PLCB2

Functionⁱ

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

2 Publications

Miscellaneous

The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha-16.

Catalytic activityⁱ

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H₂O
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
=
1D-myo-inositol 1,4,5-trisphosphate
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
a 1,2-diacyl-sn-glycerol
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs."
  Tall E., Dorman G., Garcia P., Runnels L., Shah S., Chen J., Profit A., Gu Q.M., Chaudhary A., Prestwich G.D., Rebecchi M.J.
  Biochemistry 36:7239-7248(1997) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY.
EC:
3.1.4.11
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
- Search reactions for this EC number in Rhea.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs."
  Tall E., Dorman G., Garcia P., Runnels L., Shah S., Chen J., Profit A., Gu Q.M., Chaudhary A., Prestwich G.D., Rebecchi M.J.
  Biochemistry 36:7239-7248(1997) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY.
This reaction proceeds in the
forward
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
1 Publication
Manual assertion inferred by curator fromⁱ
- Ref.5
  "Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs."
  Tall E., Dorman G., Garcia P., Runnels L., Shah S., Chen J., Profit A., Gu Q.M., Chaudhary A., Prestwich G.D., Rebecchi M.J.
  Biochemistry 36:7239-7248(1997) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY.
direction.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)
zoom
+
H₂O
=
1D-myo-inositol 1,4,5-trisphosphate
zoom
+
a 1,2-diacyl-sn-glycerol
zoom
+
H⁺
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H₂O
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
=
1D-myo-inositol 1-phosphate
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
a 1,2-diacyl-sn-glycerol
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.1
  "Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2."
  Park D., Jhon D.-Y., Kriz R., Knopf J., Rhee S.G.
  J. Biol. Chem. 267:16048-16055(1992) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH RAC1, CATALYTIC ACTIVITY.
This reaction proceeds in the
forward
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
1 Publication
Manual assertion inferred by curator fromⁱ
- Ref.1
  "Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2."
  Park D., Jhon D.-Y., Kriz R., Knopf J., Rhee S.G.
  J. Biol. Chem. 267:16048-16055(1992) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH RAC1, CATALYTIC ACTIVITY.
direction.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)
zoom
+
H₂O
=
1D-myo-inositol 1-phosphate
zoom
+
a 1,2-diacyl-sn-glycerol
zoom
+
H⁺

Cofactorⁱ

Ca²⁺Note: Binds 1 Ca²⁺ ion per subunit.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	327	PROSITE-ProRule annotation	1
Metal bindingⁱ	328	Calcium	1
Metal bindingⁱ	357	Calcium	1
Metal bindingⁱ	359	Calcium	1
Active siteⁱ	374	PROSITE-ProRule annotation	1
Metal bindingⁱ	408	Calcium	1

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Transducer
Biological process	Lipid degradation, Lipid metabolism
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS06408-MONOMER
BRENDAⁱ	3.1.4.11, 2681
PathwayCommonsⁱ	Q00722
Reactomeⁱ	R-HSA-112043, PLC beta mediated events R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol R-HSA-399997, Acetylcholine regulates insulin secretion R-HSA-4086398, Ca2+ pathway R-HSA-416476, G alpha (q) signalling events R-HSA-418217, G beta:gamma signalling through PLC beta R-HSA-434316, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-500657, Presynaptic function of Kainate receptors
SABIO-RKⁱ	Q00722
SignaLinkⁱ	Q00722
SIGNORⁱ	Q00722

Chemistry databases

SwissLipidsⁱ	SLP:000000948

SwissLipidsⁱ

SLP:000000948

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2Curated (EC:3.1.4.111 Publication) Alternative name(s): Phosphoinositide phospholipase C-beta-2 Phospholipase C-beta-2 Short name: PLC-beta-2
Gene namesⁱ	Name:PLCB2Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9055, PLCB2
MIMⁱ	604114, gene
neXtProtⁱ	NX_Q00722
VEuPathDBⁱ	HostDB:ENSG00000137841.11

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	52	Q → A: Strongly reduces interaction with RAC1. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5330
Open Targets More...OpenTargetsⁱ	ENSG00000137841
PharmGKBⁱ	PA33385

