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UniProtKB - Q01082 (SPTB2_HUMAN)

Protein

Spectrin beta chain, non-erythrocytic 1

Gene

SPTBN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

GO - Molecular functioni

  • actin binding Source: ProtInc
  • ankyrin binding Source: BHF-UCL
  • cadherin binding Source: BHF-UCL
  • calmodulin binding Source: UniProtKB-KW
  • GTPase binding Source: UniProtKB
  • phospholipid binding Source: InterPro
  • protein-containing complex binding Source: Ensembl
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome
  • RNA binding Source: UniProtKB
  • structural constituent of cytoskeleton Source: BHF-UCL
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActin capping, Actin-binding, Calmodulin-binding

Enzyme and pathway databases

ReactomeiR-HSA-373753 Nephrin family interactions
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6807878 COPI-mediated anterograde transport
SignaLinkiQ01082
SIGNORiQ01082

Names & Taxonomyi

Protein namesi
Recommended name:
Spectrin beta chain, non-erythrocytic 1
Alternative name(s):
Beta-II spectrin
Fodrin beta chain
Spectrin, non-erythroid beta chain 1
Gene namesi
Name:SPTBN1
Synonyms:SPTB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115306.15
HGNCiHGNC:11275 SPTBN1
MIMi182790 gene
neXtProtiNX_Q01082

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6711
OpenTargetsiENSG00000115306
PharmGKBiPA36104

Chemistry databases

DrugBankiDB01373 Calcium

Polymorphism and mutation databases

BioMutaiSPTBN1
DMDMi116242799

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000734612 – 2364Spectrin beta chain, non-erythrocytic 1Add BLAST2363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1
Modified residuei36PhosphoserineBy similarity1
Modified residuei90N6-acetyllysineCombined sources1
Modified residuei228PhosphoserineBy similarity1
Modified residuei817PhosphoserineCombined sources1
Modified residuei825PhosphoserineCombined sources1
Modified residuei903PhosphoserineBy similarity1
Modified residuei1057PhosphoserineCombined sources1
Modified residuei1076PhosphoserineBy similarity1
Modified residuei1079PhosphoserineBy similarity1
Modified residuei1237PhosphoserineCombined sources1
Modified residuei1388PhosphoserineCombined sources1
Modified residuei1447PhosphoserineCombined sources1
Modified residuei1557PhosphoserineCombined sources1
Modified residuei1805PhosphotyrosineBy similarity1
Modified residuei1815N6-acetyllysineCombined sources1
Modified residuei1913N6-acetyllysineCombined sources1
Modified residuei1989N6-acetyllysineCombined sources1
Modified residuei2102PhosphoserineCombined sources1
Modified residuei2128PhosphoserineCombined sources1
Modified residuei2138PhosphoserineCombined sources1
Modified residuei2147PhosphothreonineBy similarity1
Modified residuei2148PhosphoserineBy similarity1
Modified residuei2159PhosphothreonineBy similarity1
Modified residuei2160PhosphoserineCombined sources1
Modified residuei2161PhosphoserineCombined sources1
Modified residuei2164PhosphoserineCombined sources1
Modified residuei2165PhosphoserineCombined sources1
Modified residuei2169PhosphoserineCombined sources1
Modified residuei2171PhosphothreonineBy similarity1
Modified residuei2172PhosphoserineCombined sources1
Modified residuei2184PhosphoserineBy similarity1
Modified residuei2187PhosphothreonineCombined sources1
Modified residuei2195PhosphothreonineBy similarity1
Modified residuei2314PhosphoserineCombined sources1
Modified residuei2319PhosphoserineCombined sources1
Modified residuei2320PhosphothreonineCombined sources1
Glycosylationi2324O-linked (GlcNAc) serineBy similarity1
Modified residuei2328PhosphothreonineCombined sources1
Modified residuei2340PhosphoserineCombined sources1
Modified residuei2341PhosphoserineCombined sources1
Isoform 2 (identifier: Q01082-3)
Modified residuei14PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ01082
MaxQBiQ01082
PaxDbiQ01082
PeptideAtlasiQ01082
PRIDEiQ01082
ProteomicsDBi57910
57911 [Q01082-2]
57912 [Q01082-3]

PTM databases

iPTMnetiQ01082
PhosphoSitePlusiQ01082
SwissPalmiQ01082

Expressioni

Tissue specificityi

Isoform 2 is present in brain, lung and kidney (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000115306 Expressed in 256 organ(s), highest expression level in forebrain
CleanExiHS_SPTBN1
ExpressionAtlasiQ01082 baseline and differential
GenevisibleiQ01082 HS

