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Entry version 191 (11 Dec 2019)
Sequence version 2 (01 Jun 2001)
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Protein

Spectrin beta chain

Gene

beta-Spec

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Interacts with calmodulin in a calcium-dependent manner.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin capping, Actin-binding, Calmodulin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-6807878 COPI-mediated anterograde transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spectrin beta chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:beta-Spec
Synonyms:Spec-b
ORF Names:CG5870
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0250788 beta-Spec

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000734681 – 2291Spectrin beta chainAdd BLAST2291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2195Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q00963

PRoteomics IDEntifications database

More...
PRIDEi
Q00963

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q00963

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0250788 Expressed in 38 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q00963 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q00963 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Native spectrin molecule is a tetramer composed of two antiparallel heterodimers joined head to head so that each end of the native molecule includes the C-terminus of the alpha subunit and the N-terminus of the beta subunit.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
59071, 17 interactors

Database of interacting proteins

More...
DIPi
DIP-18565N

Protein interaction database and analysis system

More...
IntActi
Q00963, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0074228

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12291
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q00963

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q00963

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 154Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST105
Domaini169 – 274Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST106
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati300 – 408Spectrin 1Sequence analysisAdd BLAST109
Repeati420 – 521Spectrin 2Sequence analysisAdd BLAST102
Repeati525 – 633Spectrin 3Sequence analysisAdd BLAST109
Repeati636 – 739Spectrin 4Sequence analysisAdd BLAST104
Repeati743 – 843Spectrin 5Sequence analysisAdd BLAST101
Repeati848 – 948Spectrin 6Sequence analysisAdd BLAST101
Repeati954 – 1057Spectrin 7Sequence analysisAdd BLAST104
Repeati1060 – 1166Spectrin 8Sequence analysisAdd BLAST107
Repeati1170 – 1272Spectrin 9Sequence analysisAdd BLAST103
Repeati1276 – 1376Spectrin 10Sequence analysisAdd BLAST101
Repeati1386 – 1484Spectrin 11Sequence analysisAdd BLAST99
Repeati1488 – 1591Spectrin 12Sequence analysisAdd BLAST104
Repeati1594 – 1697Spectrin 13Sequence analysisAdd BLAST104
Repeati1701 – 1802Spectrin 14Sequence analysisAdd BLAST102
Repeati1807 – 1909Spectrin 15Sequence analysisAdd BLAST103
Repeati1913 – 2015Spectrin 16Sequence analysisAdd BLAST103
Repeati2020 – 2089Spectrin 17Sequence analysisAdd BLAST70
Domaini2147 – 2259PHPROSITE-ProRule annotationAdd BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 271Actin-bindingAdd BLAST271

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the spectrin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0035 Eukaryota
COG5069 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154864

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q00963

KEGG Orthology (KO)

More...
KOi
K06115

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q00963

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR016343 Spectrin_bsu
IPR002017 Spectrin_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 2 hits
PF15410 PH_9, 1 hit
PF00435 Spectrin, 17 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002297 Spectrin_beta_subunit, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00683 SPECTRINPH