Miscellaneous databases

Pharosⁱ	Q00722, Tbio

Pharosⁱ

Q00722, Tbio

Genetic variation databases

BioMutaⁱ	PLCB2
DMDMⁱ	215273902

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000088489	1 – 1185	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2Add BLAST		1185

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	953	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q00722
jPOSTⁱ	Q00722
MassIVEⁱ	Q00722
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q00722
PaxDbⁱ	Q00722
PeptideAtlas More...PeptideAtlasⁱ	Q00722
PRIDEⁱ	Q00722
ProteomicsDBⁱ	57870 [Q00722-1] 57871 [Q00722-2] 7525

PTM databases

iPTMnetⁱ	Q00722
MetOSiteⁱ	Q00722
PhosphoSitePlusⁱ	Q00722

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000137841, Expressed in granulocyte and 161 other tissues
ExpressionAtlasⁱ	Q00722, baseline and differential
Genevisibleⁱ	Q00722, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000137841, Tissue enhanced (bone marrow, lymphoid tissue)

HPAⁱ

ENSG00000137841, Tissue enhanced (bone marrow, lymphoid tissue)

Interactionⁱ

Subunit structureⁱ

Interacts with RAC1 (PubMed:1644792).

Forms a complex composed of at least WDR26, a G-beta:gamma unit, and PLCB2 (PubMed:23625927).

2 Publications

Binary interactionsⁱ

Q00722

With	#Exp.	IntAct
CTNNAL1 [Q9UBT7]	3	EBI-968381,EBI-514206

Protein-protein interaction databases

BioGRIDⁱ	111346, 15 interactors
Database of interacting proteins More...DIPⁱ	DIP-29259N
IntActⁱ	Q00722, 4 interactors
STRINGⁱ	9606.ENSP00000260402

Miscellaneous databases

RNActⁱ	Q00722, protein

RNActⁱ

Q00722, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	15 – 19	Combined sources	5
Beta strandⁱ	21 – 26	Combined sources	6
Turnⁱ	28 – 30	Combined sources	3
Beta strandⁱ	33 – 40	Combined sources	8
Beta strandⁱ	46 – 51	Combined sources	6
Beta strandⁱ	56 – 60	Combined sources	5
Helixⁱ	61 – 63	Combined sources	3
Beta strandⁱ	64 – 69	Combined sources	6
Helixⁱ	70 – 72	Combined sources	3
Helixⁱ	79 – 84	Combined sources	6
Turnⁱ	85 – 88	Combined sources	4
Helixⁱ	94 – 96	Combined sources	3
Beta strandⁱ	98 – 103	Combined sources	6
Beta strandⁱ	105 – 109	Combined sources	5
Beta strandⁱ	111 – 121	Combined sources	11
Helixⁱ	122 – 135	Combined sources	14
Helixⁱ	139 – 141	Combined sources	3
Helixⁱ	144 – 157	Combined sources	14
Helixⁱ	167 – 173	Combined sources	7
Helixⁱ	178 – 187	Combined sources	10
Beta strandⁱ	193 – 195	Combined sources	3
Helixⁱ	200 – 202	Combined sources	3
Helixⁱ	205 – 215	Combined sources	11
Helixⁱ	219 – 222	Combined sources	4
Helixⁱ	238 – 247	Combined sources	10
Helixⁱ	267 – 274	Combined sources	8
Helixⁱ	288 – 296	Combined sources	9
Helixⁱ	305 – 308	Combined sources	4
Helixⁱ	318 – 320	Combined sources	3
Beta strandⁱ	321 – 323	Combined sources	3
Beta strandⁱ	325 – 328	Combined sources	4
Beta strandⁱ	331 – 333	Combined sources	3
Beta strandⁱ	335 – 338	Combined sources	4
Helixⁱ	343 – 350	Combined sources	8
Beta strandⁱ	355 – 361	Combined sources	7
Turnⁱ	365 – 368	Combined sources	4
Helixⁱ	384 – 394	Combined sources	11
Turnⁱ	395 – 397	Combined sources	3
Beta strandⁱ	403 – 409	Combined sources	7
Helixⁱ	414 – 428	Combined sources	15
Helixⁱ	429 – 431	Combined sources	3
Turnⁱ	451 – 456	Combined sources	6
Beta strandⁱ	458 – 461	Combined sources	4
Helixⁱ	523 – 531	Combined sources	9
Helixⁱ	534 – 538	Combined sources	5
Helixⁱ	544 – 547	Combined sources	4
Helixⁱ	561 – 567	Combined sources	7
Beta strandⁱ	572 – 577	Combined sources	6
Helixⁱ	578 – 587	Combined sources	10
Helixⁱ	589 – 598	Combined sources	10
Beta strandⁱ	599 – 604	Combined sources	6
Helixⁱ	618 – 622	Combined sources	5
Beta strandⁱ	626 – 628	Combined sources	3
Helixⁱ	637 – 645	Combined sources	9
Turnⁱ	646 – 648	Combined sources	3
Helixⁱ	649 – 651	Combined sources	3
Beta strandⁱ	653 – 656	Combined sources	4
Helixⁱ	659 – 661	Combined sources	3
Turnⁱ	675 – 680	Combined sources	6
Beta strandⁱ	682 – 693	Combined sources	12
Beta strandⁱ	701 – 708	Combined sources	8
Beta strandⁱ	724 – 726	Combined sources	3
Beta strandⁱ	738 – 745	Combined sources	8
Helixⁱ	746 – 748	Combined sources	3
Beta strandⁱ	750 – 757	Combined sources	8
Turnⁱ	758 – 760	Combined sources	3
Beta strandⁱ	761 – 769	Combined sources	9
Helixⁱ	770 – 772	Combined sources	3
Beta strandⁱ	776 – 783	Combined sources	8
Beta strandⁱ	789 – 802	Combined sources	14

