UniProtKB - Q00954 (SCN1B_RAT)
Sodium channel subunit beta-1
Scn1b
Functioni
GO - Molecular functioni
- ion channel binding Source: GO_Central
- sodium channel inhibitor activity Source: RGD
- sodium channel regulator activity Source: UniProtKB
- voltage-gated ion channel activity Source: UniProtKB-KW
- voltage-gated sodium channel activity Source: RGD
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential Source: RGD
- voltage-gated sodium channel activity involved in Purkinje myocyte action potential Source: RGD
GO - Biological processi
- axon guidance Source: RGD
- cardiac conduction Source: RGD
- cardiac muscle cell action potential involved in contraction Source: RGD
- cardiac muscle contraction Source: RGD
- corticospinal neuron axon guidance Source: RGD
- locomotion Source: RGD
- membrane depolarization Source: RGD
- membrane depolarization during cardiac muscle cell action potential Source: RGD
- membrane depolarization during Purkinje myocyte cell action potential Source: RGD
- neuronal action potential propagation Source: RGD
- positive regulation of neuron projection development Source: RGD
- positive regulation of sodium ion transport Source: RGD
- regulation of atrial cardiac muscle cell membrane depolarization Source: RGD
- regulation of heart rate by cardiac conduction Source: RGD
- regulation of sodium ion transmembrane transporter activity Source: RGD
- regulation of sodium ion transport Source: RGD
- regulation of ventricular cardiac muscle cell membrane repolarization Source: RGD
- regulation of voltage-gated sodium channel activity Source: UniProtKB
- response to pyrethroid Source: RGD
- sodium ion transmembrane transport Source: RGD
Keywordsi
Molecular function | Ion channel, Sodium channel, Voltage-gated channel |
Biological process | Ion transport, Sodium transport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
Reactomei | R-RNO-5576892, Phase 0 - rapid depolarisation |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium channel subunit beta-1 |
Gene namesi | Name:Scn1b |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3631, Scn1b |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein By similarity
Other locations
- Perikaryon By similarity
- Cell projection By similarity
- axon 1 Publication
Note: Detected at nodes of Ranvier on the sciatic nerve.1 Publication
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
- T-tubule Source: RGD
- voltage-gated sodium channel complex Source: UniProtKB
Other locations
- intercalated disc Source: RGD
- node of Ranvier Source: RGD
- perikaryon Source: UniProtKB-SubCell
- sodium channel complex Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 160 | ExtracellularSequence analysisAdd BLAST | 142 | |
Transmembranei | 161 – 182 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 183 – 218 | CytoplasmicSequence analysisAdd BLAST | 36 |
Keywords - Cellular componenti
Cell membrane, Cell projection, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 109 – 110 | TN → AA: Strongly decreased ability to mediate rapid channel inactivation. 1 Publication | 2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Add BLAST | 18 | |
ChainiPRO_0000014929 | 19 – 218 | Sodium channel subunit beta-1Add BLAST | 200 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 21 ↔ 43 | By similarity | ||
Disulfide bondi | 40 ↔ 121 | 1 Publication | ||
Glycosylationi | 93 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 110 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 114 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 135 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q00954 |
PRIDEi | Q00954 |
PTM databases
GlyGeni | Q00954, 4 sites, 3 N-linked glycans (1 site) |
iPTMneti | Q00954 |
PhosphoSitePlusi | Q00954 |
UniCarbKBi | Q00954 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSRNOG00000021102, Expressed in skeletal muscle tissue and 21 other tissues |
ExpressionAtlasi | Q00954, baseline and differential |
Genevisiblei | Q00954, RN |
Interactioni
Subunit structurei
Component of a voltage-sensitive sodium channel complex that consists of a pore-forming alpha subunit and one or more regulatory beta subunits (PubMed:1375395, PubMed:28012039).
Interacts with SCN4A (PubMed:28012039).
Interacts with NFASC (PubMed:11470829).
Interacts with SCN10A (PubMed:15178439).
Interacts with SCN1A.
Interacts with SCN3A.
Interacts with SCN5A.
Interacts with SCN8A (By similarity).
