UniProtKB - Q00653 (NFKB2_HUMAN)
Nuclear factor NF-kappa-B p100 subunit
NFKB2
Functioni
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.
1 PublicationGO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- extracellular matrix organization Source: Ensembl
- follicular dendritic cell differentiation Source: Ensembl
- germinal center formation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: ComplexPortal
- NIK/NF-kappaB signaling Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- rhythmic process Source: UniProtKB-KW
- spleen development Source: Ensembl
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q00653 |
Reactomei | R-HSA-1810476, RIP-mediated NFkB activation via ZBP1 R-HSA-3134963, DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3214841, PKMTs methylate histone lysines R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-448706, Interleukin-1 processing R-HSA-4755510, SUMOylation of immune response proteins R-HSA-5603029, IkBA variant leads to EDA-ID R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-844456, The NLRP3 inflammasome R-HSA-933542, TRAF6 mediated NF-kB activation R-HSA-9660826, Purinergic signaling in leishmaniasis infection |
SignaLinki | Q00653 |
SIGNORi | Q00653 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear factor NF-kappa-B p100 subunitAlternative name(s): DNA-binding factor KBF2 H2TF1 Lymphocyte translocation chromosome 10 protein Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 Oncogene Lyt-10 Short name: Lyt10 Cleaved into the following chain: |
Gene namesi | Name:NFKB2 Synonyms:LYT10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7795, NFKB2 |
MIMi | 164012, gene |
neXtProti | NX_Q00653 |
VEuPathDBi | HostDB:ENSG00000077150 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- NF-kappaB complex Source: ComplexPortal
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- Bcl3/NF-kappaB2 complex Source: UniProtKB
- chromatin Source: NTNU_SB
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Immunodeficiency, common variable, 10 (CVID10)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_074035 | 865 | D → G in CVID10; unknown pathological significance; de novo mutation. 1 PublicationCorresponds to variant dbSNP:rs727502787EnsemblClinVar. | 1 | |
Natural variantiVAR_074036 | 867 | A → V in CVID10; unknown pathological significance; de novo mutation. 1 PublicationCorresponds to variant dbSNP:rs727502788EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 247 – 249 | YLL → AAA: Two-fold reduction in heterodimerization with RelA. 1 Publication | 3 | |
Mutagenesisi | 399 | P → A: No change in cleavage rate or products. 1 Publication | 1 | |
Mutagenesisi | 404 | G → A: No change in cleavage rate or products. 1 Publication | 1 | |
Mutagenesisi | 405 | A → P: No change in cleavage rate or products. 1 Publication | 1 | |
Mutagenesisi | 406 | Q → N: No change in cleavage rate or products. 1 Publication | 1 | |
Mutagenesisi | 713 | S → G: Loss of phosphorylation; when associated with A-715 and A-717. 1 Publication | 1 | |
Mutagenesisi | 715 | S → A: Loss of phosphorylation; when associated with G-713 and A-717. 1 Publication | 1 | |
Mutagenesisi | 717 | S → A: Loss of phosphorylation; when associated with G-713 and A-715. 1 Publication | 1 | |
