UniProtKB - Q00705 (MCP_SUHVS)
Protein
Major capsid protein
Gene
MCP
Organism
Suid herpesvirus 1 (strain Indiana S) (SuHV-1) (Pseudorabies virus (strain Indiana S))
Status
Functioni
Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.UniRule annotation
GO - Molecular functioni
- structural molecule activity Source: UniProtKB-UniRule
Names & Taxonomyi
Protein namesi | Recommended name: Major capsid proteinUniRule annotationShort name: MCPUniRule annotation |
Gene namesi | Name:MCPUniRule annotation |
Organismi | Suid herpesvirus 1 (strain Indiana S) (SuHV-1) (Pseudorabies virus (strain Indiana S)) |
Taxonomic identifieri | 31522 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Varicellovirus › |
Virus hosti | Sus scrofa (Pig) [TaxID: 9823] |
Subcellular locationi
- Virion UniRule annotation
- Host nucleus UniRule annotation
GO - Cellular componenti
- host cell nucleus Source: UniProtKB-SubCell
- T=16 icosahedral viral capsid Source: UniProtKB-UniRule
Keywords - Cellular componenti
Capsid protein, Host nucleus, T=16 icosahedral capsid protein, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000115708 | 1 – 1330 | Major capsid proteinAdd BLAST | 1330 |
Proteomic databases
PRIDEi | Q00705 |
Interactioni
Subunit structurei
Homomultimer. Makes the hexons and eleven out of twelve pentons.
Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of TRX1 and two molecules of TRX2.
Interacts with scaffold protein; this interaction allows efficient MCP transport to the host nucleus.
Interacts with capsid vertex component 2/CVC2.
Interacts with the small capsomere-interacting protein/SCP.
UniRule annotationProtein-protein interaction databases
DIPi | DIP-62100N |
Family & Domainsi
Sequence similaritiesi
Belongs to the herpesviridae major capsid protein family.UniRule annotation
Family and domain databases
HAMAPi | MF_04016, HSV_MCP, 1 hit |
InterProi | View protein in InterPro IPR000912, Herpes_MCP IPR023233, Herpes_MCP_upper_sf |
Pfami | View protein in Pfam PF03122, Herpes_MCP, 1 hit |
PRINTSi | PR00235, HSVCAPSIDMCP |
SUPFAMi | SSF103417, SSF103417, 1 hit |
i Sequence
Sequence statusi: Complete.
Q00705-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERPAILPSG QILSNIEVHS HRALFDIFKR FRSDDNNLYG AEFDALLGTY
60 70 80 90 100
CSTLSLVRFL ELGLSVACVC TKFPELSYVA EGTIQFEVQQ PMIARDGPHP
110 120 130 140 150
ADQPVHNYMI KRLDRRSLNA AFSIAVEALG LISGENLDGT HISSAMRLRA
160 170 180 190 200
IQQLARNVQA VLDSFERGTA DQMLRVLMEK APPLSLLAPF TLYEGRLADR
210 220 230 240 250
VACAALVSEL KRRVRDDTFF LTKHERNKDA VLDRLSDLVN CTAPSVAVAR
260 270 280 290 300
MTHADTQGRP VDGVLVTTAG VRQRLLHHVL TLADTHADVP VTYGEMVIAN
310 320 330 340 350
TNLVTALVMG KAVSNMDDVA RYLLGGEPAP DDGKPVGSAR VRADLVVVGD
360 370 380 390 400
RLVFLEALEK RVYQATQVPY PLVGNLDVTF VMPLGVFKPA ADRYARHAGS
410 420 430 440 450
FAPTPGLPDP RTHPPRAVHF FNKDGVPCHV TFEHAMGTLC HPSFLDVDAT
460 470 480 490 500
LAALRQEPAE VQCAFGAYVA DARPDALVGL MQRFLEEWPG MMPVRPRWAA
510 520 530 540 550
PAAADQLLAP GNADLRLELH PAFDFFVAPE VDVPGPFAVP QVMGQVRAMP
560 570 580 590 600
RIINGNIPLA LCPVDFRDAR GFELSVDRHR LAPATVAAVR GAFRDANYPM
610 620 630 640 650
VFYIIEAVIH GSERTFCALA RLVAQCIQSY WRNTHNAAFV NNFYMVMYIN
660 670 680 690 700
TYLGNGELPE DCAAVYKDLL EHVHALRRLI GEFTLPGDPL GNQPQEELNH
710 720 730 740 750
ALADATLLPP LIWDCDPILY RDGLAERLPE LRVNGAHFQH ILWVEMAQVN
760 770 780 790 800
FRNVGGGLVH NRPVRNENQP LHPHHDAEWS VLSKIYYYAV VPAFSRGNCC
810 820 830 840 850
TMGVRYDRVY QLVQTMVVPE TDEEVGTDDP RHPLHPRNLV PNSLNVLFHN
860 870 880 890 900
ACVAVDADAM LILQETVTNM AERTTPLLAS VAPDAGMATV ATRDMRTHDG
910 920 930 940 950
SLHHGLLMMA YQPNDATLLE GAFFYPAPVN ALFACADHLG AMRDVGAEVR
960 970 980 990 1000
AAAQHVPCVP HFLGANYYAT VRQPVAQHAA QSRADENTLS YALMAGYFKM
1010 1020 1030 1040 1050
SPVAFTHQLR RQLHPGFALT VVRQDRFATE NVLFAEKASE SYFMGQMQVA
1060 1070 1080 1090 1100
RTESGGGLHL QLTQPRANVD LGVGFTAAYA AAALRAPVTD MGNLPQNLFA
1110 1120 1130 1140 1150
TRGAPPMLDA DADDYLRRTV NAGNRLAPVP VFGQMLPQVP AGLARGQQSV
1160 1170 1180 1190 1200
CEFIATPVSV DLAYFRRACN PRGRAAGEVH GEEGLMFDHS HADPAHPHRA
1210 1220 1230 1240 1250
TANPWASQRH SYADRLYNGQ YNMSGPAYSP CFKFFTPAEA VAKSRGLARL
1260 1270 1280 1290 1300
IADTGAAASP TSNGEYQFKR PVGAGELVED PCALFQEAYP PLCASDSALL
1310 1320 1330
RTPLGAEEHF AQYLIRDESP LKGCFQHASA
Sequence databases
PIRi | A40777, VCBES5 |
Similar proteinsi
Cross-referencesi
Sequence databases
PIRi | A40777, VCBES5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
DIPi | DIP-62100N |
Proteomic databases
PRIDEi | Q00705 |
Family and domain databases
HAMAPi | MF_04016, HSV_MCP, 1 hit |
InterProi | View protein in InterPro IPR000912, Herpes_MCP IPR023233, Herpes_MCP_upper_sf |
Pfami | View protein in Pfam PF03122, Herpes_MCP, 1 hit |
PRINTSi | PR00235, HSVCAPSIDMCP |
SUPFAMi | SSF103417, SSF103417, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MCP_SUHVS | |
Accessioni | Q00705Primary (citable) accession number: Q00705 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | August 12, 2020 | |
This is version 59 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |