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Protein

Pregnancy-specific beta-1-glycoprotein 6

Gene

PSG6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • female pregnancy Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 6
Short name:
PS-beta-G-6
Short name:
PSBG-6
Short name:
Pregnancy-specific glycoprotein 6
Alternative name(s):
Pregnancy-specific beta-1-glycoprotein 10
Short name:
PS-beta-G-10
Short name:
PSBG-10
Short name:
Pregnancy-specific glycoprotein 10
Pregnancy-specific beta-1-glycoprotein 12
Short name:
PS-beta-G-12
Short name:
PSBG-12
Short name:
Pregnancy-specific glycoprotein 12
Gene namesi
Name:PSG6
Synonyms:CGM3, PSG10, PSG12, PSGGB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000170848.15
HGNCiHGNC:9523 PSG6
MIMi176395 gene
176399 gene
neXtProtiNX_Q00889

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5675
OpenTargetsiENSG00000170848
PharmGKBiPA33868

Polymorphism and mutation databases

BioMutaiPSG6
DMDMi1709853

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001491335 – 435Pregnancy-specific beta-1-glycoprotein 6Add BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi168 ↔ 216Curated
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi261 ↔ 309Curated
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi353 ↔ 393Curated
Glycosylationi386N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ00889
PeptideAtlasiQ00889
PRIDEiQ00889
ProteomicsDBi57882
57883 [Q00889-2]

PTM databases

iPTMnetiQ00889
PhosphoSitePlusiQ00889

Expressioni

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

BgeeiENSG00000170848 Expressed in 36 organ(s), highest expression level in placenta
CleanExiHS_PSG6
ExpressionAtlasiQ00889 baseline and differential
GenevisibleiQ00889 HS

Organism-specific databases

HPAiHPA046327

Interactioni

Protein-protein interaction databases

BioGridi111650, 1 interactor
STRINGi9606.ENSP00000292125

Structurei

3D structure databases

ProteinModelPortaliQ00889
SMRiQ00889
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 143Ig-like V-typeAdd BLAST109
Domaini148 – 233Ig-like C2-type 1Add BLAST86
Domaini241 – 326Ig-like C2-type 2Add BLAST86
Domaini334 – 405Ig-like C2-type 3Add BLAST72

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi126 – 128Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JG1N Eukaryota
ENOG410YTW2 LUCA
GeneTreeiENSGT00760000119187
HOGENOMiHOG000233417
HOVERGENiHBG007922
InParanoidiQ00889
KOiK06500
OMAiYAGPNTW
OrthoDBiEOG091G0AMM
PhylomeDBiQ00889
TreeFamiTF336859

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q00889-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPLSAPPCT QHITWKGLLL TASLLNFWNL PTTAQVIIEA KPPKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLTGYIWYKG QMTDLYHYIT SYVVHGQIIY GPAYSGRETV
110 120 130 140 150
YSNASLLIQN VTQEDAGSYT LHIIKRGDGT GGVTGYFTVT LYSETPKPSI
160 170 180 190 200
SSSNLNPREV MEAVRLICDP ETPDASYLWL LNGQNLPMTH RLQLSKTNRT
210 220 230 240 250
LYLFGVTKYI AGPYECEIRN PVSASRSDPV TLNLLPKLPM PYITINNLNP
260 270 280 290 300
REKKDVLAFT CEPKSRNYTY IWWLNGQSLP VSPRVKRPIE NRILILPSVT
310 320 330 340 350
RNETGPYQCE IRDRYGGIRS NPVTLNVLYG PDLPRIYPSF TYYRSGENLD
360 370 380 390 400
LSCFADSNPP AEYSWTINGK FQLSGQKLFI PQITTNHSGL YACSVRNSAT
410 420 430
GKEISKSMIV KVSETASPQV TYAGPNTWFQ EILLL
Length:435
Mass (Da):48,814
Last modified:October 1, 1996 - v1
Checksum:iD94D4B0884327C60
GO
Isoform 2 (identifier: Q00889-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     414-435: ETASPQVTYAGPNTWFQEILLL → GPCHGNQTESH

