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Entry version 175 (26 Feb 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Enhancer of split mdelta protein

Gene

E(spl)mdelta-HLH

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity). May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes (PubMed:1528887). Contributes to the neural-epidermal lineage decision during early neurogenesis (PubMed:1427040). As part of the Notch signaling pathway, required to maintain the self-renewal and identity of type II neuroblasts by regulating the expression of the transcriptional repressor erm (PubMed:28899667).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Notch signaling pathway, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Enhancer of split mdelta protein
Short name:
E(spl)mdelta
Alternative name(s):
HLH-mdelta
Split locus enhancer protein mC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:E(spl)mdelta-HLHImported
Synonyms:HLHmdeltaImported
ORF Names:CG8328Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0002734 E(spl)mdelta-HLH

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown of the protein in the type II neuroblasts lineage results in an increase in the number of type II neuroblasts. Simultaneous RNAi-mediated knockdown of the ETS protein pnt restores normal neuroblast numbers.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001271781 – 173Enhancer of split mdelta proteinAdd BLAST173

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q01071

PRoteomics IDEntifications database

More...
PRIDEi
Q01071

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In embryo, expressed during the initial stages of germ band exclusively within the neuroectoderm, both in the territory of the trunk and in cephalic regions. During stage 9, expressed within the procephalic lobe and the ventral ectoderm.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0002734 Expressed in embryo and 33 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q01071 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Transcription repression requires formation of a complex with a corepressor protein (Groucho).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P163713EBI-118907,EBI-153866

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
68050, 20 interactors

Database of interacting proteins

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DIPi
DIP-722N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q01071

Protein interaction database and analysis system

More...
IntActi
Q01071, 13 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0084328

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q01071

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 72bHLHPROSITE-ProRule annotationAdd BLAST58
Domaini93 – 126OrangePROSITE-ProRule annotationAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi170 – 173WRPW motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi72 – 75Poly-Gln4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).1 Publication
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho, a transcriptional corepressor recruited to specific target DNA by Hairy-related proteins.1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4304 Eukaryota
ENOG4111F0X LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000167178

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_068550_2_2_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q01071

KEGG Orthology (KO)

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KOi
K09090

Identification of Orthologs from Complete Genome Data

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OMAi
QGEDVWR

Database of Orthologous Groups

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OrthoDBi
1378299at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q01071

