Retinol-binding protein 4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• protein-containing complex binding Source: MGI
• retinal binding Source: UniProtKB-KW
• retinol binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Retinol-binding protein-deficient mice: biochemical basis for impaired vision."
    Vogel S., Piantedosi R., O'Byrne S.M., Kako Y., Quadro L., Gottesman M.E., Goldberg I.J., Blaner W.S.
    Biochemistry 41:15360-15368(2002) [PubMed] [Europe PMC] [Abstract]
• retinol transmembrane transporter activity Source: InterPro

GO - Biological processⁱ

• cardiac muscle tissue development Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Increased fibronectin deposition in embryonic hearts of retinol-binding protein-null mice."
    Wendler C.C., Schmoldt A., Flentke G.R., Case L.C., Quadro L., Blaner W.S., Lough J., Smith S.M.
    Circ Res 92:920-928(2003) [PubMed] [Europe PMC] [Abstract]
• detection of light stimulus involved in visual perception Source: MGIInferred from mutant phenotypeⁱ
  • "Retinol-binding protein-deficient mice: biochemical basis for impaired vision."
    Vogel S., Piantedosi R., O'Byrne S.M., Kako Y., Quadro L., Gottesman M.E., Goldberg I.J., Blaner W.S.
    Biochemistry 41:15360-15368(2002) [PubMed] [Europe PMC] [Abstract]
• embryonic organ morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiency."
    Quadro L., Hamberger L., Gottesman M.E., Wang F., Colantuoni V., Blaner W.S., Mendelsohn C.L.
    Endocrinology 146:4479-4490(2005) [PubMed] [Europe PMC] [Abstract]
• embryonic retina morphogenesis in camera-type eye Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein."
    Quadro L., Blaner W.S., Salchow D.J., Vogel S., Piantedosi R., Gouras P., Freeman S., Cosma M.P., Colantuoni V., Gottesman M.E.
    EMBO J 18:4633-4644(1999) [PubMed] [Europe PMC] [Abstract]
• embryonic skeletal system development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiency."
    Quadro L., Hamberger L., Gottesman M.E., Wang F., Colantuoni V., Blaner W.S., Mendelsohn C.L.
    Endocrinology 146:4479-4490(2005) [PubMed] [Europe PMC] [Abstract]
• eye development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiency."
    Quadro L., Hamberger L., Gottesman M.E., Wang F., Colantuoni V., Blaner W.S., Mendelsohn C.L.
    Endocrinology 146:4479-4490(2005) [PubMed] [Europe PMC] [Abstract]
• female genitalia morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiency."
    Quadro L., Hamberger L., Gottesman M.E., Wang F., Colantuoni V., Blaner W.S., Mendelsohn C.L.
    Endocrinology 146:4479-4490(2005) [PubMed] [Europe PMC] [Abstract]
• gluconeogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes."
    Yang Q., Graham T.E., Mody N., Preitner F., Peroni O.D., Zabolotny J.M., Kotani K., Quadro L., Kahn B.B.
    Nature 436:356-362(2005) [PubMed] [Europe PMC] [Abstract]
• glucose homeostasis Source: MGI
• heart development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiency."
    Quadro L., Hamberger L., Gottesman M.E., Wang F., Colantuoni V., Blaner W.S., Mendelsohn C.L.
    Endocrinology 146:4479-4490(2005) [PubMed] [Europe PMC] [Abstract]
• heart trabecula formation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Increased fibronectin deposition in embryonic hearts of retinol-binding protein-null mice."
    Wendler C.C., Schmoldt A., Flentke G.R., Case L.C., Quadro L., Blaner W.S., Lough J., Smith S.M.
    Circ Res 92:920-928(2003) [PubMed] [Europe PMC] [Abstract]
• lung development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiency."
    Quadro L., Hamberger L., Gottesman M.E., Wang F., Colantuoni V., Blaner W.S., Mendelsohn C.L.
    Endocrinology 146:4479-4490(2005) [PubMed] [Europe PMC] [Abstract]
• maintenance of gastrointestinal epithelium Source: MGI
• male gonad development Source: MGIInferred from mutant phenotypeⁱ
  • "Retinoids and spermatogenesis: lessons from mutant mice lacking the plasma retinol binding protein."
    Ghyselinck N.B., Vernet N., Dennefeld C., Giese N., Nau H., Chambon P., Viville S., Mark M.
    Dev Dyn 235:1608-1622(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cardiac muscle cell proliferation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Increased fibronectin deposition in embryonic hearts of retinol-binding protein-null mice."
    Wendler C.C., Schmoldt A., Flentke G.R., Case L.C., Quadro L., Blaner W.S., Lough J., Smith S.M.
    Circ Res 92:920-928(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of immunoglobulin production Source: BHF-UCLInferred from direct assayⁱ
  • "Retinol and retinol-binding protein: gut integrity and circulating immunoglobulins."
    Quadro L., Gamble M.V., Vogel S., Lima A.A., Piantedosi R., Moore S.R., Colantuoni V., Gottesman M.E., Guerrant R.L., Blaner W.S.
