UniProtKB - Q00765 (REEP5_HUMAN)
Protein
Receptor expression-enhancing protein 5
Gene
REEP5
Organism
Homo sapiens (Human)
Status
Functioni
May promote functional cell surface expression of olfactory receptors.
GO - Biological processi
- endoplasmic reticulum organization Source: FlyBase
- regulation of intracellular transport Source: FlyBase
Enzyme and pathway databases
PathwayCommonsi | Q00765 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
SIGNORi | Q00765 |
Names & Taxonomyi
Protein namesi | Recommended name: Receptor expression-enhancing protein 5Alternative name(s): Polyposis locus protein 1 Protein TB2 |
Gene namesi | Name:REEP5 Synonyms:C5orf18, DP1, TB2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30077, REEP5 |
MIMi | 125265, gene |
neXtProti | NX_Q00765 |
VEuPathDBi | HostDB:ENSG00000129625.12 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum 1 Publication
Other locations
- Membrane Sequence analysis; Multi-pass membrane protein Sequence analysis
Note: Localizes to endoplasmic reticulum tubular network.1 Publication
Endoplasmic reticulum
- endoplasmic reticulum tubular network Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 35 – 55 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 90 – 110 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 7905 |
OpenTargetsi | ENSG00000129625 |
PharmGKBi | PA134882361 |
Miscellaneous databases
Pharosi | Q00765, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295797 |
Genetic variation databases
BioMutai | REEP5 |
DMDMi | 82654932 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000101815 | 1 – 189 | Receptor expression-enhancing protein 5Add BLAST | 189 |
Proteomic databases
EPDi | Q00765 |
jPOSTi | Q00765 |
MassIVEi | Q00765 |
MaxQBi | Q00765 |
PaxDbi | Q00765 |
PeptideAtlasi | Q00765 |
PRIDEi | Q00765 |
ProteomicsDBi | 57872 [Q00765-1] 6755 |
TopDownProteomicsi | Q00765-1 [Q00765-1] |
PTM databases
iPTMneti | Q00765 |
PhosphoSitePlusi | Q00765 |
SwissPalmi | Q00765 |
Expressioni
Tissue specificityi
Expressed in circumvallate papillae and testis.1 Publication
Gene expression databases
Bgeei | ENSG00000129625, Expressed in middle temporal gyrus and 258 other tissues |
ExpressionAtlasi | Q00765, baseline and differential |
Genevisiblei | Q00765, HS |
Organism-specific databases
HPAi | ENSG00000129625, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsQ00765
Protein-protein interaction databases
BioGRIDi | 113637, 105 interactors |
CORUMi | Q00765 |
IntActi | Q00765, 90 interactors |
MINTi | Q00765 |
STRINGi | 9606.ENSP00000368959 |
Miscellaneous databases
RNActi | Q00765, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the DP1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1725, Eukaryota |
GeneTreei | ENSGT00940000157873 |
InParanoidi | Q00765 |
OMAi | LYYFPWY |
OrthoDBi | 1473891at2759 |
PhylomeDBi | Q00765 |
TreeFami | TF314913 |
Family and domain databases
InterProi | View protein in InterPro IPR004345, TB2_DP1_HVA22 |
PANTHERi | PTHR12300, PTHR12300, 1 hit |
Pfami | View protein in Pfam PF03134, TB2_DP1_HVA22, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q00765-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAAMRERFD RFLHEKNCMT DLLAKLEAKT GVNRSFIALG VIGLVALYLV
60 70 80 90 100
FGYGASLLCN LIGFGYPAYI SIKAIESPNK EDDTQWLTYW VVYGVFSIAE
110 120 130 140 150
FFSDIFLSWF PFYYMLKCGF LLWCMAPSPS NGAELLYKRI IRPFFLKHES
160 170 180
QMDSVVKDLK DKAKETADAI TKEAKKATVN LLGEEKKST
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE2QRG8 | E2QRG8_HUMAN | Receptor expression-enhancing prote... | REEP5 | 165 | Annotation score: | ||
B7Z510 | B7Z510_HUMAN | Receptor expression-enhancing prote... | REEP5 | 122 | Annotation score: | ||
H0Y8J8 | H0Y8J8_HUMAN | Receptor expression-enhancing prote... | REEP5 | 145 | Annotation score: | ||
B7Z332 | B7Z332_HUMAN | Receptor expression-enhancing prote... | REEP5 | 99 | Annotation score: |
Sequence cautioni
The sequence AAA60136 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAA66351 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH65926 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 115 | M → I in AAA66351 (PubMed:1651562).Curated | 1 | |
