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Entry version 126 (26 Feb 2020)
Sequence version 1 (14 Nov 2006)
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Protein
Submitted name:

Sno oncogene, isoform B

Gene

Snoo

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-201451 Signaling by BMP
R-DME-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Sno oncogene, isoform BImported
Submitted name:
Sno oncogene, isoform CImported
Submitted name:
Sno oncogene, isoform DImported
Submitted name:
Sno oncogene, isoform GImported
Submitted name:
SnoNImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SnooImported
Synonyms:CG7093Imported, CG7233Imported, Dmel\CG34421Imported, dSkiImported, DskiLImported, dSnoImported, dsnoImported, dSnoNImported, dsnoNImported, l(2)SH1402Imported, l(2)SH2 1402Imported, SnoImported, SnoAImported, SnoIImported, SnoNImported, snoNImported, SnoN2Imported, snooImported
ORF Names:CG34421Imported, Dmel_CG34421Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0085450 Snoo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0085450 Expressed in wing disc (Drosophila) and 32 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0111630

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q00G30

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini226 – 318c-SKI_SMAD_bindInterPro annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni73 – 97DisorderedSequence analysisAdd BLAST25
Regioni518 – 666DisorderedSequence analysisAdd BLAST149
Regioni679 – 698DisorderedSequence analysisAdd BLAST20
Regioni721 – 823DisorderedSequence analysisAdd BLAST103
Regioni911 – 1223DisorderedSequence analysisAdd BLAST313

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili314 – 341Sequence analysisAdd BLAST28
Coiled coili869 – 896Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi521 – 557PolyampholyteSequence analysisAdd BLAST37
Compositional biasi601 – 615Pro-richSequence analysisAdd BLAST15
Compositional biasi616 – 660PolarSequence analysisAdd BLAST45
Compositional biasi741 – 789PolarSequence analysisAdd BLAST49
Compositional biasi918 – 933AcidicSequence analysisAdd BLAST16
Compositional biasi970 – 1023PolyampholyteSequence analysisAdd BLAST54
Compositional biasi1037 – 1058AcidicSequence analysisAdd BLAST22
Compositional biasi1065 – 1102PolarSequence analysisAdd BLAST38
Compositional biasi1110 – 1125PolarSequence analysisAdd BLAST16
Compositional biasi1131 – 1149AcidicSequence analysisAdd BLAST19
Compositional biasi1152 – 1168PolarSequence analysisAdd BLAST17
Compositional biasi1194 – 1216PolarSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFDK Eukaryota
ENOG410Y8AU LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007432_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
RINKNLM

Database of Orthologous Groups

More...
OrthoDBi
750043at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.260.20, 1 hit
3.10.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014890 c-SKI_SMAD4-bd_dom
IPR009061 DNA-bd_dom_put_sf
IPR010919 SAND-like_dom_sf
IPR003380 SKI/SNO/DAC
IPR037000 Ski_DNA-bd_sf
IPR023216 Tscrpt_reg_SKI_SnoN

