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Entry version 56 (07 Oct 2020)
Sequence version 1 (14 Nov 2006)
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Protein

Replicase polyprotein 1a

Gene

1a

Organism
White bream virus (isolate Blicca bjoerkna L./Germany/DF24/00) (WBV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The 3C-like serine proteinase is responsible for the majority of cleavages.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei3492Charge relay system; for 3C-like serine proteinase activity1 Publication1
Active sitei3518Charge relay system; for 3C-like serine proteinase activity1 Publication1
Active sitei3589Charge relay system; for 3C-like serine proteinase activity1 Publication1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei3603Substrate bindingSequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
LigandMetal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Replicase polyprotein 1a
Short name:
pp1a
Alternative name(s):
ORF1a polyprotein
Cleaved into the following 8 chains:
Non-structural protein 1
Short name:
nsp1
Non-structural protein 2
Short name:
nsp2
3C-like serine proteinase (EC:3.4.21.-)
Short name:
3CLSP
Alternative name(s):
M-PRO
nsp3
p27
Non-structural protein 4
Short name:
nsp4
Non-structural protein 5
Short name:
nsp5
Non-structural protein 6
Short name:
nsp6
Non-structural protein 7
Short name:
nsp7
Non-structural protein 8
Short name:
nsp8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:1a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiWhite bream virus (isolate Blicca bjoerkna L./Germany/DF24/00) (WBV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri766180 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesNidoviralesTornidovirineaeTobaniviridaePiscanivirinaeBafinivirusBlicbavirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiBlicca bjoerkna (white bream) [TaxID: 58317]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000680 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2542 – 2564HelicalSequence analysisAdd BLAST23
Transmembranei2571 – 2593HelicalSequence analysisAdd BLAST23
Transmembranei2644 – 2664HelicalSequence analysisAdd BLAST21
Transmembranei2744 – 2764HelicalSequence analysisAdd BLAST21
Transmembranei2773 – 2793HelicalSequence analysisAdd BLAST21
Transmembranei3079 – 3099HelicalSequence analysisAdd BLAST21
Transmembranei3247 – 3267HelicalSequence analysisAdd BLAST21
Transmembranei3278 – 3298HelicalSequence analysisAdd BLAST21
Transmembranei3319 – 3339HelicalSequence analysisAdd BLAST21
Transmembranei3725 – 3745HelicalSequence analysisAdd BLAST21
Transmembranei3751 – 3771HelicalSequence analysisAdd BLAST21
Transmembranei3789 – 3809HelicalSequence analysisAdd BLAST21
Transmembranei3813 – 3833HelicalSequence analysisAdd BLAST21
Transmembranei3844 – 3864HelicalSequence analysisAdd BLAST21
Transmembranei3888 – 3908HelicalSequence analysisAdd BLAST21
Transmembranei3911 – 3931HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Host membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi3492H → A: Loss of proteolytic processing. 1 Publication1
Mutagenesisi3509D → A: No effect on proteolytic processing. 1 Publication1
Mutagenesisi3518D → A: Reduced proteolytic processing. 1 Publication1
Mutagenesisi3584T → A: Reduced proteolytic processing. 1
Mutagenesisi3589S → A: Loss of proteolytic processing. 1 Publication1
Mutagenesisi3603H → A: Loss of proteolytic processing. 1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004088951 – 4555Replicase polyprotein 1aAdd BLAST4555
ChainiPRO_00004088961 – 3071Non-structural protein 1Sequence analysisAdd BLAST3071
ChainiPRO_00004088973072 – 3442Non-structural protein 2Sequence analysisAdd BLAST371
ChainiPRO_00004088983443 – 37093C-like serine proteinaseCuratedAdd BLAST267
ChainiPRO_00004088993710 – 3985Non-structural protein 4Sequence analysisAdd BLAST276
ChainiPRO_00004089003986 – 4157Non-structural protein 5Sequence analysisAdd BLAST172
ChainiPRO_00004089014158 – 4375Non-structural protein 6Sequence analysisAdd BLAST218
ChainiPRO_00004089024376 – 4452Non-structural protein 7Sequence analysisAdd BLAST77
ChainiPRO_00004089034453 – 4555Non-structural protein 8Sequence analysisAdd BLAST103

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo by its own protease yield mature proteins. 3CL-PRO is autocatalytically processed (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei3071 – 3072Cleavage; by 3C-like serine proteinase2
Sitei3442 – 3443Cleavage; by 3C-like serine proteinase2
Sitei3709 – 3710Cleavage; by 3C-like serine proteinase2
Sitei3985 – 3986Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei4157 – 4158Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei4375 – 4376Cleavage; by 3C-like serine proteinaseSequence analysis2
Sitei4452 – 4453Cleavage; by 3C-like serine proteinaseSequence analysis2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q008X5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1637 – 1827MacroPROSITE-ProRule annotationAdd BLAST191

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2293 – 2683HD1By similarityAdd BLAST391
Regioni2889 – 3156HD2By similarityAdd BLAST268
Regioni3546 – 3732HD3By similarityAdd BLAST187

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili4212 – 4250Sequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi154 – 347Thr-richAdd BLAST194
Compositional biasi1121 – 1212Thr-richAdd BLAST92

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.By similarity

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.220.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR041698, Methyltransf_25
IPR009003, Peptidase_S1_PA
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01661, Macro, 1 hit
PF13649, Methyltransf_25, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 1 hit
SSF52949, SSF52949, 1 hit
SSF53335, SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51154, MACRO, 1 hit
PS00135, TRYPSIN_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Isoform Replicase polyprotein 1a (identifier: Q008X5-1) [UniParc]FASTAAdd to basket
Also known as: pp1a, ORF1a polyprotein

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSILFGNRQA NATKRSDMAS VARAVYEVDL ISTKYARRTQ ERLAHNKHAK
60 70 80 90 100
PSYPSVFFGR RMKAVKEPTF TPSTLFFEEA TLPKVLASKA KPDTGIKTRR
110 120 130 140 150
VYVADSLTIN GHTYPIVGHF VEMAVSKKEA FPIQPKRVKP KPLMAKPIPN
160 170 180 190 200
IRRTFLTPEE RTNTPTTPTT TTTTPFVAGE TAGPTIEYTP TSIDLPFAMP
210 220 230 240 250
TVKQIKENAH TILREQDDCL RFAQTALFKH LGTVTHTTPN HATTFQVKGR
260 270 280 290 300
TSLLTFEWRK TTQSPLTDGH FYLQTANNHA ELMQPVEGKL TTIFTTTIQQ
310 320 330 340 350
GTTHSLHLIK QESARTLKTR KPLKLVTYKQ ETPTTTITPQ SLKKTITYIP
360 370 380 390 400
GSFCINVAEP TLQSVMRRQP LTPTPNDALL QIYHKLGCTT KSPNHASTFE
410 420 430 440 450
LFGNTYTWYP VQHTNNLLHK DPNRRFFLHI TGQTPQLLIR TERKTFLTLQ
460 470 480 490 500
DEVTYISGKL FVMNHAPIQG EYKTQTAEWV GSYNMAKTPK AIKPAKTVEY
510 520 530 540 550
INTTPCHKPA TMPAPITYRQ CPYTWTLHEP SISKVQRNLF HIPKTATNCL
560 570 580 590 600
DRIQKALFPE IVTSNQHFPI GFTIQTDTTM QSYEWAILCK KVTRTYYLAV
610 620 630 640 650
QNHHATLWYK CAQVYMCLSD DIAPTTELQG SVYILNKVTD PGFYQNTRQW
660 670 680 690 700
CGSNDDLHEP KHLIKNLANG DVNNIAHCSL TPWTTTPLVY STQKNKLTRK
710 720 730 740 750
LIHYYNATYT VQVPKENPNA QPSTMKCAYK AYIDLATPTE LQIHLDLEIQ
760 770 780 790 800
GKLYSQTAQK KGSKFNKLDI PTFGDILKGT LYVFSSKVLL YEQPKRCTSV
810 820 830 840 850
CFHLPNNAQS FFFNTETIQT FEDLFARISS EEVEDNLVLI KGFVPCLGAI
860 870 880 890 900
YITKDLKFIQ PELKEDFKHP TTYYTFTTTV DPEQVLYSLH PSFTDIVPPH
910 920 930 940 950
GFPYYTFAKL NNHIDAWNIT DDQADTLAEA QPIIFQWPTE EATITTPYKV
960 970 980 990 1000
LHYEHLEGLD YISLSSFNTV ECPEETQSAH DSSSESESED EELPAHPLSN
1010 1020 1030 1040 1050
APSQASLSSV ASTAPPTSPT SSPTPSPTPL QQQVGLKGKE VPVGGWVLVS
1060 1070 1080 1090 1100
EEETPSEEVD SPKLLPNEVP LSFDFDLPIE PITRPISPEL QQPILTHYEH
1110 1120 1130 1140 1150
PTSPTPSVEI EIDFGSYENL TLQTEETVTT EVQPEPTPAP TPEPTIVTET
1160 1170 1180 1190 1200
VQETPVPTET TQESTPESTP ESTPEPTPES TSESTLEPEH VATPSQSPTH
1210 1220 1230 1240 1250
ITVTEITHEP ETPDSWSERY DSTSNIPEVF NQLSFGSTDS VKITTPKTET
1260 1270 1280 1290 1300
PDEPQQPTVE TVSAAQQLLQ IVQTATPDIA QLMSELPPYR LICIGSYCPI
1310 1320 1330 1340 1350
LAENISKQLP TAVTTPTDAD IPTVIFNVSE ETMDTVINTV KTKHQANHLT
1360 1370 1380 1390 1400
FSLTTIIALD VPKDKSLPLQ QIYDKLTQQD YNTDFIYESH HRQPKESLTH
1410 1420 1430 1440 1450
ASVLSAYTAS YKTTAIKSIA DNAVVLDIGY GKGNDGPRYA VRPLTVTGID
1460 1470 1480 1490 1500
TAARMLAIAD QNKPENVTLV KQGFFTHITK TSNTYTHVIA FNSLHYPLAS
1510 1520 1530 1540 1550
SHPDTLVQRL PTCPANILIP CHHLLEGIQT PTYSVVKDED MWCVKVTKNE
1560 1570 1580 1590 1600
FIESSYNYDV FVKALESKYH VTIGSLLDCV EKPSTRSITP TLWTAMRNFV
1610 1620 1630 1640 1650
NNDQEMQRIL SGYITFNLTP LPPKVEIIND WLDNNATVTI NNPFASNEGV
1660 1670 1680 1690 1700
TFAVHNIGAI TTTEGEFIVN AANKQLNNGT GVTGAIFAAH DKELKLTQAI
1710 1720 1730 1740 1750
KALPTYGASD KLESHQHVVQ TIIKNNNSTH AINILHAAAP IKVKCTSKNP
1760 1770 1780 1790 1800
EVLLAHNETA QSELKETYKA IVDYAQLNKL THIYLPLFGA GAYGHKPLDS
1810 1820 1830 1840 1850
LEAFLDAMRN RSPQSTTQYT LLLSDPVKPL DNPSFSYEFL NLLVTNLNIN
1860 1870 1880 1890 1900
KQFAQLIVNK YHNTCALQSA IQMNTTTDTH NFLATFIYLL YTMPYSMNTF
1910 1920 1930 1940 1950
RQTHTPEEPF TPGKMVTVVD TTIAFLTTLD ILPPCGQPCG YLPPSITKDG
1960 1970 1980 1990 2000
EYICACQKTS NWSLPFHFYN ARYNKVYHTG LNNILTHKHS AFHKSRNAAH
2010 2020 2030 2040 2050
FIAKTGPSTS SYPVYMAPVP EILAYNASYR DSCQDNAIEE QSDSQASQSP
2060 2070 2080 2090 2100
SSPVTIPVSL PTASPASSVK SALRSDIPIT TDQQSTTSAS ISTATTASTI
2110 2120 2130 2140 2150
PTAPLTSSDS NTSVVTSLYG NMEELTYLDA SGTSQDFILS ETTPFIAHIY
2160 2170 2180 2190 2200
HNNEATFIPP GYQLLDTNTN DPIEMYITPP RPIDGSPMIS LASTASTTPM
2210 2220 2230 2240 2250
TYPLLSIRLT TEELTSFFKT KTDKFHLISH KSCLTVHLFD SPTLNSIAAD
2260 2270 2280 2290 2300
STSDAHLYQQ HLKDLYTFSD CCSMYTRTEV YNCIEADTPL IRQSEQTKFH
2310 2320 2330 2340 2350
PINLDTLIEM VATFPPIVKR YSQTTTPDFT NLTVYFVSNG DIITTPTGST
2360 2370 2380 2390 2400
SEQPPQLKIF LDYQTSSKFT TLVDLTLHEQ TEANTIITYH HGEHQLLKPN
2410 2420 2430 2440 2450
PSAFYIEFQT YSSFFSRFQT FSTNFFWTLF INFLINVRFC ITADSAYFHW
2460 2470 2480 2490 2500
QGKPIETTNL NIVYSIGRLD FVLSKHTTPW LTKPTDTLNP LTLIKNTLVQ
2510 2520 2530 2540 2550
PIAINFHGRI RPLQSTNTRF GATHTPTKLP VHLLNTSLRT HYLSLLSLFQ
2560 2570 2580 2590 2600
CTFSVFLAYI ALLYSFSGHG IFTVVAYFTM LFARYYITSF INFCTSQLTA
2610 2620 2630 2640 2650
TQVTQWFAAI KAKYTGIYES SQDRVLTVNV TGTNVPYIVK YSTILTVTMY
2660 2670 2680 2690 2700
VAFMAFVWTV STYAAQYTAG ERYDRPPYQT VFQKTLNVLG LTETVTYYYP
2710 2720 2730 2740 2750
YASLNEACAA STSILCRLGS PFNFHYPSDY TQVRTVQTDT SSPFWLFIIF
2760 2770 2780 2790 2800
MPPSFLFIVL PWLILCTITP TVSIAQLLVP SIILNATIVF IYIRRKFTGH
2810 2820 2830 2840 2850
CCGPHTCIKH ADISRSLQFR PTSQIQHSLT FCGTLCAKHN WYCNNSDSPT
2860 2870 2880 2890 2900
HTLGIQLAQL IETTYKLQPG TIKPDSSYTH TTETATLPIM KVSTTSTDFT
2910 2920 2930 2940 2950
TSEPNTTVEH LHLQVIAHVT GTRISIESSS NKVQQQNTQH TRLTNKPVTG
2960 2970 2980 2990 3000
FMHTTLLQKL KRQHKDELSS YLCNFVPSDN KKDCILPHSV VHMTLTENQR
3010 3020 3030 3040 3050
TFLLKNFTFS TNVTVDPTTT GFIPSSLNIS TLPHKHFMIN VIESAMLAKL
3060 3070 3080 3090 3100
PKEVQDTLRT THLETTTLER QAMSLTTQAI LTTFALIMAT FVVAFLAFFS
3110 3120 3130 3140 3150
TAQVGKTPYA GLNPTMVGNV NAEPYIQPTT LENSILIPLH GASKVCWRAQ
3160 3170 3180 3190 3200
NGTLFFTDAI PTTECARAAV PYIGYKSEFT QTCASSNLRY PFTVYLGSIK
3210 3220 3230 3240 3250
VMYLRDGISY LTSTLSHNSN TKKLCVQVGS NAVRCASVLP TGASSNVAAL
3260 3270 3280 3290 3300
LMASVVVISM VLFYLYLLQI FKFYTNSVIM SFVIQLLTLL ATTVSTPLAV
3310 3320 3330 3340 3350
TVQLFVITYG YTNWILLTLS LLNLTVLLST PVGITFVVIY GLYKAYTLFT
3360 3370 3380 3390 3400
SSGQGCVYNE GGTIRFSGSF EQVANSTFPL TNASCVQLLS DLGITYQQLN
3410 3420 3430 3440 3450
VYASSRDRNV RRLAQALLHR QLDSASECIL YEGCSGNTIT RQALQRIRQA
3460 3470 3480 3490 3500
VTVVVTPASQ NLCKITSNQA NGIGLSCTGT FFTSTEIITC AHGIGTSDIT
3510 3520 3530 3540 3550
AVHKGITYDC KVKSINNDIA ILITTTVNLS VQNIKLDSSF SQKSDNYQRN
3560 3570 3580 3590 3600
FVQFVSFVDQ QNSDAVTINN TVMLPSGHFF AIGTEAGESG SPYTLNGNII
3610 3620 3630 3640 3650
GIHYGIDNAG SWMLASRPDG SFYVPATQHG NSAKVTFSTD AFAQQFPAIV
3660 3670 3680 3690 3700
TNKTSDQLVN EIAATNNTAF ELDTTDVSHL SNLLKHLKNN NETPKSLSDY
3710 3720 3730 3740 3750
LPVAPVTQQT SVTVGQTLTS PVNNMQTALY TLMLVSEVIT YILTPNSDLS
3760 3770 3780 3790 3800
VLISMFVTSA FLKFGASKLF YNTEMLRNTI TTFVVYRYTT LLIALVFSQY
3810 3820 3830 3840 3850
YLHILSYALK LNTLVLTVIA LTFLVTPLVL LTIRRVYYYS QNYLISCVFI
3860 3870 3880 3890 3900
ISCFASHTYT LYILTDTTVD FQTFIISEPI FSTLLCNLFI GFTLISVVPN
3910 3920 3930 3940 3950
PLYVCVVFMY ILLDCEALGF IVTCFMASYL CPKPLRSLTT FLCTDTLVLT
3960 3970 3980 3990 4000
APAYLHWYGA KGTQREYSVI YAVFDSILTP ETTIQIPVTI MEGIEQQVKF
4010 4020 4030 4040 4050
IFAVPKSANI QDEEEAYVEY NQNSDIKDLA IKNEEKVCTI TGMFRKTRTI
4060 4070 4080 4090 4100
KGTLMESFYP RHQPDSYILN QVVRHNYVLA HDPETIILTT VNPTHLESEP
4110 4120 4130 4140 4150
FQTIVKKVRK LHALYQEISE QSSDDTELCH AYILALIKST VLEAQMPTEK
4160 4170 4180 4190 4200
INFVSSQTML SPAMILIFAE AYQILTESRS FTNHITPQSD IGSMQTTLAS
4210 4220 4230 4240 4250
LAEMDTDEMT PQERKIHIKR MNVLKQEIAK MESASLKLEK FLDNMHKAEI
4260 4270 4280 4290 4300
SKRGKEDILL KVSNMLRLHL NKVANAAHCT IQTPSAGLIT LASAFDVHSL
4310 4320 4330 4340 4350
CVTQHSESVL IQTPDDDTFL VYVDGQIYTC YNPTDITGKK LVPINVMSPD
4360 4370 4380 4390 4400
NVQFPTYPVV FSLSKQDYAE EITEQNNIGY TERTHNFKLK ELASGLAVTL
4410 4420 4430 4440 4450
DGLVVVTETK ELATAFKIGQ RYFKFLNTNK TPVARNNTHA IIQLLRNNIS
4460 4470 4480 4490 4500
QQAVVRIGGS RVSNDHIAIS QVPVQTIGYL TYAGISVCRQ CATKQDHTCQ
4510 4520 4530 4540 4550
YAGYFVQIPR EHVSNIFNLT DTPPCLHNKF TCTTCQPLQQ QSKTQQPPLN

WWGSV
Note: Produced by conventional translation.
Length:4,555
Mass (Da):508,987
Last modified:November 14, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06287FC647203FF8
GO
Isoform Replicase polyprotein 1ab (identifier: Q008X6-1) [UniParc]FASTAAdd to basket
Also known as: pp1ab
The sequence of this isoform can be found in the external entry Q008X6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:6,872
Mass (Da):769,510
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ898157 Genomic RNA Translation: ABI97393.1

NCBI Reference Sequences

More...
RefSeqi
YP_803214.1, NC_008516.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4443108

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:4443108

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ898157 Genomic RNA Translation: ABI97393.1
RefSeqiYP_803214.1, NC_008516.1

3D structure databases

SMRiQ008X5
ModBaseiSearch...

Genome annotation databases

GeneIDi4443108
KEGGivg:4443108

Family and domain databases

Gene3Di3.40.220.10, 1 hit
InterProiView protein in InterPro
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR041698, Methyltransf_25
IPR009003, Peptidase_S1_PA
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF01661, Macro, 1 hit
PF13649, Methyltransf_25, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF52949, SSF52949, 1 hit
SSF53335, SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51154, MACRO, 1 hit
PS00135, TRYPSIN_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR1A_WBV24
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q008X5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: November 14, 2006
Last modified: October 7, 2020
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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