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Protein

Early growth response protein 4

Gene

Egr4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri372 – 396C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri402 – 424C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 452C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Early growth response protein 4
Short name:
EGR-4
Alternative name(s):
Early response protein NGFI-C
Nerve growth factor-induced protein C
Short name:
NGFI-C
Gene namesi
Name:Egr4
Synonyms:Egr-4, Ngfic
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2546 Egr4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471301 – 478Early growth response protein 4Add BLAST478

Proteomic databases

PaxDbiQ00911
PRIDEiQ00911

PTM databases

PhosphoSitePlusiQ00911

Expressioni

Inductioni

By nerve growth factor.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021097

Structurei

3D structure databases

ProteinModelPortaliQ00911
SMRiQ00911
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri372 – 396C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri402 – 424C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 452C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000112347
HOVERGENiHBG005574
InParanoidiQ00911
KOiK12498
PhylomeDBiQ00911

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q00911-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLHLSDFSGP DALLSKPTEG CAHTSPELPR LPARDAPSAA AYPGGDFLSW
60 70 80 90 100
ALSTCGAGGD LTDSCFLEGP APTPPSGLSY SGSFFIQAVP EHPHDPEALF
110 120 130 140 150
NLMSGILGLA PFPSPEAAAS RSPLDVPFPA GPDALLPDLY SPDLSSAAFP
160 170 180 190 200
EAFWEAAPSA GAPSQCLFEP QLSPPDVKPG LRAPPASPAL DAAASAFKGP
210 220 230 240 250
YAPWELLSAG APGNCGSQGS FQTTPEARFS AVGTKVEDLL SISCPAELPG
260 270 280 290 300
PASRLYPPGA YDAFSLAPGD LGEGTEGLPA LLTPPGGEGG SGGEGGEFLA
310 320 330 340 350
VPQAQLSPLG LRGAATADFS KALVADLPGG SGVAAPSSPA TSFPAAKARR
360 370 380 390 400
KGRRGGKCSA RCFCPRPHVK AFACPVESCV RTFARSDELN RHLRIHTGHK
410 420 430 440 450
PFQCRICLRN FSRSDHLTTH VRTHTGEKPF ACDVCGRRFA RSDEKKRHSK
460 470
VHLKQKARAE ERLKGLGFYS LGLSFAAL
Length:478
Mass (Da):49,668
Last modified:October 1, 1993 - v1
Checksum:iF85C48E7B37040F4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V7Z9G3V7Z9_RAT
Early growth response 4
Egr4 rCG_56196
478Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65008 mRNA Translation: AAA41698.1
M92433 Genomic DNA Translation: AAA41699.1
PIRiA45285
RefSeqiNP_062010.1, NM_019137.1
UniGeneiRn.31998

Genome annotation databases

GeneIDi25129
KEGGirno:25129
UCSCiRGD:2546 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65008 mRNA Translation: AAA41698.1
M92433 Genomic DNA Translation: AAA41699.1
PIRiA45285
RefSeqiNP_062010.1, NM_019137.1
UniGeneiRn.31998

3D structure databases

ProteinModelPortaliQ00911
SMRiQ00911
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021097

PTM databases

PhosphoSitePlusiQ00911

Proteomic databases

PaxDbiQ00911
PRIDEiQ00911

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25129
KEGGirno:25129
UCSCiRGD:2546 rat

Organism-specific databases

CTDi1961
RGDi2546 Egr4

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000112347
HOVERGENiHBG005574
InParanoidiQ00911
KOiK12498
PhylomeDBiQ00911

Miscellaneous databases

PROiPR:Q00911

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiEGR4_RAT
AccessioniPrimary (citable) accession number: Q00911
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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