Organism-specific databases

HPAiHPA012685
HPA013149

Interactioni

Subunit structurei

Interacts with CAMSAP1 (PubMed:24117850). Interacts with ANK2 (PubMed:15262991). Interacts with CPNE4 (via VWFA domain) (By similarity). Like erythrocyte spectrin, the spectrin-like proteins are capable to form dimers which can further associate to tetramers (By similarity). Isoform Short cannot bind to the axonal protein fodaxin.By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi112589, 145 interactors
DIPiDIP-33182N
ELMiQ01082
IntActiQ01082, 90 interactors
MINTiQ01082
STRINGi9606.ENSP00000349259

Structurei

Secondary structure

12364
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ01082
SMRiQ01082
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ01082

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 158Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST105
Domaini173 – 278Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST106
Repeati303 – 411Spectrin 1Sequence analysisAdd BLAST109
Repeati423 – 525Spectrin 2Sequence analysisAdd BLAST103
Repeati530 – 636Spectrin 3Sequence analysisAdd BLAST107
Repeati639 – 742Spectrin 4Sequence analysisAdd BLAST104
Repeati745 – 847Spectrin 5Sequence analysisAdd BLAST103
Repeati850 – 952Spectrin 6Sequence analysisAdd BLAST103
Repeati957 – 1060Spectrin 7Sequence analysisAdd BLAST104
Repeati1063 – 1166Spectrin 8Sequence analysisAdd BLAST104
Repeati1170 – 1258Spectrin 9Sequence analysisAdd BLAST89
Repeati1276 – 1376Spectrin 10Sequence analysisAdd BLAST101
Repeati1381 – 1482Spectrin 11Sequence analysisAdd BLAST102
Repeati1486 – 1590Spectrin 12Sequence analysisAdd BLAST105
Repeati1592 – 1696Spectrin 13Sequence analysisAdd BLAST105
Repeati1698 – 1801Spectrin 14Sequence analysisAdd BLAST104
Repeati1805 – 1907Spectrin 15Sequence analysisAdd BLAST103
Repeati1914 – 2014Spectrin 16Sequence analysisAdd BLAST101
Repeati2018 – 2097Spectrin 17Sequence analysisAdd BLAST80
Domaini2197 – 2307PHPROSITE-ProRule annotationAdd BLAST111

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 275Actin-bindingAdd BLAST274
Regioni1563 – 2093Interaction with ANK21 PublicationAdd BLAST531
Regioni2149 – 2177Mediates interaction with CAMSAP11 PublicationAdd BLAST29

Sequence similaritiesi

Belongs to the spectrin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0035 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118813
HOVERGENiHBG057912
InParanoidiQ01082
KOiK06115
PhylomeDBiQ01082
TreeFamiTF313446

