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Protein

Receptor expression-enhancing protein 5

Gene

REEP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May promote functional cell surface expression of olfactory receptors.

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor expression-enhancing protein 5
Alternative name(s):
Polyposis locus protein 1
Protein TB2
Gene namesi
Name:REEP5
Synonyms:C5orf18, DP1, TB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000129625.12
HGNCiHGNC:30077 REEP5
MIMi125265 gene
neXtProtiNX_Q00765

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7905
OpenTargetsiENSG00000129625
PharmGKBiPA134882361

Polymorphism and mutation databases

BioMutaiREEP5
DMDMi82654932

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001018151 – 189Receptor expression-enhancing protein 5Add BLAST189

Proteomic databases

EPDiQ00765
MaxQBiQ00765
PaxDbiQ00765
PeptideAtlasiQ00765
PRIDEiQ00765
ProteomicsDBi57872
TopDownProteomicsiQ00765-1 [Q00765-1]

PTM databases

iPTMnetiQ00765
PhosphoSitePlusiQ00765
SwissPalmiQ00765

Expressioni

Tissue specificityi

Expressed in circumvallate papillae and testis.1 Publication

Gene expression databases

BgeeiENSG00000129625 Expressed in 246 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_REEP5
ExpressionAtlasiQ00765 baseline and differential
GenevisibleiQ00765 HS

Organism-specific databases

HPAiHPA003895
HPA069960

Interactioni

Subunit structurei

Interacts with ATL1 (By similarity). Interacts with ATL2 (PubMed:19665976). Interacts with ZFYVE27 (PubMed:23969831).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LETMD1Q6P1Q03EBI-1549827,EBI-1549822

Protein-protein interaction databases

BioGridi113637, 81 interactors
CORUMiQ00765
IntActiQ00765, 41 interactors
MINTiQ00765
STRINGi9606.ENSP00000368959

Structurei

3D structure databases

ProteinModelPortaliQ00765
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1725 Eukaryota
COG5052 LUCA
GeneTreeiENSGT00550000074535
HOGENOMiHOG000172351
HOVERGENiHBG000796
InParanoidiQ00765
KOiK17279
OMAiLYYFPWY
OrthoDBiEOG091G0X58
PhylomeDBiQ00765
TreeFamiTF314913

Family and domain databases

InterProiView protein in InterPro
IPR004345 TB2_DP1_HVA22
PANTHERiPTHR12300 PTHR12300, 1 hit
PfamiView protein in Pfam
PF03134 TB2_DP1_HVA22, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q00765-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAAMRERFD RFLHEKNCMT DLLAKLEAKT GVNRSFIALG VIGLVALYLV
60 70 80 90 100
FGYGASLLCN LIGFGYPAYI SIKAIESPNK EDDTQWLTYW VVYGVFSIAE
110 120 130 140 150
FFSDIFLSWF PFYYMLKCGF LLWCMAPSPS NGAELLYKRI IRPFFLKHES
160 170 180
QMDSVVKDLK DKAKETADAI TKEAKKATVN LLGEEKKST
Length:189
Mass (Da):21,493
Last modified:November 22, 2005 - v3
Checksum:iF4E57E500CB7C831
GO
Isoform 2 (identifier: Q00765-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-189: CGFLLWCMAP...NLLGEEKKST → VWSGLGFLLPRCLL

Note: No experimental confirmation available.
Show »
Length:131
Mass (Da):14,997
Checksum:iD6B307C92BDA7E0C
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z510B7Z510_HUMAN
Receptor expression-enhancing prote...
REEP5
122Annotation score:
H0Y8J8H0Y8J8_HUMAN
Receptor expression-enhancing prote...
REEP5
145Annotation score:
E2QRG8E2QRG8_HUMAN
Receptor expression-enhancing prote...
REEP5
165Annotation score:
B7Z332B7Z332_HUMAN
cDNA FLJ50528, moderately similar t...
REEP5
99Annotation score:

Sequence cautioni

The sequence AAA60136 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAA66351 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH65926 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115M → I in AAA66351 (PubMed:1651562).Curated1
Sequence conflicti163A → S in AAA60136 (PubMed:1678319).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056633118 – 189CGFLL…EKKST → VWSGLGFLLPRCLL in isoform 2. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73547 mRNA Translation: AAA60136.1 Different initiation.
M74090 mRNA Translation: AAA66351.1 Different initiation.
AY562243 mRNA Translation: AAT70688.1
AK299902 mRNA Translation: BAH13167.1
AC008536 Genomic DNA No translation available.
AC008575 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW48994.1
CH471086 Genomic DNA Translation: EAW48995.1
BC000232 mRNA Translation: AAH00232.2
BC065926 mRNA Translation: AAH65926.1 Different initiation.
CCDSiCCDS4109.2 [Q00765-1]
PIRiA39658
RefSeqiNP_005660.4, NM_005669.4 [Q00765-1]
UniGeneiHs.429608

Genome annotation databases

EnsembliENST00000379638; ENSP00000368959; ENSG00000129625 [Q00765-1]
GeneIDi7905
KEGGihsa:7905
UCSCiuc003kqe.2 human [Q00765-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73547 mRNA Translation: AAA60136.1 Different initiation.
M74090 mRNA Translation: AAA66351.1 Different initiation.
AY562243 mRNA Translation: AAT70688.1
AK299902 mRNA Translation: BAH13167.1
AC008536 Genomic DNA No translation available.
AC008575 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW48994.1
CH471086 Genomic DNA Translation: EAW48995.1
BC000232 mRNA Translation: AAH00232.2
BC065926 mRNA Translation: AAH65926.1 Different initiation.
CCDSiCCDS4109.2 [Q00765-1]
PIRiA39658
RefSeqiNP_005660.4, NM_005669.4 [Q00765-1]
UniGeneiHs.429608

3D structure databases

ProteinModelPortaliQ00765
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113637, 81 interactors
CORUMiQ00765
IntActiQ00765, 41 interactors
MINTiQ00765
STRINGi9606.ENSP00000368959

PTM databases

iPTMnetiQ00765
PhosphoSitePlusiQ00765
SwissPalmiQ00765

Polymorphism and mutation databases

BioMutaiREEP5
DMDMi82654932

Proteomic databases

EPDiQ00765
MaxQBiQ00765
PaxDbiQ00765
PeptideAtlasiQ00765
PRIDEiQ00765
ProteomicsDBi57872
TopDownProteomicsiQ00765-1 [Q00765-1]

Protocols and materials databases

DNASUi7905
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379638; ENSP00000368959; ENSG00000129625 [Q00765-1]
GeneIDi7905
KEGGihsa:7905
UCSCiuc003kqe.2 human [Q00765-1]

Organism-specific databases

CTDi7905
DisGeNETi7905
EuPathDBiHostDB:ENSG00000129625.12
GeneCardsiREEP5
HGNCiHGNC:30077 REEP5
HPAiHPA003895
HPA069960
MIMi125265 gene
neXtProtiNX_Q00765
OpenTargetsiENSG00000129625
PharmGKBiPA134882361
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1725 Eukaryota
COG5052 LUCA
GeneTreeiENSGT00550000074535
HOGENOMiHOG000172351
HOVERGENiHBG000796
InParanoidiQ00765
KOiK17279
OMAiLYYFPWY
OrthoDBiEOG091G0X58
PhylomeDBiQ00765
TreeFamiTF314913

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiREEP5
GenomeRNAii7905
PROiPR:Q00765
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129625 Expressed in 246 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_REEP5
ExpressionAtlasiQ00765 baseline and differential
GenevisibleiQ00765 HS

Family and domain databases

InterProiView protein in InterPro
IPR004345 TB2_DP1_HVA22
PANTHERiPTHR12300 PTHR12300, 1 hit
PfamiView protein in Pfam
PF03134 TB2_DP1_HVA22, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiREEP5_HUMAN
AccessioniPrimary (citable) accession number: Q00765
Secondary accession number(s): B7Z681
, D3DT04, Q04198, Q5QGT0, Q9BWH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 22, 2005
Last modified: September 12, 2018
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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