Show more details

3D structure databases

SMRⁱ	Q00722
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q00722

EvolutionaryTraceⁱ

Q00722

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	312 – 463	PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST	152
Domainⁱ	546 – 662	PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST	117
Domainⁱ	662 – 790	C2PROSITE-ProRule annotationAdd BLAST	129

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	460 – 533	DisorderedSequence analysisAdd BLAST	74
Regionⁱ	859 – 888	DisorderedSequence analysisAdd BLAST	30
Regionⁱ	943 – 979	DisorderedSequence analysisAdd BLAST	37

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	988 – 1147	Sequence analysisAdd BLAST		160

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	464 – 481	Polar residuesSequence analysisAdd BLAST	18
Compositional biasⁱ	500 – 521	Acidic residuesSequence analysisAdd BLAST	22
Compositional biasⁱ	873 – 888	Basic and acidic residuesSequence analysisAdd BLAST	16

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG1265, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000159326
HOGENOMⁱ	CLU_002738_2_0_1
InParanoidⁱ	Q00722
OMAⁱ	TQNWAND
Database of Orthologous Groups More...OrthoDBⁱ	368239at2759
PhylomeDBⁱ	Q00722
TreeFamⁱ	TF313216

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd13361, PH_PLC_beta, 1 hit
Gene3Dⁱ	1.20.1230.10, 2 hits 2.60.40.150, 1 hit 3.20.20.190, 2 hits
InterProⁱ	View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR001192, PI-PLC_fam IPR016280, PLC-beta IPR028403, PLC-beta2 IPR014815, PLC-beta_C IPR042531, PLC-beta_C_sf IPR037862, PLC-beta_PH IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y
PANTHERⁱ	PTHR10336, PTHR10336, 1 hit PTHR10336:SF10, PTHR10336:SF10, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00168, C2, 1 hit PF09279, EF-hand_like, 1 hit PF17787, PH_14, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit PF08703, PLC-beta_C, 1 hit
PIRSFⁱ	PIRSF000956, PLC-beta, 1 hit
PRINTSⁱ	PR00390, PHPHLIPASEC
SMARTⁱ	View protein in SMART SM00239, C2, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit
SUPFAMⁱ	SSF47473, SSF47473, 1 hit SSF51695, SSF51695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50004, C2, 1 hit PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q00722-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLLNPVLLP PKVKAYLSQG ERFIKWDDET TVASPVILRV DPKGYYLYWT 
        60         70         80         90        100
YQSKEMEFLD ITSIRDTRFG KFAKMPKSQK LRDVFNMDFP DNSFLLKTLT 
       110        120        130        140        150