Show »
Length:424
Mass (Da):47,501
Checksum:i6ECB345E53CCDEA4
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MCE1B5MCE1_HUMAN
Pregnancy-specific beta-1-glycoprot...
PSG6
331Annotation score:
M0QZA7M0QZA7_HUMAN
Pregnancy-specific beta-1-glycoprot...
PSG6
157Annotation score:
M0R314M0R314_HUMAN
Pregnancy-specific beta-1-glycoprot...
PSG6
81Annotation score:
M0QXW0M0QXW0_HUMAN
Pregnancy-specific beta-1-glycoprot...
PSG6
73Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41K → Q in CAA34957 (PubMed:2271648).Curated1
Sequence conflicti148P → R in CAA34957 (PubMed:2271648).Curated1
Sequence conflicti220 – 221NP → RG in CAA34957 (PubMed:2271648).Curated2
Sequence conflicti339S → Y in CAA34957 (PubMed:2271648).Curated1
Sequence conflicti364S → F in AAA36512 (PubMed:2346748).Curated1
Sequence conflicti364S → F in CAA34957 (PubMed:2271648).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04992285H → D2 PublicationsCorresponds to variant dbSNP:rs3198831Ensembl.1
Natural variantiVAR_011723155L → F. Corresponds to variant dbSNP:rs1058674Ensembl.1
Natural variantiVAR_049923161M → T. Corresponds to variant dbSNP:rs1058679Ensembl.1
Natural variantiVAR_011724165R → L. Corresponds to variant dbSNP:rs1058680Ensembl.1
Natural variantiVAR_011725167I → T. Corresponds to variant dbSNP:rs1065505Ensembl.1
Natural variantiVAR_011726180L → W. Corresponds to variant dbSNP:rs1065507Ensembl.1
Natural variantiVAR_011727181L → M. Corresponds to variant dbSNP:rs1065508Ensembl.1
Natural variantiVAR_011728185N → S. Corresponds to variant dbSNP:rs1065509Ensembl.1
Natural variantiVAR_061324188M → R. Corresponds to variant dbSNP:rs59587483Ensembl.1
Natural variantiVAR_011729191R → S. Corresponds to variant dbSNP:rs1058688Ensembl.1
Natural variantiVAR_011730196K → E. Corresponds to variant dbSNP:rs1065511Ensembl.1
Natural variantiVAR_011731253K → N. Corresponds to variant dbSNP:rs1065513Ensembl.1
Natural variantiVAR_011732257L → S. Corresponds to variant dbSNP:rs1058710Ensembl.1
Natural variantiVAR_011733258A → T. Corresponds to variant dbSNP:rs1065515Ensembl.1
Natural variantiVAR_011735404I → S. Corresponds to variant dbSNP:rs1065525Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039344414 – 435ETASP…EILLL → GPCHGNQTESH in isoform 2. 3 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33666 mRNA Translation: AAA60206.1
M31125 mRNA Translation: AAA36512.1
X17098 mRNA Translation: CAA34957.1
AC005260 Genomic DNA Translation: AAC25619.1
AC005260 Genomic DNA Translation: AAC25620.1
BC020652 mRNA Translation: AAH20652.1
M32621, M32620 Genomic DNA Translation: AAA60201.1
AH007627 Genomic DNA Translation: AAD28501.1
AH002953 Genomic DNA Translation: AAA60202.1
CCDSiCCDS12613.1 [Q00889-1]
CCDS33038.1 [Q00889-2]
PIRiD33258
RefSeqiNP_001027020.1, NM_001031850.3 [Q00889-2]
NP_002773.1, NM_002782.4 [Q00889-1]
UniGeneiHs.646353

Genome annotation databases

EnsembliENST00000187910; ENSP00000187910; ENSG00000170848 [Q00889-2]
ENST00000292125; ENSP00000292125; ENSG00000170848 [Q00889-1]
GeneIDi5675
KEGGihsa:5675
UCSCiuc002ovg.3 human [Q00889-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33666 mRNA Translation: AAA60206.1
M31125 mRNA Translation: AAA36512.1
X17098 mRNA Translation: CAA34957.1
AC005260 Genomic DNA Translation: AAC25619.1
AC005260 Genomic DNA Translation: AAC25620.1
BC020652 mRNA Translation: AAH20652.1
M32621, M32620 Genomic DNA Translation: AAA60201.1
AH007627 Genomic DNA Translation: AAD28501.1
AH002953 Genomic DNA Translation: AAA60202.1
CCDSiCCDS12613.1 [Q00889-1]
CCDS33038.1 [Q00889-2]
PIRiD33258
RefSeqiNP_001027020.1, NM_001031850.3 [Q00889-2]
NP_002773.1, NM_002782.4 [Q00889-1]
UniGeneiHs.646353

3D structure databases

ProteinModelPortaliQ00889
SMRiQ00889
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111650, 1 interactor
STRINGi9606.ENSP00000292125

PTM databases

iPTMnetiQ00889
PhosphoSitePlusiQ00889

Polymorphism and mutation databases

BioMutaiPSG6
DMDMi1709853

Proteomic databases

PaxDbiQ00889
PeptideAtlasiQ00889
PRIDEiQ00889
ProteomicsDBi57882
57883 [Q00889-2]

Protocols and materials databases

DNASUi5675
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000187910; ENSP00000187910; ENSG00000170848 [Q00889-2]
ENST00000292125; ENSP00000292125; ENSG00000170848 [Q00889-1]
GeneIDi5675
KEGGihsa:5675
UCSCiuc002ovg.3 human [Q00889-1]

Organism-specific databases

CTDi5675
DisGeNETi5675
EuPathDBiHostDB:ENSG00000170848.15
GeneCardsiPSG6
HGNCiHGNC:9523 PSG6
HPAiHPA046327
MIMi176395 gene
176399 gene
neXtProtiNX_Q00889
OpenTargetsiENSG00000170848
PharmGKBiPA33868
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JG1N Eukaryota
ENOG410YTW2 LUCA
GeneTreeiENSGT00760000119187
HOGENOMiHOG000233417
HOVERGENiHBG007922
InParanoidiQ00889
KOiK06500
OMAiYAGPNTW
OrthoDBiEOG091G0AMM
PhylomeDBiQ00889
TreeFamiTF336859

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

ChiTaRSiPSG6 human
GeneWikiiPSG6
GenomeRNAii5675
PROiPR:Q00889
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170848 Expressed in 36 organ(s), highest expression level in placenta
CleanExiHS_PSG6
ExpressionAtlasiQ00889 baseline and differential
GenevisibleiQ00889 HS

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPSG6_HUMAN
AccessioniPrimary (citable) accession number: Q00889
Secondary accession number(s): O75244
, Q15224, Q15235, Q549K1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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