UniProtKB - Q00724 (RET4_MOUSE)
Retinol-binding protein 4
Rbp4
Functioni
Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 116 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- protein-containing complex binding Source: MGI
- retinal binding Source: UniProtKB-KW
- retinol binding Source: MGI
- retinol transmembrane transporter activity Source: InterPro
GO - Biological processi
- cardiac muscle tissue development Source: BHF-UCL
- detection of light stimulus involved in visual perception Source: MGI
- embryonic organ morphogenesis Source: BHF-UCL
- embryonic retina morphogenesis in camera-type eye Source: BHF-UCL
- embryonic skeletal system development Source: BHF-UCL
- eye development Source: BHF-UCL
- female genitalia morphogenesis Source: BHF-UCL
- gluconeogenesis Source: BHF-UCL
- glucose homeostasis Source: MGI
- heart development Source: BHF-UCL
- heart trabecula formation Source: BHF-UCL
- lung development Source: BHF-UCL
- maintenance of gastrointestinal epithelium Source: MGI
- male gonad development Source: MGI
- negative regulation of cardiac muscle cell proliferation Source: BHF-UCL
- positive regulation of immunoglobulin production Source: BHF-UCL
- positive regulation of insulin secretion Source: MGI
- response to insulin Source: MGI
- response to retinoic acid Source: MGI
- retina development in camera-type eye Source: MGI
- retinal metabolic process Source: MGI
- retinol metabolic process Source: MGI
- retinol transport Source: MGI
- spermatogenesis Source: MGI
- urinary bladder development Source: BHF-UCL
- uterus development Source: BHF-UCL
- vagina development Source: BHF-UCL
- vitamin A import Source: MGI
Keywordsi
Biological process | Transport |
Ligand | Retinol-binding, Vitamin A |
Enzyme and pathway databases
Reactomei | R-MMU-2453902, The canonical retinoid cycle in rods (twilight vision) R-MMU-975634, Retinoid metabolism and transport |
Names & Taxonomyi
Protein namesi | Recommended name: Retinol-binding protein 4Alternative name(s): Plasma retinol-binding protein Short name: PRBP Short name: RBP |
Gene namesi | Name:Rbp4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97879, Rbp4 |
VEuPathDBi | HostDB:ENSMUSG00000024990 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: BHF-UCL
Other locations
- protein-containing complex Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | By similarityAdd BLAST | 18 | |
ChainiPRO_0000017966 | 19 – 201 | Retinol-binding protein 4Add BLAST | 183 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 22 ↔ 178 | By similarity | ||
Disulfide bondi | 88 ↔ 192 | By similarity | ||
Disulfide bondi | 138 ↔ 147 | By similarity | ||
Modified residuei | 139 | Omega-N-methylarginineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, MethylationProteomic databases
CPTACi | non-CPTAC-3736 |
EPDi | Q00724 |
jPOSTi | Q00724 |
MaxQBi | Q00724 |
PaxDbi | Q00724 |
PRIDEi | Q00724 |
ProteomicsDBi | 255289 |
PTM databases
iPTMneti | Q00724 |
PhosphoSitePlusi | Q00724 |
SwissPalmi | Q00724 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000024990, Expressed in liver and 241 other tissues |
ExpressionAtlasi | Q00724, baseline and differential |
Genevisiblei | Q00724, MM |
Interactioni
Subunit structurei
Interacts with TTR. Interaction with TTR prevents its loss by filtration through the kidney glomeruli.
Interacts with STRA6.
By similarityProtein-protein interaction databases
BioGRIDi | 202830, 3 interactors |
STRINGi | 10090.ENSMUSP00000025951 |
Miscellaneous databases
RNActi | Q00724, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502RXEW, Eukaryota |
GeneTreei | ENSGT00510000047107 |
HOGENOMi | CLU_094618_0_0_1 |
InParanoidi | Q00724 |
OMAi | FATFEDT |
OrthoDBi | 1631943at2759 |
PhylomeDBi | Q00724 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR022271, Lipocalin_ApoD IPR022272, Lipocalin_CS IPR000566, Lipocln_cytosolic_FA-bd_dom IPR002449, Retinol-bd/Purpurin |
PANTHERi | PTHR11873, PTHR11873, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PIRSFi | PIRSF036893, Lipocalin_ApoD, 1 hit PIRSF500204, RBP_purpurin, 1 hit |
PRINTSi | PR01174, RETINOLBNDNG |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00213, LIPOCALIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MEWVWALVLL AALGGGSAER DCRVSSFRVK ENFDKARFSG LWYAIAKKDP
60 70 80 90 100
EGLFLQDNII AEFSVDEKGH MSATAKGRVR LLSNWEVCAD MVGTFTDTED
110 120 130 140 150
PAKFKMKYWG VASFLQRGND DHWIIDTDYD TFALQYSCRL QNLDGTCADS
160 170 180 190 200
YSFVFSRDPN GLSPETRRLV RQRQEELCLE RQYRWIEHNG YCQSRPSRNS
L
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7BWY6 | H7BWY6_MOUSE | Plasma retinol-binding protein | Rbp4 | 245 | Annotation score: | ||
A0A494B9P3 | A0A494B9P3_MOUSE | Plasma retinol-binding protein | Rbp4 | 104 | Annotation score: | ||
A0A494B9T2 | A0A494B9T2_MOUSE | Retinol-binding protein 4 | Rbp4 | 122 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 17 | S → T in AAA63395 (PubMed:1613076).Curated | 1 | |
Sequence conflicti | 20 | R → P in AAA63395 (PubMed:1613076).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U63146 mRNA Translation: AAB06955.1 AB124638 Genomic DNA Translation: BAD16678.1 AK008765 mRNA Translation: BAB25881.1 BC031809 mRNA Translation: AAH31809.1 BC093529 mRNA Translation: AAH93529.1 M74527 mRNA Translation: AAA63395.1 |
CCDSi | CCDS29784.1 |
RefSeqi | NP_001152959.1, NM_001159487.1 NP_035385.1, NM_011255.3 |
Genome annotation databases
Ensembli | ENSMUST00000112335; ENSMUSP00000107954; ENSMUSG00000024990 |
GeneIDi | 19662 |
KEGGi | mmu:19662 |
UCSCi | uc008hjd.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U63146 mRNA Translation: AAB06955.1 AB124638 Genomic DNA Translation: BAD16678.1 AK008765 mRNA Translation: BAB25881.1 BC031809 mRNA Translation: AAH31809.1 BC093529 mRNA Translation: AAH93529.1 M74527 mRNA Translation: AAA63395.1 |
CCDSi | CCDS29784.1 |
RefSeqi | NP_001152959.1, NM_001159487.1 NP_035385.1, NM_011255.3 |
3D structure databases
SMRi | Q00724 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 202830, 3 interactors |
STRINGi | 10090.ENSMUSP00000025951 |
PTM databases
iPTMneti | Q00724 |
PhosphoSitePlusi | Q00724 |
SwissPalmi | Q00724 |
Proteomic databases
CPTACi | non-CPTAC-3736 |
EPDi | Q00724 |
jPOSTi | Q00724 |
MaxQBi | Q00724 |
PaxDbi | Q00724 |
PRIDEi | Q00724 |
ProteomicsDBi | 255289 |
Protocols and materials databases
Antibodypediai | 885, 1420 antibodies from 45 providers |
DNASUi | 19662 |
Genome annotation databases
Ensembli | ENSMUST00000112335; ENSMUSP00000107954; ENSMUSG00000024990 |
GeneIDi | 19662 |
KEGGi | mmu:19662 |
UCSCi | uc008hjd.2, mouse |
Organism-specific databases
CTDi | 5950 |
MGIi | MGI:97879, Rbp4 |
VEuPathDBi | HostDB:ENSMUSG00000024990 |
Phylogenomic databases
eggNOGi | ENOG502RXEW, Eukaryota |
GeneTreei | ENSGT00510000047107 |
HOGENOMi | CLU_094618_0_0_1 |
InParanoidi | Q00724 |
OMAi | FATFEDT |
OrthoDBi | 1631943at2759 |
PhylomeDBi | Q00724 |
Enzyme and pathway databases
Reactomei | R-MMU-2453902, The canonical retinoid cycle in rods (twilight vision) R-MMU-975634, Retinoid metabolism and transport |
Miscellaneous databases
BioGRID-ORCSi | 19662, 0 hits in 65 CRISPR screens |
ChiTaRSi | Rbp4, mouse |
PROi | PR:Q00724 |
RNActi | Q00724, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024990, Expressed in liver and 241 other tissues |
ExpressionAtlasi | Q00724, baseline and differential |
Genevisiblei | Q00724, MM |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR022271, Lipocalin_ApoD IPR022272, Lipocalin_CS IPR000566, Lipocln_cytosolic_FA-bd_dom IPR002449, Retinol-bd/Purpurin |
PANTHERi | PTHR11873, PTHR11873, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PIRSFi | PIRSF036893, Lipocalin_ApoD, 1 hit PIRSF500204, RBP_purpurin, 1 hit |
PRINTSi | PR01174, RETINOLBNDNG |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00213, LIPOCALIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RET4_MOUSE | |
Accessioni | Q00724Primary (citable) accession number: Q00724 Secondary accession number(s): P70357, Q566I5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | December 15, 1998 | |
Last modified: | February 23, 2022 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families