Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptidyl-prolyl cis-trans isomerase FKBP3

Gene

FKBP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Activity regulationi

Inhibited preferentially by rapamycin over FK506.

GO - Molecular functioni

  • FK506 binding Source: ProtInc
  • peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW
  • RNA binding Source: UniProtKB
  • signaling receptor activity Source: ProtInc

Keywordsi

Molecular functionIsomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP3 (EC:5.2.1.8)
Short name:
PPIase FKBP3
Alternative name(s):
25 kDa FK506-binding protein
Short name:
25 kDa FKBP
Short name:
FKBP-25
FK506-binding protein 3
Short name:
FKBP-3
Immunophilin FKBP25
Rapamycin-selective 25 kDa immunophilin
Rotamase
Gene namesi
Name:FKBP3
Synonyms:FKBP25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100442.10
HGNCiHGNC:3719 FKBP3
MIMi186947 gene
neXtProtiNX_Q00688

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100442
PharmGKBiPA28160

Chemistry databases

ChEMBLiCHEMBL4746

Polymorphism and mutation databases

BioMutaiFKBP3
DMDMi232096

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000753072 – 224Peptidyl-prolyl cis-trans isomerase FKBP3Add BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei99N6-acetyllysineBy similarity1
Modified residuei152PhosphoserineCombined sources1
Modified residuei170N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ00688
MaxQBiQ00688
PaxDbiQ00688
PeptideAtlasiQ00688
PRIDEiQ00688
ProteomicsDBi57869
TopDownProteomicsiQ00688

PTM databases

iPTMnetiQ00688
PhosphoSitePlusiQ00688
SwissPalmiQ00688

Expressioni

Gene expression databases

BgeeiENSG00000100442 Expressed in 232 organ(s), highest expression level in biceps brachii
CleanExiHS_FKBP3
ExpressionAtlasiQ00688 baseline and differential
GenevisibleiQ00688 HS

Organism-specific databases

HPAiCAB012232
CAB012520
HPA000864

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi108577, 47 interactors
IntActiQ00688, 6 interactors
MINTiQ00688
STRINGi9606.ENSP00000216330

Chemistry databases

BindingDBiQ00688

Structurei

Secondary structure

1224
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ00688
SMRiQ00688
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ00688

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 224PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST97

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated

Phylogenomic databases

eggNOGiKOG0544 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00760000119159
HOGENOMiHOG000007963
HOVERGENiHBG105391
InParanoidiQ00688
KOiK09570
OMAiCWYTGSL
OrthoDBiEOG091G02W1
PhylomeDBiQ00688
TreeFamiTF105293

Family and domain databases

InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q00688-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ EHGSDSFLAE HKLLGNIKNV
60 70 80 90 100
AKTANKDHLV TAYNHLFETK RFKGTESISK VSEQVKNVKL NEDKPKETKS
110 120 130 140 150
EETLDEGPPK YTKSVLKKGD KTNFPKKGDV VHCWYTGTLQ DGTVFDTNIQ
160 170 180 190 200
TSAKKKKNAK PLSFKVGVGK VIRGWDEALL TMSKGEKARL EIEPEWAYGK
210 220
KGQPDAKIPP NAKLTFEVEL VDID
Length:224
Mass (Da):25,177
Last modified:April 1, 1993 - v1
Checksum:iC144C5AAB7EA9522
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V5F2G3V5F2_HUMAN
Peptidyl-prolyl cis-trans isomerase...
FKBP3
65Annotation score:

Sequence cautioni

The sequence AAA58474 differs from that shown. Reason: Frameshift at position 197.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181T → A in AAA58474 (PubMed:1375932).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96256 mRNA Translation: AAA58471.1
M90309 mRNA Translation: AAA58475.1
M90820 mRNA Translation: AAA58474.1 Frameshift.
BT006904 mRNA Translation: AAP35550.1
AK311915 mRNA Translation: BAG34856.1
CH471078 Genomic DNA Translation: EAW65785.1
BC016288 mRNA Translation: AAH16288.1
BC020809 mRNA Translation: AAH20809.1
CCDSiCCDS9683.1
PIRiJQ1522
RefSeqiNP_002004.1, NM_002013.3
UniGeneiHs.509226

Genome annotation databases

EnsembliENST00000216330; ENSP00000216330; ENSG00000100442
ENST00000396062; ENSP00000379374; ENSG00000100442
GeneIDi2287
KEGGihsa:2287
UCSCiuc010tqf.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96256 mRNA Translation: AAA58471.1
M90309 mRNA Translation: AAA58475.1
M90820 mRNA Translation: AAA58474.1 Frameshift.
BT006904 mRNA Translation: AAP35550.1
AK311915 mRNA Translation: BAG34856.1
CH471078 Genomic DNA Translation: EAW65785.1
BC016288 mRNA Translation: AAH16288.1
BC020809 mRNA Translation: AAH20809.1
CCDSiCCDS9683.1
PIRiJQ1522
RefSeqiNP_002004.1, NM_002013.3
UniGeneiHs.509226

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PBKX-ray2.50A109-224[»]
2KFVNMR-A1-73[»]
2MPHNMR-A1-224[»]
5D75X-ray1.83A109-224[»]
5GPGX-ray1.67A109-224[»]
ProteinModelPortaliQ00688
SMRiQ00688
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108577, 47 interactors
IntActiQ00688, 6 interactors
MINTiQ00688
STRINGi9606.ENSP00000216330

Chemistry databases

BindingDBiQ00688
ChEMBLiCHEMBL4746

PTM databases

iPTMnetiQ00688
PhosphoSitePlusiQ00688
SwissPalmiQ00688

Polymorphism and mutation databases

BioMutaiFKBP3
DMDMi232096

Proteomic databases

EPDiQ00688
MaxQBiQ00688
PaxDbiQ00688
PeptideAtlasiQ00688
PRIDEiQ00688
ProteomicsDBi57869
TopDownProteomicsiQ00688

Protocols and materials databases

DNASUi2287
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216330; ENSP00000216330; ENSG00000100442
ENST00000396062; ENSP00000379374; ENSG00000100442
GeneIDi2287
KEGGihsa:2287
UCSCiuc010tqf.3 human

Organism-specific databases

CTDi2287
EuPathDBiHostDB:ENSG00000100442.10
GeneCardsiFKBP3
HGNCiHGNC:3719 FKBP3
HPAiCAB012232
CAB012520
HPA000864
MIMi186947 gene
neXtProtiNX_Q00688
OpenTargetsiENSG00000100442
PharmGKBiPA28160
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0544 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00760000119159
HOGENOMiHOG000007963
HOVERGENiHBG105391
InParanoidiQ00688
KOiK09570
OMAiCWYTGSL
OrthoDBiEOG091G02W1
PhylomeDBiQ00688
TreeFamiTF105293

Miscellaneous databases

ChiTaRSiFKBP3 human
EvolutionaryTraceiQ00688
GeneWikiiFKBP3
GenomeRNAii2287
PROiPR:Q00688
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100442 Expressed in 232 organ(s), highest expression level in biceps brachii
CleanExiHS_FKBP3
ExpressionAtlasiQ00688 baseline and differential
GenevisibleiQ00688 HS

Family and domain databases

InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFKBP3_HUMAN
AccessioniPrimary (citable) accession number: Q00688
Secondary accession number(s): B2R4Q9, Q14317
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 7, 2018
This is version 179 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again