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Protein

Protein BEX3

Gene

BEX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.By similarity

Miscellaneous

Binds transition metals.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis
LigandMetal-binding

Enzyme and pathway databases

ReactomeiR-HSA-205025 NADE modulates death signalling

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BEX3Curated
Alternative name(s):
Brain-expressed X-linked protein 3Imported
Nerve growth factor receptor-associated protein 1
Ovarian granulosa cell 13.0 kDa protein HGR74
p75NTR-associated cell death executor
Gene namesi
Name:BEX3Imported
Synonyms:DXS6984E, NADE, NGFRAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000166681.13
HGNCiHGNC:13388 BEX3
MIMi300361 gene
neXtProtiNX_Q00994

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27018
OpenTargetsiENSG00000166681
PharmGKBiPA31616

Polymorphism and mutation databases

DMDMi547642

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000966881 – 111Protein BEX3Add BLAST111

Post-translational modificationi

Ubiquitinated. Degraded by the proteasome (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ00994
PeptideAtlasiQ00994
PRIDEiQ00994
ProteomicsDBi57900

Expressioni

Tissue specificityi

Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver.1 Publication

Gene expression databases

BgeeiENSG00000166681
CleanExiHS_NGFRAP1
GenevisibleiQ00994 HS

Organism-specific databases

HPAiHPA018886

Interactioni

Subunit structurei

Self-associates. Binds to the DEATH domain of p75NTR/NGFR. Interacts with 14-3-3 epsilon (YWHAE). Interacts with DIABLO/SMAC.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • nerve growth factor receptor binding Source: Ensembl

Protein-protein interaction databases

BioGridi117956, 19 interactors
IntActiQ00994, 34 interactors
MINTiQ00994
STRINGi9606.ENSP00000299872

Structurei

3D structure databases

ProteinModelPortaliQ00994
SMRiQ00994
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni68 – 111Interaction with 14-3-3 epsilonBy similarityAdd BLAST44
Regioni68 – 93Interaction with p75NTR/NGFRBy similarityAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi77 – 87Nuclear export signalBy similarityAdd BLAST11

Domaini

The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR.By similarity

Sequence similaritiesi

Belongs to the BEX family.Curated

Phylogenomic databases

eggNOGiENOG410JCIT Eukaryota
ENOG41113TP LUCA
GeneTreeiENSGT00810000125492
HOGENOMiHOG000236300
HOVERGENiHBG080240
InParanoidiQ00994
KOiK12465
OMAiLIMANIH
OrthoDBiEOG091G146U
PhylomeDBiQ00994
TreeFamiTF337909

Family and domain databases

InterProiView protein in InterPro
IPR007623 BEX
IPR021156 TF_A-like/BEX
PfamiView protein in Pfam
PF04538 BEX, 1 hit
PIRSFiPIRSF008633 BEX, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q00994-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANIHQENEE MEQPMQNGEE DRPLGGGEGH QPAGNRRGQA RRLAPNFRWA
60 70 80 90 100
IPNRQINDGM GGDGDDMEIF MEEMREIRRK LRELQLRNCL RILMGELSNH
110
HDHHDEFCLM P
Length:111
Mass (Da):12,959
Last modified:June 1, 1994 - v1
Checksum:i29AA0573282C933E
GO
Isoform 2 (identifier: Q00994-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.

Note: No experimental confirmation available.
Show »
Length:101
Mass (Da):11,762
Checksum:iED263FF37D8E838F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0463431 – 10Missing in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38188 mRNA Translation: AAA63232.1
AF187064 mRNA Translation: AAF75129.1
AY833562 mRNA Translation: AAX40680.1
AK315371 mRNA Translation: BAG37764.1
EL953547 Genomic DNA No translation available.
AL606763 Genomic DNA No translation available.
CH471190 Genomic DNA Translation: EAW54710.1
CH471190 Genomic DNA Translation: EAW54712.1
BC003190 mRNA Translation: AAH03190.1
CCDSiCCDS14508.1 [Q00994-1]
CCDS14509.1 [Q00994-2]
PIRiC35826
RefSeqiNP_055195.1, NM_014380.2 [Q00994-1]
NP_996798.1, NM_206915.2 [Q00994-1]
NP_996800.1, NM_206917.2 [Q00994-2]
UniGeneiHs.448588

Genome annotation databases

EnsembliENST00000361298; ENSP00000354843; ENSG00000166681 [Q00994-2]
ENST00000372634; ENSP00000361717; ENSG00000166681 [Q00994-2]
ENST00000372635; ENSP00000361718; ENSG00000166681 [Q00994-1]
ENST00000372645; ENSP00000361728; ENSG00000166681 [Q00994-1]
GeneIDi27018
KEGGihsa:27018
UCSCiuc004ekh.5 human [Q00994-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBEX3_HUMAN
AccessioniPrimary (citable) accession number: Q00994
Secondary accession number(s): B2RD17
, D3DXA3, Q5JQT4, Q5JQT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 18, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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