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UniProtKB - Q01082 (SPTB2_HUMAN)

Entry version 208 (16 Oct 2019)
Sequence version 2 (17 Oct 2006)
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Protein

Spectrin beta chain, non-erythrocytic 1

Gene

SPTBN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin capping, Actin-binding, Calmodulin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-373753 Nephrin family interactions
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6807878 COPI-mediated anterograde transport

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q01082

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q01082

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spectrin beta chain, non-erythrocytic 1
Alternative name(s):
Beta-II spectrin
Fodrin beta chain
Spectrin, non-erythroid beta chain 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPTBN1
Synonyms:SPTB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11275 SPTBN1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		182790 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q01082

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6711

Open Targets

More...OpenTargetsi		ENSG00000115306

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36104

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q01082

Chemistry databases

Drug and drug target database

More...DrugBanki		DB03401 1D-myo-inositol 1,4,5-trisphosphate
DB01373 Calcium

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SPTBN1

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242799

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000734612 – 2364Spectrin beta chain, non-erythrocytic 1Add BLAST2363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylthreonineCombined sources1
Modified residuei36PhosphoserineBy similarity1
Modified residuei90N6-acetyllysineCombined sources1
Modified residuei228PhosphoserineBy similarity1
Modified residuei817PhosphoserineCombined sources1
Modified residuei825PhosphoserineCombined sources1
Modified residuei903PhosphoserineBy similarity1
Modified residuei1057PhosphoserineCombined sources1
Modified residuei1076PhosphoserineBy similarity1
Modified residuei1079PhosphoserineBy similarity1
Modified residuei1237PhosphoserineCombined sources1
Modified residuei1388PhosphoserineCombined sources1
Modified residuei1447PhosphoserineCombined sources1
Modified residuei1557PhosphoserineCombined sources1
Modified residuei1805PhosphotyrosineBy similarity1
Modified residuei1815N6-acetyllysineCombined sources1
Modified residuei1913N6-acetyllysineCombined sources1
Modified residuei1989N6-acetyllysineCombined sources1
Modified residuei2102PhosphoserineCombined sources1
Modified residuei2128PhosphoserineCombined sources1
Modified residuei2138PhosphoserineCombined sources1
Modified residuei2147PhosphothreonineBy similarity1
Modified residuei2148PhosphoserineBy similarity1
Modified residuei2159PhosphothreonineBy similarity1
Modified residuei2160PhosphoserineCombined sources1
Modified residuei2161PhosphoserineCombined sources1
Modified residuei2164PhosphoserineCombined sources1
Modified residuei2165PhosphoserineCombined sources1
Modified residuei2169PhosphoserineCombined sources1
Modified residuei2171PhosphothreonineBy similarity1
Modified residuei2172PhosphoserineCombined sources1
Modified residuei2184PhosphoserineBy similarity1
Modified residuei2187PhosphothreonineCombined sources1
Modified residuei2195PhosphothreonineBy similarity1
Modified residuei2314PhosphoserineCombined sources1
Modified residuei2319PhosphoserineCombined sources1
Modified residuei2320PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi2324O-linked (GlcNAc) serineBy similarity1
Modified residuei2328PhosphothreonineCombined sources1
Modified residuei2340PhosphoserineCombined sources1
Modified residuei2341PhosphoserineCombined sources1
Isoform 2 (identifier: Q01082-3)
Modified residuei14PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-590

Encyclopedia of Proteome Dynamics

More...EPDi		Q01082

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q01082

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q01082

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q01082

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q01082

PeptideAtlas

More...PeptideAtlasi		Q01082

PRoteomics IDEntifications database

More...PRIDEi		Q01082

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57910 [Q01082-1]
57911 [Q01082-2]
57912 [Q01082-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q01082

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q01082

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q01082

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is present in brain, lung and kidney (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000115306 Expressed in 256 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q01082 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q01082 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA012685
HPA013149

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CAMSAP1 (PubMed:24117850).

Interacts with ANK2 (PubMed:15262991).

Interacts with CPNE4 (via VWFA domain) (By similarity). Like erythrocyte spectrin, the spectrin-like proteins are capable to form dimers which can further associate to tetramers (By similarity). Isoform Short cannot bind to the axonal protein fodaxin.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		112589, 178 interactors

Database of interacting proteins

More...DIPi		DIP-33182N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q01082

Protein interaction database and analysis system

More...IntActi		Q01082, 100 interactors

Molecular INTeraction database

More...MINTi		Q01082

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000349259

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12364
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q01082

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q01082

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 158Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST105
Domaini173 – 278Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST106
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati303 – 411Spectrin 1Sequence analysisAdd BLAST109
Repeati423 – 525Spectrin 2Sequence analysisAdd BLAST103
Repeati530 – 636Spectrin 3Sequence analysisAdd BLAST107
Repeati639 – 742Spectrin 4Sequence analysisAdd BLAST104
Repeati745 – 847Spectrin 5Sequence analysisAdd BLAST103
Repeati850 – 952Spectrin 6Sequence analysisAdd BLAST103
Repeati957 – 1060Spectrin 7Sequence analysisAdd BLAST104
Repeati1063 – 1166Spectrin 8Sequence analysisAdd BLAST104
Repeati1170 – 1258Spectrin 9Sequence analysisAdd BLAST89
Repeati1276 – 1376Spectrin 10Sequence analysisAdd BLAST101
Repeati1381 – 1482Spectrin 11Sequence analysisAdd BLAST102
Repeati1486 – 1590Spectrin 12Sequence analysisAdd BLAST105
Repeati1592 – 1696Spectrin 13Sequence analysisAdd BLAST105
Repeati1698 – 1801Spectrin 14Sequence analysisAdd BLAST104
Repeati1805 – 1907Spectrin 15Sequence analysisAdd BLAST103
Repeati1914 – 2014Spectrin 16Sequence analysisAdd BLAST101
Repeati2018 – 2097Spectrin 17Sequence analysisAdd BLAST80
Domaini2197 – 2307PHPROSITE-ProRule annotationAdd BLAST111

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 275Actin-bindingAdd BLAST274
Regioni1563 – 2093Interaction with ANK21 PublicationAdd BLAST531
Regioni2149 – 2177Mediates interaction with CAMSAP11 PublicationAdd BLAST29

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the spectrin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0035 Eukaryota
COG5069 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154864

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q01082

KEGG Orthology (KO)

More...KOi		K06115

Database of Orthologous Groups

More...OrthoDBi		543832at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q01082

TreeFam database of animal gene trees

More...TreeFami		TF313446

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014 CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 2 hits
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR016343 Spectrin_bsu
IPR002017 Spectrin_repeat

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00307 CH, 2 hits
PF15410 PH_9, 1 hit
PF00435 Spectrin, 17 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002297 Spectrin_beta_subunit, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00683 SPECTRINPH

