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UniProtKB - Q00722 (PLCB2_HUMAN)
Protein
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
Gene
PLCB2
Organism
Homo sapiens (Human)
Status
Functioni
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
2 PublicationsMiscellaneous
The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha-16.
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+1 PublicationEC:3.1.4.111 PublicationThis reaction proceeds in the forward1 Publication direction.
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
Cofactori
Ca2+Note: Binds 1 Ca2+ ion per subunit.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 327 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 328 | Calcium | 1 | |
Metal bindingi | 357 | Calcium | 1 | |
Metal bindingi | 359 | Calcium | 1 | |
Active sitei | 374 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 408 | Calcium | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- G-protein beta/gamma-subunit complex binding Source: Ensembl
- phosphatidylinositol phospholipase C activity Source: UniProtKB
- phospholipase C activity Source: Reactome
- phospholipid binding Source: Ensembl
GO - Biological processi
- activation of phospholipase C activity Source: ProtInc
- detection of chemical stimulus involved in sensory perception of bitter taste Source: Ensembl
- G protein-coupled receptor signaling pathway Source: Reactome
- lipid catabolic process Source: UniProtKB-KW
- phosphatidylinositol-mediated signaling Source: GO_Central
- phosphatidylinositol metabolic process Source: UniProtKB
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
- phospholipid metabolic process Source: ProtInc
Keywordsi
Molecular function | Hydrolase, Transducer |
Biological process | Lipid degradation, Lipid metabolism |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.1.4.11, 2681 |
PathwayCommonsi | Q00722 |
Reactomei | R-HSA-112043, PLC beta mediated events R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol R-HSA-399997, Acetylcholine regulates insulin secretion R-HSA-4086398, Ca2+ pathway R-HSA-416476, G alpha (q) signalling events R-HSA-418217, G beta:gamma signalling through PLC beta R-HSA-434316, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-500657, Presynaptic function of Kainate receptors R-HSA-9717207, Sensory perception of sweet, bitter, and umami (glutamate) taste |
SABIO-RKi | Q00722 |
SignaLinki | Q00722 |
SIGNORi | Q00722 |
Chemistry databases
SwissLipidsi | SLP:000000948 |
Names & Taxonomyi
Protein namesi | Recommended name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2Curated (EC:3.1.4.111 Publication)Alternative name(s): Phosphoinositide phospholipase C-beta-2 Phospholipase C-beta-2 Short name: PLC-beta-2 |
Gene namesi | Name:PLCB2Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9055, PLCB2 |
MIMi | 604114, gene |
neXtProti | NX_Q00722 |
VEuPathDBi | HostDB:ENSG00000137841 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Golgi apparatus
- Golgi apparatus Source: Ensembl
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- G-protein beta/gamma-subunit complex Source: Ensembl
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 52 | Q → A: Strongly reduces interaction with RAC1. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5330 |
OpenTargetsi | ENSG00000137841 |
PharmGKBi | PA33385 |
Miscellaneous databases
Pharosi | Q00722, Tbio |
Genetic variation databases
BioMutai | PLCB2 |
DMDMi | 215273902 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088489 | 1 – 1185 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2Add BLAST | 1185 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 953 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q00722 |