By similarity4 PublicationsBinary interactionsi
Q00954
With | #Exp. | IntAct |
---|---|---|
Syt1 [P21707] | 2 | EBI-2619363,EBI-458098 |
GO - Molecular functioni
- ion channel binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 248306, 2 interactors |
CORUMi | Q00954 |
IntActi | Q00954, 2 interactors |
STRINGi | 10116.ENSRNOP00000028653 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 150 | Ig-like C2-typeAdd BLAST | 129 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502R0UM, Eukaryota |
GeneTreei | ENSGT00390000018560 |
HOGENOMi | CLU_096296_0_0_1 |
InParanoidi | Q00954 |
OMAi | AGCVEVD |
OrthoDBi | 1345300at2759 |
PhylomeDBi | Q00954 |
TreeFami | TF332097 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013106, Ig_V-set IPR027098, Na_channel_b1/b3 |
PANTHERi | PTHR10546, PTHR10546, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MGTLLALVVG AVLVSSAWGG CVEVDSETEA VYGMTFKILC ISCKRRSETT
60 70 80 90 100
AETFTEWTFR QKGTEEFVKI LRYENEVLQL EEDERFEGRV VWNGSRGTKD
110 120 130 140 150
LQDLSIFITN VTYNHSGDYE CHVYRLLFFD NYEHNTSVVK KIHLEVVDKA
160 170 180 190 200
NRDMASIVSE IMMYVLIVVL TIWLVAEMVY CYKKIAAATE AAAQENASEY
210
LAITSESKEN CTGVQVAE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JXY6 | A0A0G2JXY6_RAT | Sodium channel subunit beta-1 | Scn1b | 185 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M91808 mRNA Translation: AAA88513.1 BC094523 mRNA Translation: AAH94523.1 |
PIRi | A42737 |
RefSeqi | NP_001257974.1, NM_001271045.1 NP_058984.1, NM_017288.2 |
Genome annotation databases
Ensembli | ENSRNOT00000028653; ENSRNOP00000028653; ENSRNOG00000021102 ENSRNOT00000079091; ENSRNOP00000074323; ENSRNOG00000021102 |
GeneIDi | 29686 |
KEGGi | rno:29686 |
UCSCi | RGD:3631, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M91808 mRNA Translation: AAA88513.1 BC094523 mRNA Translation: AAH94523.1 |
PIRi | A42737 |
RefSeqi | NP_001257974.1, NM_001271045.1 NP_058984.1, NM_017288.2 |
3D structure databases
SMRi | Q00954 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 248306, 2 interactors |
CORUMi | Q00954 |
IntActi | Q00954, 2 interactors |
STRINGi | 10116.ENSRNOP00000028653 |
PTM databases
GlyGeni | Q00954, 4 sites, 3 N-linked glycans (1 site) |
iPTMneti | Q00954 |
PhosphoSitePlusi | Q00954 |
UniCarbKBi | Q00954 |
Proteomic databases
PaxDbi | Q00954 |
PRIDEi | Q00954 |
Protocols and materials databases
ABCDi | Q00954, 1 sequenced antibody |
Genome annotation databases
Ensembli | ENSRNOT00000028653; ENSRNOP00000028653; ENSRNOG00000021102 ENSRNOT00000079091; ENSRNOP00000074323; ENSRNOG00000021102 |
GeneIDi | 29686 |
KEGGi | rno:29686 |
UCSCi | RGD:3631, rat |
Organism-specific databases
CTDi | 6324 |
RGDi | 3631, Scn1b |
Phylogenomic databases
eggNOGi | ENOG502R0UM, Eukaryota |
GeneTreei | ENSGT00390000018560 |
HOGENOMi | CLU_096296_0_0_1 |
InParanoidi | Q00954 |
OMAi | AGCVEVD |
OrthoDBi | 1345300at2759 |
PhylomeDBi | Q00954 |
TreeFami | TF332097 |
Enzyme and pathway databases
Reactomei | R-RNO-5576892, Phase 0 - rapid depolarisation |
Miscellaneous databases
PROi | PR:Q00954 |
Gene expression databases
Bgeei | ENSRNOG00000021102, Expressed in skeletal muscle tissue and 21 other tissues |
ExpressionAtlasi | Q00954, baseline and differential |
Genevisiblei | Q00954, RN |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013106, Ig_V-set IPR027098, Na_channel_b1/b3 |
PANTHERi | PTHR10546, PTHR10546, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SCN1B_RAT | |
Accessioni | Q00954Primary (citable) accession number: Q00954 Secondary accession number(s): Q505J0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families