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033 CH, 2 hits
SM00233 PH, 1 hit
SM00150 SPEC, 17 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47576 SSF47576, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: Q01082-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTTVATDYD NIEIQQQYSD VNNRWDVDDW DNENSSARLF ERSRIKALAD 
        60         70         80         90        100
EREAVQKKTF TKWVNSHLAR VSCRITDLYT DLRDGRMLIK LLEVLSGERL 
       110        120        130        140        150
PKPTKGRMRI HCLENVDKAL QFLKEQRVHL ENMGSHDIVD GNHRLTLGLI 
       160        170        180        190        200
WTIILRFQIQ DISVETEDNK EKKSAKDALL LWCQMKTAGY PNVNIHNFTT 
       210        220        230        240        250
SWRDGMAFNA LIHKHRPDLI DFDKLKKSNA HYNLQNAFNL AEQHLGLTKL 
       260        270        280        290        300
LDPEDISVDH PDEKSIITYV VTYYHYFSKM KALAVEGKRI GKVLDNAIET 
       310        320        330        340        350
EKMIEKYESL ASDLLEWIEQ TIIILNNRKF ANSLVGVQQQ LQAFNTYRTV 
       360        370        380        390        400
EKPPKFTEKG NLEVLLFTIQ SKMRANNQKV YMPREGKLIS DINKAWERLE 
       410        420        430        440        450
KAEHERELAL RNELIRQEKL EQLARRFDRK AAMRETWLSE NQRLVSQDNF 
       460        470        480        490        500
GFDLPAVEAA TKKHEAIETD IAAYEERVQA VVAVARELEA ENYHDIKRIT 
       510        520        530        540        550
ARKDNVIRLW EYLLELLRAR RQRLEMNLGL QKIFQEMLYI MDWMDEMKVL 
       560        570        580        590        600
VLSQDYGKHL LGVEDLLQKH TLVEADIGIQ AERVRGVNAS AQKFATDGEG 
       610        620        630        640        650
YKPCDPQVIR DRVAHMEFCY QELCQLAAER RARLEESRRL WKFFWEMAEE 
       660        670        680        690        700
EGWIREKEKI LSSDDYGKDL TSVMRLLSKH RAFEDEMSGR SGHFEQAIKE 
       710        720        730        740        750
GEDMIAEEHF GSEKIRERII YIREQWANLE QLSAIRKKRL EEASLLHQFQ 
       760        770        780        790        800
ADADDIDAWM LDILKIVSSS DVGHDEYSTQ SLVKKHKDVA EEIANYRPTL 
       810        820        830        840        850
DTLHEQASAL PQEHAESPDV RGRLSGIEER YKEVAELTRL RKQALQDTLA 
       860        870        880        890        900
LYKMFSEADA CELWIDEKEQ WLNNMQIPEK LEDLEVIQHR FESLEPEMNN 
       910        920        930        940        950
QASRVAVVNQ IARQLMHSGH PSEKEIKAQQ DKLNTRWSQF RELVDRKKDA 
       960        970        980        990       1000
LLSALSIQNY HLECNETKSW IREKTKVIES TQDLGNDLAG VMALQRKLTG 
      1010       1020       1030       1040       1050
MERDLVAIEA KLSDLQKEAE KLESEHPDQA QAILSRLAEI SDVWEEMKTT 
      1060       1070       1080       1090       1100
LKNREASLGE ASKLQQFLRD LDDFQSWLSR TQTAIASEDM PNTLTEAEKL 
      1110       1120       1130       1140       1150
LTQHENIKNE IDNYEEDYQK MRDMGEMVTQ GQTDAQYMFL RQRLQALDTG 
      1160       1170       1180       1190       1200
WNELHKMWEN RQNLLSQSHA YQQFLRDTKQ AEAFLNNQEY VLAHTEMPTT 
      1210       1220       1230       1240       1250
LEGAEAAIKK QEDFMTTMDA NEEKINAVVE TGRRLVSDGN INSDRIQEKV 
      1260       1270       1280       1290       1300
DSIDDRHRKN RETASELLMR LKDNRDLQKF LQDCQELSLW INEKMLTAQD 
      1310       1320       1330       1340       1350
MSYDEARNLH SKWLKHQAFM AELASNKEWL DKIEKEGMQL ISEKPETEAV 
      1360       1370       1380       1390       1400
VKEKLTGLHK MWEVLESTTQ TKAQRLFDAN KAELFTQSCA DLDKWLHGLE 
      1410       1420       1430       1440       1450
SQIQSDDYGK DLTSVNILLK KQQMLENQME VRKKEIEELQ SQAQALSQEG 
      1460       1470       1480       1490       1500
KSTDEVDSKR LTVQTKFMEL LEPLNERKHN LLASKEIHQF NRDVEDEILW 
      1510       1520       1530       1540       1550
VGERMPLATS TDHGHNLQTV QLLIKKNQTL QKEIQGHQPR IDDIFERSQN 
      1560       1570       1580       1590       1600
IVTDSSSLSA EAIRQRLADL KQLWGLLIEE TEKRHRRLEE AHRAQQYYFD 
      1610       1620       1630       1640       1650
AAEAEAWMSE QELYMMSEEK AKDEQSAVSM LKKHQILEQA VEDYAETVHQ 
      1660       1670       1680       1690       1700
LSKTSRALVA DSHPESERIS MRQSKVDKLY AGLKDLAEER RGKLDERHRL 
      1710       1720       1730       1740       1750
FQLNREVDDL EQWIAEREVV AGSHELGQDY EHVTMLQERF REFARDTGNI 
      1760       1770       1780       1790       1800
GQERVDTVNH LADELINSGH SDAATIAEWK DGLNEAWADL LELIDTRTQI 
      1810       1820       1830       1840       1850
LAASYELHKF YHDAKEIFGR IQDKHKKLPE ELGRDQNTVE TLQRMHTTFE 
      1860       1870       1880       1890       1900
HDIQALGTQV RQLQEDAARL QAAYAGDKAD DIQKRENEVL EAWKSLLDAC 
      1910       1920       1930       1940       1950
ESRRVRLVDT GDKFRFFSMV RDLMLWMEDV IRQIEAQEKP RDVSSVELLM 
      1960       1970       1980       1990       2000
NNHQGIKAEI DARNDSFTTC IELGKSLLAR KHYASEEIKE KLLQLTEKRK 
      2010       2020       2030       2040       2050
EMIDKWEDRW EWLRLILEVH QFSRDASVAE AWLLGQEPYL SSREIGQSVD 
      2060       2070       2080       2090       2100
EVEKLIKRHE AFEKSAATWD ERFSALERLT TLELLEVRRQ QEEEERKRRP 
      2110       2120       2130       2140       2150
PSPEPSTKVS EEAESQQQWD TSKGEQVSQN GLPAEQGSPR MAETVDTSEM 
      2160       2170       2180       2190       2200
VNGATEQRTS SKESSPIPSP TSDRKAKTAL PAQSAATLPA RTQETPSAQM 
      2210       2220       2230       2240       2250
EGFLNRKHEW EAHNKKASSR SWHNVYCVIN NQEMGFYKDA KTAASGIPYH 
      2260       2270       2280       2290       2300
SEVPVSLKEA VCEVALDYKK KKHVFKLRLN DGNEYLFQAK DDEEMNTWIQ 
      2310       2320       2330       2340       2350
AISSAISSDK HEVSASTQST PASSRAQTLP TSVVTITSES SPGKREKDKE 
      2360 
KDKEKRFSLF GKKK
Length:2,364
Mass (Da):274,609
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1770C3B0EB07B892
GO
Isoform Short (identifier: Q01082-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2141-2168: MAETVDTSEMVNGATEQRTSSKESSPIP → VSYRSQTYQNYKNFNSRRTASDQPWSGL
     2169-2364: Missing.

Show »
Length:2,168
Mass (Da):253,091
Checksum:i34F9C77E47199043
GO
Isoform 2 (identifier: Q01082-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: MTTTVATDYD...FERSRIKALA → MELQRTSSIS...QLEGRFKQLQ
     2141-2225: MAETVDTSEM...KASSRSWHNV → VSYRSQTYQNYKNFNSRRTASDQPWSGL
     2226-2364: Missing.

Show »
Length:2,155
Mass (Da):251,397
Checksum:i2CA864D7AAC0182C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUZ3A0A087WUZ3_HUMAN
Spectrin beta chain
SPTBN1
2,366Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W6C1F8W6C1_HUMAN
Spectrin beta chain, non-erythrocyt...
SPTBN1
690Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92985 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti583R → W in BAD92985 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0326411411D → H2 PublicationsCorresponds to variant dbSNP:rs1052790Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0260541 – 49MTTTV…IKALA → MELQRTSSISGPLSPAYTGQ VPYNYNQLEGRFKQLQ in isoform 2. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_0260552141 – 2225MAETV…SWHNV → VSYRSQTYQNYKNFNSRRTA SDQPWSGL in isoform 2. 2 PublicationsAdd BLAST85
Alternative sequenceiVSP_0007202141 – 2168MAETV…SSPIP → VSYRSQTYQNYKNFNSRRTA SDQPWSGL in isoform Short. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_0007212169 – 2364Missing in isoform Short. 1 PublicationAdd BLAST196
Alternative sequenceiVSP_0260562226 – 2364Missing in isoform 2. 2 PublicationsAdd BLAST139

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M96803 mRNA Translation: AAA60580.1
AF327441 mRNA Translation: AAO15362.1
AB209748 mRNA Translation: BAD92985.1 Different initiation.
AC093110 Genomic DNA Translation: AAY24229.1
AC092839 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00147.1
BC137282 mRNA Translation: AAI37283.1
BC137283 mRNA Translation: AAI37284.1
S65762 mRNA Translation: AAB28324.1
AJ005694 mRNA Translation: CAA06678.1
AJ238723 Genomic DNA Translation: CAB91088.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33198.1 [Q01082-1]
CCDS33199.1 [Q01082-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A44159
A47213

NCBI Reference Sequences

More...RefSeqi		NP_003119.2, NM_003128.2 [Q01082-1]
NP_842565.2, NM_178313.2 [Q01082-3]
XP_005264574.1, XM_005264517.2 [Q01082-1]
XP_006712150.1, XM_006712087.2 [Q01082-1]
XP_016860268.1, XM_017004779.1 [Q01082-1]
XP_016860269.1, XM_017004780.1 [Q01082-1]
XP_016860270.1, XM_017004781.1 [Q01082-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000333896; ENSP00000334156; ENSG00000115306 [Q01082-3]
ENST00000356805; ENSP00000349259; ENSG00000115306 [Q01082-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6711

