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Entry version 133 (12 Aug 2020)
Sequence version 3 (04 Dec 2007)
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Protein

Glycogen phosphorylase 1

Gene

glpV

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May provide energy to overcome environmental stresses.

Miscellaneous

In D.discoideum glycogen phosphorylase exists as 2 developmentally regulated forms, GP1 and GP2, which are the products of separate genes.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphate

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

During logarithmic growth and early developmental phases, the activity of GP1 is dependent on 5'AMP. It then seems to convert to an AMP independent type. This alteration in activity coincides with phosphorylation of GP1.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei91AMPBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei159Involved in the association of subunitsBy similarity1
Sitei174May be involved in allosteric controlBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAllosteric enzyme, Glycosyltransferase, Transferase
Biological processCarbohydrate metabolism, Glycogen metabolism
LigandNucleotide-binding, Pyridoxal phosphate

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-6798695, Neutrophil degranulation
R-DDI-70221, Glycogen breakdown (glycogenolysis)

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT35, Glycosyltransferase Family 35

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycogen phosphorylase 1 (EC:2.4.1.1)
Short name:
GP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:glpV
ORF Names:DDB_G0281383
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0281383, glpV

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001885461 – 853Glycogen phosphorylase 1Add BLAST853

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei27PhosphoserineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei697N6-(pyridoxal phosphate)lysineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q00766

PRoteomics IDEntifications database

More...
PRIDEi
Q00766

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Present throughout cellular differentiation.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0215010

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q00766

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycogen phosphorylase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2099, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010198_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q00766

KEGG Orthology (KO)

More...
KOi
K00688

Identification of Orthologs from Complete Genome Data

More...
OMAi
KSPIDFN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q00766

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011833, Glycg_phsphrylas
IPR000811, Glyco_trans_35
IPR035090, Pyridoxal_P_attach_site

The PANTHER Classification System

More...
PANTHERi
PTHR11468, PTHR11468, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00343, Phosphorylase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000460, Pprylas_GlgP, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02093, P_ylase, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00102, PHOSPHORYLASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q00766-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTTIPLKHT ARTTTGVVPP TEKKKGSKLF ALKTDFLKND EDSIQKDILD
60 70 80 90 100
HVEYTLARTK YNFDSFSAYQ GSAYSVRDRL IERWNETQQY YTERDPKRVY
110 120 130 140 150
YLSMEFLMGR SLQNAIYNMN LKDEYHNALL ELGFEMEDLY EEEKDAALGN
160 170 180 190 200
GGLGRLAACF MDSLATLKYP AWGYGLRYNY GMFEQGIYDG YQTEVPDYWL
210 220 230 240 250
VAGNPWEIER LDVQYTVRFY GQVTEKKSSD GSKFEWDHGE LVQAIAYDTP
260 270 280 290 300
VPGYHTTNTN NIRLWSSKPH KEFDLDAFNG GNYLSAVEAK QRSENITSVL
310 320 330 340 350
YPNDNTYSGK ELRLKQQYFF VAATLCDVIR RFKKSHQNWQ DFPNKVAIQL
360 370 380 390 400
NDTHPTIGVV ELFRKLIDEE GLQWEEAWDI VTKTFAYTNH TILPEALEMW
410 420 430 440 450
PVSLIEDLLP RHMQLIYGIN HRFLIQVTQK WPGDIGKMRG LSIIQEGEEK
460 470 480 490 500
RVRMAHLAIV GSHCVNGVAA MHSELVKHKV FPDFFCLWPE KFQNKTNGVT
510 520 530 540 550
PRRWIEQANP GLSAIFTKWL GTDKWTTNLE LVKGIKEHMD NPELIAEWKY
560 570 580 590 600
VKQGNKQRLA EFILKHCGIH VNPNALFDVH IKRIHEYKRQ LLNILSVIYR
610 620 630 640 650
YLSIKKMSPK DRAQVVPRVV IFAGKAAPGY VMAKRHIKLI NSVAEVINRD
660 670 680 690 700
KEVDQYLKVV FIANYNVSIA QVIVPASDIN QQISTAGTEA SGTSNMKFTM
710 720 730 740 750
NGSLIIGTLD GANVEIAEEV GQENMFIFGL RTSEVEAARE KMTNKEVNID
760 770 780 790 800
PRLQEVFLNI ELGTFGPPDV FRPILDSLIF SDFYLSIQDF PLYLDSQASV
810 820 830 840 850
DELWKDQSAW VKKSIINSAS TYFFSSDRAM NEYAEQIWDI KPCEVETTLN

RRY
Length:853
Mass (Da):98,277
Last modified:December 4, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF1505B7E15946368
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA44069 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti59T → R in CAA44069 (PubMed:1536877).Curated1
Sequence conflicti264L → I in CAA44069 (PubMed:1536877).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X62142 Genomic DNA Translation: CAA44069.1 Sequence problems.
AAFI02000041 Genomic DNA Translation: EAL66673.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S20595

NCBI Reference Sequences

More...
RefSeqi
XP_640695.1, XM_635603.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL66673; EAL66673; DDB_G0281383

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8623081

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0281383

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62142 Genomic DNA Translation: CAA44069.1 Sequence problems.
AAFI02000041 Genomic DNA Translation: EAL66673.1
PIRiS20595
RefSeqiXP_640695.1, XM_635603.1

3D structure databases

SMRiQ00766
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0215010

Protein family/group databases

CAZyiGT35, Glycosyltransferase Family 35

Proteomic databases

PaxDbiQ00766
PRIDEiQ00766

Genome annotation databases

EnsemblProtistsiEAL66673; EAL66673; DDB_G0281383
GeneIDi8623081
KEGGiddi:DDB_G0281383

Organism-specific databases

dictyBaseiDDB_G0281383, glpV

Phylogenomic databases

eggNOGiKOG2099, Eukaryota
HOGENOMiCLU_010198_1_1_1
InParanoidiQ00766
KOiK00688
OMAiKSPIDFN
PhylomeDBiQ00766

Enzyme and pathway databases

ReactomeiR-DDI-6798695, Neutrophil degranulation
R-DDI-70221, Glycogen breakdown (glycogenolysis)

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q00766

Family and domain databases

InterProiView protein in InterPro
IPR011833, Glycg_phsphrylas
IPR000811, Glyco_trans_35
IPR035090, Pyridoxal_P_attach_site
PANTHERiPTHR11468, PTHR11468, 1 hit
PfamiView protein in Pfam
PF00343, Phosphorylase, 1 hit
PIRSFiPIRSF000460, Pprylas_GlgP, 1 hit
TIGRFAMsiTIGR02093, P_ylase, 1 hit
PROSITEiView protein in PROSITE
PS00102, PHOSPHORYLASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHS1_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q00766
Secondary accession number(s): Q54TW6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: December 4, 2007
Last modified: August 12, 2020
This is version 133 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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