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011993 PH-like_dom_sf
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR016343 Spectrin_bsu
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF00435 Spectrin, 17 hits
PIRSFiPIRSF002297 Spectrin_beta_subunit, 1 hit
PRINTSiPR00683 SPECTRINPH
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00233 PH, 1 hit
SM00150 SPEC, 17 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50003 PH_DOMAIN, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: Q01082-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTTVATDYD NIEIQQQYSD VNNRWDVDDW DNENSSARLF ERSRIKALAD 
        60         70         80         90        100
EREAVQKKTF TKWVNSHLAR VSCRITDLYT DLRDGRMLIK LLEVLSGERL 
       110        120        130        140        150
PKPTKGRMRI HCLENVDKAL QFLKEQRVHL ENMGSHDIVD GNHRLTLGLI 
       160        170        180        190        200
WTIILRFQIQ DISVETEDNK EKKSAKDALL LWCQMKTAGY PNVNIHNFTT 
       210        220        230        240        250
SWRDGMAFNA LIHKHRPDLI DFDKLKKSNA HYNLQNAFNL AEQHLGLTKL 
       260        270        280        290        300
LDPEDISVDH PDEKSIITYV VTYYHYFSKM KALAVEGKRI GKVLDNAIET 
       310        320        330        340        350
EKMIEKYESL ASDLLEWIEQ TIIILNNRKF ANSLVGVQQQ LQAFNTYRTV 
       360        370        380        390        400
EKPPKFTEKG NLEVLLFTIQ SKMRANNQKV YMPREGKLIS DINKAWERLE 
       410        420        430        440        450
KAEHERELAL RNELIRQEKL EQLARRFDRK AAMRETWLSE NQRLVSQDNF 
       460        470        480        490        500
GFDLPAVEAA TKKHEAIETD IAAYEERVQA VVAVARELEA ENYHDIKRIT 
       510        520        530        540        550
ARKDNVIRLW EYLLELLRAR RQRLEMNLGL QKIFQEMLYI MDWMDEMKVL 
       560        570        580        590        600
VLSQDYGKHL LGVEDLLQKH TLVEADIGIQ AERVRGVNAS AQKFATDGEG 
       610        620        630        640        650
YKPCDPQVIR DRVAHMEFCY QELCQLAAER RARLEESRRL WKFFWEMAEE 
       660        670        680        690        700
EGWIREKEKI LSSDDYGKDL TSVMRLLSKH RAFEDEMSGR SGHFEQAIKE 
       710        720        730        740        750
GEDMIAEEHF GSEKIRERII YIREQWANLE QLSAIRKKRL EEASLLHQFQ 
       760        770        780        790        800
ADADDIDAWM LDILKIVSSS DVGHDEYSTQ SLVKKHKDVA EEIANYRPTL 
       810        820        830        840        850
DTLHEQASAL PQEHAESPDV RGRLSGIEER YKEVAELTRL RKQALQDTLA 
       860        870        880        890        900
LYKMFSEADA CELWIDEKEQ WLNNMQIPEK LEDLEVIQHR FESLEPEMNN 
       910        920        930        940        950
QASRVAVVNQ IARQLMHSGH PSEKEIKAQQ DKLNTRWSQF RELVDRKKDA 
       960        970        980        990       1000
LLSALSIQNY HLECNETKSW IREKTKVIES TQDLGNDLAG VMALQRKLTG 
      1010       1020       1030       1040       1050
MERDLVAIEA KLSDLQKEAE KLESEHPDQA QAILSRLAEI SDVWEEMKTT 
      1060       1070       1080       1090       1100
LKNREASLGE ASKLQQFLRD LDDFQSWLSR TQTAIASEDM PNTLTEAEKL 
      1110       1120       1130       1140       1150
LTQHENIKNE IDNYEEDYQK MRDMGEMVTQ GQTDAQYMFL RQRLQALDTG 
      1160       1170       1180       1190       1200
WNELHKMWEN RQNLLSQSHA YQQFLRDTKQ AEAFLNNQEY VLAHTEMPTT 
      1210       1220       1230       1240       1250
LEGAEAAIKK QEDFMTTMDA NEEKINAVVE TGRRLVSDGN INSDRIQEKV 
      1260       1270       1280       1290       1300
DSIDDRHRKN RETASELLMR LKDNRDLQKF LQDCQELSLW INEKMLTAQD 
      1310       1320       1330       1340       1350
MSYDEARNLH SKWLKHQAFM AELASNKEWL DKIEKEGMQL ISEKPETEAV 
      1360       1370       1380       1390       1400
VKEKLTGLHK MWEVLESTTQ TKAQRLFDAN KAELFTQSCA DLDKWLHGLE 
      1410       1420       1430       1440       1450
SQIQSDDYGK DLTSVNILLK KQQMLENQME VRKKEIEELQ SQAQALSQEG 
      1460       1470       1480       1490       1500
KSTDEVDSKR LTVQTKFMEL LEPLNERKHN LLASKEIHQF NRDVEDEILW 
      1510       1520       1530       1540       1550
VGERMPLATS TDHGHNLQTV QLLIKKNQTL QKEIQGHQPR IDDIFERSQN 
      1560       1570       1580       1590       1600
IVTDSSSLSA EAIRQRLADL KQLWGLLIEE TEKRHRRLEE AHRAQQYYFD 
      1610       1620       1630       1640       1650
AAEAEAWMSE QELYMMSEEK AKDEQSAVSM LKKHQILEQA VEDYAETVHQ 
      1660       1670       1680       1690       1700
LSKTSRALVA DSHPESERIS MRQSKVDKLY AGLKDLAEER RGKLDERHRL 
      1710       1720       1730       1740       1750
FQLNREVDDL EQWIAEREVV AGSHELGQDY EHVTMLQERF REFARDTGNI 
      1760       1770       1780       1790       1800
GQERVDTVNH LADELINSGH SDAATIAEWK DGLNEAWADL LELIDTRTQI 
      1810       1820       1830       1840       1850
LAASYELHKF YHDAKEIFGR IQDKHKKLPE ELGRDQNTVE TLQRMHTTFE 
      1860       1870       1880       1890       1900
HDIQALGTQV RQLQEDAARL QAAYAGDKAD DIQKRENEVL EAWKSLLDAC 
      1910       1920       1930       1940       1950
ESRRVRLVDT GDKFRFFSMV RDLMLWMEDV IRQIEAQEKP RDVSSVELLM 
      1960       1970       1980       1990       2000
NNHQGIKAEI DARNDSFTTC IELGKSLLAR KHYASEEIKE KLLQLTEKRK 
      2010       2020       2030       2040       2050
EMIDKWEDRW EWLRLILEVH QFSRDASVAE AWLLGQEPYL SSREIGQSVD 
      2060       2070       2080       2090       2100
EVEKLIKRHE AFEKSAATWD ERFSALERLT TLELLEVRRQ QEEEERKRRP 
      2110       2120       2130       2140       2150
PSPEPSTKVS EEAESQQQWD TSKGEQVSQN GLPAEQGSPR MAETVDTSEM 
      2160       2170       2180       2190       2200
VNGATEQRTS SKESSPIPSP TSDRKAKTAL PAQSAATLPA RTQETPSAQM 
      2210       2220       2230       2240       2250
EGFLNRKHEW EAHNKKASSR SWHNVYCVIN NQEMGFYKDA KTAASGIPYH 
      2260       2270       2280       2290       2300
SEVPVSLKEA VCEVALDYKK KKHVFKLRLN DGNEYLFQAK DDEEMNTWIQ 
      2310       2320       2330       2340       2350
AISSAISSDK HEVSASTQST PASSRAQTLP TSVVTITSES SPGKREKDKE 
      2360 
KDKEKRFSLF GKKK
Length:2,364
Mass (Da):274,609
Last modified:October 17, 2006 - v2
Checksum:i1770C3B0EB07B892
GO
Isoform Short (identifier: Q01082-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2141-2168: MAETVDTSEMVNGATEQRTSSKESSPIP → VSYRSQTYQNYKNFNSRRTASDQPWSGL
     2169-2364: Missing.

