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Protein

Inactive rhomboid protein 2

Gene

RHBDF2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding
Biological processProtein transport, Transport

Protein family/group databases

MEROPSiS54.953

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive rhomboid protein 2
Short name:
iRhom2
Alternative name(s):
Rhomboid family member 2
Rhomboid veinlet-like protein 6
Gene namesi
Name:RHBDF2
Synonyms:RHBDL6
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 9

Organism-specific databases

VGNCiVGNC:45547 RHBDF2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 380CytoplasmicSequence analysisAdd BLAST380
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Topological domaini402 – 631LumenalSequence analysisAdd BLAST230
Transmembranei632 – 652HelicalSequence analysisAdd BLAST21
Topological domaini653 – 663CytoplasmicSequence analysisAdd BLAST11
Transmembranei664 – 684HelicalSequence analysisAdd BLAST21
Topological domaini685 – 686LumenalSequence analysis2
Transmembranei687 – 707HelicalSequence analysisAdd BLAST21
Topological domaini708 – 718CytoplasmicSequence analysisAdd BLAST11
Transmembranei719 – 739HelicalSequence analysisAdd BLAST21
Topological domaini740 – 744LumenalSequence analysis5
Transmembranei745 – 765HelicalSequence analysisAdd BLAST21
Topological domaini766 – 773CytoplasmicSequence analysis8
Transmembranei774 – 794HelicalSequence analysisAdd BLAST21
Topological domaini795 – 827LumenalSequence analysisAdd BLAST33

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003419371 – 827Inactive rhomboid protein 2Add BLAST827

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineBy similarity1
Modified residuei84PhosphoserineBy similarity1
Modified residuei88PhosphoserineBy similarity1
Modified residuei294PhosphoserineBy similarity1
Modified residuei296PhosphoserineBy similarity1
Modified residuei299PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ00M95
PRIDEiQ00M95

Expressioni

Tissue specificityi

Detected in retina and spleen.1 Publication

Gene expression databases

BgeeiENSCAFG00000005097 Expressed in 3 organ(s), highest expression level in liver

Interactioni

Subunit structurei

Interacts with EGF.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000007595

Structurei

3D structure databases

ProteinModelPortaliQ00M95
SMRiQ00M95
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S54 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2290 Eukaryota
COG0705 LUCA
GeneTreeiENSGT00390000012532
HOGENOMiHOG000154118
HOVERGENiHBG059673
InParanoidiQ00M95
OMAiQEVPSFQ
OrthoDBiEOG091G021G
TreeFamiTF312988

Family and domain databases

Gene3Di1.20.1540.10, 1 hit
InterProiView protein in InterPro
IPR002610 Peptidase_S54_rhomboid
IPR022764 Peptidase_S54_rhomboid_dom
IPR035952 Rhomboid-like_sf
IPR022241 Rhomboid_SP
PANTHERiPTHR22936 PTHR22936, 1 hit
PfamiView protein in Pfam
PF01694 Rhomboid, 1 hit
PF12595 Rhomboid_SP, 1 hit

Sequencei

Sequence statusi: Complete.