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 2 hits
SM00233 PH, 1 hit
SM00150 SPEC, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q00963-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTDISIVRW DPSQGPGNEY IDEYEYDGGN SSSRLFERSR IKALAEERES
60 70 80 90 100
VQKKTFTKWV NSHLCRVNCR IADLYVDMRD GKHLIKLLEV LSGERLPKPT
110 120 130 140 150
KGKMRIHCLE NVDKALQFLR EQRVHLENIG SHDIVDGNAS LNLGLIWTII
160 170 180 190 200
LRFQIQDITI EEVDNKETKS AKDALLLWCQ MKTAGYHNVN VRNFTTSWRD
210 220 230 240 250
GLAFNAIIHK HRPDLVQFEK LSKTNAIHNL NNAFDVAEDK LGLAKLLDAE
260 270 280 290 300
DVFVEHPDEK SIITYVVTYY HYFSKLKQET VQGKRIGKVV GIAMENDKMV
310 320 330 340 350
HDYENFTSDL LKWIETTIQS LGEREFENSL AGVQGQLAQF SNYRTIEKPP
360 370 380 390 400
KFVEKGNLEV LLFTLQSKMR ANNQKPYTPK EGKMISDINK AWERLEKAEH
410 420 430 440 450
ERELALREEL IRQEKLEQLA ARFDRKASMR ETWLSENQRL VSQDNFGFDL
460 470 480 490 500
AAVEAAAKKH EAIETDIFAY EERVQAVVAV CDELESERYH DVKRILLRKD
510 520 530 540 550
NVMRLWTYLL ELLRARRMRL EISLQLQQNF QEMLYILDNM EEIKQLLMTD
560 570 580 590 600
DYGKHLMGVE DLLQKHSLVE ADINILGERV KVVVQNSQKF LSDDPESYKP
610 620 630 640 650
CDPEIIVSRV QQLEDAYAEL VRLAVERRSR LEESRKLWQF YWDTADEENW
660 670 680 690 700
IKEKEQIVST DEVGHDLTTV NLMLSKHKAL ESEITSHDPQ LQNVAKVGSE
710 720 730 740 750
LITEGHFGAD RIKDRLKEIL NKWDHLLDLT KYRRQRLENA VEYFQLFADA
760 770 780 790 800
DDVDNWMLDT LRIVSSEDVG RDEANVQSLL KKHKDVADEL KNYAEVIDAL
810 820 830 840 850
HKQAESLKLN EAEKANVDKR LEAIDNRYKE LTELAKLRKQ RLLDALSLYK
860 870 880 890 900
LMSEADGVEQ WIKEKTKMLD TMTPGKDIED VEIMKHRFEG FDKEMNANAS
910 920 930 940 950
RVAVVNQLAR QLLHVEHPNS DEILERQNHL NQEWSTLREK AEAKMDDLKS
960 970 980 990 1000
AHGVQTFYIE CRETISWIED KKRILTETDS LEMDLTGVMT LQRRLSGMDR
1010 1020 1030 1040 1050
DLAAIQAKLS SLEREANSIE DEHPEEAKII RERIAQIELI WEQLTQMLKE
1060 1070 1080 1090 1100
RDSKLEEAGD LHRFLRDLDH FQTWLTKTQT DVASEDTPTS LPEAEKLLNQ
1110 1120 1130 1140 1150
HQSIREEIDN YTEDYKNMME YGERLTSEGS TSDDPQYMFL RERLNALKDG
1160 1170 1180 1190 1200
WEELHQMWEN RQVLLSQSLD QQLFNRDARQ TEVLLSQQEH FLSKDDTPVN
1210 1220 1230 1240 1250
LEQAENQLKR HEAFLTTMEA NDDKINTLLQ VADTLVEKDH FDADKIGKRA
1260 1270 1280 1290 1300
ENITGRRDDN RQRALDQHEK LKNQVKLHEF LQDLEELAEW VQEKYATSQD
1310 1320 1330 1340 1350
ESYRSAKTIH SKWTRHQAFE AEIAANKERL FEAEKSAQEL SKEKPEFKDV
1360 1370 1380 1390 1400
IEPKLKELAK QFDDLEVHTK EKGAMLFDAN REVLVQQTCD DIDSYITDLE
1410 1420 1430 1440 1450
KQIVSGDTAN DLTSVNILMQ KQQVIQTQMA VKARQVEEID KQTEYLQKTV
1460 1470 1480 1490 1500
PEEKIEPIVV KKTAVLERFE KIKAPLLERQ KALEKKKEAF QFCRDVEDEK
1510 1520 1530 1540 1550
LWIDEKLPVA NSPDYGNSLF NVHVLKKKNQ SLATEIDNHE PRINAICNNG
1560 1570 1580 1590 1600
RKLIDEGHED AKKFEALISD LTQKWQELKD AIENRRKHLL ESEKVQQYFF
1610 1620 1630 1640 1650
DAQEAESWMS EQELYMMVED RGKDEISAQN LMKKHENLEQ SVEDYANTIR
1660 1670 1680 1690 1700
QLGEVARQFS GDDISSGDAV AVKQSQLDKL YAGLKDLAGE RRARLNEALQ
1710 1720 1730 1740 1750
LFMLSREVDD LEQWITDREV VAGSQELGQD FDHVTLLSER FNEFARDTEA
1760 1770 1780 1790 1800
VGGERVAKVN GIADNLIQAG HSDSATIAEW KDNLNESWQD LLELIETRTQ
1810 1820 1830 1840 1850
MLAASRELHK FFHDCKDVLG RILEKQHGVS DELGRDAGSV STLQRKHYNF
1860 1870 1880 1890 1900
LQDLITLYSQ VQQIQEESAK LQDAYAGDKA KEITNREQEV LHAWDNLQAM
1910 1920 1930 1940 1950
CDARKQKLAD TGDLFRFFNM VRILMIWMED LVRQMNTSEK PRDVSGVELL
1960 1970 1980 1990 2000
MNNHQSLKAE IDTREDNFGA CISLGKELLT RNHYASADIK DRLMTLSNSR
2010 2020 2030 2040 2050
NALLRRWEER WENLQLILEV YQFARDAAVA EAWLIAQEPY LLSSELGHTI
2060 2070 2080 2090 2100
DEVENLIKKH EAFEKSAAAQ EERFSALERL TTFELKEMKR RQELAEEAER
2110 2120 2130 2140 2150
QRIKEEQEAK AASEAAEQAK REAERRDDVD VGASHDDSER GGTPGAGEGH
2160 2170 2180 2190 2200
EGYVTRKHEW DSTTKKASNR SWDKVYMAAK AGRISFYKDQ KGYKSNPELT
2210 2220 2230 2240 2250
FRGEPSYDLQ NAAIEIASDY TKKKHVLRVK LANGALFLLQ AHDDTEMSQW
2260 2270 2280 2290
VTSLKAQSDS TAVAASRSQT LPATSQKDEP KRRSFFTLKK K
Length:2,291
Mass (Da):265,739
Last modified:June 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5CDFB0C548BBC39B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PHG4M9PHG4_DROME
Spectrin beta chain
beta-Spec anon-EST:fe1B3, b spectrin, B-spec, b-Spec, beta
2,147Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PF16M9PF16_DROME
Spectrin beta chain
beta-Spec anon-EST:fe1B3, b spectrin, B-spec, b-Spec, beta
2,308Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAR82828 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2278D → Y in AAA28399 (PubMed:1631106).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M92288 mRNA Translation: AAA28399.1
AE014298 Genomic DNA Translation: AAF48751.1
BT011160 mRNA Translation: AAR82828.1 Sequence problems.

