REEP5

Functionⁱ

May promote functional cell surface expression of olfactory receptors.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Receptor expression-enhancing protein 5 Alternative name(s): Polyposis locus protein 1 Protein TB2
Gene namesⁱ	Name:REEP5 Synonyms:C5orf18, DP1, TB2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000129625.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30077 REEP5
MIMⁱ	125265 gene
neXtProtⁱ	NX_Q00765

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	35 – 55	HelicalSequence analysisAdd BLAST		21
Transmembraneⁱ	90 – 110	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7905
Open Targets More...OpenTargetsⁱ	ENSG00000129625
PharmGKBⁱ	PA134882361

Polymorphism and mutation databases

BioMutaⁱ	REEP5
DMDMⁱ	82654932

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000101815	1 – 189	Receptor expression-enhancing protein 5Add BLAST		189

Proteomic databases

EPDⁱ	Q00765
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q00765
PaxDbⁱ	Q00765
PeptideAtlas More...PeptideAtlasⁱ	Q00765
PRIDEⁱ	Q00765
ProteomicsDBⁱ	57872
TopDownProteomicsⁱ	Q00765-1 [Q00765-1]

PTM databases

iPTMnetⁱ	Q00765
PhosphoSitePlusⁱ	Q00765
SwissPalmⁱ	Q00765

Expressionⁱ

Tissue specificityⁱ

Expressed in circumvallate papillae and testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000129625 Expressed in 246 organ(s), highest expression level in middle temporal gyrus
CleanExⁱ	HS_REEP5
ExpressionAtlasⁱ	Q00765 baseline and differential
Genevisibleⁱ	Q00765 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003895 HPA069960

HPAⁱ

HPA003895
HPA069960

Interactionⁱ

Subunit structureⁱ

Interacts with ATL1 (By similarity). Interacts with ATL2 (PubMed:19665976). Interacts with ZFYVE27 (PubMed:23969831).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
LETMD1	Q6P1Q0	3	EBI-1549827,EBI-1549822

With

Entry

#Exp.

IntAct

Notes

LETMD1

Q6P1Q0

3

EBI-1549827,EBI-1549822

Protein-protein interaction databases

BioGridⁱ	113637, 81 interactors
CORUMⁱ	Q00765
IntActⁱ	Q00765, 41 interactors
Molecular INTeraction database More...MINTⁱ	Q00765
STRINGⁱ	9606.ENSP00000368959

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q00765
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the DP1 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1725 Eukaryota COG5052 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074535
HOGENOMⁱ	HOG000172351
HOVERGENⁱ	HBG000796
InParanoidⁱ	Q00765
KEGG Orthology (KO) More...KOⁱ	K17279
OMAⁱ	LYYFPWY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0X58
PhylomeDBⁱ	Q00765
TreeFamⁱ	TF314913

Family and domain databases

InterProⁱ	View protein in InterPro IPR004345 TB2_DP1_HVA22
PANTHERⁱ	PTHR12300 PTHR12300, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03134 TB2_DP1_HVA22, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q00765-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAAMRERFD RFLHEKNCMT DLLAKLEAKT GVNRSFIALG VIGLVALYLV 
        60         70         80         90        100
FGYGASLLCN LIGFGYPAYI SIKAIESPNK EDDTQWLTYW VVYGVFSIAE 
       110        120        130        140        150
FFSDIFLSWF PFYYMLKCGF LLWCMAPSPS NGAELLYKRI IRPFFLKHES 
       160        170        180 
QMDSVVKDLK DKAKETADAI TKEAKKATVN LLGEEKKST

Length:189

Mass (Da):21,493

Last modified:November 22, 2005 - v3

Checksum:ⁱF4E57E500CB7C831

GO

Isoform 2 (identifier: Q00765-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
118-189: CGFLLWCMAP...NLLGEEKKST → VWSGLGFLLPRCLL

« Hide

        10         20         30         40         50
MSAAMRERFD RFLHEKNCMT DLLAKLEAKT GVNRSFIALG VIGLVALYLV 
        60         70         80         90        100
FGYGASLLCN LIGFGYPAYI SIKAIESPNK EDDTQWLTYW VVYGVFSIAE 
       110        120        130 
FFSDIFLSWF PFYYMLKVWS GLGFLLPRCL L

Note: No experimental confirmation available.

Show »

Length:131

Mass (Da):14,997

Checksum:ⁱD6B307C92BDA7E0C

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B7Z510	B7Z510_HUMAN	Receptor expression-enhancing prote... Receptor expression-enhancing protein	REEP5	122	Annotation score:
H0Y8J8	H0Y8J8_HUMAN	Receptor expression-enhancing prote... Receptor expression-enhancing protein	REEP5	145	Annotation score:
E2QRG8	E2QRG8_HUMAN	Receptor expression-enhancing prote... Receptor expression-enhancing protein	REEP5	165	Annotation score:
B7Z332	B7Z332_HUMAN	cDNA FLJ50528, moderately similar t... cDNA FLJ50528, moderately similar to Receptor expression-enhancing protein 5	REEP5	99	Annotation score:

Sequence cautionⁱ

The sequence AAA60136 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAA66351 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH65926 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	115	M → I in AAA66351 (PubMed:1651562).Curated		1
Sequence conflictⁱ	163	A → S in AAA60136 (PubMed:1678319).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056633	118 – 189	CGFLL…EKKST → VWSGLGFLLPRCLL in isoform 2. 1 PublicationAdd BLAST		72

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M73547 mRNA Translation: AAA60136.1 Different initiation. M74090 mRNA Translation: AAA66351.1 Different initiation. AY562243 mRNA Translation: AAT70688.1 AK299902 mRNA Translation: BAH13167.1 AC008536 Genomic DNA No translation available. AC008575 Genomic DNA No translation available. CH471086 Genomic DNA Translation: EAW48994.1 CH471086 Genomic DNA Translation: EAW48995.1 BC000232 mRNA Translation: AAH00232.2 BC065926 mRNA Translation: AAH65926.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4109.2 [Q00765-1]
PIRⁱ	A39658
NCBI Reference Sequences More...RefSeqⁱ	NP_005660.4, NM_005669.4 [Q00765-1]
UniGeneⁱ	Hs.429608

Genome annotation databases

Ensemblⁱ	ENST00000379638; ENSP00000368959; ENSG00000129625 [Q00765-1]
GeneIDⁱ	7905
KEGGⁱ	hsa:7905
UCSC genome browser More...UCSCⁱ	uc003kqe.2 human [Q00765-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q00765	Receptor expression-enhancing protein		PANTR		189	UniRef100_Q00765
Receptor expression-enhancing protein		MACMU		189
Receptor expression-enhancing protein		CERAT		189
Receptor expression-enhancing protein		RHIRO		189
Receptor expression-enhancing protein		PAPAN		189
+6
Q00765-2	Receptor expression-enhancing protein (Fragment)		HUMAN		145	UniRef100_Q00765-2

Protein	Similar proteins		Species	Score	Length	Source
Q00765	Receptor expression-enhancing protein		PANTR		189	UniRef90_Q00765
Receptor expression-enhancing protein		MACMU		189
Receptor expression-enhancing protein		CERAT		189
Receptor expression-enhancing protein		RHIRO		189
Receptor expression-enhancing protein		PAPAN		189
+6
Q00765-2	Receptor expression-enhancing protein (Fragment)		HUMAN		145	UniRef90_Q00765-2
Receptor expression-enhancing protein (Fragment)		PONAB		144
Receptor expression-enhancing protein (Fragment)		PANTR		144
Receptor expression-enhancing protein		PROCO		122
Receptor expression-enhancing protein		MACMU		122
+17

Protein	Similar proteins		Species	Score	Length	Source
Q00765	Receptor expression-enhancing protein		PANTR		189	UniRef50_Q00765
Receptor expression-enhancing protein		MACMU		189
Receptor expression-enhancing protein		CERAT		189
Receptor expression-enhancing protein		RHIRO		189
Receptor expression-enhancing protein		PAPAN		189
+18
Q00765-2	Receptor expression-enhancing protein (Fragment)		HUMAN		145	UniRef50_Q00765-2
Receptor expression-enhancing protein (Fragment)		PONAB		144
Receptor expression-enhancing protein (Fragment)		PANTR		144
Receptor expression-enhancing protein		MACMU		122
Receptor expression-enhancing protein		CERAT		122
+27

