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Protein

Sorbitol dehydrogenase

Gene

SORD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.By similarity1 Publication

Miscellaneous

The polyol pathway is proposed to be involved the cellular toxicity of diabetic hyperglycemia.

Catalytic activityi

L-iditol + NAD+ = L-sorbose + NADH.

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45Zinc; catalytic1 Publication1
Binding sitei51SubstrateBy similarity1
Metal bindingi70Zinc; catalytic1 Publication1
Metal bindingi71Zinc; catalytic1 Publication1
Binding sitei156SubstrateBy similarity1
Binding sitei299SubstrateBy similarity1
Binding sitei300SubstrateBy similarity1

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB
  • D-xylulose reductase activity Source: Reactome
  • identical protein binding Source: IntAct
  • L-iditol 2-dehydrogenase activity Source: UniProtKB
  • NAD binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BRENDAi1.1.1.14 2681
ReactomeiR-HSA-5652227 Fructose biosynthesis
R-HSA-5661270 Formation of xylulose-5-phosphate
SABIO-RKiQ00796

Names & Taxonomyi

Protein namesi
Recommended name:
Sorbitol dehydrogenase (EC:1.1.1.14)
Alternative name(s):
L-iditol 2-dehydrogenase
Gene namesi
Name:SORD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140263.13
HGNCiHGNC:11184 SORD
MIMi182500 gene
neXtProtiNX_Q00796

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum, Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi6652
OpenTargetsiENSG00000140263
PharmGKBiPA36021

Chemistry databases

ChEMBLiCHEMBL2275
DrugBankiDB00157 NADH

Polymorphism and mutation databases

BioMutaiSORD
DMDMi292495088

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources2 Publications
ChainiPRO_00001608172 – 357Sorbitol dehydrogenaseAdd BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei211PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ00796
MaxQBiQ00796
PaxDbiQ00796
PeptideAtlasiQ00796
PRIDEiQ00796
ProteomicsDBi57873

2D gel databases

REPRODUCTION-2DPAGEiIPI00216057

PTM databases

iPTMnetiQ00796
PhosphoSitePlusiQ00796

Expressioni

Tissue specificityi

Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level).3 Publications

Inductioni

Up-regulated by androgens and down-regulated by castration.1 Publication

Gene expression databases

BgeeiENSG00000140263 Expressed in 137 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_SORD
ExpressionAtlasiQ00796 baseline and differential
GenevisibleiQ00796 HS

Organism-specific databases

HPAiHPA040260
HPA040621

Interactioni

Subunit structurei

Homotetramer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-750068,EBI-750068

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112535, 57 interactors
IntActiQ00796, 7 interactors
MINTiQ00796
STRINGi9606.ENSP00000267814

Chemistry databases

BindingDBiQ00796

Structurei

Secondary structure

1357
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ00796
SMRiQ00796
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ00796

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0024 Eukaryota
COG1063 LUCA
GeneTreeiENSGT00550000074781
HOGENOMiHOG000294670
HOVERGENiHBG005484
InParanoidiQ00796
KOiK00008
OMAiGVFHNTP
OrthoDBiEOG091G0AQY
PhylomeDBiQ00796
TreeFamiTF313060

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q00796-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAKPNNL SLVVHGPGDL RLENYPIPEP GPNEVLLRMH SVGICGSDVH
60 70 80 90 100
YWEYGRIGNF IVKKPMVLGH EASGTVEKVG SSVKHLKPGD RVAIEPGAPR
110 120 130 140 150
ENDEFCKMGR YNLSPSIFFC ATPPDDGNLC RFYKHNAAFC YKLPDNVTFE
160 170 180 190 200
EGALIEPLSV GIHACRRGGV TLGHKVLVCG AGPIGMVTLL VAKAMGAAQV
210 220 230 240 250
VVTDLSATRL SKAKEIGADL VLQISKESPQ EIARKVEGQL GCKPEVTIEC
260 270 280 290 300
TGAEASIQAG IYATRSGGNL VLVGLGSEMT TVPLLHAAIR EVDIKGVFRY
310 320 330 340 350
CNTWPVAISM LASKSVNVKP LVTHRFPLEK ALEAFETFKK GLGLKIMLKC

DPSDQNP
Length:357
Mass (Da):38,325
Last modified:March 23, 2010 - v4
Checksum:iFF13DDD5EBE47754
GO
Isoform 2 (identifier: Q00796-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-99: DRVAIEPGAP → FLTMSPLRKA
     100-356: Missing.