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6711

UCSC genome browser

More...UCSCi		uc002rxu.4 human [Q01082-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96803 mRNA Translation: AAA60580.1
AF327441 mRNA Translation: AAO15362.1
AB209748 mRNA Translation: BAD92985.1 Different initiation.
AC093110 Genomic DNA Translation: AAY24229.1
AC092839 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00147.1
BC137282 mRNA Translation: AAI37283.1
BC137283 mRNA Translation: AAI37284.1
S65762 mRNA Translation: AAB28324.1
AJ005694 mRNA Translation: CAA06678.1
AJ238723 Genomic DNA Translation: CAB91088.1
CCDSiCCDS33198.1 [Q01082-1]
CCDS33199.1 [Q01082-3]
PIRiA44159
A47213
RefSeqiNP_003119.2, NM_003128.2 [Q01082-1]
NP_842565.2, NM_178313.2 [Q01082-3]
XP_005264574.1, XM_005264517.2 [Q01082-1]
XP_006712150.1, XM_006712087.2 [Q01082-1]
XP_016860268.1, XM_017004779.1 [Q01082-1]
XP_016860269.1, XM_017004780.1 [Q01082-1]
XP_016860270.1, XM_017004781.1 [Q01082-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AA2X-ray2.00A173-280[»]
1BKRX-ray1.10A172-280[»]
3EDVX-ray1.95A/B1697-2015[»]
SMRiQ01082
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112589, 178 interactors
DIPiDIP-33182N
ELMiQ01082
IntActiQ01082, 100 interactors
MINTiQ01082
STRINGi9606.ENSP00000349259

Chemistry databases

DrugBankiDB03401 1D-myo-inositol 1,4,5-trisphosphate
DB01373 Calcium

PTM databases

iPTMnetiQ01082
PhosphoSitePlusiQ01082
SwissPalmiQ01082

Polymorphism and mutation databases

BioMutaiSPTBN1
DMDMi116242799

Proteomic databases

CPTACiCPTAC-590
EPDiQ01082
jPOSTiQ01082
MassIVEiQ01082
MaxQBiQ01082
PaxDbiQ01082
PeptideAtlasiQ01082
PRIDEiQ01082
ProteomicsDBi57910 [Q01082-1]
57911 [Q01082-2]
57912 [Q01082-3]

Genome annotation databases

EnsembliENST00000333896; ENSP00000334156; ENSG00000115306 [Q01082-3]
ENST00000356805; ENSP00000349259; ENSG00000115306 [Q01082-1]
GeneIDi6711
KEGGihsa:6711
UCSCiuc002rxu.4 human [Q01082-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6711
DisGeNETi6711

GeneCards: human genes, protein and diseases

More...GeneCardsi		SPTBN1
HGNCiHGNC:11275 SPTBN1
HPAiHPA012685
HPA013149
MIMi182790 gene
neXtProtiNX_Q01082
OpenTargetsiENSG00000115306
PharmGKBiPA36104

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0035 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000154864
InParanoidiQ01082
KOiK06115
OrthoDBi543832at2759
PhylomeDBiQ01082
TreeFamiTF313446

Enzyme and pathway databases

ReactomeiR-HSA-373753 Nephrin family interactions
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6807878 COPI-mediated anterograde transport
SignaLinkiQ01082
SIGNORiQ01082

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SPTBN1 human
EvolutionaryTraceiQ01082

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SPTBN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6711
PharosiQ01082

Protein Ontology

More...PROi		PR:Q01082

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000115306 Expressed in 256 organ(s), highest expression level in forebrain
ExpressionAtlasiQ01082 baseline and differential
GenevisibleiQ01082 HS

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR016343 Spectrin_bsu
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF15410 PH_9, 1 hit
PF00435 Spectrin, 17 hits
PIRSFiPIRSF002297 Spectrin_beta_subunit, 1 hit
PRINTSiPR00683 SPECTRINPH
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00233 PH, 1 hit
SM00150 SPEC, 17 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPTB2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01082
Secondary accession number(s): B2RP63
, O60837, Q16057, Q53R99, Q59ER3, Q8IX99
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: October 16, 2019
This is version 208 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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