Show »
Length:2,168
Mass (Da):253,091
Checksum:i34F9C77E47199043
GO
Isoform 2 (identifier: Q01082-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: MTTTVATDYD...FERSRIKALA → MELQRTSSIS...QLEGRFKQLQ
     2141-2225: MAETVDTSEM...KASSRSWHNV → VSYRSQTYQNYKNFNSRRTASDQPWSGL
     2226-2364: Missing.

Show »
Length:2,155
Mass (Da):251,397
Checksum:i2CA864D7AAC0182C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUZ3A0A087WUZ3_HUMAN
Spectrin beta chain
SPTBN1
2,366Annotation score:
F8W6C1F8W6C1_HUMAN
Spectrin beta chain, non-erythrocyt...
SPTBN1
690Annotation score:

Sequence cautioni

The sequence BAD92985 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti583R → W in BAD92985 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0326411411D → H2 PublicationsCorresponds to variant dbSNP:rs1052790Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0260541 – 49MTTTV…IKALA → MELQRTSSISGPLSPAYTGQ VPYNYNQLEGRFKQLQ in isoform 2. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_0260552141 – 2225MAETV…SWHNV → VSYRSQTYQNYKNFNSRRTA SDQPWSGL in isoform 2. 2 PublicationsAdd BLAST85
Alternative sequenceiVSP_0007202141 – 2168MAETV…SSPIP → VSYRSQTYQNYKNFNSRRTA SDQPWSGL in isoform Short. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_0007212169 – 2364Missing in isoform Short. 1 PublicationAdd BLAST196
Alternative sequenceiVSP_0260562226 – 2364Missing in isoform 2. 2 PublicationsAdd BLAST139

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96803 mRNA Translation: AAA60580.1
AF327441 mRNA Translation: AAO15362.1
AB209748 mRNA Translation: BAD92985.1 Different initiation.
AC093110 Genomic DNA Translation: AAY24229.1
AC092839 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00147.1
BC137282 mRNA Translation: AAI37283.1
BC137283 mRNA Translation: AAI37284.1
S65762 mRNA Translation: AAB28324.1
AJ005694 mRNA Translation: CAA06678.1
AJ238723 Genomic DNA Translation: CAB91088.1
CCDSiCCDS33198.1 [Q01082-1]
CCDS33199.1 [Q01082-3]
PIRiA44159
A47213
RefSeqiNP_003119.2, NM_003128.2 [Q01082-1]
NP_842565.2, NM_178313.2 [Q01082-3]
XP_005264574.1, XM_005264517.2 [Q01082-1]
XP_006712150.1, XM_006712087.2 [Q01082-1]
XP_016860268.1, XM_017004779.1 [Q01082-1]
XP_016860269.1, XM_017004780.1 [Q01082-1]
XP_016860270.1, XM_017004781.1 [Q01082-1]
UniGeneiHs.503178
Hs.705692

