SORD

Functionⁱ

Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.By similarity1 Publication

Miscellaneous

The polyol pathway is proposed to be involved the cellular toxicity of diabetic hyperglycemia.

Catalytic activityⁱ

L-iditol + NAD⁺ = L-sorbose + NADH.

Cofactorⁱ

Zn²⁺1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	45	Zinc; catalytic1 Publication	1
Binding siteⁱ	51	SubstrateBy similarity	1
Metal bindingⁱ	70	Zinc; catalytic1 Publication	1
Metal bindingⁱ	71	Zinc; catalytic1 Publication	1
Binding siteⁱ	156	SubstrateBy similarity	1
Binding siteⁱ	299	SubstrateBy similarity	1
Binding siteⁱ	300	SubstrateBy similarity	1

GO - Molecular functionⁱ

carbohydrate binding
Source: UniProtKB
Non-traceable author statementⁱ
- 12962626
D-xylulose reductase activity
Source: Reactome
Inferred from experimentⁱ
- 3365415
- 8487505
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 16189514
- 21516116
L-iditol 2-dehydrogenase activity
Source: UniProtKB
Inferred from direct assayⁱ
NAD binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12962626
zinc ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12962626

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

flagellated sperm motility Source: UniProtKB
fructose biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
glucose metabolic process
Source: UniProtKB
Traceable author statementⁱ
- 14965227
glucuronate catabolic process to xylulose 5-phosphate Source: Reactome
L-xylitol catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 8487505
L-xylitol metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 3365415
response to cadmium ion Source: Ensembl
response to copper ion Source: Ensembl
response to drug Source: Ensembl
response to hormone Source: Ensembl
response to nutrient levels Source: Ensembl
response to osmotic stress Source: Ensembl
sorbitol catabolic process
Source: UniProtKB
Inferred from direct assayⁱ

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	Metal-binding, NAD, Zinc

Enzyme and pathway databases

BRENDAⁱ	1.1.1.14 2681
Reactomeⁱ	R-HSA-5652227 Fructose biosynthesis R-HSA-5661270 Formation of xylulose-5-phosphate
SABIO-RKⁱ	Q00796

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sorbitol dehydrogenase (EC:1.1.1.14) Alternative name(s): L-iditol 2-dehydrogenase
Gene namesⁱ	Name:SORD
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000140263.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11184 SORD
MIMⁱ	182500 gene
neXtProtⁱ	NX_Q00796

Keywords - Cellular componentⁱ

Cell projection, Cilium, Flagellum, Membrane, Mitochondrion

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6652
Open Targets More...OpenTargetsⁱ	ENSG00000140263
PharmGKBⁱ	PA36021

Chemistry databases

ChEMBLⁱ	CHEMBL2275
Drug and drug target database More...DrugBankⁱ	DB00157 NADH

Polymorphism and mutation databases

BioMutaⁱ	SORD
DMDMⁱ	292495088

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources2 Publications
ChainⁱPRO_0000160817	2 – 357	Sorbitol dehydrogenaseAdd BLAST		356

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	211	PhosphoserineCombined sources	1
Modified residueⁱ	225	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q00796
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q00796
PaxDbⁱ	Q00796
PeptideAtlas More...PeptideAtlasⁱ	Q00796
PRIDEⁱ	Q00796
ProteomicsDBⁱ	57873

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00216057

REPRODUCTION-2DPAGEⁱ

IPI00216057

PTM databases

iPTMnetⁱ	Q00796
PhosphoSitePlusⁱ	Q00796

Expressionⁱ

Tissue specificityⁱ

Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level).3 Publications

Inductionⁱ

Up-regulated by androgens and down-regulated by castration.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000140263 Expressed in 137 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_SORD
ExpressionAtlasⁱ	Q00796 baseline and differential
Genevisibleⁱ	Q00796 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040260 HPA040621

HPAⁱ

HPA040260
HPA040621

Interactionⁱ

Subunit structureⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		4	EBI-750068,EBI-750068

With

Entry

#Exp.