Protein sequence database of the Protein Information Resource

More...
PIRi
A46147

NCBI Reference Sequences

More...
RefSeqi
NP_523388.1, NM_078664.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0074454; FBpp0074228; FBgn0250788

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
32746

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG5870

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92288 mRNA Translation: AAA28399.1
AE014298 Genomic DNA Translation: AAF48751.1
BT011160 mRNA Translation: AAR82828.1 Sequence problems.
PIRiA46147
RefSeqiNP_523388.1, NM_078664.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DRONMR-A2142-2262[»]
SMRiQ00963
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi59071, 17 interactors
DIPiDIP-18565N
IntActiQ00963, 3 interactors
STRINGi7227.FBpp0074228

PTM databases

iPTMnetiQ00963

Proteomic databases

PaxDbiQ00963
PRIDEiQ00963

Genome annotation databases

EnsemblMetazoaiFBtr0074454; FBpp0074228; FBgn0250788
GeneIDi32746
KEGGidme:Dmel_CG5870

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
32746
FlyBaseiFBgn0250788 beta-Spec

Phylogenomic databases

eggNOGiKOG0035 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000154864
InParanoidiQ00963
KOiK06115
PhylomeDBiQ00963

Enzyme and pathway databases

ReactomeiR-DME-6807878 COPI-mediated anterograde transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
beta-Spec fly
EvolutionaryTraceiQ00963

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
32746

Protein Ontology

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PROi
PR:Q00963

Gene expression databases

BgeeiFBgn0250788 Expressed in 38 organ(s), highest expression level in embryo
ExpressionAtlasiQ00963 differential
GenevisibleiQ00963 DM

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR016343 Spectrin_bsu
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF15410 PH_9, 1 hit
PF00435 Spectrin, 17 hits
PIRSFiPIRSF002297 Spectrin_beta_subunit, 1 hit
PRINTSiPR00683 SPECTRINPH
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00233 PH, 1 hit
SM00150 SPEC, 17 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPTCB_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q00963
Secondary accession number(s): Q6NNX2, Q9VX30
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: June 1, 2001
Last modified: December 11, 2019
This is version 191 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
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