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00083 HLH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47459 SSF47459, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q01071-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVQGQRFMT KTQHYRKVTK PLLERKRRAR MNLYLDELKD LIVDTMDAQG
60 70 80 90 100
EQVSKLEKAD ILELTVNYLK AQQQQRVANP QSPPPDQVNL DKFRAGYTQA
110 120 130 140 150
AYEVSHIFST VPGLDLKFGT HLMKQLGHQL KDMKQEEEII DMAEEPVNLA
160 170
DQKRSKSPRE EDIHHGEEVW RPW
Length:173
Mass (Da):20,195
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF44DA6100CE0874F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti82S → W in CAA47433 (PubMed:1528887).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti121H → R in strain: NVIII-42 and NVIII-18. 1
Natural varianti162D → V in strain: NVIII-m11. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X67048 mRNA Translation: CAA47433.1
M96168 Genomic DNA Translation: AAA28911.1
AY779906 Genomic DNA Translation: AAV59045.1
AY779907 Genomic DNA Translation: AAV59057.1
AY779908 Genomic DNA Translation: AAV59069.1
AY779909 Genomic DNA Translation: AAV59081.1
AY779910 Genomic DNA Translation: AAV59093.1
AY779911 Genomic DNA Translation: AAV59105.1
AY779912 Genomic DNA Translation: AAV59117.1
AY779913 Genomic DNA Translation: AAV59129.1
AY779914 Genomic DNA Translation: AAV59141.1
AY779915 Genomic DNA Translation: AAV59153.1
AY779916 Genomic DNA Translation: AAV59165.1
AY779917 Genomic DNA Translation: AAV59177.1
AY779918 Genomic DNA Translation: AAV59189.1
AY779919 Genomic DNA Translation: AAV59201.1
AY779920 Genomic DNA Translation: AAV59213.1
AY779921 Genomic DNA Translation: AAV59225.1
AE014297 Genomic DNA Translation: AAF56544.1
BT022133 mRNA Translation: AAY51528.2
AY905719 Genomic DNA Translation: AAX60065.1
AY905720 Genomic DNA Translation: AAX60066.1
AY905721 Genomic DNA Translation: AAX60067.1
AY905722 Genomic DNA Translation: AAX60068.1
AY905723 Genomic DNA Translation: AAX60069.1
AY905724 Genomic DNA Translation: AAX60070.1
AY905725 Genomic DNA Translation: AAX60071.1
AY905726 Genomic DNA Translation: AAX60072.1
AY905727 Genomic DNA Translation: AAX60073.1
AY905728 Genomic DNA Translation: AAX60074.1
AY905729 Genomic DNA Translation: AAX60075.1
AY905730 Genomic DNA Translation: AAX60076.1
AY905731 Genomic DNA Translation: AAX60077.1
AY905732 Genomic DNA Translation: AAX60078.1
AY905733 Genomic DNA Translation: AAX60079.1
AY905734 Genomic DNA Translation: AAX60080.1
AY905735 Genomic DNA Translation: AAX60081.1
AY905736 Genomic DNA Translation: AAX60082.1
AY905737 Genomic DNA Translation: AAX60083.1
AY905738 Genomic DNA Translation: AAX60084.1
AY905739 Genomic DNA Translation: AAX60085.1
AY905740 Genomic DNA Translation: AAX60086.1
AY905741 Genomic DNA Translation: AAX60087.1
AY905742 Genomic DNA Translation: AAX60088.1
AY905743 Genomic DNA Translation: AAX60089.1
AY905744 Genomic DNA Translation: AAX60090.1
AY905745 Genomic DNA Translation: AAX60091.1
AY905746 Genomic DNA Translation: AAX60092.1
AY905747 Genomic DNA Translation: AAX60093.1
AY905748 Genomic DNA Translation: AAX60094.1
AY905749 Genomic DNA Translation: AAX60095.1
AY905750 Genomic DNA Translation: AAX60096.1
AY905751 Genomic DNA Translation: AAX60097.1
AY905752 Genomic DNA Translation: AAX60098.1
AY905753 Genomic DNA Translation: AAX60099.1
AY905754 Genomic DNA Translation: AAX60100.1
AY905755 Genomic DNA Translation: AAX60101.1
AY905756 Genomic DNA Translation: AAX60102.1
AY905757 Genomic DNA Translation: AAX60103.1
AY905758 Genomic DNA Translation: AAX60104.1
AY905759 Genomic DNA Translation: AAX60105.1
AY905760 Genomic DNA Translation: AAX60106.1
AY905761 Genomic DNA Translation: AAX60107.1
AY905762 Genomic DNA Translation: AAX60108.1
AY905763 Genomic DNA Translation: AAX60109.1
AY905764 Genomic DNA Translation: AAX60110.1
AY905765 Genomic DNA Translation: AAX60111.1
AY905766 Genomic DNA Translation: AAX60112.1
AY905767 Genomic DNA Translation: AAX60113.1
AY905768 Genomic DNA Translation: AAX60114.1
AY905769 Genomic DNA Translation: AAX60115.1
AY905770 Genomic DNA Translation: AAX60116.1
AY905771 Genomic DNA Translation: AAX60117.1
AY905772 Genomic DNA Translation: AAX60118.1
AY905773 Genomic DNA Translation: AAX60119.1
AY905774 Genomic DNA Translation: AAX60120.1
AY905775 Genomic DNA Translation: AAX60121.1
AY905776 Genomic DNA Translation: AAX60122.1
AY905777 Genomic DNA Translation: AAX60123.1
AY905778 Genomic DNA Translation: AAX60124.1
AY905779 Genomic DNA Translation: AAX60125.1
AY905780 Genomic DNA Translation: AAX60126.1
AY905781 Genomic DNA Translation: AAX60127.1
AY905782 Genomic DNA Translation: AAX60128.1
AY905783 Genomic DNA Translation: AAX60129.1
AY905784 Genomic DNA Translation: AAX60130.1
AY905785 Genomic DNA Translation: AAX60131.1
AY905786 Genomic DNA Translation: AAX60132.1
AY905787 Genomic DNA Translation: AAX60133.1
AY905788 Genomic DNA Translation: AAX60134.1
AY905789 Genomic DNA Translation: AAX60135.1
AY905790 Genomic DNA Translation: AAX60136.1
AY905791 Genomic DNA Translation: AAX60137.1
AY905792 Genomic DNA Translation: AAX60138.1
AY905793 Genomic DNA Translation: AAX60139.1
AY905794 Genomic DNA Translation: AAX60140.1
AY905795 Genomic DNA Translation: AAX60141.1
AY905796 Genomic DNA Translation: AAX60142.1
AY905797 Genomic DNA Translation: AAX60143.1
AY905798 Genomic DNA Translation: AAX60144.1
AY905799 Genomic DNA Translation: AAX60145.1
AY905800 Genomic DNA Translation: AAX60146.1
AY905801 Genomic DNA Translation: AAX60147.1
AY905802 Genomic DNA Translation: AAX60148.1
AY905803 Genomic DNA Translation: AAX60149.1
AY905804 Genomic DNA Translation: AAX60150.1
AY905805 Genomic DNA Translation: AAX60151.1
AY905806 Genomic DNA Translation: AAX60152.1
AY905807 Genomic DNA Translation: AAX60153.1
AY905808 Genomic DNA Translation: AAX60154.1
AY905809 Genomic DNA Translation: AAX60155.1
AY905810 Genomic DNA Translation: AAX60156.1
AY905811 Genomic DNA Translation: AAX60157.1