jPOSTi | Q00722 |
MassIVEi | Q00722 |
MaxQBi | Q00722 |
PaxDbi | Q00722 |
PeptideAtlasi | Q00722 |
PRIDEi | Q00722 |
ProteomicsDBi | 57870 [Q00722-1] 57871 [Q00722-2] 7525 |
PTM databases
iPTMneti | Q00722 |
MetOSitei | Q00722 |
PhosphoSitePlusi | Q00722 |
Expressioni
Gene expression databases
Bgeei | ENSG00000137841, Expressed in granulocyte and 161 other tissues |
ExpressionAtlasi | Q00722, baseline and differential |
Genevisiblei | Q00722, HS |
Organism-specific databases
HPAi | ENSG00000137841, Tissue enhanced (bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Binary interactionsi
Q00722
With | #Exp. | IntAct |
---|---|---|
CTNNAL1 [Q9UBT7] | 3 | EBI-968381,EBI-514206 |
Protein-protein interaction databases
BioGRIDi | 111346, 16 interactors |
DIPi | DIP-29259N |
IntActi | Q00722, 4 interactors |
STRINGi | 9606.ENSP00000260402 |
Miscellaneous databases
RNActi | Q00722, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q00722 |
SMRi | Q00722 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q00722 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 312 – 463 | PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST | 152 | |
Domaini | 546 – 662 | PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST | 117 | |
Domaini | 662 – 790 | C2PROSITE-ProRule annotationAdd BLAST | 129 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 460 – 533 | DisorderedSequence analysisAdd BLAST | 74 | |
Regioni | 859 – 888 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 943 – 979 | DisorderedSequence analysisAdd BLAST | 37 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 988 – 1147 | Sequence analysisAdd BLAST | 160 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 464 – 481 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 500 – 521 | Acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 873 – 888 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG1265, Eukaryota |
GeneTreei | ENSGT00940000159326 |
HOGENOMi | CLU_002738_2_0_1 |
InParanoidi | Q00722 |
OMAi | NMALFEY |
OrthoDBi | 368239at2759 |
PhylomeDBi | Q00722 |
TreeFami | TF313216 |
Family and domain databases
CDDi | cd13361, PH_PLC_beta, 1 hit |
Gene3Di | 1.20.1230.10, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR001192, PI-PLC_fam IPR016280, PLC-beta IPR028403, PLC-beta2 IPR014815, PLC-beta_C IPR042531, PLC-beta_C_sf IPR037862, PLC-beta_PH IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y |
PANTHERi | PTHR10336, PTHR10336, 1 hit PTHR10336:SF10, PTHR10336:SF10, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF09279, EF-hand_like, 1 hit PF17787, PH_14, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit PF08703, PLC-beta_C, 1 hit |
PIRSFi | PIRSF000956, PLC-beta, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF49562, SSF49562, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q00722-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLLNPVLLP PKVKAYLSQG ERFIKWDDET TVASPVILRV DPKGYYLYWT
60 70 80 90 100
YQSKEMEFLD ITSIRDTRFG KFAKMPKSQK LRDVFNMDFP DNSFLLKTLT
110 120 130 140 150
VVSGPDMVDL TFHNFVSYKE NVGKAWAEDV LALVKHPLTA NASRSTFLDK
160 170 180 190 200
ILVKLKMQLN SEGKIPVKNF FQMFPADRKR VEAALSACHL PKGKNDAINP
210 220 230 240 250
EDFPEPVYKS FLMSLCPRPE IDEIFTSYHA KAKPYMTKEH LTKFINQKQR
260 270 280 290 300
DSRLNSLLFP PARPDQVQGL IDKYEPSGIN AQRGQLSPEG MVWFLCGPEN
310 320 330 340 350
SVLAQDKLLL HHDMTQPLNH YFINSSHNTY LTAGQFSGLS SAEMYRQVLL
360 370 380 390 400
SGCRCVELDC WKGKPPDEEP IITHGFTMTT DIFFKEAIEA IAESAFKTSP
410 420 430 440 450
YPIILSFENH VDSPRQQAKM AEYCRTIFGD MLLTEPLEKF PLKPGVPLPS
460 470 480 490 500
PEDLRGKILI KNKKNQFSGP TSSSKDTGGE AEGSSPPSAP AGEGTVWAGE
510 520 530 540 550
EGTELEEEEV EEEEEEESGN LDEEEIKKMQ SDEGTAGLEV TAYEEMSSLV