IntAct

Notes

itself

4

EBI-750068,EBI-750068

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 16189514
- 21516116

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112535, 57 interactors
IntActⁱ	Q00796, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q00796
STRINGⁱ	9606.ENSP00000267814

Chemistry databases

BindingDBⁱ

Q00796

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	10 – 16	Combined sources	7
Beta strandⁱ	19 – 24	Combined sources	6
Beta strandⁱ	34 – 44	Combined sources	11
Helixⁱ	46 – 54	Combined sources	9
Beta strandⁱ	55 – 57	Combined sources	3
Beta strandⁱ	71 – 79	Combined sources	9
Beta strandⁱ	91 – 94	Combined sources	4
Beta strandⁱ	96 – 98	Combined sources	3
Helixⁱ	104 – 107	Combined sources	4
Helixⁱ	111 – 113	Combined sources	3
Beta strandⁱ	130 – 136	Combined sources	7
Helixⁱ	137 – 139	Combined sources	3
Beta strandⁱ	140 – 142	Combined sources	3
Helixⁱ	149 – 168	Combined sources	20
Beta strandⁱ	175 – 179	Combined sources	5
Helixⁱ	183 – 194	Combined sources	12
Beta strandⁱ	198 – 205	Combined sources	8
Helixⁱ	207 – 215	Combined sources	9
Beta strandⁱ	219 – 223	Combined sources	5
Helixⁱ	229 – 240	Combined sources	12
Beta strandⁱ	245 – 249	Combined sources	5
Helixⁱ	254 – 263	Combined sources	10
Beta strandⁱ	269 – 272	Combined sources	4
Helixⁱ	284 – 289	Combined sources	6
Beta strandⁱ	293 – 296	Combined sources	4
Helixⁱ	304 – 312	Combined sources	9
Helixⁱ	319 – 321	Combined sources	3
Beta strandⁱ	322 – 327	Combined sources	6
Helixⁱ	328 – 330	Combined sources	3
Helixⁱ	331 – 339	Combined sources	9
Beta strandⁱ	344 – 349	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	Q00796
SMRⁱ	Q00796
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q00796

EvolutionaryTraceⁱ

Q00796

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the zinc-containing alcohol dehydrogenase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0024 Eukaryota COG1063 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074781
HOGENOMⁱ	HOG000294670
HOVERGENⁱ	HBG005484
InParanoidⁱ	Q00796
KEGG Orthology (KO) More...KOⁱ	K00008
OMAⁱ	GVFHNTP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AQY
PhylomeDBⁱ	Q00796
TreeFamⁱ	TF313060

Family and domain databases

InterProⁱ	View protein in InterPro IPR013149 ADH_C IPR013154 ADH_N IPR002328 ADH_Zn_CS IPR011032 GroES-like_sf IPR036291 NAD(P)-bd_dom_sf IPR020843 PKS_ER
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08240 ADH_N, 1 hit PF00107 ADH_zinc_N, 1 hit
SMARTⁱ	View protein in SMART SM00829 PKS_ER, 1 hit
SUPFAMⁱ	SSF50129 SSF50129, 1 hit SSF51735 SSF51735, 1 hit
PROSITEⁱ	View protein in PROSITE PS00059 ADH_ZINC, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q00796-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAKPNNL SLVVHGPGDL RLENYPIPEP GPNEVLLRMH SVGICGSDVH 
        60         70         80         90        100
YWEYGRIGNF IVKKPMVLGH EASGTVEKVG SSVKHLKPGD RVAIEPGAPR 
       110        120        130        140        150
ENDEFCKMGR YNLSPSIFFC ATPPDDGNLC RFYKHNAAFC YKLPDNVTFE 
       160        170        180        190        200
EGALIEPLSV GIHACRRGGV TLGHKVLVCG AGPIGMVTLL VAKAMGAAQV 
       210        220        230        240        250
VVTDLSATRL SKAKEIGADL VLQISKESPQ EIARKVEGQL GCKPEVTIEC 
       260        270        280        290        300
TGAEASIQAG IYATRSGGNL VLVGLGSEMT TVPLLHAAIR EVDIKGVFRY 
       310        320        330        340        350
CNTWPVAISM LASKSVNVKP LVTHRFPLEK ALEAFETFKK GLGLKIMLKC 

DPSDQNP

Length:357

Mass (Da):38,325

Last modified:March 23, 2010 - v4

Checksum:ⁱFF13DDD5EBE47754

GO

Isoform 2 (identifier: Q00796-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
90-99: DRVAIEPGAP → FLTMSPLRKA
100-356: Missing.

« Hide

        10         20         30         40         50
MAAAAKPNNL SLVVHGPGDL RLENYPIPEP GPNEVLLRMH SVGICGSDVH 
        60         70         80         90        100
YWEYGRIGNF IVKKPMVLGH EASGTVEKVG SSVKHLKPGF LTMSPLRKAP

Note: No experimental confirmation available.

Show »

Length:100

Mass (Da):10,812

Checksum:ⁱC02F3F45EE9F6D11

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YLA4	H0YLA4_HUMAN	Sorbitol dehydrogenase Sorbitol dehydrogenase	SORD	336	Annotation score:
H0YKB3	H0YKB3_HUMAN	Sorbitol dehydrogenase Sorbitol dehydrogenase	SORD	117	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	5	Missing AA sequence (PubMed:2691249).Curated	1
Sequence conflictⁱ	59	N → D AA sequence (PubMed:2691249).Curated	1
Sequence conflictⁱ	186	M → E AA sequence (PubMed:2691249).Curated	1
Sequence conflictⁱ	281	T → S AA sequence (PubMed:2691249).Curated	1
Sequence conflictⁱ	289	I → T AA sequence (PubMed:2691249).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_000430	239	Q → L1 PublicationCorresponds to variant dbSNP:rs1042079Ensembl.		1
Natural variantⁱVAR_060351	269	N → T5 PublicationsCorresponds to variant dbSNP:rs930337Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056353	90 – 99	DRVAIEPGAP → FLTMSPLRKA in isoform 2. 1 Publication		10
Alternative sequenceⁱVSP_056354	100 – 356	Missing in isoform 2. 1 PublicationAdd BLAST		257

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U07361 mRNA Translation: AAA66064.1 L29008 mRNA Translation: AAA80565.1 L29254 L29253 Genomic DNA Translation: AAA80566.1 U67243 U67242 Genomic DNA Translation: AAB61898.1 AK295656 mRNA Translation: BAH12142.1 AK312444 mRNA Translation: BAG35352.1 AC090888 Genomic DNA No translation available. AC091117 Genomic DNA No translation available. BC021085 mRNA Translation: AAH21085.1 BC025295 mRNA Translation: AAH25295.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10116.1 [Q00796-1]
PIRⁱ	A54674
NCBI Reference Sequences More...RefSeqⁱ	NP_003095.2, NM_003104.5 [Q00796-1]
UniGeneⁱ	Hs.878

Genome annotation databases

Ensemblⁱ	ENST00000267814; ENSP00000267814; ENSG00000140263 [Q00796-1] ENST00000558789; ENSP00000453904; ENSG00000140263 [Q00796-2]
GeneIDⁱ	6652
KEGGⁱ	hsa:6652
UCSC genome browser More...UCSCⁱ	uc001zul.5 human [Q00796-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q00796	Sorbitol dehydrogenase		PONAB		357	UniRef90_Q00796
Sorbitol dehydrogenase		MACFA		357
Sorbitol dehydrogenase		SAIBB		409
Sorbitol dehydrogenase (Fragment)		ATECH		29
Uncharacterized protein		AOTNA		357
+50
Q00796-2	SORD isoform 7		PANTR		100	UniRef90_A0A2J8NTK9
SORD isoform 1		PONAB		100

Protein	Similar proteins		Species	Score	Length	Source
Q00796	Sorbitol dehydrogenase		MACFA		357	UniRef50_Q00796
Sorbitol dehydrogenase		PONAB		357
Sorbitol dehydrogenase		CHICK		355
Sorbitol dehydrogenase		SAIBB		409
Sorbitol dehydrogenase (Fragment)		ATECH		29
+154
Q00796-2	Sorbitol dehydrogenase (Fragment)		PIG		97	UniRef50_Q29318
SORD isoform 7		PANTR		100
SORD isoform 1		PONAB		100
Sorbitol dehydrogenase		TUPCH		116
UPI00098A0BE0		MICMU		96

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U07361 mRNA Translation: AAA66064.1 L29008 mRNA Translation: AAA80565.1 L29254 L29253 Genomic DNA Translation: AAA80566.1 U67243 U67242 Genomic DNA Translation: AAB61898.1 AK295656 mRNA Translation: BAH12142.1 AK312444 mRNA Translation: BAG35352.1 AC090888 Genomic DNA No translation available. AC091117 Genomic DNA No translation available. BC021085 mRNA Translation: AAH21085.1 BC025295 mRNA Translation: AAH25295.1
CCDSⁱ	CCDS10116.1 [Q00796-1]
PIRⁱ	A54674
RefSeqⁱ	NP_003095.2, NM_003104.5 [Q00796-1]
UniGeneⁱ	Hs.878