Mutagenesisi | 866 | S → A: Decrease in MAP3K14-induced phosphorylation; no inducible processing occurs; when associated with A-869. 1 Publication | 1 | |
Mutagenesisi | 870 | S → A: Decrease in MAP3K14-induced phosphorylation; no inducible processing occurs; when associated with A-865. 1 Publication | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 490 – 491 | Breakpoint for translocation to form NFKB2-IGHA1 oncogene | 2 |
Keywords - Diseasei
Disease variant, Proto-oncogeneOrganism-specific databases
DisGeNETi | 4791 |
MalaCardsi | NFKB2 |
MIMi | 615577, phenotype |
OpenTargetsi | ENSG00000077150 |
Orphaneti | 1572, Common variable immunodeficiency 293978, Deficiency in anterior pituitary function-variable immunodeficiency syndrome |
PharmGKBi | PA31600 |
Miscellaneous databases
Pharosi | Q00653, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3003 |
DrugBanki | DB05767, Andrographolide DB05487, Custirsen DB00843, Donepezil DB13961, Fish oil DB13751, Glycyrrhizic acid DB05212, HE3286 DB05559, NF-kappaB Decoy DB05464, NOX-700 DB05451, P54 DB14059, SC-236 DB05471, SGN-30 |
DrugCentrali | Q00653 |
Genetic variation databases
BioMutai | NFKB2 |
DMDMi | 116242678 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000030321 | 1 – 900 | Nuclear factor NF-kappa-B p100 subunitAdd BLAST | 900 | |
ChainiPRO_0000030322 | 1 – 454 | Nuclear factor NF-kappa-B p52 subunitAdd BLAST | 454 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 23 | PhosphoserineCombined sources | 1 | |
Modified residuei | 161 | PhosphoserineCombined sources | 1 | |
Modified residuei | 429 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 713 | Phosphoserine1 Publication | 1 | |
Modified residuei | 715 | Phosphoserine1 Publication | 1 | |
Modified residuei | 717 | Phosphoserine1 Publication | 1 | |
Modified residuei | 812 | PhosphoserineCombined sources | 1 | |
Cross-linki | 855 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Modified residuei | 866 | Phosphoserine; by MAP3K141 Publication | 1 | |
Modified residuei | 870 | Phosphoserine; by MAP3K141 Publication | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 454 – 455 | Cleavage (when cotranslationally processed) | 2 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-721 |
EPDi | Q00653 |
jPOSTi | Q00653 |
MassIVEi | Q00653 |
MaxQBi | Q00653 |
PaxDbi | Q00653 |
PeptideAtlasi | Q00653 |
PRIDEi | Q00653 |
ProteomicsDBi | 57866 [Q00653-1] 57867 [Q00653-3] 57868 [Q00653-4] |
PTM databases
CarbonylDBi | Q00653 |
GlyGeni | Q00653, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q00653 |
PhosphoSitePlusi | Q00653 |
SwissPalmi | Q00653 |
Expressioni
Gene expression databases
Bgeei | ENSG00000077150, Expressed in left lobe of thyroid gland and 187 other tissues |
ExpressionAtlasi | Q00653, baseline and differential |
Genevisiblei | Q00653, HS |
Organism-specific databases
HPAi | ENSG00000077150, Low tissue specificity |
Interactioni
Subunit structurei
Component of the NF-kappa-B RelB-p52 complex. Homodimer; component of the NF-kappa-B p52-p52 complex.
Component of the NF-kappa-B p65-p52 complex.
Component of the NF-kappa-B p52-c-Rel complex. NFKB2/p52 interacts with NFKBIE.
Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Directly interacts with MEN1.
6 PublicationsBinary interactionsi
Q00653
Nuclear factor NF-kappa-B p52 subunit (PRO_0000030322)
With | #Exp. | IntAct |
---|---|---|
MEN1 - isoform 2 [O00255-2] | 3 | EBI-9869360,EBI-9869387 |
Protein-protein interaction databases
BioGRIDi | 110858, 114 interactors |
ComplexPortali | CPX-5829, NF-kappaB DNA-binding transcription factor complex, p52/p65 CPX-5830, NF-kappaB DNA-binding transcription factor complex, p52/c-Rel CPX-5831, NF-kappaB DNA-binding transcription factor complex, p52/RelB CPX-5837, NF-kappaB transcription regulation complex, p50/p52 CPX-5839, NF-kappaB transcription regulation complex, p52/p52 |
CORUMi | Q00653 |
DIPi | DIP-24239N DIP-27535N |
IntActi | Q00653, 48 interactors |
MINTi | Q00653 |
STRINGi | 9606.ENSP00000358983 |
Miscellaneous databases
RNActi | Q00653, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q00653 |
SMRi | Q00653 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q00653 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 343 | RHDPROSITE-ProRule annotationAdd BLAST | 306 | |
Repeati | 487 – 519 | ANK 1Add BLAST | 33 | |
Repeati | 526 – 555 | ANK 2Add BLAST | 30 | |
Repeati | 559 – 591 | ANK 3Add BLAST | 33 | |
Repeati | 599 – 628 | ANK 4Add BLAST | 30 | |
Repeati | 633 – 663 | ANK 5Add BLAST | 31 | |
Repeati | 667 – 696 | ANK 6Add BLAST | 30 | |
Repeati | 729 – 758 | ANK 7Add BLAST | 30 | |
Domaini | 764 – 851 | DeathAdd BLAST | 88 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 346 – 377 | GRRAdd BLAST | 32 | |
Regioni | 404 – 435 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 698 – 734 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 849 – 900 | DisorderedSequence analysisAdd BLAST | 52 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 337 – 341 | Nuclear localization signalSequence analysis | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 715 – 729 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Domaini
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG0504, Eukaryota |
GeneTreei | ENSGT00940000160968 |
HOGENOMi | CLU_004343_1_1_1 |
InParanoidi | Q00653 |
OMAi | EQMAHII |
OrthoDBi | 916931at2759 |
PhylomeDBi | Q00653 |
TreeFami | TF325632 |
Family and domain databases
CDDi | cd01177, IPT_NFkappaB, 1 hit |
DisProti | DP03039 |
Gene3Di | 1.10.533.10, 1 hit 1.25.40.20, 1 hit 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR033926, IPT_NFkappaB IPR000451, NFkB/Dor IPR030497, NFkB_p100 IPR008967, p53-like_TF_DNA-bd IPR030492, RHD_CS IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR24169, PTHR24169, 1 hit PTHR24169:SF21, PTHR24169:SF21, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF00531, Death, 1 hit PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR01415, ANKYRIN PR00057, NFKBTNSCPFCT |
SMARTi | View protein in SMART SM00248, ANK, 6 hits SM00005, DEATH, 1 hit SM00429, IPT, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF48403, SSF48403, 1 hit SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 5 hits PS01204, REL_1, 1 hit PS50254, REL_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MESCYNPGLD GIIEYDDFKL NSSIVEPKEP APETADGPYL VIVEQPKQRG
60 70 80 90 100
FRFRYGCEGP SHGGLPGASS EKGRKTYPTV KICNYEGPAK IEVDLVTHSD
110 120 130 140 150
PPRAHAHSLV GKQCSELGIC AVSVGPKDMT AQFNNLGVLH VTKKNMMGTM
160 170 180 190 200
IQKLQRQRLR SRPQGLTEAE QRELEQEAKE LKKVMDLSIV RLRFSAFLRA
210 220 230 240 250
SDGSFSLPLK PVISQPIHDS KSPGASNLKI SRMDKTAGSV RGGDEVYLLC
260 270 280 290 300
DKVQKDDIEV RFYEDDENGW QAFGDFSPTD VHKQYAIVFR TPPYHKMKIE
310 320 330 340 350
RPVTVFLQLK RKRGGDVSDS KQFTYYPLVE DKEEVQRKRR KALPTFSQPF
360 370 380 390 400
GGGSHMGGGS GGAAGGYGGA GGGGSLGFFP SSLAYSPYQS GAGPMGCYPG
410 420 430 440 450
GGGGAQMAAT VPSRDSGEEA AEPSAPSRTP QCEPQAPEML QRAREYNARL
460 470 480 490 500
FGLAQRSARA LLDYGVTADA RALLAGQRHL LTAQDENGDT PLHLAIIHGQ
510 520 530 540 550
TSVIEQIVYV IHHAQDLGVV NLTNHLHQTP LHLAVITGQT SVVSFLLRVG
560 570 580 590 600
ADPALLDRHG DSAMHLALRA GAGAPELLRA LLQSGAPAVP QLLHMPDFEG
610 620 630 640 650
LYPVHLAVRA RSPECLDLLV DSGAEVEATE RQGGRTALHL ATEMEELGLV
660 670 680 690 700
THLVTKLRAN VNARTFAGNT PLHLAAGLGY PTLTRLLLKA GADIHAENEE
710 720 730 740 750
PLCPLPSPPT SDSDSDSEGP EKDTRSSFRG HTPLDLTCST KVKTLLLNAA
760 770 780 790 800
QNTMEPPLTP PSPAGPGLSL GDTALQNLEQ LLDGPEAQGS WAELAERLGL
810 820 830 840 850
RSLVDTYRQT TSPSGSLLRS YELAGGDLAG LLEALSDMGL EEGVRLLRGP
860 870 880 890 900
ETRDKLPSTA EVKEDSAYGS QSVEQEAEKL GPPPEPPGGL CHGHPQPQVH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0QZX1 | M0QZX1_HUMAN | Nuclear factor NF-kappa-B p100 subu... | NFKB2 | 22 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 144 | K → E in AAB21124 (PubMed:1531086).Curated | 1 | |
Sequence conflicti | 213 | I → T in CAA43715 (PubMed:1876189).Curated | 1 | |
Sequence conflicti | 213 | I → T in CAA43716 (PubMed:1876189).Curated | 1 | |
Sequence conflicti | 213 | I → T in AAA68171 (PubMed:7969113).Curated | 1 | |
Sequence conflicti | 396 | G → R in CAA43715 (PubMed:1876189).Curated | 1 | |
Sequence conflicti | 433 – 434 | EP → DA in AAB21124 (PubMed:1531086).Curated | 2 | |
Sequence conflicti | 459 | R → K AA sequence (PubMed:8360178).Curated | 1 | |
Sequence conflicti | 465 | G → C in CAA43715 (PubMed:1876189).Curated | 1 | |
Sequence conflicti | 470 | A → R in CAA43715 (PubMed:1876189).Curated | 1 | |
Sequence conflicti | 470 | A → R in AAB21124 (PubMed:1531086).Curated | 1 | |
Sequence conflicti | 741 | K → L in CAA43715 (PubMed:1876189).Curated | 1 | |
Sequence conflicti | 860 | A → T in AAB21124 (PubMed:1531086).Curated | 1 | |
Sequence conflicti | 876 | E → K in AAB21124 (PubMed:1531086).Curated | 1 | |
Sequence conflicti | 891 | C → S in CAA43715 (PubMed:1876189).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022223 | 14 | E → K1 PublicationCorresponds to variant dbSNP:rs45581936EnsemblClinVar. | 1 | |
Natural variantiVAR_022224 | 351 | G → R1 PublicationCorresponds to variant dbSNP:rs45580031EnsemblClinVar. | 1 | |
Natural variantiVAR_051781 | 392 | A → G. Corresponds to variant dbSNP:rs11574848Ensembl. | 1 | |
Natural variantiVAR_022225 | 452 | G → R1 PublicationCorresponds to variant dbSNP:rs45471103Ensembl. | 1 | |
Natural variantiVAR_018452 | 618 – 900 | Missing in truncated form EB308. Add BLAST | 283 | |
Natural variantiVAR_006909 | 667 – 669 | AGN → SAS in truncated form p80HT. | 3 | |
Natural variantiVAR_006910 | 670 – 900 | Missing in truncated form p80HT. Add BLAST | 231 | |
Natural variantiVAR_018453 | 703 – 900 | Missing in truncated form LB40. Add BLAST | 198 | |
Natural variantiVAR_074035 | 865 | D → G in CVID10; unknown pathological significance; de novo mutation. 1 PublicationCorresponds to variant dbSNP:rs727502787EnsemblClinVar. | 1 | |
Natural variantiVAR_074036 | 867 | A → V in CVID10; unknown pathological significance; de novo mutation. 1 PublicationCorresponds to variant dbSNP:rs727502788EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040082 | 374 – 428 | GSLGF…SAPSR → EGVLMEGGVKVREAVEEKNL GEAGRGLHACNPALWEAKAG RLPEIRSSRPAWPTA in isoform 3. 1 PublicationAdd BLAST | 55 | |
Alternative sequenceiVSP_040083 | 429 – 900 | Missing in isoform 3. 1 PublicationAdd BLAST | 472 | |
Alternative sequenceiVSP_040084 | 860 | Missing in isoform 4. 4 Publications | 1 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000189444.11; ENSP00000189444.6; ENSG00000077150.20 [Q00653-4] ENST00000369966.8; ENSP00000358983.3; ENSG00000077150.20 ENST00000428099.6; ENSP00000410256.1; ENSG00000077150.20 [Q00653-4] ENST00000652277.1; ENSP00000498308.1; ENSG00000077150.20 [Q00653-4] ENST00000661543.1; ENSP00000499294.1; ENSG00000077150.20 |
GeneIDi | 4791 |
KEGGi | hsa:4791 |
MANE-Selecti | ENST00000661543.1; ENSP00000499294.1; NM_001322934.2; NP_001309863.1 |
UCSCi | uc001kva.4, human [Q00653-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
NIEHS-SNPs |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1A3Q | X-ray | 2.10 | A/B | 37-327 | [»] | |
2D96 | NMR | - | A | 766-859 | [»] | |
3DO7 | X-ray | 3.05 | B | 37-329 | [»] | |
4OT9 | X-ray | 3.35 | A | 407-765 | [»] | |
5ZMC | X-ray | 2.99 | A | 35-329 | [»] | |
7CLI | X-ray | 3.00 | A/B | 1-398 | [»] | |
7VUP | X-ray | 3.40 | A/B | 1-398 | [»] | |
7VUQ | X-ray | 3.10 | A/B | 1-398 | [»] | |
7W7L | X-ray | 3.00 | A/B | 1-327 | [»] | |
AlphaFoldDBi | Q00653 | |||||
SMRi | Q00653 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110858, 114 interactors |
ComplexPortali | CPX-5829, NF-kappaB DNA-binding transcription factor complex, p52/p65 CPX-5830, NF-kappaB DNA-binding transcription factor complex, p52/c-Rel CPX-5831, NF-kappaB DNA-binding transcription factor complex, p52/RelB CPX-5837, NF-kappaB transcription regulation complex, p50/p52 CPX-5839, NF-kappaB transcription regulation complex, p52/p52 |
CORUMi | Q00653 |
DIPi | DIP-24239N DIP-27535N |
IntActi | Q00653, 48 interactors |
MINTi | Q00653 |
STRINGi | 9606.ENSP00000358983 |
Chemistry databases
ChEMBLi | CHEMBL3003 |
DrugBanki | DB05767, Andrographolide DB05487, Custirsen DB00843, Donepezil DB13961, Fish oil DB13751, Glycyrrhizic acid DB05212, HE3286 DB05559, NF-kappaB Decoy DB05464, NOX-700 DB05451, P54 DB14059, SC-236 DB05471, SGN-30 |
DrugCentrali | Q00653 |
PTM databases
CarbonylDBi | Q00653 |
GlyGeni | Q00653, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | Q00653 |
PhosphoSitePlusi | Q00653 |
SwissPalmi | Q00653 |
Genetic variation databases
BioMutai | NFKB2 |
DMDMi | 116242678 |
Proteomic databases
CPTACi | CPTAC-721 |
EPDi | Q00653 |
jPOSTi | Q00653 |
MassIVEi | Q00653 |
MaxQBi | Q00653 |
PaxDbi | Q00653 |
PeptideAtlasi | Q00653 |
PRIDEi | Q00653 |
ProteomicsDBi | 57866 [Q00653-1] 57867 [Q00653-3] 57868 [Q00653-4] |
Protocols and materials databases
ABCDi | Q00653, 1 sequenced antibody |
Antibodypediai | 1322, 1010 antibodies from 47 providers |
CPTCi | Q00653, 1 antibody |
DNASUi | 4791 |
Genome annotation databases
Ensembli | ENST00000189444.11; ENSP00000189444.6; ENSG00000077150.20 [Q00653-4] ENST00000369966.8; ENSP00000358983.3; ENSG00000077150.20 ENST00000428099.6; ENSP00000410256.1; ENSG00000077150.20 [Q00653-4] ENST00000652277.1; ENSP00000498308.1; ENSG00000077150.20 [Q00653-4] ENST00000661543.1; ENSP00000499294.1; ENSG00000077150.20 |
GeneIDi | 4791 |
