Gjb2

Functionⁱ

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functionⁱ

gap junction channel activity
Source: MGI
Inferred from direct assayⁱ
- 11501764
identical protein binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aging Source: Ensembl
cell-cell signaling
Source: MGI
Inferred from direct assayⁱ
- 11501764
cellular response to dexamethasone stimulus Source: Ensembl
cellular response to glucagon stimulus Source: Ensembl
cellular response to oxidative stress Source: Ensembl
decidualization Source: Ensembl
epididymis development Source: Ensembl
gap junction assembly
Source: MGI
Inferred from mutant phenotypeⁱ
- 24590285
inner ear development Source: Ensembl
response to antibiotic Source: Ensembl
response to estradiol Source: Ensembl
response to human chorionic gonadotropin Source: Ensembl
response to ischemia Source: Ensembl
response to lipopolysaccharide Source: Ensembl
response to progesterone Source: Ensembl
response to retinoic acid Source: Ensembl
sensory perception of sound Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Hearing

Biological process

Hearing

Enzyme and pathway databases

Reactomeⁱ	R-MMU-190872 Transport of connexons to the plasma membrane

Reactomeⁱ

R-MMU-190872 Transport of connexons to the plasma membrane

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Gap junction beta-2 protein Alternative name(s): Connexin-26 Short name: Cx26
Gene namesⁱ	Name:Gjb2 Synonyms:Cxn-26
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 14

Organism-specific databases

MGIⁱ	MGI:95720 Gjb2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 20	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	21 – 40	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	41 – 75	ExtracellularSequence analysisAdd BLAST	35
Transmembraneⁱ	76 – 98	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	99 – 139	CytoplasmicSequence analysisAdd BLAST	41
Transmembraneⁱ	140 – 162	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	163 – 192	ExtracellularSequence analysisAdd BLAST	30
Transmembraneⁱ	193 – 215	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	216 – 226	CytoplasmicSequence analysisAdd BLAST	11

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000057858	1 – 226	Gap junction beta-2 proteinAdd BLAST		226

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	53 ↔ 180	By similarity
Disulfide bondⁱ	60 ↔ 174	By similarity
Disulfide bondⁱ	64 ↔ 169	By similarity

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	Q00977
PeptideAtlas More...PeptideAtlasⁱ	Q00977
PRIDEⁱ	Q00977

PTM databases

iPTMnetⁱ	Q00977
PhosphoSitePlusⁱ	Q00977

Expressionⁱ

Tissue specificityⁱ

Liver, kidney, intestine, lung, spleen, stomach, testis and brain, but not heart and adult skeletal muscle.

Gene expression databases

Bgeeⁱ	ENSMUSG00000046352 Expressed in 244 organ(s), highest expression level in cochlea
CleanExⁱ	MM_GJB2
ExpressionAtlasⁱ	Q00977 baseline and differential
Genevisibleⁱ	Q00977 MM

Interactionⁱ

Subunit structureⁱ

A connexon is composed of a hexamer of connexins. Interacts with CNST.1 Publication

GO - Molecular functionⁱ

identical protein binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	199932, 1 interactor
IntActⁱ	Q00977, 1 interactor
STRINGⁱ	10090.ENSMUSP00000054343

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q00977
SMRⁱ	Q00977
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the connexin family. Beta-type (group I) subfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IFM8 Eukaryota ENOG410Y7VN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144026
HOGENOMⁱ	HOG000231127
HOVERGENⁱ	HBG009576
InParanoidⁱ	Q00977
KEGG Orthology (KO) More...KOⁱ	K07621
OMAⁱ	VMYDGFA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FKH
PhylomeDBⁱ	Q00977
TreeFamⁱ	TF329606

Family and domain databases

Gene3Dⁱ	1.20.1440.80, 1 hit
InterProⁱ	View protein in InterPro IPR000500 Connexin IPR002268 Connexin26 IPR019570 Connexin_CCC IPR017990 Connexin_CS IPR013092 Connexin_N IPR038359 Connexin_N_sf
PANTHERⁱ	PTHR11984 PTHR11984, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00029 Connexin, 1 hit
PRINTSⁱ	PR00206 CONNEXIN PR01139 CONNEXINB2
SMARTⁱ	View protein in SMART SM00037 CNX, 1 hit SM01089 Connexin_CCC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00407 CONNEXINS_1, 1 hit PS00408 CONNEXINS_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q00977-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDWGTLQSIL GGVNKHSTSI GKIWLTVLFI FRIMILVVAA KEVWGDEQAD 
        60         70         80         90        100
FVCNTLQPGC KNVCYDHHFP ISHIRLWALQ LIMVSTPALL VAMHVAYRRH 
       110        120        130        140        150
EKKRKFMKGE IKNEFKDIEE IKTQKVRIEG SLWWTYTTSI FFRVIFEAVF 
       160        170        180        190        200
MYVFYIMYNG FFMQRLVKCN AWPCPNTVDC FISRPTEKTV FTVFMISVSG 
       210        220 
ICILLNITEL CYLFVRYCSG KSKRPV