VVSGPDMVDL TFHNFVSYKE NVGKAWAEDV LALVKHPLTA NASRSTFLDK 
       160        170        180        190        200
ILVKLKMQLN SEGKIPVKNF FQMFPADRKR VEAALSACHL PKGKNDAINP 
       210        220        230        240        250
EDFPEPVYKS FLMSLCPRPE IDEIFTSYHA KAKPYMTKEH LTKFINQKQR 
       260        270        280        290        300
DSRLNSLLFP PARPDQVQGL IDKYEPSGIN AQRGQLSPEG MVWFLCGPEN 
       310        320        330        340        350
SVLAQDKLLL HHDMTQPLNH YFINSSHNTY LTAGQFSGLS SAEMYRQVLL 
       360        370        380        390        400
SGCRCVELDC WKGKPPDEEP IITHGFTMTT DIFFKEAIEA IAESAFKTSP 
       410        420        430        440        450
YPIILSFENH VDSPRQQAKM AEYCRTIFGD MLLTEPLEKF PLKPGVPLPS 
       460        470        480        490        500
PEDLRGKILI KNKKNQFSGP TSSSKDTGGE AEGSSPPSAP AGEGTVWAGE 
       510        520        530        540        550
EGTELEEEEV EEEEEEESGN LDEEEIKKMQ SDEGTAGLEV TAYEEMSSLV 
       560        570        580        590        600
NYIQPTKFVS FEFSAQKNRS YVISSFTELK AYDLLSKASV QFVDYNKRQM 
       610        620        630        640        650
SRIYPKGTRM DSSNYMPQMF WNAGCQMVAL NFQTMDLPMQ QNMAVFEFNG 
       660        670        680        690        700
QSGYLLKHEF MRRPDKQFNP FSVDRIDVVV ATTLSITVIS GQFLSERSVR 
       710        720        730        740        750
TYVEVELFGL PGDPKRRYRT KLSPSTNSIN PVWKEEPFVF EKILMPELAS 
       760        770        780        790        800
LRVAVMEEGN KFLGHRIIPI NALNSGYHHL CLHSESNMPL TMPALFIFLE 
       810        820        830        840        850
MKDYIPGAWA DLTVALANPI KFFSAHDTKS VKLKEAMGGL PEKPFPLASP 
       860        870        880        890        900
VASQVNGALA PTSNGSPAAR AGAREEAMKE AAEPRTASLE ELRELKGVVK 
       910        920        930        940        950
LQRRHEKELR ELERRGARRW EELLQRGAAQ LAELGPPGVG GVGACKLGPG 
       960        970        980        990       1000
KGSRKKRSLP REESAGAAPG EGPEGVDGRV RELKDRLELE LLRQGEEQYE 
      1010       1020       1030       1040       1050
CVLKRKEQHV AEQISKMMEL AREKQAAELK ALKETSENDT KEMKKKLETK 
      1060       1070       1080       1090       1100
RLERIQGMTK VTTDKMAQER LKREINNSHI QEVVQVIKQM TENLERHQEK 
      1110       1120       1130       1140       1150
LEEKQAACLE QIREMEKQFQ KEALAEYEAR MKGLEAEVKE SVRACLRTCF 
      1160       1170       1180 
PSEAKDKPER ACECPPELCE QDPLIAKADA QESRL

Length:1,185

Mass (Da):134,024

Last modified:November 25, 2008 - v2

Checksum:ⁱA0397309D943672A

GO

Isoform 2 (identifier: Q00722-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
492-495: Missing.

