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Entry version 117 (29 Sep 2021)
Sequence version 2 (26 May 2009)
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Protein

Chitin synthase B

Gene

chsB

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell wall biogenesis/degradation

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.1.16, 517

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT2, Glycosyltransferase Family 2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chitin synthase B (EC:2.4.1.16)
Alternative name(s):
Chitin-UDP acetyl-glucosaminyl transferase B
Class-III chitin synthase B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:chsB
ORF Names:AN2523
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri227321 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Nidulantes
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000560 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VII
  • UP000005890 Componenti: Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:AN2523

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei544 – 561HelicalSequence analysisAdd BLAST18
Transmembranei588 – 608HelicalSequence analysisAdd BLAST21
Transmembranei629 – 649HelicalSequence analysisAdd BLAST21
Transmembranei664 – 684HelicalSequence analysisAdd BLAST21
Transmembranei716 – 736HelicalSequence analysisAdd BLAST21
Transmembranei845 – 865HelicalSequence analysisAdd BLAST21
Transmembranei884 – 904HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001936921 – 916Chitin synthase BAdd BLAST916

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
162425.CADANIAP00009248

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 75DisorderedSequence analysisAdd BLAST75
Regioni118 – 141DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi16 – 31Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi32 – 51Polar residuesSequence analysisAdd BLAST20
Compositional biasi60 – 75Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2571, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004760_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q00757

Identification of Orthologs from Complete Genome Data

More...
OMAi
FWIFSNA

Database of Orthologous Groups

More...
OrthoDBi
256142at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004835, Chitin_synth
IPR004834, Chitin_synth_fun
IPR013616, Chitin_synth_N
IPR029044, Nucleotide-diphossugar_trans

The PANTHER Classification System

More...
PANTHERi
PTHR22914, PTHR22914, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01644, Chitin_synth_1, 1 hit
PF08407, Chitin_synth_1N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53448, SSF53448, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q00757-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYHGSGPQS PGEHTYDDGH QLRDLSHSNT SYEEEASHGL LSSQQSPFAG
60 70 80 90 100
PFDDPHQQRG LTASPVQRPT SGYSLTESYA PDAAYHDPYS ANQSVYSGHS
110 120 130 140 150
ENPAAAFGVP GRVASPYARS ETSSTEAWRQ RQAGAAGGGN GLRRYATRKV
160 170 180 190 200
KLVQGSVLSV DYPVPSAIQN AIQAKYRNDL EGGSEEFTHM RYTAATCDPN
210 220 230 240 250
EFTLHNGYNL RPAMYNRHTE LLIAITYYNE DKTLTARTLH GVMQNIRDIV
260 270 280 290 300
NLKKSEFWNK GGPAWQKIVV CLVFDGIDPC DKDTLDVLAT VGIYQDGVMK
310 320 330 340 350
RDVDGKETVA HIFEYTTQLS VTPNQQLIRP TDDGPSTLPP VQMMFCLKQK
360 370 380 390 400
NSKKINSHRW LFNAFGRILN PEVCILLDAG TKPGPKSLLY LWEAFYNDKD
410 420 430 440 450
LGGACGEIHA MLGKGWKKLL NPLVAAQNFE YKISNILDKP LESSFGYVSV
460 470 480 490 500
LPGAFSAYRF RAIMGRPLEQ YFHGDHTLSK QLGKKGIEGM NIFKKNMFLA
510 520 530 540 550
EDRILCFELV AKAGSKWHLS YVKASKGETD VPEGAPEFIS QRRRWLNGSF
560 570 580 590 600
AAGIYSLMHF GRMYKSGHNI VRMFFLHLQM LYNWFSTFLT WFSLASYWLT
610 620 630 640 650
TSVIMDLVGT PSSSNGYTAF PFGKTATPII NTLVKYIYLA FLLLQFILAL
660 670 680 690 700
GNRPKGSKLS YLASFVAFGI IQLYVVVDAL YLVVRAFTGG APMDFNTDDG
710 720 730 740 750
IGAFLSSFFG SSGAGIIIIA LAATFGLYFV ASFMYLDPWH MFTSFPAYMA
760 770 780 790 800
VQSSYINILN VYAFSNWHDV SWGTKGSDKA DALPSAKTTG GKGEEAVIEE
810 820 830 840 850
IDKPQADIDS QFEATVKRAL TPYVPPEEKE EKSLDDSYKS FRTRLVTLWL
860 870 880 890 900
FSNGLLAVCI TSEGLDKFGF TNTSTERTSR FFQALLWSNA VVALIRFIGA
910
TWFLGKTGLL CCFARR
Length:916
Mass (Da):101,882
Last modified:May 26, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i622356DC99AA4B5E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti136 – 137AG → RR in BAA04807 (PubMed:7765508).Curated2
Sequence conflicti136 – 137AG → RR in BAA11845 (Ref. 2) Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D21269 Genomic DNA Translation: BAA04807.1
D83216 mRNA Translation: BAA11845.1
AACD01000043 Genomic DNA Translation: EAA64628.1
BN001307 Genomic DNA Translation: CBF87020.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC2315

NCBI Reference Sequences

More...
RefSeqi
XP_660127.1, XM_655035.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CBF87020; CBF87020; ANIA_02523
EAA64628; EAA64628; AN2523.2

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2874737

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ani:AN2523.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21269 Genomic DNA Translation: BAA04807.1
D83216 mRNA Translation: BAA11845.1
AACD01000043 Genomic DNA Translation: EAA64628.1
BN001307 Genomic DNA Translation: CBF87020.1
PIRiJC2315
RefSeqiXP_660127.1, XM_655035.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi162425.CADANIAP00009248

Protein family/group databases

CAZyiGT2, Glycosyltransferase Family 2

Genome annotation databases

EnsemblFungiiCBF87020; CBF87020; ANIA_02523
EAA64628; EAA64628; AN2523.2
GeneIDi2874737
KEGGiani:AN2523.2

Organism-specific databases

VEuPathDBiFungiDB:AN2523

Phylogenomic databases

eggNOGiKOG2571, Eukaryota
HOGENOMiCLU_004760_0_1_1
InParanoidiQ00757
OMAiFWIFSNA
OrthoDBi256142at2759

Enzyme and pathway databases

BRENDAi2.4.1.16, 517

Family and domain databases

InterProiView protein in InterPro
IPR004835, Chitin_synth
IPR004834, Chitin_synth_fun
IPR013616, Chitin_synth_N
IPR029044, Nucleotide-diphossugar_trans
PANTHERiPTHR22914, PTHR22914, 1 hit
PfamiView protein in Pfam
PF01644, Chitin_synth_1, 1 hit
PF08407, Chitin_synth_1N, 1 hit
SUPFAMiSSF53448, SSF53448, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHSB_EMENI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q00757
Secondary accession number(s): C8VPK2, P87326, Q5BAA7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 26, 2009
Last modified: September 29, 2021
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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