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Protein

Versicolorin reductase

Gene

stcU

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of versicolorin A to sterigmatocystin.

Pathwayi: sterigmatocystin biosynthesis

This protein is involved in the pathway sterigmatocystin biosynthesis, which is part of Mycotoxin biosynthesis.
View all proteins of this organism that are known to be involved in the pathway sterigmatocystin biosynthesis and in Mycotoxin biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei146SubstrateBy similarity1
Active sitei160Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 39NADPBy similarityAdd BLAST25

GO - Molecular functioni

  • versicolorin reductase activity Source: AspGD

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

UniPathwayi
UPA00377

Names & Taxonomyi

Protein namesi
Recommended name:
Versicolorin reductase (EC:1.1.-.-)
Gene namesi
Name:stcU
Synonyms:verA
ORF Names:AN7806
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome IV
  • UP000005890 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000547811 – 264Versicolorin reductaseAdd BLAST264

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00000947

Structurei

3D structure databases

ProteinModelPortaliQ00791
SMRiQ00791
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ00791
KOiK17739
OMAiGPARWIN
OrthoDBiEOG092C3TSH

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q00791-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSDNYRLD GKVALVTGAG RGIGAAIAVA LGQRGAKVVV NYANSREAAE
60 70 80 90 100
KVVDEIKSNG SDAISIQADV GDPDAVTKLM DQAVEHFGYL DIVSSNAGIV
110 120 130 140 150
SFGHVKDVTP DEFDRVFRVN TRGQFFVARE AYRHLREGGR IILTSSNTAS
160 170 180 190 200
VKGVPRHAVY SGSKGAIDTF VRCLAIDCGD KKITVNAVAP GAIKTDMFLS
210 220 230 240 250
VSREYIPNGE TFTDEQVDEC AAWLSPLNRV GLPVDVARVV SFLASDAAEW
260
ISGKIIGVDG GAFR
Length:264
Mass (Da):28,056
Last modified:May 1, 2007 - v2
Checksum:iB300687B7688B0A1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34R → P in AAA53572 (PubMed:8017929).Curated1
Sequence conflicti60 – 62GSD → AQS in AAA53572 (PubMed:8017929).Curated3
Sequence conflicti60 – 62GSD → AQT in AAC49205 (PubMed:8643646).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27825 Genomic DNA Translation: AAA53572.1
U34740 Genomic DNA Translation: AAC49205.1
AACD01000132 Genomic DNA Translation: EAA61594.1
BN001304 Genomic DNA Translation: CBF80146.1
RefSeqiXP_681075.1, XM_675983.1

Genome annotation databases

EnsemblFungiiCBF80146; CBF80146; ANIA_07806
EAA61594; EAA61594; AN7806.2
GeneIDi2869435
KEGGiani:AN7806.2

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27825 Genomic DNA Translation: AAA53572.1
U34740 Genomic DNA Translation: AAC49205.1
AACD01000132 Genomic DNA Translation: EAA61594.1
BN001304 Genomic DNA Translation: CBF80146.1
RefSeqiXP_681075.1, XM_675983.1

3D structure databases

ProteinModelPortaliQ00791
SMRiQ00791
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi162425.CADANIAP00000947

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCBF80146; CBF80146; ANIA_07806
EAA61594; EAA61594; AN7806.2
GeneIDi2869435
KEGGiani:AN7806.2

Phylogenomic databases

InParanoidiQ00791
KOiK17739
OMAiGPARWIN
OrthoDBiEOG092C3TSH

Enzyme and pathway databases

UniPathwayi
UPA00377

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTCU_EMENI
AccessioniPrimary (citable) accession number: Q00791
Secondary accession number(s): C8VDS8, Q00726, Q5AV74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 2007
Last modified: November 7, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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