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Protein

Retinol-binding protein 1

Gene

Rbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytoplasmic retinol-binding protein. Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41RetinolBy similarity1
Binding sitei63RetinolBy similarity1
Binding sitei109RetinolBy similarity1

GO - Molecular functioni

  • all-trans-retinol binding Source: UniProtKB
  • retinal binding Source: UniProtKB-KW
  • retinoid binding Source: MGI
  • retinol binding Source: MGI

GO - Biological processi

Keywordsi

Biological processTransport
LigandRetinol-binding, Vitamin A

Enzyme and pathway databases

ReactomeiR-MMU-2453902 The canonical retinoid cycle in rods (twilight vision)
R-MMU-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 1
Alternative name(s):
Cellular retinol-binding protein
Short name:
CRBP
Cellular retinol-binding protein I
Short name:
CRBP-I
Short name:
mCRBPI
Gene namesi
Name:Rbp1
Synonyms:Crbpi, Rbp-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97876 Rbp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Lipid droplet

Pathology & Biotechi

Disruption phenotypei

No visible phenotype when mice are kept on a vitamin A-enriched diet. Still, mutant mice have impaired vitamin A homeostasis. Four week old mice have reduced levels of retinoids in the liver, due to more rapid vitamin A turnover. When mice are kept on a vitamin A-deficient diet after weaning, they gain weight normally during the first 5 weeks, and then stop gaining weight. Their hepatic retinyl palmitate stores begin to decrease from the moment they are fed a vitamin A-deficient diet and become undetectable after 14 weeks, After this, serum retinol levels decrease rapidly and approach undetectable levels after 24 weeks on a vitamin A-deficient diet. After 23 weeks on a vitamin A-deficient diet, electroretinograms show dramatically decreased amplitudes of the a and b waves in response to light. At the same time, their eyes show impaired contact between the retinal pigment epithelium and the outer segment photoreceptors.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000673931 – 135Retinol-binding protein 1Add BLAST135

Proteomic databases

PaxDbiQ00915
PeptideAtlasiQ00915
PRIDEiQ00915

2D gel databases

REPRODUCTION-2DPAGEiQ00915

PTM databases

iPTMnetiQ00915
PhosphoSitePlusiQ00915

Expressioni

Gene expression databases

BgeeiENSMUSG00000046402 Expressed in 335 organ(s), highest expression level in camera-type eye
CleanExiMM_RBP1
ExpressionAtlasiQ00915 baseline and differential
GenevisibleiQ00915 MM

Interactioni

Subunit structurei

Interacts (only as retinol-free apoprotein) with STRA6.By similarity

Protein-protein interaction databases

BioGridi202827, 1 interactor
IntActiQ00915, 1 interactor
MINTiQ00915
STRINGi10090.ENSMUSP00000059749

Structurei

3D structure databases

ProteinModelPortaliQ00915
SMRiQ00915
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 32Important for interaction with STRA6By similarityAdd BLAST11

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004831
HOVERGENiHBG005633
InParanoidiQ00915
OMAiGDEMHLE
OrthoDBiEOG091G0QSV
PhylomeDBiQ00915
TreeFamiTF316894

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR031264 CRBP1
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF56 PTHR11955:SF56, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequencei

Sequence statusi: Complete.

Q00915-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVDFNGYWK MLSNENFEEY LRALDVNVAL RKIANLLKPD KEIVQDGDHM
60 70 80 90 100
IIRTLSTFRN YIMDFQVGKE FEEDLTGIDD RKCMTTVSWD GDKLQCVQKG
110 120 130
EKEGRGWTQW IEGDELHLEM RAEGVICKQV FKKVH
Length:135
Mass (Da):15,846
Last modified:January 23, 2007 - v2
Checksum:i6816E73284BD28B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60367 mRNA Translation: CAA42919.1
BC018254 mRNA Translation: AAH18254.1
CCDSiCCDS23424.1
PIRiS16355
RefSeqiNP_035384.1, NM_011254.5
UniGeneiMm.279741

Genome annotation databases

EnsembliENSMUST00000052068; ENSMUSP00000059749; ENSMUSG00000046402
GeneIDi19659
KEGGimmu:19659
UCSCiuc009rdj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60367 mRNA Translation: CAA42919.1
BC018254 mRNA Translation: AAH18254.1
CCDSiCCDS23424.1
PIRiS16355
RefSeqiNP_035384.1, NM_011254.5
UniGeneiMm.279741

3D structure databases

ProteinModelPortaliQ00915
SMRiQ00915
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202827, 1 interactor
IntActiQ00915, 1 interactor
MINTiQ00915
STRINGi10090.ENSMUSP00000059749

PTM databases

iPTMnetiQ00915
PhosphoSitePlusiQ00915

2D gel databases

REPRODUCTION-2DPAGEiQ00915

Proteomic databases

PaxDbiQ00915
PeptideAtlasiQ00915
PRIDEiQ00915

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052068; ENSMUSP00000059749; ENSMUSG00000046402
GeneIDi19659
KEGGimmu:19659
UCSCiuc009rdj.1 mouse

Organism-specific databases

CTDi5947
MGIiMGI:97876 Rbp1

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004831
HOVERGENiHBG005633
InParanoidiQ00915
OMAiGDEMHLE
OrthoDBiEOG091G0QSV
PhylomeDBiQ00915
TreeFamiTF316894

Enzyme and pathway databases

ReactomeiR-MMU-2453902 The canonical retinoid cycle in rods (twilight vision)
R-MMU-975634 Retinoid metabolism and transport

Miscellaneous databases

PROiPR:Q00915
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046402 Expressed in 335 organ(s), highest expression level in camera-type eye
CleanExiMM_RBP1
ExpressionAtlasiQ00915 baseline and differential
GenevisibleiQ00915 MM

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR031264 CRBP1
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF56 PTHR11955:SF56, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRET1_MOUSE
AccessioniPrimary (citable) accession number: Q00915
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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