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Protein

Vasopressin V2 receptor

Gene

Avpr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:1534150). Involved in renal water reabsorption (By similarity).By similarity1 Publication

GO - Molecular functioni

  • peptide hormone binding Source: RGD
  • vasopressin receptor activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-388479 Vasopressin-like receptors
R-RNO-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-RNO-8856825 Cargo recognition for clathrin-mediated endocytosis
R-RNO-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V2 receptor
Short name:
V2R
Alternative name(s):
AVPR V2
Antidiuretic hormone receptor
Renal-type arginine vasopressin receptor
Gene namesi
Name:Avpr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi2186 Avpr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 63Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini64 – 77CytoplasmicSequence analysisAdd BLAST14
Transmembranei78 – 98Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini99 – 113ExtracellularSequence analysisAdd BLAST15
Transmembranei114 – 135Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini136 – 159CytoplasmicSequence analysisAdd BLAST24
Transmembranei160 – 180Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini181 – 200ExtracellularSequence analysisAdd BLAST20
Transmembranei201 – 220Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini221 – 271CytoplasmicSequence analysisAdd BLAST51
Transmembranei272 – 293Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini294 – 308ExtracellularSequence analysisAdd BLAST15
Transmembranei309 – 328Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini329 – 371CytoplasmicSequence analysisAdd BLAST43

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3766
GuidetoPHARMACOLOGYi368

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702111 – 371Vasopressin V2 receptorAdd BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi185N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi341S-palmitoyl cysteineBy similarity1
Lipidationi342S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ00788
PRIDEiQ00788

PTM databases

PhosphoSitePlusiQ00788

Expressioni

Tissue specificityi

Kidney.

Gene expression databases

BgeeiENSRNOG00000059862 Expressed in 8 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiQ00788 baseline and differential
GenevisibleiQ00788 RN

Interactioni

Subunit structurei

Interacts with ARRDC4. Identified in a complex containing at least ARRDC4, V2R and HGS.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053179

Chemistry databases

BindingDBiQ00788

Structurei

Secondary structure

1371
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ00788
SMRiQ00788
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ00788

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119156
HOGENOMiHOG000237331
HOVERGENiHBG105710
InParanoidiQ00788
KOiK04228
OMAiGGARWNR
OrthoDBiEOG091G0DB6
PhylomeDBiQ00788
TreeFamiTF106499

Family and domain databases

CDDicd15388 7tmA_V2R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001817 Vasoprsn_rcpt
IPR000161 Vprsn_rcpt_V2
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00896 VASOPRESSINR
PR00898 VASOPRSNV2R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q00788-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLVSTVSAV PGLFSPPSSP SNSSQEELLD DRDPLLVRAE LALLSTIFVA
60 70 80 90 100
VALSNGLVLG ALIRRGRRGR WAPMHVFISH LCLADLAVAL FQVLPQLAWD
110 120 130 140 150
ATDRFHGPDA LCRAVKYLQM VGMYASSYMI LAMTLDRHRA ICRPMLAYRH
160 170 180 190 200
GGGARWNRPV LVAWAFSLLL SLPQLFIFAQ RDVGNGSGVF DCWARFAEPW
210 220 230 240 250
GLRAYVTWIA LMVFVAPALG IAACQVLIFR EIHASLVPGP SERAGRRRRG
260 270 280 290 300
RRTGSPSEGA HVSAAMAKTV RMTLVIVIVY VLCWAPFFLV QLWAAWDPEA
310 320 330 340 350
PLERPPFVLL MLLASLNSCT NPWIYASFSS SVSSELRSLL CCAQRHTTHS
360 370
LGPQDESCAT ASSSLMKDTP S
Length:371
Mass (Da):40,749
Last modified:February 1, 1994 - v2
Checksum:i480636F298087D3C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JT42A0A0G2JT42_RAT
Vasopressin V2 receptor
Avpr2
309Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti246 – 254RRRRGRRTG → TPQRAPDR in CAA77989 (PubMed:1534150).Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11932 mRNA Translation: CAA77989.1
Z22758 Genomic DNA Translation: CAA80439.1
AY338195 mRNA Translation: AAQ01565.1
PIRiS44045
RefSeqiNP_062009.1, NM_019136.1
XP_006229611.1, XM_006229549.3
UniGeneiRn.209041

Genome annotation databases

EnsembliENSRNOT00000091495; ENSRNOP00000071931; ENSRNOG00000059862
GeneIDi25108
KEGGirno:25108

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11932 mRNA Translation: CAA77989.1
Z22758 Genomic DNA Translation: CAA80439.1
AY338195 mRNA Translation: AAQ01565.1
PIRiS44045
RefSeqiNP_062009.1, NM_019136.1
XP_006229611.1, XM_006229549.3
UniGeneiRn.209041

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JX4NMR-A226-271[»]
ProteinModelPortaliQ00788
SMRiQ00788
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053179

Chemistry databases

BindingDBiQ00788
ChEMBLiCHEMBL3766
GuidetoPHARMACOLOGYi368

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ00788

Proteomic databases

PaxDbiQ00788
PRIDEiQ00788

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000091495; ENSRNOP00000071931; ENSRNOG00000059862
GeneIDi25108
KEGGirno:25108

Organism-specific databases

CTDi554
RGDi2186 Avpr2

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119156
HOGENOMiHOG000237331
HOVERGENiHBG105710
InParanoidiQ00788
KOiK04228
OMAiGGARWNR
OrthoDBiEOG091G0DB6
PhylomeDBiQ00788
TreeFamiTF106499

Enzyme and pathway databases

ReactomeiR-RNO-388479 Vasopressin-like receptors
R-RNO-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-RNO-8856825 Cargo recognition for clathrin-mediated endocytosis
R-RNO-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

EvolutionaryTraceiQ00788
PROiPR:Q00788

Gene expression databases

BgeeiENSRNOG00000059862 Expressed in 8 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiQ00788 baseline and differential
GenevisibleiQ00788 RN

Family and domain databases

CDDicd15388 7tmA_V2R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001817 Vasoprsn_rcpt
IPR000161 Vprsn_rcpt_V2
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00896 VASOPRESSINR
PR00898 VASOPRSNV2R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiV2R_RAT
AccessioniPrimary (citable) accession number: Q00788
Secondary accession number(s): Q53ZC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: February 1, 1994
Last modified: September 12, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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