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M73547 mRNA Translation: AAA60136.1 Different initiation. M74090 mRNA Translation: AAA66351.1 Different initiation. AY562243 mRNA Translation: AAT70688.1 AK299902 mRNA Translation: BAH13167.1 AC008536 Genomic DNA No translation available. AC008575 Genomic DNA No translation available. CH471086 Genomic DNA Translation: EAW48994.1 CH471086 Genomic DNA Translation: EAW48995.1 BC000232 mRNA Translation: AAH00232.2 BC065926 mRNA Translation: AAH65926.1 Different initiation.
CCDSⁱ	CCDS4109.2 [Q00765-1]
PIRⁱ	A39658
RefSeqⁱ	NP_005660.4, NM_005669.4 [Q00765-1]
UniGeneⁱ	Hs.429608

3D structure databases

ProteinModelPortalⁱ	Q00765
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113637, 81 interactors
CORUMⁱ	Q00765
IntActⁱ	Q00765, 41 interactors
MINTⁱ	Q00765
STRINGⁱ	9606.ENSP00000368959

PTM databases

iPTMnetⁱ	Q00765
PhosphoSitePlusⁱ	Q00765
SwissPalmⁱ	Q00765

Polymorphism and mutation databases

BioMutaⁱ	REEP5
DMDMⁱ	82654932

Proteomic databases

EPDⁱ	Q00765
MaxQBⁱ	Q00765
PaxDbⁱ	Q00765
PeptideAtlasⁱ	Q00765
PRIDEⁱ	Q00765
ProteomicsDBⁱ	57872
TopDownProteomicsⁱ	Q00765-1 [Q00765-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7905
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000379638; ENSP00000368959; ENSG00000129625 [Q00765-1]
GeneIDⁱ	7905
KEGGⁱ	hsa:7905
UCSCⁱ	uc003kqe.2 human [Q00765-1]

Organism-specific databases

CTDⁱ	7905
DisGeNETⁱ	7905
EuPathDBⁱ	HostDB:ENSG00000129625.12
GeneCardsⁱ	REEP5
HGNCⁱ	HGNC:30077 REEP5
HPAⁱ	HPA003895 HPA069960
MIMⁱ	125265 gene
neXtProtⁱ	NX_Q00765
OpenTargetsⁱ	ENSG00000129625
PharmGKBⁱ	PA134882361
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1725 Eukaryota COG5052 LUCA
GeneTreeⁱ	ENSGT00550000074535
HOGENOMⁱ	HOG000172351
HOVERGENⁱ	HBG000796
InParanoidⁱ	Q00765
KOⁱ	K17279
OMAⁱ	LYYFPWY
OrthoDBⁱ	EOG091G0X58
PhylomeDBⁱ	Q00765
TreeFamⁱ	TF314913

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381753 Olfactory Signaling Pathway

Reactomeⁱ

R-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiⁱ	REEP5
GenomeRNAiⁱ	7905
Protein Ontology More...PROⁱ	PR:Q00765
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000129625 Expressed in 246 organ(s), highest expression level in middle temporal gyrus
CleanExⁱ	HS_REEP5
ExpressionAtlasⁱ	Q00765 baseline and differential
Genevisibleⁱ	Q00765 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR004345 TB2_DP1_HVA22
PANTHERⁱ	PTHR12300 PTHR12300, 1 hit
Pfamⁱ	View protein in Pfam PF03134 TB2_DP1_HVA22, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	REEP5_HUMAN
Accessionⁱ	Q00765Primary (citable) accession number: Q00765 Secondary accession number(s): B7Z681 , D3DT04, Q04198, Q5QGT0, Q9BWH9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	November 22, 2005
	Last modified:	September 12, 2018
	This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

UniProtKB

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UniProtKB - Q00765 (REEP5_HUMAN)

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Receptor expression-enhancing protein 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Other locations

Endoplasmic reticulum

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