    J Infect Dis 182 Suppl 1:S97-S102(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of insulin secretion Source: MGI
• response to insulin Source: MGIInferred from mutant phenotypeⁱ
  • "Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes."
    Yang Q., Graham T.E., Mody N., Preitner F., Peroni O.D., Zabolotny J.M., Kotani K., Quadro L., Kahn B.B.
    Nature 436:356-362(2005) [PubMed] [Europe PMC] [Abstract]
• response to retinoic acid Source: MGI
• retina development in camera-type eye Source: MGIInferred from mutant phenotypeⁱ
  • "Preservation of light signaling to the suprachiasmatic nucleus in vitamin A-deficient mice."
    Thompson C.L., Blaner W.S., Van Gelder R.N., Lai K., Quadro L., Colantuoni V., Gottesman M.E., Sancar A.
    Proc Natl Acad Sci U S A 98:11708-11713(2001) [PubMed] [Europe PMC] [Abstract]
• retinal metabolic process Source: MGIInferred from mutant phenotypeⁱ
  • "Preservation of light signaling to the suprachiasmatic nucleus in vitamin A-deficient mice."
    Thompson C.L., Blaner W.S., Van Gelder R.N., Lai K., Quadro L., Colantuoni V., Gottesman M.E., Sancar A.
    Proc Natl Acad Sci U S A 98:11708-11713(2001) [PubMed] [Europe PMC] [Abstract]
• retinol metabolic process Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis."
    Kim Y.K., Wassef L., Hamberger L., Piantedosi R., Palczewski K., Blaner W.S., Quadro L.
    J Biol Chem 283:5611-5621(2008) [PubMed] [Europe PMC] [Abstract]
• retinol transport Source: MGIInferred from mutant phenotypeⁱ
  • "Preservation of light signaling to the suprachiasmatic nucleus in vitamin A-deficient mice."
    Thompson C.L., Blaner W.S., Van Gelder R.N., Lai K., Quadro L., Colantuoni V., Gottesman M.E., Sancar A.
    Proc Natl Acad Sci U S A 98:11708-11713(2001) [PubMed] [Europe PMC] [Abstract]
  • "Retinol-binding protein-deficient mice: biochemical basis for impaired vision."
    Vogel S., Piantedosi R., O'Byrne S.M., Kako Y., Quadro L., Gottesman M.E., Goldberg I.J., Blaner W.S.
    Biochemistry 41:15360-15368(2002) [PubMed] [Europe PMC] [Abstract]
  • "The role of extrahepatic retinol binding protein in the mobilization of retinoid stores."
    Quadro L., Blaner W.S., Hamberger L., Novikoff P.M., Vogel S., Piantedosi R., Gottesman M.E., Colantuoni V.
    J Lipid Res 45:1975-1982(2004) [PubMed] [Europe PMC] [Abstract]
  • "Retinoids and spermatogenesis: lessons from mutant mice lacking the plasma retinol binding protein."
    Ghyselinck N.B., Vernet N., Dennefeld C., Giese N., Nau H., Chambon P., Viville S., Mark M.
    Dev Dyn 235:1608-1622(2006) [PubMed] [Europe PMC] [Abstract]
  • "Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis."
    Kim Y.K., Wassef L., Hamberger L., Piantedosi R., Palczewski K., Blaner W.S., Quadro L.
    J Biol Chem 283:5611-5621(2008) [PubMed] [Europe PMC] [Abstract]
• spermatogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Retinoids and spermatogenesis: lessons from mutant mice lacking the plasma retinol binding protein."
    Ghyselinck N.B., Vernet N., Dennefeld C., Giese N., Nau H., Chambon P., Viville S., Mark M.
    Dev Dyn 235:1608-1622(2006) [PubMed] [Europe PMC] [Abstract]
• urinary bladder development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiency."
    Quadro L., Hamberger L., Gottesman M.E., Wang F., Colantuoni V., Blaner W.S., Mendelsohn C.L.
    Endocrinology 146:4479-4490(2005) [PubMed] [Europe PMC] [Abstract]
• uterus development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiency."
    Quadro L., Hamberger L., Gottesman M.E., Wang F., Colantuoni V., Blaner W.S., Mendelsohn C.L.
    Endocrinology 146:4479-4490(2005) [PubMed] [Europe PMC] [Abstract]
• vagina development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiency."
    Quadro L., Hamberger L., Gottesman M.E., Wang F., Colantuoni V., Blaner W.S., Mendelsohn C.L.
    Endocrinology 146:4479-4490(2005) [PubMed] [Europe PMC] [Abstract]
• vitamin A import Source: MGIInferred from mutant phenotypeⁱ
  • "Retinol-binding protein-deficient mice: biochemical basis for impaired vision."
    Vogel S., Piantedosi R., O'Byrne S.M., Kako Y., Quadro L., Gottesman M.E., Goldberg I.J., Blaner W.S.
    Biochemistry 41:15360-15368(2002) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MEWVWALVLL AALGGGSAER DCRVSSFRVK ENFDKARFSG LWYAIAKKDP 
        60         70         80         90        100
EGLFLQDNII AEFSVDEKGH MSATAKGRVR LLSNWEVCAD MVGTFTDTED 
       110        120        130        140        150
PAKFKMKYWG VASFLQRGND DHWIIDTDYD TFALQYSCRL QNLDGTCADS 
       160        170        180        190        200
YSFVFSRDPN GLSPETRRLV RQRQEELCLE RQYRWIEHNG YCQSRPSRNS 

L                                                      

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families