Sequence conflicti | 163 | A → S in AAA60136 (PubMed:1678319).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056633 | 118 – 189 | CGFLL…EKKST → VWSGLGFLLPRCLL in isoform 2. 1 PublicationAdd BLAST | 72 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M73547 mRNA Translation: AAA60136.1 Different initiation. M74090 mRNA Translation: AAA66351.1 Different initiation. AY562243 mRNA Translation: AAT70688.1 AK299902 mRNA Translation: BAH13167.1 AC008536 Genomic DNA No translation available. AC008575 Genomic DNA No translation available. CH471086 Genomic DNA Translation: EAW48994.1 CH471086 Genomic DNA Translation: EAW48995.1 BC000232 mRNA Translation: AAH00232.2 BC065926 mRNA Translation: AAH65926.1 Different initiation. |
CCDSi | CCDS4109.2 [Q00765-1] |
PIRi | A39658 |
RefSeqi | NP_005660.4, NM_005669.4 [Q00765-1] |
Genome annotation databases
Ensembli | ENST00000379638; ENSP00000368959; ENSG00000129625 [Q00765-1] |
GeneIDi | 7905 |
KEGGi | hsa:7905 |
UCSCi | uc003kqe.2, human [Q00765-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M73547 mRNA Translation: AAA60136.1 Different initiation. M74090 mRNA Translation: AAA66351.1 Different initiation. AY562243 mRNA Translation: AAT70688.1 AK299902 mRNA Translation: BAH13167.1 AC008536 Genomic DNA No translation available. AC008575 Genomic DNA No translation available. CH471086 Genomic DNA Translation: EAW48994.1 CH471086 Genomic DNA Translation: EAW48995.1 BC000232 mRNA Translation: AAH00232.2 BC065926 mRNA Translation: AAH65926.1 Different initiation. |
CCDSi | CCDS4109.2 [Q00765-1] |
PIRi | A39658 |
RefSeqi | NP_005660.4, NM_005669.4 [Q00765-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 113637, 105 interactors |
CORUMi | Q00765 |
IntActi | Q00765, 90 interactors |
MINTi | Q00765 |
STRINGi | 9606.ENSP00000368959 |
Chemistry databases
ChEMBLi | CHEMBL4295797 |
PTM databases
iPTMneti | Q00765 |
PhosphoSitePlusi | Q00765 |
SwissPalmi | Q00765 |
Genetic variation databases
BioMutai | REEP5 |
DMDMi | 82654932 |
Proteomic databases
EPDi | Q00765 |
jPOSTi | Q00765 |
MassIVEi | Q00765 |
MaxQBi | Q00765 |
PaxDbi | Q00765 |
PeptideAtlasi | Q00765 |
PRIDEi | Q00765 |
ProteomicsDBi | 57872 [Q00765-1] 6755 |
TopDownProteomicsi | Q00765-1 [Q00765-1] |
Protocols and materials databases
Antibodypediai | 25369, 275 antibodies |
DNASUi | 7905 |
Genome annotation databases
Ensembli | ENST00000379638; ENSP00000368959; ENSG00000129625 [Q00765-1] |
GeneIDi | 7905 |
KEGGi | hsa:7905 |
UCSCi | uc003kqe.2, human [Q00765-1] |
Organism-specific databases
CTDi | 7905 |
DisGeNETi | 7905 |
GeneCardsi | REEP5 |
HGNCi | HGNC:30077, REEP5 |
HPAi | ENSG00000129625, Low tissue specificity |
MIMi | 125265, gene |
neXtProti | NX_Q00765 |
OpenTargetsi | ENSG00000129625 |
PharmGKBi | PA134882361 |
VEuPathDBi | HostDB:ENSG00000129625.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1725, Eukaryota |
GeneTreei | ENSGT00940000157873 |
InParanoidi | Q00765 |
OMAi | LYYFPWY |
OrthoDBi | 1473891at2759 |
PhylomeDBi | Q00765 |
TreeFami | TF314913 |
Enzyme and pathway databases
PathwayCommonsi | Q00765 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
SIGNORi | Q00765 |
Miscellaneous databases
BioGRID-ORCSi | 7905, 9 hits in 874 CRISPR screens |
ChiTaRSi | REEP5, human |
GeneWikii | REEP5 |
GenomeRNAii | 7905 |
Pharosi | Q00765, Tbio |
PROi | PR:Q00765 |
RNActi | Q00765, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000129625, Expressed in middle temporal gyrus and 258 other tissues |
ExpressionAtlasi | Q00765, baseline and differential |
Genevisiblei | Q00765, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004345, TB2_DP1_HVA22 |
PANTHERi | PTHR12300, PTHR12300, 1 hit |
Pfami | View protein in Pfam PF03134, TB2_DP1_HVA22, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | REEP5_HUMAN | |
Accessioni | Q00765Primary (citable) accession number: Q00765 Secondary accession number(s): B7Z681 Q9BWH9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | November 22, 2005 | |
Last modified: | February 10, 2021 | |
This is version 167 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM