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Protein

Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Gene

Csf2ra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.

GO - Molecular functioni

  • cytokine binding Source: GO_Central
  • cytokine receptor activity Source: GO_Central
  • granulocyte colony-stimulating factor binding Source: MGI
  • granulocyte colony-stimulating factor receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-5683826 Surfactant metabolism
R-MMU-912526 Interleukin receptor SHC signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Short name:
GM-CSF-R-alpha
Short name:
GMCSFR-alpha
Short name:
GMR-alpha
Alternative name(s):
CD_antigen: CD116
Gene namesi
Name:Csf2ra
Synonyms:Csfgmra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1339754 Csf2ra

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 327ExtracellularSequence analysisAdd BLAST298
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Topological domaini349 – 388CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001087330 – 388Granulocyte-macrophage colony-stimulating factor receptor subunit alphaAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi132N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi237N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ00941
PRIDEiQ00941

PTM databases

PhosphoSitePlusiQ00941
SwissPalmiQ00941

Expressioni

Gene expression databases

BgeeiENSMUSG00000059326 Expressed in 251 organ(s), highest expression level in bone marrow
GenevisibleiQ00941 MM

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075423

Structurei

3D structure databases

ProteinModelPortaliQ00941
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini228 – 324Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST97

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi310 – 314WSXWS motif5
Motifi359 – 367Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKK3 Eukaryota
ENOG411157B LUCA
GeneTreeiENSGT00520000055993
HOVERGENiHBG051129
InParanoidiQ00941
KOiK05066
OMAiNWSSWSE
OrthoDBiEOG091G0935
TreeFamiTF331549

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR003532 Short_hematopoietin_rcpt_2_CS
IPR015321 TypeI_recpt_CBD
PfamiView protein in Pfam
PF09240 IL6Ra-bind, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS01356 HEMATOPO_REC_S_F2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00941-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSSHAMNIT PLAQLALLFS TLLLPGTQAL LAPTTPDAGS ALNLTFDPWT
60 70 80 90 100
RTLTWACDTA AGNVTVTSCT VTSREAGIHR RVSPFGCRCW FRRMMALHHG
110 120 130 140 150
VTLDVNGTVG GAAAHWRLSF VNEGAAGSGA ENLTCEIRAA RFLSCAWREG
160 170 180 190 200
PAAPADVRYS LRVLNSTGHD VARCMADPGD DVITQCIAND LSLLGSEAYL
210 220 230 240 250
VVTGRSGAGP VRFLDDVVAT KALERLGPPR DVTASCNSSH CTVSWAPPST
260 270 280 290 300
WASLTARDFQ FEVQWQSAEP GSTPRKVLVV EETRLAFPSP APHGGHKVKV
310 320 330 340 350
RAGDTRMKHW GEWSPAHPLE AEDTRVPGAL LYAVTACAVL LCALALGVTC
360 370 380
RRFEVTRRLF PPIPGIRDKV SDDVRVNPET LRKDLLQP
Length:388
Mass (Da):41,769
Last modified:July 27, 2011 - v2
Checksum:i8877B0743D99B0FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124G → S in AAA37421 (PubMed:1533931).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85078 mRNA Translation: AAA37421.1
AC165327 Genomic DNA No translation available.
CCDSiCCDS29946.1
PIRiA45304
RefSeqiNP_034100.2, NM_009970.2
UniGeneiMm.287228

Genome annotation databases

EnsembliENSMUST00000076046; ENSMUSP00000075423; ENSMUSG00000059326
GeneIDi12982
KEGGimmu:12982
UCSCiuc008icj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85078 mRNA Translation: AAA37421.1
AC165327 Genomic DNA No translation available.
CCDSiCCDS29946.1
PIRiA45304
RefSeqiNP_034100.2, NM_009970.2
UniGeneiMm.287228

3D structure databases

ProteinModelPortaliQ00941
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075423

PTM databases

PhosphoSitePlusiQ00941
SwissPalmiQ00941

Proteomic databases

PaxDbiQ00941
PRIDEiQ00941

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076046; ENSMUSP00000075423; ENSMUSG00000059326
GeneIDi12982
KEGGimmu:12982
UCSCiuc008icj.2 mouse

Organism-specific databases

CTDi1438
MGIiMGI:1339754 Csf2ra

Phylogenomic databases

eggNOGiENOG410IKK3 Eukaryota
ENOG411157B LUCA
GeneTreeiENSGT00520000055993
HOVERGENiHBG051129
InParanoidiQ00941
KOiK05066
OMAiNWSSWSE
OrthoDBiEOG091G0935
TreeFamiTF331549

Enzyme and pathway databases

ReactomeiR-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-5683826 Surfactant metabolism
R-MMU-912526 Interleukin receptor SHC signaling

Miscellaneous databases

PROiPR:Q00941
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059326 Expressed in 251 organ(s), highest expression level in bone marrow
GenevisibleiQ00941 MM

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR003532 Short_hematopoietin_rcpt_2_CS
IPR015321 TypeI_recpt_CBD
PfamiView protein in Pfam
PF09240 IL6Ra-bind, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS01356 HEMATOPO_REC_S_F2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSF2R_MOUSE
AccessioniPrimary (citable) accession number: Q00941
Secondary accession number(s): E9QJX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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