Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alpha-1-antitrypsin 1-4

Gene

Serpina1d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of serine proteases. Can inhibit trypsin and chymotrypsin; relatively ineffective against elastase.2 Publications

Miscellaneous

Murine alpha-1-antitrypsin is represented by a cluster of up to 6 individual Serpina1-related genes. The precise complement of Serpina1-related genes present varies according to the strain of the animal.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei377 – 378Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

  • negative regulation of endopeptidase activity Source: GO_Central
  • response to cytokine Source: MGI
  • response to peptide hormone Source: MGI

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-204005 COPII-mediated vesicle transport
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-5694530 Cargo concentration in the ER
R-MMU-6798695 Neutrophil degranulation
R-MMU-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI04.001

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-antitrypsin 1-4
Alternative name(s):
Alpha-1 protease inhibitor 4
Serine protease inhibitor 1-4
Serine protease inhibitor A1d
Short name:
Serpin A1d
Gene namesi
Name:Serpina1d
Synonyms:Dom4, Spi1-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:891968 Serpina1d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000003239125 – 413Alpha-1-antitrypsin 1-4Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ00897
PaxDbiQ00897
PeptideAtlasiQ00897
PRIDEiQ00897

PTM databases

iPTMnetiQ00897
PhosphoSitePlusiQ00897

Expressioni

Gene expression databases

BgeeiENSMUSG00000071177 Expressed in 23 organ(s), highest expression level in liver

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ00897, 1 interactor
MINTiQ00897
STRINGi10090.ENSMUSP00000077909

Structurei

3D structure databases

ProteinModelPortaliQ00897
SMRiQ00897
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni368 – 387RCLAdd BLAST20

Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina1-related genes may determine target protease specificity.By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOGENOMiHOG000238521
HOVERGENiHBG005957
InParanoidiQ00897
KOiK03984
OMAiNESFICY
OrthoDBiEOG091G0ION
PhylomeDBiQ00897
TreeFamiTF343201

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00897-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPSISWSLL LLAGLCCLVP SFLAEDVQET DTSQKDQSPA SHEIATNLGD
60 70 80 90 100
FALRLYRELV HQSNTSNIFF SPVSIATAFA MLSLGSKGDT HTQILEGLQF
110 120 130 140 150
NLTQTSEADI HKSFQHLLQT LNRPDSELQL STGNGLFVNN DLKLVEKFLE
160 170 180 190 200
EAKNHYQAEV FSVNFAESEE AKKVINDFVE KGTQGKIVEA VKKLDQDTVF
210 220 230 240 250
ALANYILFKG KWKQPFDPEN TEEAEFHVDE STTVKVPMMT LSGMLDVHHC
260 270 280 290 300
SMLSSWVLLM DYAGNTTAVF LLPDDGKMQH LEQTLNKELI SQFLLNRRRS
310 320 330 340 350
DAQIHIPRLS ISGNYNLKTL MSPLGITRIF NNGADLSGIT EENAPLKLSK
360 370 380 390 400
AVHKAVLTID ETGTEAAAAT VLQVATYSMP PIVRFDHPFL FIIFEEHTQS
410
PIFVGKVVDP THK
Length:413
Mass (Da):45,998
Last modified:November 1, 1996 - v1
Checksum:iD8A90477F371A902
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75718 mRNA Translation: AAC28867.1
AK002537 mRNA Translation: BAB22173.1
CCDSiCCDS26139.1
PIRiI49473
RefSeqiNP_033272.1, NM_009246.3
UniGeneiMm.439695

Genome annotation databases

EnsembliENSMUST00000078869; ENSMUSP00000077909; ENSMUSG00000071177
GeneIDi20703
KEGGimmu:20703
UCSCiuc007owg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75718 mRNA Translation: AAC28867.1
AK002537 mRNA Translation: BAB22173.1
CCDSiCCDS26139.1
PIRiI49473
RefSeqiNP_033272.1, NM_009246.3
UniGeneiMm.439695

3D structure databases

ProteinModelPortaliQ00897
SMRiQ00897
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ00897, 1 interactor
MINTiQ00897
STRINGi10090.ENSMUSP00000077909

Protein family/group databases

MEROPSiI04.001

PTM databases

iPTMnetiQ00897
PhosphoSitePlusiQ00897

Proteomic databases

MaxQBiQ00897
PaxDbiQ00897
PeptideAtlasiQ00897
PRIDEiQ00897

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078869; ENSMUSP00000077909; ENSMUSG00000071177
GeneIDi20703
KEGGimmu:20703
UCSCiuc007owg.1 mouse

Organism-specific databases

CTDi20703
MGIiMGI:891968 Serpina1d

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOGENOMiHOG000238521
HOVERGENiHBG005957
InParanoidiQ00897
KOiK03984
OMAiNESFICY
OrthoDBiEOG091G0ION
PhylomeDBiQ00897
TreeFamiTF343201

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-204005 COPII-mediated vesicle transport
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-5694530 Cargo concentration in the ER
R-MMU-6798695 Neutrophil degranulation
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

PROiPR:Q00897
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071177 Expressed in 23 organ(s), highest expression level in liver

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA1AT4_MOUSE
AccessioniPrimary (citable) accession number: Q00897
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again