Note: No experimental confirmation available.
Show »
Length:100
Mass (Da):10,812
Checksum:iC02F3F45EE9F6D11
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YLA4H0YLA4_HUMAN
Sorbitol dehydrogenase
SORD
336Annotation score:
H0YKB3H0YKB3_HUMAN
Sorbitol dehydrogenase
SORD
117Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5Missing AA sequence (PubMed:2691249).Curated1
Sequence conflicti59N → D AA sequence (PubMed:2691249).Curated1
Sequence conflicti186M → E AA sequence (PubMed:2691249).Curated1
Sequence conflicti281T → S AA sequence (PubMed:2691249).Curated1
Sequence conflicti289I → T AA sequence (PubMed:2691249).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_000430239Q → L1 PublicationCorresponds to variant dbSNP:rs1042079Ensembl.1
Natural variantiVAR_060351269N → T5 PublicationsCorresponds to variant dbSNP:rs930337Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05635390 – 99DRVAIEPGAP → FLTMSPLRKA in isoform 2. 1 Publication10
Alternative sequenceiVSP_056354100 – 356Missing in isoform 2. 1 PublicationAdd BLAST257

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07361 mRNA Translation: AAA66064.1
L29008 mRNA Translation: AAA80565.1
L29254
, L29249, L29250, L29251, L29252, L29253 Genomic DNA Translation: AAA80566.1
U67243
, U67236, U67237, U67238, U67239, U67240, U67241, U67242 Genomic DNA Translation: AAB61898.1
AK295656 mRNA Translation: BAH12142.1
AK312444 mRNA Translation: BAG35352.1
AC090888 Genomic DNA No translation available.
AC091117 Genomic DNA No translation available.
BC021085 mRNA Translation: AAH21085.1
BC025295 mRNA Translation: AAH25295.1
CCDSiCCDS10116.1 [Q00796-1]
PIRiA54674
RefSeqiNP_003095.2, NM_003104.5 [Q00796-1]
UniGeneiHs.878

Genome annotation databases

EnsembliENST00000267814; ENSP00000267814; ENSG00000140263 [Q00796-1]
ENST00000558789; ENSP00000453904; ENSG00000140263 [Q00796-2]
GeneIDi6652
KEGGihsa:6652
UCSCiuc001zul.5 human [Q00796-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07361 mRNA Translation: AAA66064.1
L29008 mRNA Translation: AAA80565.1
L29254
, L29249, L29250, L29251, L29252, L29253 Genomic DNA Translation: AAA80566.1
U67243
, U67236, U67237, U67238, U67239, U67240, U67241, U67242 Genomic DNA Translation: AAB61898.1
AK295656 mRNA Translation: BAH12142.1
AK312444 mRNA Translation: BAG35352.1
AC090888 Genomic DNA No translation available.
AC091117 Genomic DNA No translation available.
BC021085 mRNA Translation: AAH21085.1
BC025295 mRNA Translation: AAH25295.1
CCDSiCCDS10116.1 [Q00796-1]
PIRiA54674
RefSeqiNP_003095.2, NM_003104.5 [Q00796-1]
UniGeneiHs.878

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PL6X-ray2.00A/B/C/D2-357[»]
1PL7X-ray2.20A/B/C/D2-357[»]
1PL8X-ray1.90A/B/C/D2-357[»]
ProteinModelPortaliQ00796
SMRiQ00796
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112535, 57 interactors
IntActiQ00796, 7 interactors
MINTiQ00796
STRINGi9606.ENSP00000267814

Chemistry databases

BindingDBiQ00796
ChEMBLiCHEMBL2275
DrugBankiDB00157 NADH

PTM databases

iPTMnetiQ00796
PhosphoSitePlusiQ00796

Polymorphism and mutation databases

BioMutaiSORD
DMDMi292495088

2D gel databases

REPRODUCTION-2DPAGEiIPI00216057

Proteomic databases

EPDiQ00796
MaxQBiQ00796
PaxDbiQ00796
PeptideAtlasiQ00796
PRIDEiQ00796
ProteomicsDBi57873

Protocols and materials databases

DNASUi6652
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267814; ENSP00000267814; ENSG00000140263 [Q00796-1]
ENST00000558789; ENSP00000453904; ENSG00000140263 [Q00796-2]
GeneIDi6652
KEGGihsa:6652
UCSCiuc001zul.5 human [Q00796-1]

Organism-specific databases

CTDi6652
DisGeNETi6652
EuPathDBiHostDB:ENSG00000140263.13
GeneCardsiSORD
HGNCiHGNC:11184 SORD
HPAiHPA040260
HPA040621
MIMi182500 gene
neXtProtiNX_Q00796
OpenTargetsiENSG00000140263
PharmGKBiPA36021
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0024 Eukaryota
COG1063 LUCA
GeneTreeiENSGT00550000074781
HOGENOMiHOG000294670
HOVERGENiHBG005484
InParanoidiQ00796
KOiK00008
OMAiGVFHNTP
OrthoDBiEOG091G0AQY
PhylomeDBiQ00796
TreeFamiTF313060

Enzyme and pathway databases

BRENDAi1.1.1.14 2681
ReactomeiR-HSA-5652227 Fructose biosynthesis
R-HSA-5661270 Formation of xylulose-5-phosphate
SABIO-RKiQ00796

Miscellaneous databases

ChiTaRSiSORD human
EvolutionaryTraceiQ00796
GeneWikiiSORD
GenomeRNAii6652
PROiPR:Q00796
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140263 Expressed in 137 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_SORD
ExpressionAtlasiQ00796 baseline and differential
GenevisibleiQ00796 HS

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDHSO_HUMAN
AccessioniPrimary (citable) accession number: Q00796
Secondary accession number(s): B2R655
, B7Z3A6, J3JZZ5, Q16682, Q9UMD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: March 23, 2010
Last modified: September 12, 2018
This is version 199 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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