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Protein

Gap junction beta-2 protein

Gene

Gjb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

  • gap junction channel activity Source: MGI
  • identical protein binding Source: MGI

GO - Biological processi

Keywordsi

Biological processHearing

Enzyme and pathway databases

ReactomeiR-MMU-190872 Transport of connexons to the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-2 protein
Alternative name(s):
Connexin-26
Short name:
Cx26
Gene namesi
Name:Gjb2
Synonyms:Cxn-26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:95720 Gjb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 40HelicalSequence analysisAdd BLAST20
Topological domaini41 – 75ExtracellularSequence analysisAdd BLAST35
Transmembranei76 – 98HelicalSequence analysisAdd BLAST23
Topological domaini99 – 139CytoplasmicSequence analysisAdd BLAST41
Transmembranei140 – 162HelicalSequence analysisAdd BLAST23
Topological domaini163 – 192ExtracellularSequence analysisAdd BLAST30
Transmembranei193 – 215HelicalSequence analysisAdd BLAST23
Topological domaini216 – 226CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578581 – 226Gap junction beta-2 proteinAdd BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 180By similarity
Disulfide bondi60 ↔ 174By similarity
Disulfide bondi64 ↔ 169By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ00977
PeptideAtlasiQ00977
PRIDEiQ00977

PTM databases

iPTMnetiQ00977
PhosphoSitePlusiQ00977

Expressioni

Tissue specificityi

Liver, kidney, intestine, lung, spleen, stomach, testis and brain, but not heart and adult skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000046352 Expressed in 244 organ(s), highest expression level in cochlea
CleanExiMM_GJB2
ExpressionAtlasiQ00977 baseline and differential
GenevisibleiQ00977 MM

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199932, 1 interactor
IntActiQ00977, 1 interactor
STRINGi10090.ENSMUSP00000054343

Structurei

3D structure databases

ProteinModelPortaliQ00977
SMRiQ00977
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFM8 Eukaryota
ENOG410Y7VN LUCA
GeneTreeiENSGT00910000144026
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiQ00977
KOiK07621
OMAiVMYDGFA
OrthoDBiEOG091G0FKH
PhylomeDBiQ00977
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002268 Connexin26
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01139 CONNEXINB2
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q00977-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDWGTLQSIL GGVNKHSTSI GKIWLTVLFI FRIMILVVAA KEVWGDEQAD
60 70 80 90 100
FVCNTLQPGC KNVCYDHHFP ISHIRLWALQ LIMVSTPALL VAMHVAYRRH
110 120 130 140 150
EKKRKFMKGE IKNEFKDIEE IKTQKVRIEG SLWWTYTTSI FFRVIFEAVF
160 170 180 190 200
MYVFYIMYNG FFMQRLVKCN AWPCPNTVDC FISRPTEKTV FTVFMISVSG
210 220
ICILLNITEL CYLFVRYCSG KSKRPV
Length:226
Mass (Da):26,411
Last modified:April 1, 1993 - v1
Checksum:i0D8178F7A339E0B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81445 Genomic DNA Translation: AAA37495.1
M63803 mRNA Translation: AAA37276.1
BC013634 mRNA Translation: AAH13634.1
BC051437 mRNA Translation: AAH51437.1
CCDSiCCDS27153.1
RefSeqiNP_032151.1, NM_008125.3
UniGeneiMm.390683

Genome annotation databases

EnsembliENSMUST00000055698; ENSMUSP00000054343; ENSMUSG00000046352
GeneIDi14619
KEGGimmu:14619
UCSCiuc007ucx.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81445 Genomic DNA Translation: AAA37495.1
M63803 mRNA Translation: AAA37276.1
BC013634 mRNA Translation: AAH13634.1
BC051437 mRNA Translation: AAH51437.1
CCDSiCCDS27153.1
RefSeqiNP_032151.1, NM_008125.3
UniGeneiMm.390683

3D structure databases

ProteinModelPortaliQ00977
SMRiQ00977
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199932, 1 interactor
IntActiQ00977, 1 interactor
STRINGi10090.ENSMUSP00000054343

PTM databases

iPTMnetiQ00977
PhosphoSitePlusiQ00977

Proteomic databases

PaxDbiQ00977
PeptideAtlasiQ00977
PRIDEiQ00977

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055698; ENSMUSP00000054343; ENSMUSG00000046352
GeneIDi14619
KEGGimmu:14619
UCSCiuc007ucx.2 mouse

Organism-specific databases

CTDi2706
MGIiMGI:95720 Gjb2

Phylogenomic databases

eggNOGiENOG410IFM8 Eukaryota
ENOG410Y7VN LUCA
GeneTreeiENSGT00910000144026
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiQ00977
KOiK07621
OMAiVMYDGFA
OrthoDBiEOG091G0FKH
PhylomeDBiQ00977
TreeFamiTF329606

Enzyme and pathway databases

ReactomeiR-MMU-190872 Transport of connexons to the plasma membrane

Miscellaneous databases

PROiPR:Q00977
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046352 Expressed in 244 organ(s), highest expression level in cochlea
CleanExiMM_GJB2
ExpressionAtlasiQ00977 baseline and differential
GenevisibleiQ00977 MM

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002268 Connexin26
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01139 CONNEXINB2
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXB2_MOUSE
AccessioniPrimary (citable) accession number: Q00977
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 10, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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