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1PL6	X-ray	2.00	A/B/C/D	2-357	[»]
	1PL7	X-ray	2.20	A/B/C/D	2-357	[»]
	1PL8	X-ray	1.90	A/B/C/D	2-357	[»]
ProteinModelPortalⁱ	Q00796
SMRⁱ	Q00796
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112535, 57 interactors
IntActⁱ	Q00796, 7 interactors
MINTⁱ	Q00796
STRINGⁱ	9606.ENSP00000267814

Chemistry databases

BindingDBⁱ	Q00796
ChEMBLⁱ	CHEMBL2275
DrugBankⁱ	DB00157 NADH

PTM databases

iPTMnetⁱ	Q00796
PhosphoSitePlusⁱ	Q00796

Polymorphism and mutation databases

BioMutaⁱ	SORD
DMDMⁱ	292495088

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00216057

REPRODUCTION-2DPAGEⁱ

IPI00216057

Proteomic databases

EPDⁱ	Q00796
MaxQBⁱ	Q00796
PaxDbⁱ	Q00796
PeptideAtlasⁱ	Q00796
PRIDEⁱ	Q00796
ProteomicsDBⁱ	57873

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6652
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000267814; ENSP00000267814; ENSG00000140263 [Q00796-1] ENST00000558789; ENSP00000453904; ENSG00000140263 [Q00796-2]
GeneIDⁱ	6652
KEGGⁱ	hsa:6652
UCSCⁱ	uc001zul.5 human [Q00796-1]

Organism-specific databases

CTDⁱ	6652
DisGeNETⁱ	6652
EuPathDBⁱ	HostDB:ENSG00000140263.13
GeneCardsⁱ	SORD
HGNCⁱ	HGNC:11184 SORD
HPAⁱ	HPA040260 HPA040621
MIMⁱ	182500 gene
neXtProtⁱ	NX_Q00796
OpenTargetsⁱ	ENSG00000140263
PharmGKBⁱ	PA36021
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0024 Eukaryota COG1063 LUCA
GeneTreeⁱ	ENSGT00550000074781
HOGENOMⁱ	HOG000294670
HOVERGENⁱ	HBG005484
InParanoidⁱ	Q00796
KOⁱ	K00008
OMAⁱ	GVFHNTP
OrthoDBⁱ	EOG091G0AQY
PhylomeDBⁱ	Q00796
TreeFamⁱ	TF313060

Enzyme and pathway databases

BRENDAⁱ	1.1.1.14 2681
Reactomeⁱ	R-HSA-5652227 Fructose biosynthesis R-HSA-5661270 Formation of xylulose-5-phosphate
SABIO-RKⁱ	Q00796

Miscellaneous databases

ChiTaRSⁱ	SORD human
EvolutionaryTraceⁱ	Q00796
GeneWikiⁱ	SORD
GenomeRNAiⁱ	6652
Protein Ontology More...PROⁱ	PR:Q00796
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000140263 Expressed in 137 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_SORD
ExpressionAtlasⁱ	Q00796 baseline and differential
Genevisibleⁱ	Q00796 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR013149 ADH_C IPR013154 ADH_N IPR002328 ADH_Zn_CS IPR011032 GroES-like_sf IPR036291 NAD(P)-bd_dom_sf IPR020843 PKS_ER
Pfamⁱ	View protein in Pfam PF08240 ADH_N, 1 hit PF00107 ADH_zinc_N, 1 hit
SMARTⁱ	View protein in SMART SM00829 PKS_ER, 1 hit
SUPFAMⁱ	SSF50129 SSF50129, 1 hit SSF51735 SSF51735, 1 hit
PROSITEⁱ	View protein in PROSITE PS00059 ADH_ZINC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DHSO_HUMAN
Accessionⁱ	Q00796Primary (citable) accession number: Q00796 Secondary accession number(s): B2R655 , B7Z3A6, J3JZZ5, Q16682, Q9UMD6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	March 23, 2010
	Last modified:	September 12, 2018
	This is version 199 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q00796 (DHSO_HUMAN)

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Sorbitol dehydrogenase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Other locations

Cytosol

Extracellular region or secreted

Mitochondrion

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