« Hide

        10         20         30         40         50
MSLLNPVLLP PKVKAYLSQG ERFIKWDDET TVASPVILRV DPKGYYLYWT 
        60         70         80         90        100
YQSKEMEFLD ITSIRDTRFG KFAKMPKSQK LRDVFNMDFP DNSFLLKTLT 
       110        120        130        140        150
VVSGPDMVDL TFHNFVSYKE NVGKAWAEDV LALVKHPLTA NASRSTFLDK 
       160        170        180        190        200
ILVKLKMQLN SEGKIPVKNF FQMFPADRKR VEAALSACHL PKGKNDAINP 
       210        220        230        240        250
EDFPEPVYKS FLMSLCPRPE IDEIFTSYHA KAKPYMTKEH LTKFINQKQR 
       260        270        280        290        300
DSRLNSLLFP PARPDQVQGL IDKYEPSGIN AQRGQLSPEG MVWFLCGPEN 
       310        320        330        340        350
SVLAQDKLLL HHDMTQPLNH YFINSSHNTY LTAGQFSGLS SAEMYRQVLL 
       360        370        380        390        400
SGCRCVELDC WKGKPPDEEP IITHGFTMTT DIFFKEAIEA IAESAFKTSP 
       410        420        430        440        450
YPIILSFENH VDSPRQQAKM AEYCRTIFGD MLLTEPLEKF PLKPGVPLPS 
       460        470        480        490        500
PEDLRGKILI KNKKNQFSGP TSSSKDTGGE AEGSSPPSAP AVWAGEEGTE 
       510        520        530        540        550
LEEEEVEEEE EEESGNLDEE EIKKMQSDEG TAGLEVTAYE EMSSLVNYIQ 
       560        570        580        590        600
PTKFVSFEFS AQKNRSYVIS SFTELKAYDL LSKASVQFVD YNKRQMSRIY 
       610        620        630        640        650
PKGTRMDSSN YMPQMFWNAG CQMVALNFQT MDLPMQQNMA VFEFNGQSGY 
       660        670        680        690        700
LLKHEFMRRP DKQFNPFSVD RIDVVVATTL SITVISGQFL SERSVRTYVE 
       710        720        730        740        750
VELFGLPGDP KRRYRTKLSP STNSINPVWK EEPFVFEKIL MPELASLRVA 
       760        770        780        790        800
VMEEGNKFLG HRIIPINALN SGYHHLCLHS ESNMPLTMPA LFIFLEMKDY 
       810        820        830        840        850
IPGAWADLTV ALANPIKFFS AHDTKSVKLK EAMGGLPEKP FPLASPVASQ 
       860        870        880        890        900
VNGALAPTSN GSPAARAGAR EEAMKEAAEP RTASLEELRE LKGVVKLQRR 
       910        920        930        940        950
HEKELRELER RGARRWEELL QRGAAQLAEL GPPGVGGVGA CKLGPGKGSR 
       960        970        980        990       1000
KKRSLPREES AGAAPGEGPE GVDGRVRELK DRLELELLRQ GEEQYECVLK 
      1010       1020       1030       1040       1050
RKEQHVAEQI SKMMELAREK QAAELKALKE TSENDTKEMK KKLETKRLER 
      1060       1070       1080       1090       1100
IQGMTKVTTD KMAQERLKRE INNSHIQEVV QVIKQMTENL ERHQEKLEEK 
      1110       1120       1130       1140       1150
QAACLEQIRE MEKQFQKEAL AEYEARMKGL EAEVKESVRA CLRTCFPSEA 
      1160       1170       1180 
KDKPERACEC PPELCEQDPL IAKADAQESR L

Show »

Length:1,181

Mass (Da):133,680

Checksum:ⁱ7A6889F204D17FA4

GO

Isoform 3 (identifier: Q00722-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
868-882: Missing.

« Hide

        10         20         30         40         50
MSLLNPVLLP PKVKAYLSQG ERFIKWDDET TVASPVILRV DPKGYYLYWT 
        60         70         80         90        100
YQSKEMEFLD ITSIRDTRFG KFAKMPKSQK LRDVFNMDFP DNSFLLKTLT 
       110        120        130        140        150
VVSGPDMVDL TFHNFVSYKE NVGKAWAEDV LALVKHPLTA NASRSTFLDK 
       160        170        180        190        200
ILVKLKMQLN SEGKIPVKNF FQMFPADRKR VEAALSACHL PKGKNDAINP 
       210        220        230        240        250
EDFPEPVYKS FLMSLCPRPE IDEIFTSYHA KAKPYMTKEH LTKFINQKQR 
       260        270        280        290        300
DSRLNSLLFP PARPDQVQGL IDKYEPSGIN AQRGQLSPEG MVWFLCGPEN 
       310        320        330        340        350
SVLAQDKLLL HHDMTQPLNH YFINSSHNTY LTAGQFSGLS SAEMYRQVLL 
       360        370        380        390        400
SGCRCVELDC WKGKPPDEEP IITHGFTMTT DIFFKEAIEA IAESAFKTSP 
       410        420        430        440        450
YPIILSFENH VDSPRQQAKM AEYCRTIFGD MLLTEPLEKF PLKPGVPLPS 
       460        470        480        490        500
PEDLRGKILI KNKKNQFSGP TSSSKDTGGE AEGSSPPSAP AGEGTVWAGE 
       510        520        530        540        550
EGTELEEEEV EEEEEEESGN LDEEEIKKMQ SDEGTAGLEV TAYEEMSSLV 
       560        570        580        590        600
NYIQPTKFVS FEFSAQKNRS YVISSFTELK AYDLLSKASV QFVDYNKRQM 
       610        620        630        640        650
SRIYPKGTRM DSSNYMPQMF WNAGCQMVAL NFQTMDLPMQ QNMAVFEFNG 
       660        670        680        690        700
QSGYLLKHEF MRRPDKQFNP FSVDRIDVVV ATTLSITVIS GQFLSERSVR 
       710        720        730        740        750
TYVEVELFGL PGDPKRRYRT KLSPSTNSIN PVWKEEPFVF EKILMPELAS 
       760        770        780        790        800
LRVAVMEEGN KFLGHRIIPI NALNSGYHHL CLHSESNMPL TMPALFIFLE 
       810        820        830        840        850
MKDYIPGAWA DLTVALANPI KFFSAHDTKS VKLKEAMGGL PEKPFPLASP 
       860        870        880        890        900
VASQVNGALA PTSNGSPEPR TASLEELREL KGVVKLQRRH EKELRELERR 
       910        920        930        940        950
GARRWEELLQ RGAAQLAELG PPGVGGVGAC KLGPGKGSRK KRSLPREESA 
       960        970        980        990       1000
GAAPGEGPEG VDGRVRELKD RLELELLRQG EEQYECVLKR KEQHVAEQIS 
      1010       1020       1030       1040       1050
KMMELAREKQ AAELKALKET SENDTKEMKK KLETKRLERI QGMTKVTTDK 
      1060       1070       1080       1090       1100
MAQERLKREI NNSHIQEVVQ VIKQMTENLE RHQEKLEEKQ AACLEQIREM 
      1110       1120       1130       1140       1150
EKQFQKEALA EYEARMKGLE AEVKESVRAC LRTCFPSEAK DKPERACECP 
      1160       1170
PELCEQDPLI AKADAQESRL

Show »

