UniProtKB - Q00816 (REG1_YEAST)
Protein
Resistance to glucose repression protein 1
Gene
REG1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in RNA processing and negative regulation of glucose repression. Regulates the level of two antigens, P43 and P70. Binds to protein phosphatase type 1. Functions with REG2 and SNF1 protein kinase to regulate growth. Might regulate SNF1 directly or indirectly.1 Publication
Miscellaneous
Present with 2560 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- protein phosphatase regulator activity Source: SGD
GO - Biological processi
- cellular response to glucose starvation Source: SGD
- negative regulation of DNA-binding transcription factor activity Source: SGD
- protein catabolic process in the vacuole Source: SGD
- response to unfolded protein Source: SGD
- transfer RNA gene-mediated silencing Source: SGD
Names & Taxonomyi
Protein namesi | Recommended name: Resistance to glucose repression protein 1Alternative name(s): Protein HEX2 Second-site suppressor of the rna1-1 mutation 1 |
Gene namesi | Name:REG1 Synonyms:HEX2, PZF240, SPP43, SRN1 Ordered Locus Names:YDR028C ORF Names:YD9813.06C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YDR028C |
SGDi | S000002435, REG1 |
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: UniProtKB-SubCell
Vacuole
- vacuole Source: GOC
Other locations
- cytoplasm Source: SGD
- protein phosphatase type 1 complex Source: SGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000083953 | 2 – 1014 | Resistance to glucose repression protein 1Add BLAST | 1013 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 73 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 75 | PhosphoserineCombined sources | 1 | |
Modified residuei | 242 | PhosphoserineCombined sources | 1 | |
Modified residuei | 254 | PhosphoserineCombined sources | 1 | |
Modified residuei | 311 | PhosphoserineCombined sources | 1 | |
Modified residuei | 421 | PhosphoserineCombined sources | 1 | |
Modified residuei | 480 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 490 | PhosphoserineCombined sources | 1 | |
Modified residuei | 570 | PhosphoserineCombined sources | 1 | |
Modified residuei | 572 | PhosphoserineCombined sources | 1 | |
Modified residuei | 576 | PhosphoserineCombined sources | 1 | |
Modified residuei | 610 | PhosphoserineCombined sources | 1 | |
Modified residuei | 614 | PhosphoserineCombined sources | 1 | |
Modified residuei | 680 | PhosphoserineCombined sources | 1 | |
Modified residuei | 896 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 898 | PhosphoserineCombined sources | 1 | |
Modified residuei | 980 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
MaxQBi | Q00816 |
PaxDbi | Q00816 |
PRIDEi | Q00816 |
PTM databases
iPTMneti | Q00816 |
Interactioni
Subunit structurei
Interacts with SAK1.
2 PublicationsBinary interactionsi
Hide detailsQ00816
With | #Exp. | IntAct |
---|---|---|
GLC7 [P32598] | 4 | EBI-8270,EBI-13715 |
SNF1 [P06782] | 7 | EBI-8270,EBI-17516 |
Protein-protein interaction databases
BioGRIDi | 32078, 139 interactors |
ComplexPortali | CPX-1266, REG1-GLC7 phosphatase complex |
DIPi | DIP-2513N |
ELMi | Q00816 |
IntActi | Q00816, 24 interactors |
MINTi | Q00816 |
STRINGi | 4932.YDR028C |
Miscellaneous databases
RNActi | Q00816, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 277 – 283 | Nuclear localization signalSequence analysis | 7 | |
Motifi | 595 – 599 | Nuclear localization signalSequence analysis | 5 | |
Motifi | 873 – 879 | Nuclear localization signalSequence analysis | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 543 – 552 | Ser-rich | 10 | |
Compositional biasi | 742 – 760 | Asp/Glu-rich (acidic)Add BLAST | 19 | |
Compositional biasi | 834 – 844 | Asp/Glu-rich (acidic)Add BLAST | 11 |
Phylogenomic databases
eggNOGi | ENOG502QSII, Eukaryota |
HOGENOMi | CLU_012586_0_0_1 |
InParanoidi | Q00816 |
OMAi | WKYIILK |
Family and domain databases
InterProi | View protein in InterPro IPR013860, AreA_GATA |
Pfami | View protein in Pfam PF08550, DUF1752, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q00816-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTNLANYFA GKKDIENEHV NRNASHESNS KSDVKISGND NDNDEDMGPS
