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Entry version 158 (10 Feb 2021)
Sequence version 2 (11 Jan 2001)
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Protein

Response regulator protein PilR

Gene

pilR

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Member of the two-component regulatory system PilS/PilR that regulates the expression of multiple genes including the type IV pilus (T4P) major subunit PilA (PubMed:8097014, PubMed:7911557). Thereby, plays a major role in the regulation of multiple motility pathways (PubMed:30042200). Upon appropriate environmental signals, the histidine kinase PilS transfers the phosphoryl group onto PilR (PubMed:8097014). In turn, PilR functions as a transcriptional activator by direct binding to a cis-acting sequence upstream of the pilin gene promoter leading to its activation (PubMed:1317379, PubMed:7715443).5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi163 – 170ATPPROSITE-ProRule annotation8
Nucleotide bindingi226 – 235ATPPROSITE-ProRule annotation10
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi418 – 437H-T-H motifBy similarityAdd BLAST20

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PAER208964:G1FZ6-4640-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Response regulator protein PilR1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pilR
Ordered Locus Names:PA4547
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri208964 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002438 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Pseudomonas genome database

More...
PseudoCAPi
PA4547

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Deletion mutant results in changes in swimming, swarming and/or twitching motility associated with virulence in specific hosts.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000812051 – 445Response regulator protein PilRAdd BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei114-aspartylphosphatePROSITE-ProRule annotation1
Modified residuei544-aspartylphosphatePROSITE-ProRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PilS.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q00934

PRoteomics IDEntifications database

More...
PRIDEi
Q00934

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q00934

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 119Response regulatoryPROSITE-ProRule annotationAdd BLAST115
Domaini135 – 364Sigma-54 factor interactionPROSITE-ProRule annotationAdd BLAST230

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000445_0_6_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q00934

Identification of Orthologs from Complete Genome Data

More...
OMAi
QAPIYIS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q00934

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00156, REC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR011006, CheY-like_superfamily
IPR009057, Homeobox-like_sf
IPR002197, HTH_Fis
IPR027417, P-loop_NTPase
IPR001789, Sig_transdc_resp-reg_receiver
IPR002078, Sigma_54_int
IPR025662, Sigma_54_int_dom_ATP-bd_1
IPR025943, Sigma_54_int_dom_ATP-bd_2
IPR025944, Sigma_54_int_dom_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02954, HTH_8, 1 hit
PF00072, Response_reg, 1 hit
PF00158, Sigma54_activat, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01590, HTHFIS

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 1 hit
SM00448, REC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit
SSF52172, SSF52172, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50110, RESPONSE_REGULATORY, 1 hit
PS00675, SIGMA54_INTERACT_1, 1 hit
PS00676, SIGMA54_INTERACT_2, 1 hit
PS00688, SIGMA54_INTERACT_3, 1 hit
PS50045, SIGMA54_INTERACT_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q00934-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRQKALIVD DEPDIRELLE ITLGRMKLDT RSARNVKEAR ELLAREPFDL
60 70 80 90 100
CLTDMRLPDG SGLDLVQYIQ QRHPQTPVAM ITAYGSLDTA IQALKAGAFD
110 120 130 140 150
FLTKPVDLGR LRELVATALR LRNPEAEEAP VDNRLLGESP PMRALRNQIG
160 170 180 190 200
KLARSQAPVY ISGESGSGKE LVARLIHEQG PRIERPFVPV NCGAIPSELM
210 220 230 240 250
ESEFFGHKKG SFTGAIEDKQ GLFQAASGGT LFLDEVADLP MAMQVKLLRA
260 270 280 290 300
IQEKAVRAVG GQQEVAVDVR ILCATHKDLA AEVGAGRFRQ DLYYRLNVIE
310 320 330 340 350
LRVPPLRERR EDIPLLAERI LKRLAGDTGL PAARLTGDAQ EKLKNYRFPG
360 370 380 390 400
NVRELENMLE RAYTLCEDDQ IQPHDLRLAD APGASQEGAA SLSEIDNLED
410 420 430 440
YLEDIERKLI MQALEETRWN RTAAAQRLGL TFRSMRYRLK KLGID
Length:445
Mass (Da):49,737
Last modified:January 11, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F9A3382A4421FDE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti108 – 109LG → FDF in strain: PAK. 2
Natural varianti269V → L in strain: PAK. 1
Natural varianti353R → G in strain: PAK. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M83311 Genomic DNA Translation: AAA25956.1
Z12154 Genomic DNA Translation: CAA78139.1
L22436 Unassigned DNA Translation: AAA20188.1
AE004091 Genomic DNA Translation: AAG07935.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A41896
A83078

NCBI Reference Sequences

More...
RefSeqi
NP_253237.1, NC_002516.2
WP_003094694.1, NZ_QZGE01000004.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAG07935; AAG07935; PA4547

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
877622

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pae:PA4547

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|208964.12.peg.4759

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83311 Genomic DNA Translation: AAA25956.1
Z12154 Genomic DNA Translation: CAA78139.1
L22436 Unassigned DNA Translation: AAA20188.1
AE004091 Genomic DNA Translation: AAG07935.1
PIRiA41896
A83078
RefSeqiNP_253237.1, NC_002516.2
WP_003094694.1, NZ_QZGE01000004.1

3D structure databases

SMRiQ00934
ModBaseiSearch...

Proteomic databases

PaxDbiQ00934
PRIDEiQ00934

Genome annotation databases

EnsemblBacteriaiAAG07935; AAG07935; PA4547
GeneIDi877622
KEGGipae:PA4547
PATRICifig|208964.12.peg.4759

Organism-specific databases

PseudoCAPiPA4547

Phylogenomic databases

HOGENOMiCLU_000445_0_6_6
InParanoidiQ00934
OMAiQAPIYIS
PhylomeDBiQ00934

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-4640-MONOMER

Family and domain databases

CDDicd00156, REC, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR011006, CheY-like_superfamily
IPR009057, Homeobox-like_sf
IPR002197, HTH_Fis
IPR027417, P-loop_NTPase
IPR001789, Sig_transdc_resp-reg_receiver
IPR002078, Sigma_54_int
IPR025662, Sigma_54_int_dom_ATP-bd_1
IPR025943, Sigma_54_int_dom_ATP-bd_2
IPR025944, Sigma_54_int_dom_CS
PfamiView protein in Pfam
PF02954, HTH_8, 1 hit
PF00072, Response_reg, 1 hit
PF00158, Sigma54_activat, 1 hit
PRINTSiPR01590, HTHFIS
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SM00448, REC, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
SSF52172, SSF52172, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50110, RESPONSE_REGULATORY, 1 hit
PS00675, SIGMA54_INTERACT_1, 1 hit
PS00676, SIGMA54_INTERACT_2, 1 hit
PS00688, SIGMA54_INTERACT_3, 1 hit
PS50045, SIGMA54_INTERACT_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPILR_PSEAE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q00934
Secondary accession number(s): Q9HVN2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 11, 2001
Last modified: February 10, 2021
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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