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Entry version 122 (26 Feb 2020)
Sequence version 2 (01 Jan 1999)
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Protein

Quinate repressor protein

Gene

qutR

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multi-domain repressor protein that negatively regulates transcription of the quinate utilization pathway genes. May mediate its repressor activity by binding directly to the qutA activator protein.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processQuinate metabolism, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Quinate repressor protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:qutR
ORF Names:AN1132
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri227321 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000560 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VIII
  • UP000005890 Componenti: Unassembled WGS sequence

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004024361 – 901Quinate repressor proteinAdd BLAST901

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q00784

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with qutA; transcriptional activator of the quinate utilization pathway genes.

2 Publications

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
162425.CADANIAP00001497

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q00784

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 88Sufficient for repressionAdd BLAST88

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Is homologous throughout its length with the C-terminal 3 domains of the pentafunctional AROM protein. The function of the 2 C-terminal domains may be to act as a molecular sensor that detects the presence of quinate pathway intermediates as a prerequisite for the presumed conformational changes necessary for the control of transcription regulation.3 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the shikimate kinase family.Curated
In the 2nd section; belongs to the type-I 3-dehydroquinase family.Curated
In the C-terminal section; belongs to the shikimate dehydrogenase family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008871_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q00784

Identification of Orthologs from Complete Genome Data

More...
OMAi
MIVSCIP

Database of Orthologous Groups

More...
OrthoDBi
187464at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00502 DHQase_I, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785 Aldolase_TIM
IPR001381 DHquinase_I
IPR036291 NAD(P)-bd_dom_sf
IPR027417 P-loop_NTPase
IPR041121 SDH_C
IPR031322 Shikimate/glucono_kinase
IPR013708 Shikimate_DH-bd_N
IPR006151 Shikm_DH/Glu-tRNA_Rdtase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01487 DHquinase_I, 1 hit
PF18317 SDH_C, 1 hit
PF01488 Shikimate_DH, 1 hit
PF08501 Shikimate_dh_N, 1 hit
PF01202 SKI, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q00784-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSILVRPPKR RLADTENLDQ NHRRVLRDFG QGNSASTPIN TSADYGRFDE
60 70 80 90 100
RPGSGDGSRY ASPFQELSSS QGSLTRVEDS LQTRRKFPPN ASIVLIGIRG
110 120 130 140 150
TGKSSLAVML AASYGRRVIE ADLYFQRVTG RCRGVYKREH TLSEYRRQEA
160 170 180 190 200
IVMESLLMEH QENCVIVCGP GDVERNGQMR LREYAKTHPV IHIVRDLESI
210 220 230 240 250
QSYLKARDTE KVRRFLELSG PIYRSCSNLE FFNVSEKGIS DQPSAKDSQH
260 270 280 290 300
YTQWDAEVDQ RTQTTTPFLM LKRLQRDFLR FVALATGNIP ELRNQLSPFP
310 320 330 340 350
LHMQPIESRK FTYAATVPIS HLLENDVDIE ELESTADAFE LKIDVSAAPS
360 370 380 390 400
ARLGTESNLA DSISHTVATV RRNIIVPMIY HVESSVFPDS APLRRSDASY
410 420 430 440 450
LELVLHGLRL GPEFVTVDLS FEDSILSQII GTKGSSKVIG HYSQTQPPPQ
460 470 480 490 500
GWSDPEYEAI YERAKKLGCD MVRLTQPATT IDDNFAVERF RHQIKTLPGP
510 520 530 540 550
QLPVIAYNSG PLGRQSCCFN PVLTPVIPRS LISQSGTKGL PSITIQEAQE
560 570 580 590 600
ALYSSFVLDP MQFFVFGANT TYSLSPAMHN AAFKVRGMPH IYRIHQSPTL
610 620 630 640 650
RGINYLVENP NFGGTSVSLP YKTEVIPLLH SMSPHARAIG AVNTLIPIRN
660 670 680 690 700
LEGSTDNALD LEKNRAGPIK GLHGDNTDWI GIGICIRRGL SPANAIRPST
710 720 730 740 750
TGLIIGAGGM ARAGIYAMIH LGVQNIFIWN RTVANAEKLA QHYMRLNLCT
760 770 780 790 800
LGGSGSASYT IHVLKSLQES WPANYKQPTI VVSGIPAHRI GDQPAPNFQL
810 820 830 840 850
PPQWIESPTG GVVVDLAYKP LNTPLMRQIR SLSHRGWAAL DGLDVLPEQG
860 870 880 890 900
FAQFELFTGC RAPRRLMRTV ILQEYKEEEQ GEEYDQSAMR TRLENLDGQP

M
Length:901
Mass (Da):100,343
Last modified:January 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02306409F0DDF228
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M77664 Genomic DNA Translation: AAC79663.1
M59935 Genomic DNA Translation: AAC61876.1
AACD01000016 Genomic DNA Translation: EAA66250.1
BN001308 Genomic DNA Translation: CBF88080.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JH0262

NCBI Reference Sequences

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RefSeqi
XP_658736.1, XM_653644.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CBF88080; CBF88080; ANIA_01132
EAA66250; EAA66250; AN1132.2

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2876909

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ani:AN1132.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77664 Genomic DNA Translation: AAC79663.1
M59935 Genomic DNA Translation: AAC61876.1
AACD01000016 Genomic DNA Translation: EAA66250.1
BN001308 Genomic DNA Translation: CBF88080.1
PIRiJH0262
RefSeqiXP_658736.1, XM_653644.1

3D structure databases

SMRiQ00784
ModBaseiSearch...

Protein-protein interaction databases

STRINGi162425.CADANIAP00001497

Proteomic databases

PRIDEiQ00784

Genome annotation databases

EnsemblFungiiCBF88080; CBF88080; ANIA_01132
EAA66250; EAA66250; AN1132.2
GeneIDi2876909
KEGGiani:AN1132.2

Phylogenomic databases

HOGENOMiCLU_008871_0_1_1
InParanoidiQ00784
OMAiMIVSCIP
OrthoDBi187464at2759

Family and domain databases

CDDicd00502 DHQase_I, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001381 DHquinase_I
IPR036291 NAD(P)-bd_dom_sf
IPR027417 P-loop_NTPase
IPR041121 SDH_C
IPR031322 Shikimate/glucono_kinase
IPR013708 Shikimate_DH-bd_N
IPR006151 Shikm_DH/Glu-tRNA_Rdtase
PfamiView protein in Pfam
PF01487 DHquinase_I, 1 hit
PF18317 SDH_C, 1 hit
PF01488 Shikimate_DH, 1 hit
PF08501 Shikimate_dh_N, 1 hit
PF01202 SKI, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQUTR_EMENI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q00784
Secondary accession number(s): C8VTB5, Q04133, Q5BE98
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: January 1, 1999
Last modified: February 26, 2020
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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