Length:226

Mass (Da):26,411

Last modified:April 1, 1993 - v1

Checksum:ⁱ0D8178F7A339E0B6

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M81445 Genomic DNA Translation: AAA37495.1 M63803 mRNA Translation: AAA37276.1 BC013634 mRNA Translation: AAH13634.1 BC051437 mRNA Translation: AAH51437.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27153.1
NCBI Reference Sequences More...RefSeqⁱ	NP_032151.1, NM_008125.3
UniGeneⁱ	Mm.390683

Genome annotation databases

Ensemblⁱ	ENSMUST00000055698; ENSMUSP00000054343; ENSMUSG00000046352
GeneIDⁱ	14619
KEGGⁱ	mmu:14619
UCSC genome browser More...UCSCⁱ	uc007ucx.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q00977	Gap junction protein		MOUSE		226	UniRef100_Q00977

Protein	Similar proteins		Species	Score	Length	Source
Q00977	Gap junction beta-2 protein		RAT		226	UniRef90_P21994
Gap junction beta-2 protein		BOVIN		226
Gap junction beta-2 protein		MACMU		226
Gap junction beta-2 protein		PONPY		226
Gap junction beta-2 protein		SHEEP		226
+113

Protein	Similar proteins		Species	Score	Length	Source
Q00977	Gap junction beta-1 protein	)	HUMAN		283	UniRef50_P08034
Gap junction beta-1 protein		BOVIN		284
Gap junction beta-1 protein		MACFA		283
Gap junction beta-1 protein		HORSE		283
Gap junction beta-1 protein		MOUSE		283
+264

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M81445 Genomic DNA Translation: AAA37495.1 M63803 mRNA Translation: AAA37276.1 BC013634 mRNA Translation: AAH13634.1 BC051437 mRNA Translation: AAH51437.1
CCDSⁱ	CCDS27153.1
RefSeqⁱ	NP_032151.1, NM_008125.3
UniGeneⁱ	Mm.390683

3D structure databases

ProteinModelPortalⁱ	Q00977
SMRⁱ	Q00977
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199932, 1 interactor
IntActⁱ	Q00977, 1 interactor
STRINGⁱ	10090.ENSMUSP00000054343

PTM databases

iPTMnetⁱ	Q00977
PhosphoSitePlusⁱ	Q00977

Proteomic databases

PaxDbⁱ	Q00977
PeptideAtlasⁱ	Q00977
PRIDEⁱ	Q00977

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000055698; ENSMUSP00000054343; ENSMUSG00000046352
GeneIDⁱ	14619
KEGGⁱ	mmu:14619
UCSCⁱ	uc007ucx.2 mouse

Organism-specific databases

CTDⁱ	2706
MGIⁱ	MGI:95720 Gjb2

Phylogenomic databases

eggNOGⁱ	ENOG410IFM8 Eukaryota ENOG410Y7VN LUCA
GeneTreeⁱ	ENSGT00910000144026
HOGENOMⁱ	HOG000231127
HOVERGENⁱ	HBG009576
InParanoidⁱ	Q00977
KOⁱ	K07621
OMAⁱ	VMYDGFA
OrthoDBⁱ	EOG091G0FKH
PhylomeDBⁱ	Q00977
TreeFamⁱ	TF329606

Enzyme and pathway databases

Reactomeⁱ	R-MMU-190872 Transport of connexons to the plasma membrane

Reactomeⁱ

R-MMU-190872 Transport of connexons to the plasma membrane

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q00977
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000046352 Expressed in 244 organ(s), highest expression level in cochlea
CleanExⁱ	MM_GJB2
ExpressionAtlasⁱ	Q00977 baseline and differential
Genevisibleⁱ	Q00977 MM

Family and domain databases

Gene3Dⁱ	1.20.1440.80, 1 hit
InterProⁱ	View protein in InterPro IPR000500 Connexin IPR002268 Connexin26 IPR019570 Connexin_CCC IPR017990 Connexin_CS IPR013092 Connexin_N IPR038359 Connexin_N_sf
PANTHERⁱ	PTHR11984 PTHR11984, 1 hit
Pfamⁱ	View protein in Pfam PF00029 Connexin, 1 hit
PRINTSⁱ	PR00206 CONNEXIN PR01139 CONNEXINB2
SMARTⁱ	View protein in SMART SM00037 CNX, 1 hit SM01089 Connexin_CCC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00407 CONNEXINS_1, 1 hit PS00408 CONNEXINS_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CXB2_MOUSE
Accessionⁱ	Q00977Primary (citable) accession number: Q00977
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	April 1, 1993
	Last modified:	October 10, 2018
	This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q00977 (CXB2_MOUSE)

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Gap junction beta-2 protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Cytosol

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