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UniProtKB - Q00994 (BEX3_HUMAN)
Protein
Protein BEX3
Gene
BEX3
Organism
Homo sapiens (Human)
Status
Functioni
May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity).
May play an important role in the pathogenesis of neurogenetic diseases.
By similarityMiscellaneous
Binds transition metals.By similarity
GO - Molecular functioni
- cysteine-type endopeptidase activator activity involved in apoptotic process Source: Reactome
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
- nerve growth factor receptor binding Source: Ensembl
- signaling receptor binding Source: GO_Central
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Reactome
- extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
- multicellular organism development Source: ProtInc
- signal transduction Source: GO_Central
Keywordsi
Biological process | Apoptosis |
Ligand | Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q00994 |
Reactomei | R-HSA-205025, NADE modulates death signalling |
SignaLinki | Q00994 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein BEX3CuratedAlternative name(s): Brain-expressed X-linked protein 3Imported Nerve growth factor receptor-associated protein 1 Ovarian granulosa cell 13.0 kDa protein HGR74 p75NTR-associated cell death executor |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13388, BEX3 |
MIMi | 300361, gene |
neXtProti | NX_Q00994 |
VEuPathDBi | HostDB:ENSG00000166681 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 27018 |
OpenTargetsi | ENSG00000166681 |
PharmGKBi | PA31616 |
Miscellaneous databases
Pharosi | Q00994, Tbio |
Genetic variation databases
BioMutai | BEX3 |
DMDMi | 547642 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000096688 | 1 – 111 | Protein BEX3Add BLAST | 111 |
Post-translational modificationi
Ubiquitinated. Degraded by the proteasome (By similarity).By similarity
Keywords - PTMi
Ubl conjugationProteomic databases
MassIVEi | Q00994 |
PaxDbi | Q00994 |
PeptideAtlasi | Q00994 |
PRIDEi | Q00994 |
ProteomicsDBi | 57900 [Q00994-1] |
PTM databases
iPTMneti | Q00994 |
PhosphoSitePlusi | Q00994 |
Expressioni
Tissue specificityi
Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver.1 Publication
Gene expression databases
Bgeei | ENSG00000166681, Expressed in cerebellar vermis and 252 other tissues |
Genevisiblei | Q00994, HS |
Organism-specific databases
HPAi | ENSG00000166681, Low tissue specificity |
Interactioni
Subunit structurei
Self-associates. Binds to the DEATH domain of p75NTR/NGFR.
Interacts with 14-3-3 epsilon (YWHAE).
Interacts with DIABLO/SMAC.
By similarityBinary interactionsi
Q00994
GO - Molecular functioni
- identical protein binding Source: IntAct
- nerve growth factor receptor binding Source: Ensembl
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 117956, 34 interactors |
IntActi | Q00994, 44 interactors |
MINTi | Q00994 |
STRINGi | 9606.ENSP00000361728 |
Miscellaneous databases
RNActi | Q00994, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 63 | DisorderedSequence analysisAdd BLAST | 63 | |
Regioni | 68 – 111 | Interaction with 14-3-3 epsilonBy similarityAdd BLAST | 44 | |
Regioni | 68 – 93 | Interaction with p75NTR/NGFRBy similarityAdd BLAST | 26 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 77 – 87 | Nuclear export signalBy similarityAdd BLAST | 11 |
Domaini
The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR.By similarity
Sequence similaritiesi
Belongs to the BEX family.Curated
Phylogenomic databases
eggNOGi | ENOG502TF4N, Eukaryota |
GeneTreei | ENSGT00940000153412 |
HOGENOMi | CLU_123122_0_0_1 |
InParanoidi | Q00994 |
OMAi | PMQNREE |
OrthoDBi | 1340122at2759 |
PhylomeDBi | Q00994 |
TreeFami | TF337909 |
Family and domain databases
InterProi | View protein in InterPro IPR007623, BEX IPR021156, TF_A-like/BEX |
PANTHERi | PTHR19430, PTHR19430, 1 hit |
Pfami | View protein in Pfam PF04538, BEX, 1 hit |
PIRSFi | PIRSF008633, BEX, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q00994-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MANIHQENEE MEQPMQNGEE DRPLGGGEGH QPAGNRRGQA RRLAPNFRWA
60 70 80 90 100
IPNRQINDGM GGDGDDMEIF MEEMREIRRK LRELQLRNCL RILMGELSNH
110
HDHHDEFCLM P
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046343 | 1 – 10 | Missing in isoform 2. 1 Publication | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M38188 mRNA Translation: AAA63232.1 AF187064 mRNA Translation: AAF75129.1 AY833562 mRNA Translation: AAX40680.1 AK315371 mRNA Translation: BAG37764.1 EL953547 Genomic DNA No translation available. AL606763 Genomic DNA No translation available. CH471190 Genomic DNA Translation: EAW54710.1 CH471190 Genomic DNA Translation: EAW54712.1 BC003190 mRNA Translation: AAH03190.1 |
CCDSi | CCDS14508.1 [Q00994-1] CCDS14509.1 [Q00994-2] |
PIRi | C35826 |
RefSeqi | NP_055195.1, NM_014380.2 [Q00994-1] NP_996798.1, NM_206915.2 [Q00994-1] NP_996800.1, NM_206917.2 [Q00994-2] |
Genome annotation databases
Ensembli | ENST00000361298; ENSP00000354843; ENSG00000166681 [Q00994-2] ENST00000372634; ENSP00000361717; ENSG00000166681 [Q00994-2] ENST00000372635; ENSP00000361718; ENSG00000166681 ENST00000372645; ENSP00000361728; ENSG00000166681 |
GeneIDi | 27018 |
KEGGi | hsa:27018 |
MANE-Selecti | ENST00000361298.9; ENSP00000354843.4; NM_206917.3; NP_996800.1 [Q00994-2] |
UCSCi | uc004ekh.5, human [Q00994-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M38188 mRNA Translation: AAA63232.1 AF187064 mRNA Translation: AAF75129.1 AY833562 mRNA Translation: AAX40680.1 AK315371 mRNA Translation: BAG37764.1 EL953547 Genomic DNA No translation available. AL606763 Genomic DNA No translation available. CH471190 Genomic DNA Translation: EAW54710.1 CH471190 Genomic DNA Translation: EAW54712.1 BC003190 mRNA Translation: AAH03190.1 |
CCDSi | CCDS14508.1 [Q00994-1] CCDS14509.1 [Q00994-2] |
PIRi | C35826 |
RefSeqi | NP_055195.1, NM_014380.2 [Q00994-1] NP_996798.1, NM_206915.2 [Q00994-1] NP_996800.1, NM_206917.2 [Q00994-2] |
3D structure databases
SMRi | Q00994 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117956, 34 interactors |
IntActi | Q00994, 44 interactors |
MINTi | Q00994 |
STRINGi | 9606.ENSP00000361728 |
PTM databases
iPTMneti | Q00994 |
PhosphoSitePlusi | Q00994 |
Genetic variation databases
BioMutai | BEX3 |
DMDMi | 547642 |
Proteomic databases
MassIVEi | Q00994 |
PaxDbi | Q00994 |
PeptideAtlasi | Q00994 |
PRIDEi | Q00994 |
ProteomicsDBi | 57900 [Q00994-1] |
Protocols and materials databases
Antibodypediai | 540, 264 antibodies from 36 providers |
DNASUi | 27018 |
Genome annotation databases
Ensembli | ENST00000361298; ENSP00000354843; ENSG00000166681 [Q00994-2] ENST00000372634; ENSP00000361717; ENSG00000166681 [Q00994-2] ENST00000372635; ENSP00000361718; ENSG00000166681 ENST00000372645; ENSP00000361728; ENSG00000166681 |
GeneIDi | 27018 |
KEGGi | hsa:27018 |
MANE-Selecti | ENST00000361298.9; ENSP00000354843.4; NM_206917.3; NP_996800.1 [Q00994-2] |
UCSCi | uc004ekh.5, human [Q00994-1] |
Organism-specific databases
CTDi | 27018 |
DisGeNETi | 27018 |
GeneCardsi | BEX3 |
HGNCi | HGNC:13388, BEX3 |
HPAi | ENSG00000166681, Low tissue specificity |
MIMi | 300361, gene |
neXtProti | NX_Q00994 |
OpenTargetsi | ENSG00000166681 |
PharmGKBi | PA31616 |
VEuPathDBi | HostDB:ENSG00000166681 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TF4N, Eukaryota |
GeneTreei | ENSGT00940000153412 |
HOGENOMi | CLU_123122_0_0_1 |
InParanoidi | Q00994 |
OMAi | PMQNREE |
OrthoDBi | 1340122at2759 |
PhylomeDBi | Q00994 |
TreeFami | TF337909 |
Enzyme and pathway databases
PathwayCommonsi | Q00994 |
Reactomei | R-HSA-205025, NADE modulates death signalling |
SignaLinki | Q00994 |
Miscellaneous databases
BioGRID-ORCSi | 27018, 8 hits in 636 CRISPR screens |
ChiTaRSi | BEX3, human |
GeneWikii | NGFRAP1 |
GenomeRNAii | 27018 |
Pharosi | Q00994, Tbio |
PROi | PR:Q00994 |
RNActi | Q00994, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166681, Expressed in cerebellar vermis and 252 other tissues |
Genevisiblei | Q00994, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007623, BEX IPR021156, TF_A-like/BEX |
PANTHERi | PTHR19430, PTHR19430, 1 hit |
Pfami | View protein in Pfam PF04538, BEX, 1 hit |
PIRSFi | PIRSF008633, BEX, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BEX3_HUMAN | |
Accessioni | Q00994Primary (citable) accession number: Q00994 Secondary accession number(s): B2RD17 Q5JQT5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families