Q00M95-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSTDKNGES VSSVSSSRLQ SRKPPNLSIT IPPPEASAPG EQASMLPQRP
60 70 80 90 100
RNPAYMKSVS LQEQRGRWQE GSSEKRPGFR RQASLSQSIR KGTAQWFGVS
110 120 130 140 150
GDWEAKRQHW QRRSLHHCSV RYGRLKASCQ RDLELPSQEV PSFQGTESPK
160 170 180 190 200
PCKMPKIVDP LARGRAFRHP DEVDRPHAPH PPLTPGVLSL TSFTSVRSGH
210 220 230 240 250
SHLPRRKRMS VAHMSFQAAA ALLKGRSVLD ATGQRCRVVK RSFAYPSFLE
260 270 280 290 300
EDVVDGADTF DSSFFSKEEM SSMPDDVFES PPLSASYFRG IPRSASPVSP
310 320 330 340 350
DGVQIPLKEY GRPPVAGTRR GKRIASKVKH FAFDRKKRHY GLGVVGNWLN
360 370 380 390 400
RSYRRSISST VQRQLESFDS HRPYFTYWLT FVHIIITLLV ICTYGIAPVG
410 420 430 440 450
FAQHVTTQLV LRNKGVYESV KYIQQENFWI GPSSIDLIHL GAKFSPCIRK
460 470 480 490 500
DQQIEQLVLR ERDLERDSGC CVQNDHSGCI QTQRKDCSET LATFVKWQDD
510 520 530 540 550
TGPPMDKSDL GQKRTSGAVC HQDPRTCEEP ASSGAHIWPD DITKWPICTE
560 570 580 590 600
QAKSNRTGFL HMDCQIKGRP CCISTKGSCE ITTREYCEFM HGYFHEEATL
610 620 630 640 650
CSQVHCLDKV CGLLPFLNPE VPDQFYRLWL SLFLHAGVVH CLVSVVFQMT
660 670 680 690 700
ILRDLEKLAG WHRIAIIFIL SGITGNLASA IFLPYRAEVG PAGSQFGLLA
710 720 730 740 750
CLFVELFQSW QLLERPWKAF LNLSAIVLFL FICGLLPWID NIAHIFGFLS
760 770 780 790 800
GLLLAFAFLP YITFGTSDKY RKRALILVSL LVFAGLFASL VIWLYVYPIN
810 820
WPWIEYLTCF PFTSRFCEKY ELDQVLH
Length:827
Mass (Da):93,610
Last modified:November 14, 2006 - v1
Checksum:i7E93F39DC8AC2D93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ336163 mRNA Translation: ABC74872.1
RefSeqiNP_001070906.1, NM_001077438.1
XP_005624022.1, XM_005623965.2
XP_013971670.1, XM_014116195.1
UniGeneiCfa.26174

Genome annotation databases

EnsembliENSCAFT00000008200; ENSCAFP00000007595; ENSCAFG00000005097
GeneIDi483332
KEGGicfa:483332

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ336163 mRNA Translation: ABC74872.1
RefSeqiNP_001070906.1, NM_001077438.1
XP_005624022.1, XM_005623965.2
XP_013971670.1, XM_014116195.1
UniGeneiCfa.26174

3D structure databases

ProteinModelPortaliQ00M95
SMRiQ00M95
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000007595

Protein family/group databases

MEROPSiS54.953

Proteomic databases

PaxDbiQ00M95
PRIDEiQ00M95

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000008200; ENSCAFP00000007595; ENSCAFG00000005097
GeneIDi483332
KEGGicfa:483332

Organism-specific databases

CTDi79651
VGNCiVGNC:45547 RHBDF2

Phylogenomic databases

eggNOGiKOG2290 Eukaryota
COG0705 LUCA
GeneTreeiENSGT00390000012532
HOGENOMiHOG000154118
HOVERGENiHBG059673
InParanoidiQ00M95
OMAiQEVPSFQ
OrthoDBiEOG091G021G
TreeFamiTF312988

Gene expression databases

BgeeiENSCAFG00000005097 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

Gene3Di1.20.1540.10, 1 hit
InterProiView protein in InterPro
IPR002610 Peptidase_S54_rhomboid
IPR022764 Peptidase_S54_rhomboid_dom
IPR035952 Rhomboid-like_sf
IPR022241 Rhomboid_SP
PANTHERiPTHR22936 PTHR22936, 1 hit
PfamiView protein in Pfam
PF01694 Rhomboid, 1 hit
PF12595 Rhomboid_SP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRHDF2_CANLF
AccessioniPrimary (citable) accession number: Q00M95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: November 14, 2006
Last modified: September 12, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
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Main funding by: National Institutes of Health

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