The PANTHER Classification System

More...
PANTHERi
PTHR10005 PTHR10005, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08782 c-SKI_SMAD_bind, 1 hit
PF02437 Ski_Sno, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01046 c-SKI_SMAD_bind, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46955 SSF46955, 1 hit
SSF63763 SSF63763, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q00G30-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEYVTPMIS TVLKKYQTSA TKSLQGPGHA LTTAGVLDIV TNGRSESPGL
60 70 80 90 100
NGKCQASPPV VALIKKEILS SPEPQDLHHH ECSTRGTPPQ IYSPATPPRE
110 120 130 140 150
LSQPILSVAD AGCGELYETK LEGKTIGCFS VGGEMRLCLP QFLNNVLNDF
160 170 180 190 200
SLEQINRIFD ELGIYCSQCT HDQLVEFKAA KILPSDVKAS GLITRTDAER
210 220 230 240 250
LCAALLHRSD RNSYVPIESL AKGALSFHVY HKCFGKCEGI CTPDMYSYQK
260 270 280 290 300
PTCIKCLECD GWFSPQKFVG HVHRKFENHT CHWGFDSRNW HDYLHVALDV
310 320 330 340 350
ENREKYQIIL DQLKEVELKE MHKAQRELEH KKRKAEMLMD DGMLGSGPVL
360 370 380 390 400
GLAGHPHGLV GALAPPPPPP MKQPQMDIPS GKKQLQQLKG ATVAASALEY
410 420 430 440 450
QYQVMYAHCV QKEREREREH LPHSHPLPRQ HRAVLVATTP YPHLPQYPTP
460 470 480 490 500
PTLNSSSAFR PWGPDTTKAF LHAYGATLSS LPYACQEPPE LQNPERVVRS
510 520 530 540 550
TDKRYAERTY QPNVALAPRK SILSKERDKD RERMEREVME RQRLREKETD
560 570 580 590 600
HQVVHIKQER SQTPTPPTAS PPDGVVLPLD VVEPPHPSSS GSNSPLPAHL
610 620 630 640 650
PAAPATAPPN AGGAPPTPTN LRNMRSPEEF SAGGSNEITS STSPHHQQSS
660 670 680 690 700
HHQVVQPTAG APPPSQHIIA TVNQHAKLLP SSSSLPNGNG SSSLAATNNE
710 720 730 740 750
PSRIRINKNL MSQQPVVAVS GMTPHHHQHH PTHMHHFSHG YYKSQASSPT
760 770 780 790 800
QSSSAGLNLS THSSNVVSSP HHATQPKTHH SSVGSGNHGL QNGKPHLGSE
810 820 830 840 850
FELSTDTDDT DSLNGEPDSS AMLPPWEQAV ESLRETRPKD RERVLLILQR
860 870 880 890 900
LLQENDQYRY NNIQLSELLH KQDAHIADLT EQLQRYRRQF EEQVCKVDLR
910 920 930 940 950
KMPFKHQTRL ENVVEAGRGE AEEDEELEED EMEDRANNNN QQELSPLIKA
960 970 980 990 1000
PANGLRRSVT PPNCCASEGG DCEKPDEPES KRIKLQVGEK AEDKQVENEE
1010 1020 1030 1040 1050
SPSNGTESHD LEKLEKNDDK TDPTNNPKSP QPSQISSDDE MEEDDEDEDE
1060 1070 1080 1090 1100
EDEDEEVQVE APHSSALATP PTATTPLSPD SAATAGQLFD SSNSSDESSM
1110 1120 1130 1140 1150
KKAQMSACHA LEKMSSNVGS DENNQRLAEE SQEDEAEEDP EEEDSDDDEM
1160 1170 1180 1190 1200
PLQQRQQQQR QRVAPQNVLS GPSVAGHHPA PAHPPMATKA SKKQTPPAPP
1210 1220
TAAATTTASA TTNCELQIKK EIA
Length:1,223
Mass (Da):135,080
Last modified:November 14, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F1CCEF5D0CAEF93
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF52579.3
DQ831952 mRNA Translation: ABJ09067.1
DQ831953 mRNA Translation: ABJ09068.1
DQ831954 mRNA Translation: ABJ09069.1
AE014134 Genomic DNA Translation: ABV53643.1
AE014134 Genomic DNA Translation: ABV53644.1
AE014134 Genomic DNA Translation: ABV53645.1

NCBI Reference Sequences

More...
RefSeqi
NP_001097115.1, NM_001103645.4
NP_001097116.1, NM_001103646.4
NP_001097117.1, NM_001103647.3
NP_609164.3, NM_135320.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0112717; FBpp0111629; FBgn0085450
FBtr0112718; FBpp0111630; FBgn0085450
FBtr0112719; FBpp0111631; FBgn0085450
FBtr0343409; FBpp0310055; FBgn0085450

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5740414

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG34421

UCSC genome browser

More...
UCSCi
CG34421-RB d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF52579.3
DQ831952 mRNA Translation: ABJ09067.1
DQ831953 mRNA Translation: ABJ09068.1
DQ831954 mRNA Translation: ABJ09069.1
AE014134 Genomic DNA Translation: ABV53643.1
AE014134 Genomic DNA Translation: ABV53644.1
AE014134 Genomic DNA Translation: ABV53645.1
RefSeqiNP_001097115.1, NM_001103645.4
NP_001097116.1, NM_001103646.4
NP_001097117.1, NM_001103647.3
NP_609164.3, NM_135320.3

3D structure databases

SMRiQ00G30
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0111630

Genome annotation databases

EnsemblMetazoaiFBtr0112717; FBpp0111629; FBgn0085450
FBtr0112718; FBpp0111630; FBgn0085450
FBtr0112719; FBpp0111631; FBgn0085450
FBtr0343409; FBpp0310055; FBgn0085450
GeneIDi5740414
KEGGidme:Dmel_CG34421
UCSCiCG34421-RB d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5740414
FlyBaseiFBgn0085450 Snoo

Phylogenomic databases

eggNOGiENOG410IFDK Eukaryota
ENOG410Y8AU LUCA
HOGENOMiCLU_007432_0_0_1
OMAiRINKNLM
OrthoDBi750043at2759

Enzyme and pathway databases

ReactomeiR-DME-201451 Signaling by BMP
R-DME-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5740414

Gene expression databases

BgeeiFBgn0085450 Expressed in wing disc (Drosophila) and 32 other tissues

Family and domain databases

Gene3Di3.10.260.20, 1 hit
3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR014890 c-SKI_SMAD4-bd_dom
IPR009061 DNA-bd_dom_put_sf
IPR010919 SAND-like_dom_sf
IPR003380 SKI/SNO/DAC
IPR037000 Ski_DNA-bd_sf
IPR023216 Tscrpt_reg_SKI_SnoN
PANTHERiPTHR10005 PTHR10005, 1 hit
PfamiView protein in Pfam
PF08782 c-SKI_SMAD_bind, 1 hit
PF02437 Ski_Sno, 1 hit
SMARTiView protein in SMART
SM01046 c-SKI_SMAD_bind, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
SSF63763 SSF63763, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ00G30_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q00G30
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: February 26, 2020
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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