Length:1,170

Mass (Da):132,511

Checksum:ⁱBC9DC96247E5762D

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YNI4	H0YNI4_HUMAN	1-phosphatidylinositol 4,5-bisphosp... 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	PLCB2	74	Annotation score:
H0YKR9	H0YKR9_HUMAN	1-phosphatidylinositol 4,5-bisphosp... 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	PLCB2	87	Annotation score:
Q9BVT6	Q9BVT6_HUMAN	1-phosphatidylinositol 4,5-bisphosp... 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2 protein) (Phospholipase C, beta 2) (Phospholipase C, beta 2, isoform CRA_a)	PLCB2 hCG_38956	199	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	119	K → R in BAF84346 (PubMed:14702039).Curated		1
Sequence conflictⁱ	1060	K → R in BAF84346 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_047509	324	N → I. Corresponds to variant dbSNP:rs45628633Ensembl.	1
Natural variantⁱVAR_047510	598	R → H. Corresponds to variant dbSNP:rs8025153Ensembl.	1
Natural variantⁱVAR_047511	664	P → L. Corresponds to variant dbSNP:rs9972332Ensembl.	1
Natural variantⁱVAR_047512	712	G → R. Corresponds to variant dbSNP:rs28395835Ensembl.	1
Natural variantⁱVAR_047513	1095	E → G1 PublicationCorresponds to variant dbSNP:rs936212Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_035770	492 – 495	Missing in isoform 2. 1 Publication		4
Alternative sequenceⁱVSP_054490	868 – 882	Missing in isoform 3. 1 PublicationAdd BLAST		15

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M95678 mRNA Translation: AAA36453.1 AK291657 mRNA Translation: BAF84346.1 AC020658 Genomic DNA No translation available. BC136467 mRNA Translation: AAI36468.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42020.1 [Q00722-1] CCDS61591.1 [Q00722-3] CCDS61592.1 [Q00722-2]
PIRⁱ	A43346
NCBI Reference Sequences More...RefSeqⁱ	NP_001271226.1, NM_001284297.1 [Q00722-2] NP_001271227.1, NM_001284298.1 [Q00722-3] NP_004564.2, NM_004573.2 [Q00722-1]

Genome annotation databases

Ensemblⁱ	ENST00000260402; ENSP00000260402; ENSG00000137841 [Q00722-1] ENST00000456256; ENSP00000411991; ENSG00000137841 [Q00722-3] ENST00000557821; ENSP00000453975; ENSG00000137841 [Q00722-2]
GeneIDⁱ	5330
KEGGⁱ	hsa:5330
UCSC genome browser More...UCSCⁱ	uc001zld.4, human [Q00722-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase		MACMU		1302	UniRef90_Q00722
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase		PANPR		1193
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase		PONAB		1185
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase		CEBIM		1185
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase		GORGO		1185
+75

Protein	Similar proteins		Species	Score	Length	Source
Q00722	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2		RAT		1183	UniRef50_Q00722
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2		MOUSE		1181
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase		MACMU		1302
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase		PANPR		1193
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase		SAIBB		1185
+497

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M95678 mRNA Translation: AAA36453.1 AK291657 mRNA Translation: BAF84346.1 AC020658 Genomic DNA No translation available. BC136467 mRNA Translation: AAI36468.1
CCDSⁱ	CCDS42020.1 [Q00722-1] CCDS61591.1 [Q00722-3] CCDS61592.1 [Q00722-2]
PIRⁱ	A43346
RefSeqⁱ	NP_001271226.1, NM_001284297.1 [Q00722-2] NP_001271227.1, NM_001284298.1 [Q00722-3] NP_004564.2, NM_004573.2 [Q00722-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2FJU	X-ray	2.20	B	1-803	[»]
	2ZKM	X-ray	1.62	X	1-803	[»]
SMRⁱ	Q00722
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	111346, 15 interactors
DIPⁱ	DIP-29259N
IntActⁱ	Q00722, 4 interactors
STRINGⁱ	9606.ENSP00000260402

Chemistry databases

SwissLipidsⁱ	SLP:000000948

SwissLipidsⁱ

SLP:000000948

PTM databases

iPTMnetⁱ	Q00722
MetOSiteⁱ	Q00722
PhosphoSitePlusⁱ	Q00722

Genetic variation databases

BioMutaⁱ	PLCB2
DMDMⁱ	215273902

Proteomic databases

EPDⁱ	Q00722
jPOSTⁱ	Q00722
MassIVEⁱ	Q00722
MaxQBⁱ	Q00722
PaxDbⁱ	Q00722
PeptideAtlasⁱ	Q00722
PRIDEⁱ	Q00722
ProteomicsDBⁱ	57870 [Q00722-1] 57871 [Q00722-2] 7525

Protocols and materials databases

Antibodypediaⁱ	4002, 177 antibodies
The DNASU plasmid repository More...DNASUⁱ	5330

