UniProtKB - Q00779 (AT2A2_FELCA)
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
ATP2A2
Functioni
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation. Also modulates ER contacts with lipid droplets, mitochondria and endosomes.
By similarityInvolved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca2+ signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca2+ spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca2+ signaling cascades that promote osteoclast differentiation and activation.
By similarityCatalytic activityi
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 304 | Calcium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 305 | Calcium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 307 | Calcium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 309 | Calcium 1By similarity | 1 | |
Active sitei | 351 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 351 | MagnesiumBy similarity | 1 | |
Metal bindingi | 353 | Magnesium; via carbonyl oxygenBy similarity | 1 | |
Binding sitei | 353 | ATPBy similarity | 1 | |
Binding sitei | 442 | ATPBy similarity | 1 | |
Binding sitei | 489 | ATPBy similarity | 1 | |
Binding sitei | 514 | ATPBy similarity | 1 | |
Binding sitei | 559 | ATPBy similarity | 1 | |
Binding sitei | 677 | ATPBy similarity | 1 | |
Binding sitei | 683 | ATPBy similarity | 1 | |
Metal bindingi | 702 | MagnesiumBy similarity | 1 | |
Binding sitei | 705 | ATPBy similarity | 1 | |
Metal bindingi | 767 | Calcium 2By similarity | 1 | |
Metal bindingi | 770 | Calcium 2By similarity | 1 | |
Metal bindingi | 795 | Calcium 1By similarity | 1 | |
Metal bindingi | 798 | Calcium 2By similarity | 1 | |
Metal bindingi | 799 | Calcium 1By similarity | 1 | |
Metal bindingi | 799 | Calcium 2By similarity | 1 | |
Metal bindingi | 907 | Calcium 2By similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
- P-type calcium transporter activity Source: GO_Central
- P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential Source: UniProtKB
- P-type ion transporter activity Source: GO_Central
GO - Biological processi
- autophagosome assembly Source: UniProtKB
- autophagosome membrane docking Source: UniProtKB
- calcium ion transmembrane transport Source: UniProtKB
- cellular calcium ion homeostasis Source: GO_Central
- ion transmembrane transport Source: GO_Central
- mitochondrion-endoplasmic reticulum membrane tethering Source: UniProtKB
- organelle localization by membrane tethering Source: UniProtKB
- regulation of cardiac muscle contraction by calcium ion signaling Source: GO_Central
Keywordsi
Molecular function | Translocase |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (EC:7.2.2.10)Short name: SERCA2 Short name: SR Ca(2+)-ATPase 2 Alternative name(s): Calcium pump 2 Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform Endoplasmic reticulum class 1/2 Ca(2+) ATPase |
Gene namesi | Name:ATP2A2 |
Organismi | Felis catus (Cat) (Felis silvestris catus) |
Taxonomic identifieri | 9685 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Sequence analysis
Other locations
- Sarcoplasmic reticulum membrane By similarity; Multi-pass membrane protein Sequence analysis
Endoplasmic reticulum
- sarcoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 48 | CytoplasmicCuratedAdd BLAST | 48 | |
Transmembranei | 49 – 69 | Helical; Name=1By similarityAdd BLAST | 21 | |
Topological domaini | 70 – 89 | LumenalCuratedAdd BLAST | 20 | |
Transmembranei | 90 – 110 | Helical; Name=2By similarityAdd BLAST | 21 | |
Topological domaini | 111 – 253 | CytoplasmicCuratedAdd BLAST | 143 | |
Transmembranei | 254 – 273 | Helical; Name=3By similarityAdd BLAST | 20 | |
Topological domaini | 274 – 295 | LumenalCuratedAdd BLAST | 22 | |
Transmembranei | 296 – 313 | Helical; Name=4By similarityAdd BLAST | 18 | |
Topological domaini | 314 – 756 | CytoplasmicCuratedAdd BLAST | 443 | |
Transmembranei | 757 – 776 | Helical; Name=5By similarityAdd BLAST | 20 | |
Topological domaini | 777 – 786 | LumenalCurated | 10 | |
Transmembranei | 787 – 807 | Helical; Name=6By similarityAdd BLAST | 21 | |
Topological domaini | 808 – 827 | CytoplasmicCuratedAdd BLAST | 20 | |
Transmembranei | 828 – 850 | Helical; Name=7By similarityAdd BLAST | 23 | |
Topological domaini | 851 – 896 | LumenalCuratedAdd BLAST | 46 | |
Transmembranei | 897 – 916 | Helical; Name=8By similarityAdd BLAST | 20 | |
Topological domaini | 917 – 929 | CytoplasmicCuratedAdd BLAST | 13 | |
Transmembranei | 930 – 948 | Helical; Name=9By similarityAdd BLAST | 19 | |
Topological domaini | 949 – 963 | LumenalCuratedAdd BLAST | 15 | |
Transmembranei | 964 – 984 | Helical; Name=10By similarityAdd BLAST | 21 | |
Topological domaini | 985 – 997 | CytoplasmicCuratedAdd BLAST | 13 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, Sarcoplasmic reticulumPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046195 | 1 – 997 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2Add BLAST | 997 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 38 | PhosphoserineBy similarity | 1 | |
Modified residuei | 294 | 3'-nitrotyrosineBy similarity | 1 | |
Modified residuei | 295 | 3'-nitrotyrosineBy similarity | 1 | |
Modified residuei | 441 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 531 | PhosphoserineBy similarity | 1 | |
Modified residuei | 580 | PhosphoserineBy similarity | 1 | |
Modified residuei | 661 | PhosphoserineBy similarity | 1 | |
Modified residuei | 663 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 875 ↔ 887 | By similarity |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Nitration, PhosphoproteinExpressioni
Tissue specificityi
Interactioni
Subunit structurei
Interacts with sarcolipin (SLN); the interaction inhibits ATP2A2 Ca2+ affinity.
Interacts with phospholamban (PLN); the interaction inhibits ATP2A2 Ca2+ affinity (By similarity).
Interacts with myoregulin (MRLN) (By similarity).
Interacts with DWORF (By similarity).
Interacts with HAX1 (By similarity).
Interacts with S100A8 and S100A9 (By similarity).
Interacts with SLC35G1 and STIM1.
Interacts with TMEM203 (By similarity).
Interacts with TMEM64 and PDIA3 (By similarity).
Interacts with TMX2 (By similarity).
Interacts with VMP1; VMP1 competes with PLN and SLN to prevent them from forming an inhibitory complex with ATP2A2.
Interacts with ULK1 (By similarity).
Interacts with S100A1 in a Ca2+-dependent manner (By similarity).
Interacts with TUNAR (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9685.ENSFCAP00000024370 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 575 – 594 | Interaction with HAX1By similarityAdd BLAST | 20 | |
Regioni | 787 – 807 | Interaction with PLNBy similarityAdd BLAST | 21 | |
Regioni | 788 – 997 | Interaction with TMEM64 and PDIA3By similarityAdd BLAST | 210 | |
Regioni | 931 – 942 | Interaction with PLNBy similarityAdd BLAST | 12 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0202, Eukaryota |
InParanoidi | Q00779 |
OrthoDBi | 100699at2759 |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005782, P-type_ATPase_IIA IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01116, ATPase-IIA1_Ca, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MENAHTKTVE EVLGYFGVNE STGLSLEQVK KLKERWGSNE LPAEEGKTLL
60 70 80 90 100
ELVIEQFEDL LVRILLLAAC ISFVLAWFEE GEETITAFVE PFVILLILVA
110 120 130 140 150
NAIVGVWQER NAENAIEALK EYEPEMGKVY RQDRKSVQRI KAKDIVPGDI
160 170 180 190 200
VEIAVGDKVP ADIRLTSIKS TTLRVDQSIL TGESVSVIKH TDPVPDPRAV
210 220 230 240 250
NQDKKNMLFS GTNIAAGKAM GVVVATGVNT EIGKIRDEMV ATEQERTPLQ
260 270 280 290 300
QKLDEFGEQL SKVISLICIA VWIINIGHFN DPVHGGSWIR GAIYYFKIAV
310 320 330 340 350
ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS
360 370 380 390 400
DKTGTLTTNQ MSVCRMFILD KVEGDTCSLN EFTITGSTYA PIGEVHKDDK
410 420 430 440 450
PVKCHQYDGL VELATICALC NDSALDYNEA KGVYKKFGEA TETALTCLVE
460 470 480 490 500
KMNVFDTELK GLSKIERANA CNSVIKQLMK KEFTLEFSRD RKSMSVYCTP
510 520 530 540 550
NKPSRTSMSK MFVKGAPEGV IDRCTHIRVG STKVPMTPGV KQKVMSVIRE
560 570 580 590 600
WGSGSDTLRC LALATHDNPL RREEMNLEDS ANFIKYETNL TFVGCVGMLD
610 620 630 640 650
PPRIEVASSV KLCRQAGIRV IMITGDNKGT AVAICRRIGI FGQDEDVTSK
660 670 680 690 700
AFTGREFDEL SPSAQRDACL NARCFARVEP SHKSKIVEFL QSFDEITAMT
710 720 730 740 750
GDGVNDAPAL KKSEIGIAMG SGTAVAKTAS EMVLADDNFS TIVAAVEEGR
760 770 780 790 800
AIYNNMKQFI RYLISSNVGE VVCIFLTAAL GFPEALIPVQ LLWVNLVTDG
810 820 830 840 850
LPATALGFNP PDLDIMNKPP RNPKEPLISG WLFFRYLAIG CYVGAATVGA
860 870 880 890 900
AAWWFIAADG GPRVSFYQLS HFLQCKDDNP DFEGVDCAIF ESPYPMTMAL
910 920 930 940 950
SVLVTIEMCN ALNSLSENQS LLRMPPWENI WLVGSICLSM SLHFLILYVE
960 970 980 990
PLPLIFQITP LNLTQWLMVL KISLPVILMD ETLKFVARNY LEPAILE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z11500 mRNA Translation: CAA77576.1 |
PIRi | S23444 |
RefSeqi | NP_001009216.1, NM_001009216.1 [Q00779-1] |
Genome annotation databases
GeneIDi | 493691 |
KEGGi | fca:493691 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z11500 mRNA Translation: CAA77576.1 |
PIRi | S23444 |
RefSeqi | NP_001009216.1, NM_001009216.1 [Q00779-1] |
3D structure databases
AlphaFoldDBi | Q00779 |
SMRi | Q00779 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9685.ENSFCAP00000024370 |
Genome annotation databases
GeneIDi | 493691 |
KEGGi | fca:493691 |
Organism-specific databases
CTDi | 488 |
Phylogenomic databases
eggNOGi | KOG0202, Eukaryota |
InParanoidi | Q00779 |
OrthoDBi | 100699at2759 |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR005782, P-type_ATPase_IIA IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01116, ATPase-IIA1_Ca, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AT2A2_FELCA | |
Accessioni | Q00779Primary (citable) accession number: Q00779 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | May 25, 2022 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families