Genome annotation databases

EnsembliENST00000333896; ENSP00000334156; ENSG00000115306 [Q01082-3]
ENST00000356805; ENSP00000349259; ENSG00000115306 [Q01082-1]
GeneIDi6711
KEGGihsa:6711
UCSCiuc002rxu.4 human [Q01082-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96803 mRNA Translation: AAA60580.1
AF327441 mRNA Translation: AAO15362.1
AB209748 mRNA Translation: BAD92985.1 Different initiation.
AC093110 Genomic DNA Translation: AAY24229.1
AC092839 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00147.1
BC137282 mRNA Translation: AAI37283.1
BC137283 mRNA Translation: AAI37284.1
S65762 mRNA Translation: AAB28324.1
AJ005694 mRNA Translation: CAA06678.1
AJ238723 Genomic DNA Translation: CAB91088.1
CCDSiCCDS33198.1 [Q01082-1]
CCDS33199.1 [Q01082-3]
PIRiA44159
A47213
RefSeqiNP_003119.2, NM_003128.2 [Q01082-1]
NP_842565.2, NM_178313.2 [Q01082-3]
XP_005264574.1, XM_005264517.2 [Q01082-1]
XP_006712150.1, XM_006712087.2 [Q01082-1]
XP_016860268.1, XM_017004779.1 [Q01082-1]
XP_016860269.1, XM_017004780.1 [Q01082-1]
XP_016860270.1, XM_017004781.1 [Q01082-1]
UniGeneiHs.503178
Hs.705692

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AA2X-ray2.00A173-280[»]
1BKRX-ray1.10A172-280[»]
3EDVX-ray1.95A/B1697-2015[»]
ProteinModelPortaliQ01082
SMRiQ01082
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112589, 145 interactors
DIPiDIP-33182N
ELMiQ01082
IntActiQ01082, 90 interactors
MINTiQ01082
STRINGi9606.ENSP00000349259

Chemistry databases

DrugBankiDB01373 Calcium

PTM databases

iPTMnetiQ01082
PhosphoSitePlusiQ01082
SwissPalmiQ01082

Polymorphism and mutation databases

BioMutaiSPTBN1
DMDMi116242799

Proteomic databases

EPDiQ01082
MaxQBiQ01082
PaxDbiQ01082
PeptideAtlasiQ01082
PRIDEiQ01082
ProteomicsDBi57910
57911 [Q01082-2]
57912 [Q01082-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333896; ENSP00000334156; ENSG00000115306 [Q01082-3]
ENST00000356805; ENSP00000349259; ENSG00000115306 [Q01082-1]
GeneIDi6711
KEGGihsa:6711
UCSCiuc002rxu.4 human [Q01082-1]

Organism-specific databases

CTDi6711
DisGeNETi6711
EuPathDBiHostDB:ENSG00000115306.15
GeneCardsiSPTBN1
H-InvDBiHIX0002055
HGNCiHGNC:11275 SPTBN1
HPAiHPA012685
HPA013149
MIMi182790 gene
neXtProtiNX_Q01082
OpenTargetsiENSG00000115306
PharmGKBiPA36104
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0035 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118813
HOVERGENiHBG057912
InParanoidiQ01082
KOiK06115
PhylomeDBiQ01082
TreeFamiTF313446

Enzyme and pathway databases

ReactomeiR-HSA-373753 Nephrin family interactions
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6807878 COPI-mediated anterograde transport
SignaLinkiQ01082
SIGNORiQ01082

Miscellaneous databases

ChiTaRSiSPTBN1 human
EvolutionaryTraceiQ01082
GeneWikiiSPTBN1
GenomeRNAii6711
PROiPR:Q01082
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115306 Expressed in 256 organ(s), highest expression level in forebrain
CleanExiHS_SPTBN1
ExpressionAtlasiQ01082 baseline and differential
GenevisibleiQ01082 HS

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011993 PH-like_dom_sf
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR016343 Spectrin_bsu
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF00435 Spectrin, 17 hits
PIRSFiPIRSF002297 Spectrin_beta_subunit, 1 hit
PRINTSiPR00683 SPECTRINPH
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00233 PH, 1 hit
SM00150 SPEC, 17 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPTB2_HUMAN
AccessioniPrimary (citable) accession number: Q01082
Secondary accession number(s): B2RP63
, O60837, Q16057, Q53R99, Q59ER3, Q8IX99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 199 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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