 215 interactors |
DIPi | DIP-33182N |
ELMi | Q01082 |
IntActi | Q01082, 108 interactors |
MINTi | Q01082 |
STRINGi | 9606.ENSP00000349259 |
Chemistry databases
DrugBanki | DB03401, 1D-myo-inositol 1,4,5-trisphosphate DB01373, Calcium |
PTM databases
GlyGeni | Q01082, 4 sites, 1 O-linked glycan (4 sites) |
iPTMneti | Q01082 |
MetOSitei | Q01082 |
PhosphoSitePlusi | Q01082 |
SwissPalmi | Q01082 |
Genetic variation databases
BioMutai | SPTBN1 |
DMDMi | 116242799 |
Proteomic databases
CPTACi | CPTAC-590 |
EPDi | Q01082 |
jPOSTi | Q01082 |
MassIVEi | Q01082 |
MaxQBi | Q01082 |
PaxDbi | Q01082 |
PeptideAtlasi | Q01082 |
PRIDEi | Q01082 |
ProteomicsDBi | 57910 [Q01082-1] 57911 [Q01082-2] 57912 [Q01082-3] |
Protocols and materials databases
Antibodypediai | 2181, 174 antibodies |
Genome annotation databases
Ensembli | ENST00000333896; ENSP00000334156; ENSG00000115306 [Q01082-3] ENST00000356805; ENSP00000349259; ENSG00000115306 [Q01082-1] |
GeneIDi | 6711 |
KEGGi | hsa:6711 |
UCSCi | uc002rxu.4, human [Q01082-1] |
Organism-specific databases
CTDi | 6711 |
DisGeNETi | 6711 |
GeneCardsi | SPTBN1 |
HGNCi | HGNC:11275, SPTBN1 |
HPAi | ENSG00000115306, Low tissue specificity |
MIMi | 182790, gene |
neXtProti | NX_Q01082 |
OpenTargetsi | ENSG00000115306 |
PharmGKBi | PA36104 |
VEuPathDBi | HostDB:ENSG00000115306.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0517, Eukaryota |
GeneTreei | ENSGT00940000154864 |
HOGENOMi | CLU_000146_0_0_1 |
InParanoidi | Q01082 |
PhylomeDBi | Q01082 |
TreeFami | TF313446 |
Enzyme and pathway databases
PathwayCommonsi | Q01082 |
Reactomei | R-HSA-373753, Nephrin family interactions R-HSA-375165, NCAM signaling for neurite out-growth R-HSA-445095, Interaction between L1 and Ankyrins R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6807878, COPI-mediated anterograde transport R-HSA-9703465, Signaling by FLT3 fusion proteins |
SignaLinki | Q01082 |
SIGNORi | Q01082 |
Miscellaneous databases
BioGRID-ORCSi | 6711, 10 hits in 1004 CRISPR screens |
ChiTaRSi | SPTBN1, human |
EvolutionaryTracei | Q01082 |
GeneWikii | SPTBN1 |
GenomeRNAii | 6711 |
Pharosi | Q01082, Tbio |
PROi | PR:Q01082 |
RNActi | Q01082, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115306, Expressed in forebrain and 264 other tissues |
ExpressionAtlasi | Q01082, baseline and differential |
Genevisiblei | Q01082, HS |
Family and domain databases
CDDi | cd00014, CH, 2 hits |
Gene3Di | 1.10.418.10, 2 hits 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR001589, Actinin_actin-bd_CS IPR001715, CH-domain IPR036872, CH_dom_sf IPR011993, PH-like_dom_sf IPR041681, PH_9 IPR001605, PH_dom-spectrin-type IPR001849, PH_domain IPR018159, Spectrin/alpha-actinin IPR016343, Spectrin_bsu IPR002017, Spectrin_repeat |
Pfami | View protein in Pfam PF00307, CH, 2 hits PF15410, PH_9, 1 hit PF00435, Spectrin, 17 hits |
PIRSFi | PIRSF002297, Spectrin_beta_subunit, 1 hit |
PRINTSi | PR00683, SPECTRINPH |
SMARTi | View protein in SMART SM00033, CH, 2 hits SM00233, PH, 1 hit SM00150, SPEC, 17 hits |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS00019, ACTININ_1, 1 hit PS00020, ACTININ_2, 1 hit PS50021, CH, 2 hits PS50003, PH_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SPTB2_HUMAN | |
Accessioni | Q01082Primary (citable) accession number: Q01082 Secondary accession number(s): B2RP63 Q8IX99 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | October 17, 2006 | |
Last modified: | April 7, 2021 | |
This is version 218 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families