Protein sequence database of the Protein Information Resource

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PIRi
A46177

NCBI Reference Sequences

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RefSeqi
NP_524503.2, NM_079779.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0084954; FBpp0084328; FBgn0002734

Database of genes from NCBI RefSeq genomes

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GeneIDi
43150

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8328

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67048 mRNA Translation: CAA47433.1
M96168 Genomic DNA Translation: AAA28911.1
AY779906 Genomic DNA Translation: AAV59045.1
AY779907 Genomic DNA Translation: AAV59057.1
AY779908 Genomic DNA Translation: AAV59069.1
AY779909 Genomic DNA Translation: AAV59081.1
AY779910 Genomic DNA Translation: AAV59093.1
AY779911 Genomic DNA Translation: AAV59105.1
AY779912 Genomic DNA Translation: AAV59117.1
AY779913 Genomic DNA Translation: AAV59129.1
AY779914 Genomic DNA Translation: AAV59141.1
AY779915 Genomic DNA Translation: AAV59153.1
AY779916 Genomic DNA Translation: AAV59165.1
AY779917 Genomic DNA Translation: AAV59177.1
AY779918 Genomic DNA Translation: AAV59189.1
AY779919 Genomic DNA Translation: AAV59201.1
AY779920 Genomic DNA Translation: AAV59213.1
AY779921 Genomic DNA Translation: AAV59225.1
AE014297 Genomic DNA Translation: AAF56544.1
BT022133 mRNA Translation: AAY51528.2
AY905719 Genomic DNA Translation: AAX60065.1
AY905720 Genomic DNA Translation: AAX60066.1
AY905721 Genomic DNA Translation: AAX60067.1
AY905722 Genomic DNA Translation: AAX60068.1
AY905723 Genomic DNA Translation: AAX60069.1
AY905724 Genomic DNA Translation: AAX60070.1
AY905725 Genomic DNA Translation: AAX60071.1
AY905726 Genomic DNA Translation: AAX60072.1
AY905727 Genomic DNA Translation: AAX60073.1
AY905728 Genomic DNA Translation: AAX60074.1
AY905729 Genomic DNA Translation: AAX60075.1
AY905730 Genomic DNA Translation: AAX60076.1
AY905731 Genomic DNA Translation: AAX60077.1
AY905732 Genomic DNA Translation: AAX60078.1
AY905733 Genomic DNA Translation: AAX60079.1
AY905734 Genomic DNA Translation: AAX60080.1
AY905735 Genomic DNA Translation: AAX60081.1
AY905736 Genomic DNA Translation: AAX60082.1
AY905737 Genomic DNA Translation: AAX60083.1
AY905738 Genomic DNA Translation: AAX60084.1
AY905739 Genomic DNA Translation: AAX60085.1
AY905740 Genomic DNA Translation: AAX60086.1
AY905741 Genomic DNA Translation: AAX60087.1
AY905742 Genomic DNA Translation: AAX60088.1
AY905743 Genomic DNA Translation: AAX60089.1
AY905744 Genomic DNA Translation: AAX60090.1
AY905745 Genomic DNA Translation: AAX60091.1
AY905746 Genomic DNA Translation: AAX60092.1
AY905747 Genomic DNA Translation: AAX60093.1
AY905748 Genomic DNA Translation: AAX60094.1
AY905749 Genomic DNA Translation: AAX60095.1
AY905750 Genomic DNA Translation: AAX60096.1
AY905751 Genomic DNA Translation: AAX60097.1
AY905752 Genomic DNA Translation: AAX60098.1
AY905753 Genomic DNA Translation: AAX60099.1
AY905754 Genomic DNA Translation: AAX60100.1
AY905755 Genomic DNA Translation: AAX60101.1
AY905756 Genomic DNA Translation: AAX60102.1
AY905757 Genomic DNA Translation: AAX60103.1
AY905758 Genomic DNA Translation: AAX60104.1
AY905759 Genomic DNA Translation: AAX60105.1
AY905760 Genomic DNA Translation: AAX60106.1
AY905761 Genomic DNA Translation: AAX60107.1
AY905762 Genomic DNA Translation: AAX60108.1
AY905763 Genomic DNA Translation: AAX60109.1
AY905764 Genomic DNA Translation: AAX60110.1
AY905765 Genomic DNA Translation: AAX60111.1
AY905766 Genomic DNA Translation: AAX60112.1
AY905767 Genomic DNA Translation: AAX60113.1
AY905768 Genomic DNA Translation: AAX60114.1
AY905769 Genomic DNA Translation: AAX60115.1
AY905770 Genomic DNA Translation: AAX60116.1
AY905771 Genomic DNA Translation: AAX60117.1
AY905772 Genomic DNA Translation: AAX60118.1
AY905773 Genomic DNA Translation: AAX60119.1
AY905774 Genomic DNA Translation: AAX60120.1
AY905775 Genomic DNA Translation: AAX60121.1
AY905776 Genomic DNA Translation: AAX60122.1
AY905777 Genomic DNA Translation: AAX60123.1
AY905778 Genomic DNA Translation: AAX60124.1
AY905779 Genomic DNA Translation: AAX60125.1
AY905780 Genomic DNA Translation: AAX60126.1
AY905781 Genomic DNA Translation: AAX60127.1
AY905782 Genomic DNA Translation: AAX60128.1
AY905783 Genomic DNA Translation: AAX60129.1
AY905784 Genomic DNA Translation: AAX60130.1
AY905785 Genomic DNA Translation: AAX60131.1
AY905786 Genomic DNA Translation: AAX60132.1
AY905787 Genomic DNA Translation: AAX60133.1
AY905788 Genomic DNA Translation: AAX60134.1
AY905789 Genomic DNA Translation: AAX60135.1
AY905790 Genomic DNA Translation: AAX60136.1
AY905791 Genomic DNA Translation: AAX60137.1
AY905792 Genomic DNA Translation: AAX60138.1
AY905793 Genomic DNA Translation: AAX60139.1
AY905794 Genomic DNA Translation: AAX60140.1
AY905795 Genomic DNA Translation: AAX60141.1
AY905796 Genomic DNA Translation: AAX60142.1
AY905797 Genomic DNA Translation: AAX60143.1
AY905798 Genomic DNA Translation: AAX60144.1
AY905799 Genomic DNA Translation: AAX60145.1
AY905800 Genomic DNA Translation: AAX60146.1
AY905801 Genomic DNA Translation: AAX60147.1
AY905802 Genomic DNA Translation: AAX60148.1
AY905803 Genomic DNA Translation: AAX60149.1
AY905804 Genomic DNA Translation: AAX60150.1
AY905805 Genomic DNA Translation: AAX60151.1
AY905806 Genomic DNA Translation: AAX60152.1
AY905807 Genomic DNA Translation: AAX60153.1
AY905808 Genomic DNA Translation: AAX60154.1
AY905809 Genomic DNA Translation: AAX60155.1
AY905810 Genomic DNA Translation: AAX60156.1
AY905811 Genomic DNA Translation: AAX60157.1
PIRiA46177
RefSeqiNP_524503.2, NM_079779.3

3D structure databases

SMRiQ01071
ModBaseiSearch...

Protein-protein interaction databases

BioGridi68050, 20 interactors
DIPiDIP-722N
ELMiQ01071
IntActiQ01071, 13 interactors
STRINGi7227.FBpp0084328

Proteomic databases

PaxDbiQ01071
PRIDEiQ01071

Genome annotation databases

EnsemblMetazoaiFBtr0084954; FBpp0084328; FBgn0002734
GeneIDi43150
KEGGidme:Dmel_CG8328

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
43150
FlyBaseiFBgn0002734 E(spl)mdelta-HLH

Phylogenomic databases

eggNOGiKOG4304 Eukaryota
ENOG4111F0X LUCA
GeneTreeiENSGT00940000167178
HOGENOMiCLU_068550_2_2_1
InParanoidiQ01071
KOiK09090
OMAiQGEDVWR
OrthoDBi1378299at2759
PhylomeDBiQ01071

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
43150

Protein Ontology

More...
PROi
PR:Q01071

Gene expression databases

BgeeiFBgn0002734 Expressed in embryo and 33 other tissues
GenevisibleiQ01071 DM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiESMD_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q01071
Secondary accession number(s): Q01897
, Q4V723, Q56MT6, Q56MU1, Q56MU3, Q56MU4, Q56MU6, Q56MU8, Q56MV0, Q56MV5, Q56MV6, Q56MW2, Q56MW7, Q56MW9, Q56MX9, Q56MY0, Q56MY1, Q56N19, Q56N23, Q5S485, Q5S4A9, Q5S4K5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: February 26, 2020
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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