KEGGi | hsa:4791 |
MANE-Selecti | ENST00000661543.1; ENSP00000499294.1; NM_001322934.2; NP_001309863.1 |
UCSCi | uc001kva.4, human [Q00653-1] |
Organism-specific databases
CTDi | 4791 |
DisGeNETi | 4791 |
GeneCardsi | NFKB2 |
HGNCi | HGNC:7795, NFKB2 |
HPAi | ENSG00000077150, Low tissue specificity |
MalaCardsi | NFKB2 |
MIMi | 164012, gene 615577, phenotype |
neXtProti | NX_Q00653 |
OpenTargetsi | ENSG00000077150 |
Orphaneti | 1572, Common variable immunodeficiency 293978, Deficiency in anterior pituitary function-variable immunodeficiency syndrome |
PharmGKBi | PA31600 |
VEuPathDBi | HostDB:ENSG00000077150 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0504, Eukaryota |
GeneTreei | ENSGT00940000160968 |
HOGENOMi | CLU_004343_1_1_1 |
InParanoidi | Q00653 |
OMAi | EQMAHII |
OrthoDBi | 916931at2759 |
PhylomeDBi | Q00653 |
TreeFami | TF325632 |
Enzyme and pathway databases
PathwayCommonsi | Q00653 |
Reactomei | R-HSA-1810476, RIP-mediated NFkB activation via ZBP1 R-HSA-3134963, DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-3214841, PKMTs methylate histone lysines R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-448706, Interleukin-1 processing R-HSA-4755510, SUMOylation of immune response proteins R-HSA-5603029, IkBA variant leads to EDA-ID R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-844456, The NLRP3 inflammasome R-HSA-933542, TRAF6 mediated NF-kB activation R-HSA-9660826, Purinergic signaling in leishmaniasis infection |
SignaLinki | Q00653 |
SIGNORi | Q00653 |
Miscellaneous databases
BioGRID-ORCSi | 4791, 39 hits in 1106 CRISPR screens |
ChiTaRSi | NFKB2, human |
EvolutionaryTracei | Q00653 |
GeneWikii | NFKB2 |
GenomeRNAii | 4791 |
Pharosi | Q00653, Tchem |
PROi | PR:Q00653 |
RNActi | Q00653, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000077150, Expressed in left lobe of thyroid gland and 187 other tissues |
ExpressionAtlasi | Q00653, baseline and differential |
Genevisiblei | Q00653, HS |
Family and domain databases
CDDi | cd01177, IPT_NFkappaB, 1 hit |
DisProti | DP03039 |
Gene3Di | 1.10.533.10, 1 hit 1.25.40.20, 1 hit 2.60.40.10, 1 hit 2.60.40.340, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR002909, IPT_dom IPR033926, IPT_NFkappaB IPR000451, NFkB/Dor IPR030497, NFkB_p100 IPR008967, p53-like_TF_DNA-bd IPR030492, RHD_CS IPR032397, RHD_dimer IPR011539, RHD_DNA_bind_dom IPR037059, RHD_DNA_bind_dom_sf |
PANTHERi | PTHR24169, PTHR24169, 1 hit PTHR24169:SF21, PTHR24169:SF21, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits PF00531, Death, 1 hit PF16179, RHD_dimer, 1 hit PF00554, RHD_DNA_bind, 1 hit |
PRINTSi | PR01415, ANKYRIN PR00057, NFKBTNSCPFCT |
SMARTi | View protein in SMART SM00248, ANK, 6 hits SM00005, DEATH, 1 hit SM00429, IPT, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF48403, SSF48403, 1 hit SSF49417, SSF49417, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 5 hits PS01204, REL_1, 1 hit PS50254, REL_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NFKB2_HUMAN | |
Accessioni | Q00653Primary (citable) accession number: Q00653 Secondary accession number(s): A8K9D9 Q9H472 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1993 |
Last sequence update: | October 17, 2006 | |
Last modified: | May 25, 2022 | |
This is version 249 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references