60 70 80 90 100
VSMAVQAKND DDFHKSTFNL KRTRSMGLLD EYIDPTKKLL GRSDDLYDND
110 120 130 140 150
NEYYDNSSNN SSSNSSDDDY DDGYQEHSTS VSPPPADNDS YLIPQDDNDV
160 170 180 190 200
VVEPERHVDY LSHEWKESEI SNSWKYIILK KKKRDVDLVN AARLENASWR
210 220 230 240 250
TWAKARNNLK TVSPEVVNWS KDSDVTWLYG PIVRDSEGNA QSEEEHDLER
260 270 280 290 300
GYGSDDENSK RISMPTKNSK SIAAAPKPIL KKRTVTEIIE DNALWKLNEA
310 320 330 340 350
RKHMTEMKHA SVIMDPNGNK NVHDDFDALA AQVNAQYYHY PKESNSSVSL
360 370 380 390 400
KSQHSDKKDN STIPNPVGEN SNGGGDKGEE DLHLKSALHV QNNRSTAQSN
410 420 430 440 450
KSILENSTND RKANLDQNLN SPDNNRFPSS TSSSNRDNEN NSMGLSSILT
460 470 480 490 500
SNPSEKSNKP TKNRHIHFND RVEQCMALRY PASQSEDDES DDENKQYVDV
510 520 530 540 550
NNNANVTTIN NNRTPLLAIQ HKSIPINSAT EHLNKNTSDD DTSSQSSSSS
560 570 580 590 600
HSDDEEHGGL YINARFSRRS DSGVHSPITD NSSVASSTTS RAHVRPIIKL
610 620 630 640 650
LPDTTLNYGS DEESDNGEFN GYGNAVSHNV NTSRGYDYIY DYNSVYTGDT
660 670 680 690 700
SSFLPVDSCD IVDVPEGMDL QTAIADDNAS NYEFNNAVES KEKHVPQLHK
710 720 730 740 750
ASANNTTRQH GSHMLLYDDD NYSSSSDSEQ QFIEDSQYNS SDDEEEEDDD
760 770 780 790 800
DQEVDDNHDE GLSLRRTLSL GKSGSTNSLY DLAQPSLSSA TPQQKNPTNF
810 820 830 840 850
TGGKTDVDKD AQLAVRPYPL KRNSSSGNFI FNSDSEEESS SEEEQRPLPA
860 870 880 890 900
NSQLVNRSVL KGSVTPANIS SQKKKALPKQ PKASDSSQSF RIVNNTPSPA
910 920 930 940 950
EVGASDVAIE GYFSPRNESI KSVVSGGNMM DHQDHSEMDT LAKGFENCHI
960 970 980 990 1000
NNASKLKDKK VDSVQTTRKE ASLTDSSNES LHKVVQNARG MASKYLHSWK
1010
KSDVKPQENG NDSS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 376 – 377 | DK → EE in AAA34670 (PubMed:1889400).Curated | 2 | |
Sequence conflicti | 534 | N → K in AAA34670 (PubMed:1889400).Curated | 1 | |
Sequence conflicti | 657 | D → H in AAA34670 (PubMed:1889400).Curated | 1 | |
Sequence conflicti | 889 | S → T in AAA34670 (PubMed:1889400).Curated | 1 | |
Sequence conflicti | 988 – 1014 | ARGMA…GNDSS → QEVWQASTCTLGKRVTSSHK KMEMTAVRRKNFEVNMKRK (PubMed:1889400).CuratedAdd BLAST | 27 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M33703 Genomic DNA Translation: AAA34670.1 M90540 Genomic DNA Translation: AAB59326.1 Z47814 Genomic DNA Translation: CAA87807.1 Z74324 Genomic DNA Translation: CAA98850.1 X95966 Genomic DNA Translation: CAA65223.1 BK006938 Genomic DNA Translation: DAA11873.1 |
PIRi | S32613 |
RefSeqi | NP_010311.1, NM_001180336.1 |
Genome annotation databases
EnsemblFungii | YDR028C_mRNA; YDR028C; YDR028C |
GeneIDi | 851592 |
KEGGi | sce:YDR028C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M33703 Genomic DNA Translation: AAA34670.1 M90540 Genomic DNA Translation: AAB59326.1 Z47814 Genomic DNA Translation: CAA87807.1 Z74324 Genomic DNA Translation: CAA98850.1 X95966 Genomic DNA Translation: CAA65223.1 BK006938 Genomic DNA Translation: DAA11873.1 |
PIRi | S32613 |
RefSeqi | NP_010311.1, NM_001180336.1 |
3D structure databases
SMRi | Q00816 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 32078, 139 interactors |
ComplexPortali | CPX-1266, REG1-GLC7 phosphatase complex |
DIPi | DIP-2513N |
ELMi | Q00816 |
IntActi | Q00816, 24 interactors |
MINTi | Q00816 |
STRINGi | 4932.YDR028C |
PTM databases
iPTMneti | Q00816 |
Proteomic databases
MaxQBi | Q00816 |
PaxDbi | Q00816 |
PRIDEi | Q00816 |
Genome annotation databases
EnsemblFungii | YDR028C_mRNA; YDR028C; YDR028C |
GeneIDi | 851592 |
KEGGi | sce:YDR028C |
Organism-specific databases
EuPathDBi | FungiDB:YDR028C |
SGDi | S000002435, REG1 |
Phylogenomic databases
eggNOGi | ENOG502QSII, Eukaryota |
HOGENOMi | CLU_012586_0_0_1 |
InParanoidi | Q00816 |
OMAi | WKYIILK |
Miscellaneous databases
ChiTaRSi | REG1, yeast |
PROi | PR:Q00816 |
RNActi | Q00816, protein |
Family and domain databases
InterProi | View protein in InterPro IPR013860, AreA_GATA |
Pfami | View protein in Pfam PF08550, DUF1752, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | REG1_YEAST | |
Accessioni | Q00816Primary (citable) accession number: Q00816 Secondary accession number(s): D6VS13 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | October 7, 2020 | |
This is version 182 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names