UniProtKB - Q00G26 (PLIN5_HUMAN)
Protein
Perilipin-5
Gene
PLIN5
Organism
Homo sapiens (Human)
Status
Functioni
Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity).By similarity1 Publication
GO - Molecular functioni
- identical protein binding Source: Ensembl
- lipase binding Source: Ensembl
GO - Biological processi
- lipid droplet organization Source: UniProtKB
- lipid storage Source: GO_Central
- mitochondrion localization Source: Ensembl
- negative regulation of fatty acid beta-oxidation Source: UniProtKB
- negative regulation of lipase activity Source: UniProtKB
- negative regulation of peroxisome proliferator activated receptor signaling pathway Source: UniProtKB
- negative regulation of reactive oxygen species metabolic process Source: UniProtKB
- negative regulation of triglyceride catabolic process Source: UniProtKB
- positive regulation of fatty acid beta-oxidation Source: UniProtKB
- positive regulation of lipase activity Source: UniProtKB
- positive regulation of lipid storage Source: UniProtKB
- positive regulation of sequestering of triglyceride Source: UniProtKB
- positive regulation of triglyceride biosynthetic process Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q00G26 |
Names & Taxonomyi
Protein namesi | Recommended name: Perilipin-5Alternative name(s): Lipid storage droplet protein 5 |
Gene namesi | Name:PLIN5 Synonyms:LSDP5, OXPAT, PAT-1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000214456.8 |
HGNCi | HGNC:33196, PLIN5 |
MIMi | 613248, gene |
neXtProti | NX_Q00G26 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Other locations
- Lipid droplet 1 Publication
- Cytoplasm By similarity
Note: Lipid droplet surface-associated. Exchanges between lipid droplets and the cytoplasm.By similarity
Cytosol
- cytosol Source: GO_Central
Mitochondrion
- mitochondrion Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
- lipid droplet Source: HPA
Keywords - Cellular componenti
Cytoplasm, Lipid droplet, MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 440503 |
OpenTargetsi | ENSG00000214456 |
PharmGKBi | PA165394043 |
Miscellaneous databases
Pharosi | Q00G26, Tbio |
Polymorphism and mutation databases
BioMutai | PLIN5 |
DMDMi | 292495026 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000338982 | 1 – 463 | Perilipin-5Add BLAST | 463 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | PhosphoserineBy similarity | 1 | |
Modified residuei | 148 | PhosphoserineBy similarity | 1 | |
Modified residuei | 322 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated by PKA. Phosphorylated on serine in skeletal muscle at rest or upon lipolytic stimulation (By similarity).By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q00G26 |
MassIVEi | Q00G26 |
PaxDbi | Q00G26 |
PeptideAtlasi | Q00G26 |
PRIDEi | Q00G26 |
ProteomicsDBi | 57901 |
PTM databases
iPTMneti | Q00G26 |
PhosphoSitePlusi | Q00G26 |
Expressioni
Tissue specificityi
Expressed in skeletal muscle, liver, heart and kidney.1 Publication
Inductioni
Increased by endurance and sprint interval training.1 Publication
Gene expression databases
Bgeei | ENSG00000214456, Expressed in fundus of stomach and 198 other tissues |
ExpressionAtlasi | Q00G26, baseline and differential |
Genevisiblei | Q00G26, HS |
Organism-specific databases
HPAi | ENSG00000214456, Tissue enhanced (liver, salivary gland, skeletal muscle) |
Interactioni
Subunit structurei
Homooligomer.
Interacts with PNPLA2; prevents interaction of PNPLA2 with ABHD5.
Interacts with ABHD5; targets ABHD5 to lipid droplets and promotes interaction of ABHD5 with PNPLA2.
Interacts with LIPE (By similarity).
By similarityBinary interactionsi
Q00G26
With | #Exp. | IntAct |
---|---|---|
ABHD5 [Q8WTS1] | 3 | EBI-21732470,EBI-2813554 |
GO - Molecular functioni
- identical protein binding Source: Ensembl
- lipase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 136635, 6 interactors |
IntActi | Q00G26, 6 interactors |
STRINGi | 9606.ENSP00000371272 |
Chemistry databases
BindingDBi | Q00G26 |
Miscellaneous databases
RNActi | Q00G26, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 173 | Essential for lipid droplet targetingBy similarityAdd BLAST | 173 | |
Regioni | 1 – 108 | Interaction with LIPEBy similarityAdd BLAST | 108 | |
Regioni | 185 – 463 | Interaction with PNPLA2 and ABHD5By similarityAdd BLAST | 279 | |
Regioni | 444 – 463 | Recruits mitochondria at the lipid droplet surfaceBy similarityAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the perilipin family.Curated
Phylogenomic databases
eggNOGi | KOG4790, Eukaryota |
GeneTreei | ENSGT00950000182920 |
HOGENOMi | CLU_035133_1_0_1 |
InParanoidi | Q00G26 |
OMAi | IHVLIYA |
OrthoDBi | 1437332at2759 |
PhylomeDBi | Q00G26 |
TreeFami | TF328397 |
Family and domain databases
InterProi | View protein in InterPro IPR004279, Perilipin |
Pfami | View protein in Pfam PF03036, Perilipin, 1 hit |
PIRSFi | PIRSF036881, PAT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q00G26-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEEEAAQIP RSSVWEQDQQ NVVQRVVALP LVRATCTAVC DVYSAAKDRH
60 70 80 90 100
PLLGSACRLA ENCVCGLTTR ALDHAQPLLE HLQPQLATMN SLACRGLDKL
110 120 130 140 150
EEKLPFLQQP SETVVTSAKD VVASSVTGVV DLARRGRRWS VELKRSVSHA
160 170 180 190 200
VDVVLEKSEE LVDHFLPMTE EELAALAAEA EGPEVGSVED QRRQQGYFVR
210 220 230 240 250
LGSLSARIRH LAYEHSVGKL RQSKHRAQDT LAQLQETLEL IDHMQCGVTP
260 270 280 290 300
TAPACPGKVH ELWGEWGQRP PESRRRSQAE LETLVLSRSL TQELQGTVEA
310 320 330 340 350
LESSVRGLPA GAQEKVAEVR RSVDALQTAF ADARCFRDVP AAALAEGRGR
360 370 380 390 400
VAHAHACVDE LLELVVQAVP LPWLVGPFAP ILVERPEPLP DLADLVDEVI
410 420 430 440 450
GGPDPRWAHL DWPAQQRAWE AEHRDGSGNG DGDRMGVAGD ICEQEPETPS
460
CPVKHTLMPE LDF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketK7EIX1 | K7EIX1_HUMAN | Perilipin-5 | PLIN5 | 58 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043850 | 6 | A → V. Corresponds to variant dbSNP:rs10407239Ensembl. | 1 | |
Natural variantiVAR_043851 | 255 | C → R2 PublicationsCorresponds to variant dbSNP:rs1610090Ensembl. | 1 | |
Natural variantiVAR_043852 | 306 | R → W1 PublicationCorresponds to variant dbSNP:rs1062223Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ839131 mRNA Translation: ABH07519.1 AC011498 mRNA No translation available. BC131524 mRNA Translation: AAI31525.1 AK127689 mRNA Translation: BAC87086.1 Sequence problems. |
CCDSi | CCDS42473.1 |
RefSeqi | NP_001013728.2, NM_001013706.2 |
Genome annotation databases
Ensembli | ENST00000381848; ENSP00000371272; ENSG00000214456 |
GeneIDi | 440503 |
KEGGi | hsa:440503 |
UCSCi | uc002mas.5, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ839131 mRNA Translation: ABH07519.1 AC011498 mRNA No translation available. BC131524 mRNA Translation: AAI31525.1 AK127689 mRNA Translation: BAC87086.1 Sequence problems. |
CCDSi | CCDS42473.1 |
RefSeqi | NP_001013728.2, NM_001013706.2 |
3D structure databases
SMRi | Q00G26 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 136635, 6 interactors |
IntActi | Q00G26, 6 interactors |
STRINGi | 9606.ENSP00000371272 |
Chemistry databases
BindingDBi | Q00G26 |
PTM databases
iPTMneti | Q00G26 |
PhosphoSitePlusi | Q00G26 |
Polymorphism and mutation databases
BioMutai | PLIN5 |
DMDMi | 292495026 |
Proteomic databases
jPOSTi | Q00G26 |
MassIVEi | Q00G26 |
PaxDbi | Q00G26 |
PeptideAtlasi | Q00G26 |
PRIDEi | Q00G26 |
ProteomicsDBi | 57901 |
Protocols and materials databases
Antibodypediai | 23670, 159 antibodies |
Genome annotation databases
Ensembli | ENST00000381848; ENSP00000371272; ENSG00000214456 |
GeneIDi | 440503 |
KEGGi | hsa:440503 |
UCSCi | uc002mas.5, human |
Organism-specific databases
CTDi | 440503 |
DisGeNETi | 440503 |
EuPathDBi | HostDB:ENSG00000214456.8 |
GeneCardsi | PLIN5 |
HGNCi | HGNC:33196, PLIN5 |
HPAi | ENSG00000214456, Tissue enhanced (liver, salivary gland, skeletal muscle) |
MIMi | 613248, gene |
neXtProti | NX_Q00G26 |
OpenTargetsi | ENSG00000214456 |
PharmGKBi | PA165394043 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4790, Eukaryota |
GeneTreei | ENSGT00950000182920 |
HOGENOMi | CLU_035133_1_0_1 |
InParanoidi | Q00G26 |
OMAi | IHVLIYA |
OrthoDBi | 1437332at2759 |
PhylomeDBi | Q00G26 |
TreeFami | TF328397 |
Enzyme and pathway databases
PathwayCommonsi | Q00G26 |
Miscellaneous databases
BioGRID-ORCSi | 440503, 3 hits in 843 CRISPR screens |
ChiTaRSi | PLIN5, human |
GenomeRNAii | 440503 |
Pharosi | Q00G26, Tbio |
PROi | PR:Q00G26 |
RNActi | Q00G26, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000214456, Expressed in fundus of stomach and 198 other tissues |
ExpressionAtlasi | Q00G26, baseline and differential |
Genevisiblei | Q00G26, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004279, Perilipin |
Pfami | View protein in Pfam PF03036, Perilipin, 1 hit |
PIRSFi | PIRSF036881, PAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLIN5_HUMAN | |
Accessioni | Q00G26Primary (citable) accession number: Q00G26 Secondary accession number(s): A2RRC1, Q6ZS68 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | March 23, 2010 | |
Last modified: | December 2, 2020 | |
This is version 106 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations