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Protein

Epithelial cell-transforming sequence 2 oncogene-like

Gene

ECT2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a guanine nucleotide exchange factor (GEF).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial cell-transforming sequence 2 oncogene-like
Alternative name(s):
Lung-specific F-box and DH domain-containing protein
Putative guanine nucleotide exchange factor LFDH
Gene namesi
Name:ECT2L
Synonyms:C6orf91, LFDH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000203734.11
HGNCiHGNC:21118 ECT2L
neXtProtiNX_Q008S8

Pathology & Biotechi

Organism-specific databases

DisGeNETi345930
OpenTargetsiENSG00000203734
PharmGKBiPA134893289

Polymorphism and mutation databases

BioMutaiECT2L
DMDMi189046616

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003360751 – 904Epithelial cell-transforming sequence 2 oncogene-likeAdd BLAST904

Proteomic databases

EPDiQ008S8
PaxDbiQ008S8
PeptideAtlasiQ008S8
PRIDEiQ008S8
ProteomicsDBi57884

PTM databases

iPTMnetiQ008S8
PhosphoSitePlusiQ008S8

Expressioni

Gene expression databases

BgeeiENSG00000203734 Expressed in 72 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ008S8 baseline and differential

Organism-specific databases

HPAiHPA035488

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi131369, 3 interactors
STRINGi9606.ENSP00000356655

Structurei

3D structure databases

ProteinModelPortaliQ008S8
SMRiQ008S8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 121F-boxAdd BLAST47
Domaini566 – 754DHPROSITE-ProRule annotationAdd BLAST189

Phylogenomic databases

eggNOGiENOG410IRSS Eukaryota
ENOG4110R79 LUCA
GeneTreeiENSGT00530000063689
HOGENOMiHOG000067954
InParanoidiQ008S8
OMAiCDEEISF
OrthoDBiEOG091G018T
PhylomeDBiQ008S8
TreeFamiTF343796

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR025592 DUF4347
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR011993 PH-like_dom_sf
PfamiView protein in Pfam
PF14252 DUF4347, 1 hit
PF12937 F-box-like, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q008S8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESFHTRFSA WTPFSNKSLN RQLFQERVAL ISHWFDLWTN KQRQEFLFAI
60 70 80 90 100
FLRCTKSQLR FVQDWFSERM QVAKVDFSTV LPRFISLYIF SFLSPKDLCA
110 120 130 140 150
AAQVSWPWKF LTEQDCLWMP KCVKFGWFLP YTPTDNEYGA WKRHYIACVS
160 170 180 190 200
HLDWLTPREA AATYGTLNEP KTEDEELLER QREKCLRKRI WEKIALRKKE
210 220 230 240 250
LFKVRPPWVS GTCCSSVLKP RCQPRLSQTV RERVGLHEAL EKQLVLTSLE
260 270 280 290 300
TLPKRSNISG SHSYPLLSKK NWHGVHKNDD RSSYALRPHF MLISSRIPAY
310 320 330 340 350
EMVMESVKAG VVSVVYEHSV TLESLLYLIE KALDGQKAQS IGIFSDGDSR
360 370 380 390 400
EINLLQGYKI GVKNLLRPEV RDFWEKLGSY VATEEEGGHV DFFVPLGASE
410 420 430 440 450
AGIEVLSQLS QLTGTFFTAP TGIATGSYQH ILSDWLGSQW GKAPSSIYFC
460 470 480 490 500
ESKLQTWSSF TDFLEETLKT VRKQLYPFFK ELQKSISGRM IGQFMFDTMG
510 520 530 540 550
MTNILNNQDT AQALADGLME LSKEDSERNV VEDNSWDTKS RLSKNDLNFE
560 570 580 590 600
ALINLERILQ KDSAEKRARV VRELLQSERK YVQILEIVRD VYVAPLKAAL
610 620 630 640 650
SSNRAILSAA NIQIIFCDIL QILSLNRQFL DNLRDRLQEW GPAHCVGEIV
660 670 680 690 700
TKFGSQLNTY TNFFNNYPVI LKTIEKCREM IPAFRTFLKR HDKTIVTKML
710 720 730 740 750
SLPELLLYPS RRFEEYLNLL YAVRLHTPAE HVDRGDLTTA IDQIKKYKGY
760 770 780 790 800
IDQMKQNITM KDHLSDIQRI IWGCPTLSEV NRYLIRVQDV AQLHCCDEEI
810 820 830 840 850
SFSLRLYEHI HDLSLFLFND ALLVSSRGTS HTPFERTSKT TYQFIASVAL
860 870 880 890 900
HRLLIENIPD SKYVKNAFIL QGPKYKWICA TEIEDDKFLW LSVLRNAIKS

SMEK
Length:904
Mass (Da):104,880
Last modified:May 20, 2008 - v2
Checksum:iCF4AD8C84D94E983
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZBI6B7ZBI6_HUMAN
Epithelial cell-transforming sequen...
ECT2L
77Annotation score:

Sequence cautioni

The sequence ABI98401 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60R → S in ABI98401 (Ref. 3) Curated1
Sequence conflicti64D → E in ABI98401 (Ref. 3) Curated1
Sequence conflicti472R → K in ABI98401 (Ref. 3) Curated1
Sequence conflicti641G → D in ABI98401 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051984483Q → H. Corresponds to variant dbSNP:rs12198781Ensembl.1
Natural variantiVAR_043482527E → K. Corresponds to variant dbSNP:rs1529151EnsemblClinVar.1
Natural variantiVAR_043483594A → T. Corresponds to variant dbSNP:rs11968285EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121834 Genomic DNA No translation available.
BC146884 mRNA Translation: AAI46885.1
DQ904331 mRNA Translation: ABI98401.1 Different initiation.
CCDSiCCDS43508.1
RefSeqiNP_001071174.1, NM_001077706.2
NP_001181966.1, NM_001195037.2
UniGeneiHs.660603

Genome annotation databases

EnsembliENST00000367682; ENSP00000356655; ENSG00000203734
ENST00000423192; ENSP00000387388; ENSG00000203734
ENST00000541398; ENSP00000442307; ENSG00000203734
GeneIDi345930
KEGGihsa:345930
UCSCiuc003qif.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121834 Genomic DNA No translation available.
BC146884 mRNA Translation: AAI46885.1
DQ904331 mRNA Translation: ABI98401.1 Different initiation.
CCDSiCCDS43508.1
RefSeqiNP_001071174.1, NM_001077706.2
NP_001181966.1, NM_001195037.2
UniGeneiHs.660603

3D structure databases

ProteinModelPortaliQ008S8
SMRiQ008S8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131369, 3 interactors
STRINGi9606.ENSP00000356655

PTM databases

iPTMnetiQ008S8
PhosphoSitePlusiQ008S8

Polymorphism and mutation databases

BioMutaiECT2L
DMDMi189046616

Proteomic databases

EPDiQ008S8
PaxDbiQ008S8
PeptideAtlasiQ008S8
PRIDEiQ008S8
ProteomicsDBi57884

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367682; ENSP00000356655; ENSG00000203734
ENST00000423192; ENSP00000387388; ENSG00000203734
ENST00000541398; ENSP00000442307; ENSG00000203734
GeneIDi345930
KEGGihsa:345930
UCSCiuc003qif.2 human

Organism-specific databases

CTDi345930
DisGeNETi345930
EuPathDBiHostDB:ENSG00000203734.11
GeneCardsiECT2L
HGNCiHGNC:21118 ECT2L
HPAiHPA035488
neXtProtiNX_Q008S8
OpenTargetsiENSG00000203734
PharmGKBiPA134893289
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRSS Eukaryota
ENOG4110R79 LUCA
GeneTreeiENSGT00530000063689
HOGENOMiHOG000067954
InParanoidiQ008S8
OMAiCDEEISF
OrthoDBiEOG091G018T
PhylomeDBiQ008S8
TreeFamiTF343796

Miscellaneous databases

ChiTaRSiECT2L human
GeneWikiiECT2L
GenomeRNAii345930
PROiPR:Q008S8

Gene expression databases

BgeeiENSG00000203734 Expressed in 72 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ008S8 baseline and differential

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR025592 DUF4347
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR011993 PH-like_dom_sf
PfamiView protein in Pfam
PF14252 DUF4347, 1 hit
PF12937 F-box-like, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiECT2L_HUMAN
AccessioniPrimary (citable) accession number: Q008S8
Secondary accession number(s): B2RUV6
, Q5JWK2, Q5JWK3, Q5JWK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 7, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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