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Entry version 111 (16 Oct 2019)
Sequence version 2 (03 Oct 2012)
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Protein

Heterogeneous nuclear ribonucleoprotein U-like protein 2

Gene

Hnrnpul2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein U-like protein 2
Alternative name(s):
MLF1-associated nuclear protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hnrnpul2
Synonyms:Hnrpul2, ManpImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1915943 Hnrnpul2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002781431 – 745Heterogeneous nuclear ribonucleoprotein U-like protein 2Add BLAST745

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei159PhosphoserineCombined sources1
Modified residuei163PhosphothreonineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei183PhosphoserineCombined sources1
Modified residuei186PhosphoserineCombined sources1
Modified residuei224PhosphoserineCombined sources1
Modified residuei226PhosphoserineCombined sources1
Modified residuei654Omega-N-methylarginineCombined sources1
Modified residuei682Omega-N-methylarginineCombined sources1
Modified residuei736Omega-N-methylarginineCombined sources1
Modified residuei745Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q00PI9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q00PI9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q00PI9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q00PI9

PeptideAtlas

More...
PeptideAtlasi
Q00PI9

PRoteomics IDEntifications database

More...
PRIDEi
Q00PI9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q00PI9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q00PI9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q00PI9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000071659 Expressed in 296 organ(s), highest expression level in secondary oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q00PI9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to MLF1 and retains it in the nucleus.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
212995, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q00PI9, 8 interactors

Molecular INTeraction database

More...
MINTi
Q00PI9

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000094515

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q00PI9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 37SAPPROSITE-ProRule annotationAdd BLAST35
Domaini224 – 417B30.2/SPRYPROSITE-ProRule annotationAdd BLAST194

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi75 – 239Glu-richSequence analysisAdd BLAST165
Compositional biasi666 – 744Tyr-richSequence analysisAdd BLAST79

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KD8N Eukaryota
ENOG41101YN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160376

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000253920

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q00PI9

Identification of Orthologs from Complete Genome Data

More...
OMAi
DSRGLKM

Database of Orthologous Groups

More...
OrthoDBi
778148at2759

TreeFam database of animal gene trees

More...
TreeFami
TF317301

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12884 SPRY_hnRNP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.720.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR027417 P-loop_NTPase
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
IPR003877 SPRY_dom
IPR035778 SPRY_hnRNP_U

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02037 SAP, 1 hit
PF00622 SPRY, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00513 SAP, 1 hit
SM00449 SPRY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit
SSF52540 SSF52540, 1 hit
SSF68906 SSF68906, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50800 SAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q00PI9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVKRLKVTE LRSELQRRGL DSRGLKMDLA QRLQEALDAE MLEDEAGVGG
60 70 80 90 100
AGPGGACKAE PRPVAASGGG PGGDEEEEDD DEEEDEEALL EDEDEEPPPA
110 120 130 140 150
QALGQAAQPP PEPPETSAME AESEASDTPA EATAGSGGVN GGEEHDNGKG
160 170 180 190 200
EEDGPEERSG DETPGSEAPG DKAVEEQGDD QDSEKSKPAG SDGERRGVKR
210 220 230 240 250
QRDEKDEHGR AYYEFREEAY HSRSKSPPPP EEEAKDEEED QTLVNLDTYT
260 270 280 290 300
SDLHFQISKD RYGGQPLFSE KFPTLWSGAR STYGVTKGKV CFEAKVTQNL
310 320 330 340 350
PMKEGCTEVS LLRVGWSVDF SCSQLGEDEF SYGFDGRGLK AENGQFEEFG
360 370 380 390 400
QTFGENDVIG CFANFETEEV ELSFSKNGED LGVAFRISKE SLADRALLPH
410 420 430 440 450
VLCKNCVVEL NFGQKEEPFF PPPEEFVFIH AVPVEERVRT AVPPKTIEEC
460 470 480 490 500
EVILMVGLPG SGKTQWALKY AKDNPERRYN VLGAETVLTQ MRMKGLEEPE
510 520 530 540 550
MDPKSRDLLV QQASQCLSKL VQIASRSKRN FILDQCNVYN SGQRRKLLLF
560 570 580 590 600
KTFSRKVVVV VPNEEDWKRR LELRKEVEGD DVPESIMLEM KANFSLPEKC
610 620 630 640 650
DYMDEVTYGE LEKEEAQPIV TKYKEEARKL LPPSEKRTNR RNNRNKRNRQ
660 670 680 690 700
NRSRGQGYVG GQRRGYDNRA YGQQYWGQSG NRGGYRNFYD RYRGDYERFY
710 720 730 740
SRDYEYNRYR DYYRQYNRDW QNYYYHHQQD RDRYYRNYYG YQGYR
Length:745
Mass (Da):84,940
Last modified:October 3, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE89D3F94E9D6488
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti277S → F in AAY44301 (PubMed:17008314).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ000354 mRNA Translation: AAY44301.1
AC129217 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37908.1

NCBI Reference Sequences

More...
RefSeqi
NP_001074665.1, NM_001081196.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000096753; ENSMUSP00000094515; ENSMUSG00000071659

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
68693

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:68693

UCSC genome browser

More...
UCSCi
uc008gng.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ000354 mRNA Translation: AAY44301.1
AC129217 Genomic DNA No translation available.
CCDSiCCDS37908.1
RefSeqiNP_001074665.1, NM_001081196.1

3D structure databases

SMRiQ00PI9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi212995, 11 interactors
IntActiQ00PI9, 8 interactors
MINTiQ00PI9
STRINGi10090.ENSMUSP00000094515

PTM databases

iPTMnetiQ00PI9
PhosphoSitePlusiQ00PI9
SwissPalmiQ00PI9

Proteomic databases

EPDiQ00PI9
jPOSTiQ00PI9
MaxQBiQ00PI9
PaxDbiQ00PI9
PeptideAtlasiQ00PI9
PRIDEiQ00PI9

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
68693

Genome annotation databases

EnsembliENSMUST00000096753; ENSMUSP00000094515; ENSMUSG00000071659
GeneIDi68693
KEGGimmu:68693
UCSCiuc008gng.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
221092
MGIiMGI:1915943 Hnrnpul2

Phylogenomic databases

eggNOGiENOG410KD8N Eukaryota
ENOG41101YN LUCA
GeneTreeiENSGT00940000160376
HOGENOMiHOG000253920
InParanoidiQ00PI9
OMAiDSRGLKM
OrthoDBi778148at2759
TreeFamiTF317301

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Hnrnpul2 mouse

Protein Ontology

More...
PROi
PR:Q00PI9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000071659 Expressed in 296 organ(s), highest expression level in secondary oocyte
GenevisibleiQ00PI9 MM

Family and domain databases

CDDicd12884 SPRY_hnRNP, 1 hit
Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR027417 P-loop_NTPase
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
IPR003877 SPRY_dom
IPR035778 SPRY_hnRNP_U
PfamiView protein in Pfam
PF02037 SAP, 1 hit
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00513 SAP, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF52540 SSF52540, 1 hit
SSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50800 SAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHNRL2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q00PI9
Secondary accession number(s): F8VPM4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 3, 2012
Last modified: October 16, 2019
This is version 111 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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