560 570 580 590 600
NYIQPTKFVS FEFSAQKNRS YVISSFTELK AYDLLSKASV QFVDYNKRQM
610 620 630 640 650
SRIYPKGTRM DSSNYMPQMF WNAGCQMVAL NFQTMDLPMQ QNMAVFEFNG
660 670 680 690 700
QSGYLLKHEF MRRPDKQFNP FSVDRIDVVV ATTLSITVIS GQFLSERSVR
710 720 730 740 750
TYVEVELFGL PGDPKRRYRT KLSPSTNSIN PVWKEEPFVF EKILMPELAS
760 770 780 790 800
LRVAVMEEGN KFLGHRIIPI NALNSGYHHL CLHSESNMPL TMPALFIFLE
810 820 830 840 850
MKDYIPGAWA DLTVALANPI KFFSAHDTKS VKLKEAMGGL PEKPFPLASP
860 870 880 890 900
VASQVNGALA PTSNGSPAAR AGAREEAMKE AAEPRTASLE ELRELKGVVK
910 920 930 940 950
LQRRHEKELR ELERRGARRW EELLQRGAAQ LAELGPPGVG GVGACKLGPG
960 970 980 990 1000
KGSRKKRSLP REESAGAAPG EGPEGVDGRV RELKDRLELE LLRQGEEQYE
1010 1020 1030 1040 1050
CVLKRKEQHV AEQISKMMEL AREKQAAELK ALKETSENDT KEMKKKLETK
1060 1070 1080 1090 1100
RLERIQGMTK VTTDKMAQER LKREINNSHI QEVVQVIKQM TENLERHQEK
1110 1120 1130 1140 1150
LEEKQAACLE QIREMEKQFQ KEALAEYEAR MKGLEAEVKE SVRACLRTCF
1160 1170 1180
PSEAKDKPER ACECPPELCE QDPLIAKADA QESRL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YNI4 | H0YNI4_HUMAN | 1-phosphatidylinositol 4,5-bisphosp... | PLCB2 | 74 | Annotation score: | ||
H0YKR9 | H0YKR9_HUMAN | 1-phosphatidylinositol 4,5-bisphosp... | PLCB2 | 87 | Annotation score: | ||
Q9BVT6 | Q9BVT6_HUMAN | 1-phosphatidylinositol 4,5-bisphosp... | PLCB2 hCG_38956 | 199 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 119 | K → R in BAF84346 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1060 | K → R in BAF84346 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047509 | 324 | N → I. Corresponds to variant dbSNP:rs45628633Ensembl. | 1 | |
Natural variantiVAR_047510 | 598 | R → H. Corresponds to variant dbSNP:rs8025153Ensembl. | 1 | |
Natural variantiVAR_047511 | 664 | P → L. Corresponds to variant dbSNP:rs9972332Ensembl. | 1 | |
Natural variantiVAR_047512 | 712 | G → R. Corresponds to variant dbSNP:rs28395835Ensembl. | 1 | |
Natural variantiVAR_047513 | 1095 | E → G1 PublicationCorresponds to variant dbSNP:rs936212Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035770 | 492 – 495 | Missing in isoform 2. 1 Publication | 4 | |
Alternative sequenceiVSP_054490 | 868 – 882 | Missing in isoform 3. 1 PublicationAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M95678 mRNA Translation: AAA36453.1 AK291657 mRNA Translation: BAF84346.1 AC020658 Genomic DNA No translation available. BC136467 mRNA Translation: AAI36468.1 |
CCDSi | CCDS42020.1 [Q00722-1] CCDS61591.1 [Q00722-3] CCDS61592.1 [Q00722-2] |
PIRi | A43346 |
RefSeqi | NP_001271226.1, NM_001284297.1 [Q00722-2] NP_001271227.1, NM_001284298.1 [Q00722-3] NP_004564.2, NM_004573.2 [Q00722-1] |
Genome annotation databases
Ensembli | ENST00000260402.8; ENSP00000260402.3; ENSG00000137841.12 ENST00000456256.6; ENSP00000411991.2; ENSG00000137841.12 [Q00722-3] ENST00000557821.5; ENSP00000453975.1; ENSG00000137841.12 [Q00722-2] |
GeneIDi | 5330 |
KEGGi | hsa:5330 |
MANE-Selecti | ENST00000260402.8; ENSP00000260402.3; NM_004573.3; NP_004564.2 |
UCSCi | uc001zld.4, human [Q00722-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M95678 mRNA Translation: AAA36453.1 AK291657 mRNA Translation: BAF84346.1 AC020658 Genomic DNA No translation available. BC136467 mRNA Translation: AAI36468.1 |
CCDSi | CCDS42020.1 [Q00722-1] CCDS61591.1 [Q00722-3] CCDS61592.1 [Q00722-2] |
PIRi | A43346 |
RefSeqi | NP_001271226.1, NM_001284297.1 [Q00722-2] NP_001271227.1, NM_001284298.1 [Q00722-3] NP_004564.2, NM_004573.2 [Q00722-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2FJU | X-ray | 2.20 | B | 1-803 | [»] | |
2ZKM | X-ray | 1.62 | X | 1-803 | [»] | |
AlphaFoldDBi | Q00722 | |||||
SMRi | Q00722 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111346, 16 interactors |
DIPi | DIP-29259N |
IntActi | Q00722, 4 interactors |
STRINGi | 9606.ENSP00000260402 |
Chemistry databases
SwissLipidsi | SLP:000000948 |
PTM databases
iPTMneti | Q00722 |
MetOSitei | Q00722 |
PhosphoSitePlusi | Q00722 |
Genetic variation databases
BioMutai | PLCB2 |
DMDMi | 215273902 |
Proteomic databases
EPDi | Q00722 |
jPOSTi | Q00722 |
MassIVEi | Q00722 |
MaxQBi | Q00722 |
PaxDbi | Q00722 |
PeptideAtlasi | Q00722 |
PRIDEi | Q00722 |
ProteomicsDBi | 57870 [Q00722-1] 57871 [Q00722-2] 7525 |
Protocols and materials databases
Antibodypediai | 4002, 183 antibodies from 28 providers |
DNASUi | 5330 |
Genome annotation databases
Ensembli | ENST00000260402.8; ENSP00000260402.3; ENSG00000137841.12 ENST00000456256.6; ENSP00000411991.2; ENSG00000137841.12 [Q00722-3] ENST00000557821.5; ENSP00000453975.1; ENSG00000137841.12 [Q00722-2] |
GeneIDi | 5330 |
KEGGi | hsa:5330 |
MANE-Selecti | ENST00000260402.8; ENSP00000260402.3; NM_004573.3; NP_004564.2 |
UCSCi | uc001zld.4, human [Q00722-1] |
Organism-specific databases
CTDi | 5330 |
DisGeNETi | 5330 |
GeneCardsi | PLCB2 |
HGNCi | HGNC:9055, PLCB2 |
HPAi | ENSG00000137841, Tissue enhanced (bone marrow, lymphoid tissue) |
MIMi | 604114, gene |
neXtProti | NX_Q00722 |
OpenTargetsi | ENSG00000137841 |
PharmGKBi | PA33385 |
VEuPathDBi | HostDB:ENSG00000137841 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1265, Eukaryota |
GeneTreei | ENSGT00940000159326 |
HOGENOMi | CLU_002738_2_0_1 |
InParanoidi | Q00722 |
OMAi | NMALFEY |
OrthoDBi | 368239at2759 |
PhylomeDBi | Q00722 |
TreeFami | TF313216 |
Enzyme and pathway databases
BRENDAi | 3.1.4.11, 2681 |
PathwayCommonsi | Q00722 |
Reactomei | R-HSA-112043, PLC beta mediated events R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol R-HSA-399997, Acetylcholine regulates insulin secretion R-HSA-4086398, Ca2+ pathway R-HSA-416476, G alpha (q) signalling events R-HSA-418217, G beta:gamma signalling through PLC beta R-HSA-434316, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-500657, Presynaptic function of Kainate receptors R-HSA-9717207, Sensory perception of sweet, bitter, and umami (glutamate) taste |
SABIO-RKi | Q00722 |
SignaLinki | Q00722 |
SIGNORi | Q00722 |
Miscellaneous databases
BioGRID-ORCSi | 5330, 15 hits in 1078 CRISPR screens |
ChiTaRSi | PLCB2, human |
EvolutionaryTracei | Q00722 |
GeneWikii | PLCB2 |
GenomeRNAii | 5330 |
Pharosi | Q00722, Tbio |
PROi | PR:Q00722 |
RNActi | Q00722, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137841, Expressed in granulocyte and 161 other tissues |
ExpressionAtlasi | Q00722, baseline and differential |
Genevisiblei | Q00722, HS |
Family and domain databases
CDDi | cd13361, PH_PLC_beta, 1 hit |
Gene3Di | 1.20.1230.10, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR001192, PI-PLC_fam IPR016280, PLC-beta IPR028403, PLC-beta2 IPR014815, PLC-beta_C IPR042531, PLC-beta_C_sf IPR037862, PLC-beta_PH IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y |
PANTHERi | PTHR10336, PTHR10336, 1 hit PTHR10336:SF10, PTHR10336:SF10, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF09279, EF-hand_like, 1 hit PF17787, PH_14, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit PF08703, PLC-beta_C, 1 hit |
PIRSFi | PIRSF000956, PLC-beta, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF49562, SSF49562, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PLCB2_HUMAN | |
Accessioni | Q00722Primary (citable) accession number: Q00722 Secondary accession number(s): A8K6J2, B9EGH5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | November 25, 2008 | |
Last modified: | May 25, 2022 | |
This is version 200 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references