Genome annotation databases

Ensemblⁱ	ENST00000260402; ENSP00000260402; ENSG00000137841 [Q00722-1] ENST00000456256; ENSP00000411991; ENSG00000137841 [Q00722-3] ENST00000557821; ENSP00000453975; ENSG00000137841 [Q00722-2]
GeneIDⁱ	5330
KEGGⁱ	hsa:5330
UCSCⁱ	uc001zld.4, human [Q00722-1]

Organism-specific databases

CTDⁱ	5330
DisGeNETⁱ	5330
GeneCardsⁱ	PLCB2
HGNCⁱ	HGNC:9055, PLCB2
HPAⁱ	ENSG00000137841, Tissue enhanced (bone marrow, lymphoid tissue)
MIMⁱ	604114, gene
neXtProtⁱ	NX_Q00722
OpenTargetsⁱ	ENSG00000137841
PharmGKBⁱ	PA33385
VEuPathDBⁱ	HostDB:ENSG00000137841.11
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1265, Eukaryota
GeneTreeⁱ	ENSGT00940000159326
HOGENOMⁱ	CLU_002738_2_0_1
InParanoidⁱ	Q00722
OMAⁱ	TQNWAND
OrthoDBⁱ	368239at2759
PhylomeDBⁱ	Q00722
TreeFamⁱ	TF313216

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS06408-MONOMER
BRENDAⁱ	3.1.4.11, 2681
PathwayCommonsⁱ	Q00722
Reactomeⁱ	R-HSA-112043, PLC beta mediated events R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol R-HSA-399997, Acetylcholine regulates insulin secretion R-HSA-4086398, Ca2+ pathway R-HSA-416476, G alpha (q) signalling events R-HSA-418217, G beta:gamma signalling through PLC beta R-HSA-434316, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-500657, Presynaptic function of Kainate receptors
SABIO-RKⁱ	Q00722
SignaLinkⁱ	Q00722
SIGNORⁱ	Q00722

Miscellaneous databases

BioGRID-ORCSⁱ	5330, 9 hits in 996 CRISPR screens
ChiTaRSⁱ	PLCB2, human
EvolutionaryTraceⁱ	Q00722
GeneWikiⁱ	PLCB2
GenomeRNAiⁱ	5330
Pharosⁱ	Q00722, Tbio
Protein Ontology More...PROⁱ	PR:Q00722
RNActⁱ	Q00722, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000137841, Expressed in granulocyte and 161 other tissues
ExpressionAtlasⁱ	Q00722, baseline and differential
Genevisibleⁱ	Q00722, HS

Family and domain databases

CDDⁱ	cd13361, PH_PLC_beta, 1 hit
Gene3Dⁱ	1.20.1230.10, 2 hits 2.60.40.150, 1 hit 3.20.20.190, 2 hits
InterProⁱ	View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR001192, PI-PLC_fam IPR016280, PLC-beta IPR028403, PLC-beta2 IPR014815, PLC-beta_C IPR042531, PLC-beta_C_sf IPR037862, PLC-beta_PH IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y
PANTHERⁱ	PTHR10336, PTHR10336, 1 hit PTHR10336:SF10, PTHR10336:SF10, 1 hit
Pfamⁱ	View protein in Pfam PF00168, C2, 1 hit PF09279, EF-hand_like, 1 hit PF17787, PH_14, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit PF08703, PLC-beta_C, 1 hit
PIRSFⁱ	PIRSF000956, PLC-beta, 1 hit
PRINTSⁱ	PR00390, PHPHLIPASEC
SMARTⁱ	View protein in SMART SM00239, C2, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit
SUPFAMⁱ	SSF47473, SSF47473, 1 hit SSF51695, SSF51695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50004, C2, 1 hit PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLCB2_HUMAN
Accessionⁱ	Q00722Primary (citable) accession number: Q00722 Secondary accession number(s): A8K6J2, B9EGH5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	November 25, 2008
	Last modified:	June 2, 2021
	This is version 197 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q00722 (PLCB2_HUMAN)

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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

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Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Cytosol

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q00722

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