Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Protein Vpr



Human immunodeficiency virus 1
Unreviewed-Annotation score: -Protein inferred from homologyi


During virus entry, plays a role in the transport of the viral pre-integration (PIC) complex to the host nucleus. This function is crucial for viral infection of non-dividing macrophages. May act directly at the nuclear pore complex, by binding nucleoporins phenylalanine-glycine (FG)-repeat regions.UniRule annotation
During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest. Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 E3 ligase complex by direct interaction with host VPRPB/DCAF-1. Cell cycle arrest reportedly occurs within hours of infection and is not blocked by antiviral agents, suggesting that it is initiated by the VPR carried into the virion. Additionally, VPR induces apoptosis in a cell cycle dependent manner suggesting that these two effects are mechanistically linked. Detected in the serum and cerebrospinal fluid of AIDS patient, VPR may also induce cell death to bystander cells.UniRule annotation

GO - Biological processi


Molecular functionActivatorUniRule annotationSAAS annotation
Biological processCell cycleUniRule annotationSAAS annotation, Host-virus interactionUniRule annotationSAAS annotation, Transcription, Transcription regulationUniRule annotationSAAS annotation, Viral penetration into host nucleusUniRule annotationSAAS annotation, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Protein VprUniRule annotationSAAS annotation
Alternative name(s):
Viral protein RUniRule annotation
Gene namesi
Name:vprUniRule annotationImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesOrterviralesRetroviridaeOrthoretrovirinaeLentivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
  • UP000109925 Componenti: Genome
  • UP000169170 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleusUniRule annotationSAAS annotation, VirionUniRule annotationSAAS annotation

Family & Domainsi

Family and domain databases

HAMAPiMF_04080 HIV_VPR, 1 hit
InterProiView protein in InterPro
IPR000012 RetroV_VpR/X
PfamiView protein in Pfam
PF00522 VPR, 1 hit


Sequence statusi: Complete.

Q00C63-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
60 70 80 90
Mass (Da):11,295
Last modified:November 14, 2006 - v1

Sequence databases

Select the link destinations:
Links Updated
DQ853441 Genomic RNA Translation: ABI79828.1
DQ853454 Genomic RNA Translation: ABI79942.1
DQ854074 Genomic RNA Translation: ABI80102.1
DQ854076 Genomic RNA Translation: ABI80106.1
DQ854077 Genomic RNA Translation: ABI80108.1
DQ854081 Genomic RNA Translation: ABI80116.1
DQ854083 Genomic RNA Translation: ABI80120.1
DQ854090 Genomic RNA Translation: ABI80134.1
DQ854099 Genomic RNA Translation: ABI80152.1
DQ854100 Genomic RNA Translation: ABI80154.1
DQ854102 Genomic RNA Translation: ABI80158.1
DQ854105 Genomic RNA Translation: ABI80164.1
DQ854107 Genomic RNA Translation: ABI80168.1
DQ854112 Genomic RNA Translation: ABI80177.1
DQ854122 Genomic RNA Translation: ABI80197.1
DQ854125 Genomic RNA Translation: ABI80203.1
DQ854127 Genomic RNA Translation: ABI80206.1
DQ854132 Genomic RNA Translation: ABI80216.1
DQ854134 Genomic RNA Translation: ABI80220.1
DQ854146 Genomic RNA Translation: ABI80243.1
DQ854147 Genomic RNA Translation: ABI80245.1
DQ854150 Genomic RNA Translation: ABI80251.1
DQ854151 Genomic RNA Translation: ABI80253.1
DQ854156 Genomic RNA Translation: ABI80263.1
DQ854166 Genomic RNA Translation: ABI80283.1

Similar proteinsi

Entry informationi

Entry nameiQ00C63_9HIV1
AccessioniPrimary (citable) accession number: Q00C63
Entry historyiIntegrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: September 12, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)


Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again