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UniProtKB - Q00653 (NFKB2_HUMAN)

Protein

Nuclear factor NF-kappa-B p100 subunit

Gene

NFKB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.1 Publication

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1810476 RIP-mediated NFkB activation via ZBP1
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-448706 Interleukin-1 processing
R-HSA-4755510 SUMOylation of immune response proteins
R-HSA-5603029 IkBA variant leads to EDA-ID
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-844456 The NLRP3 inflammasome
R-HSA-933542 TRAF6 mediated NF-kB activation
SIGNORiQ00653

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor NF-kappa-B p100 subunit
Alternative name(s):
DNA-binding factor KBF2
H2TF1
Lymphocyte translocation chromosome 10 protein
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
Oncogene Lyt-10
Short name:
Lyt10
Cleaved into the following chain:
Nuclear factor NF-kappa-B p52 subunit
Gene namesi
Name:NFKB2
Synonyms:LYT10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000077150.17
HGNCiHGNC:7795 NFKB2
MIMi164012 gene
neXtProtiNX_Q00653

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving NFKB2 is found in a case of B-cell non Hodgkin lymphoma (B-NHL). Translocation t(10;14)(q24;q32) with IGHA1. The resulting oncogene is also called Lyt-10C alpha variant.
A chromosomal aberration involving NFKB2 is found in a cutaneous T-cell leukemia (C-TCL) cell line. This rearrangement produces the p80HT gene which codes for a truncated 80 kDa protein (p80HT).
In B-cell leukemia (B-CLL) cell line, LB40 and EB308, can be found after heterogeneous chromosomal aberrations, such as internal deletions.
Immunodeficiency, common variable, 10 (CVID10)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency characterized by childhood-onset of recurrent infections, hypogammaglobulinemia, and decreased numbers of memory and marginal zone B-cells. Some patients may develop autoimmune features and have circulating autoantibodies. An unusual feature is central adrenal insufficiency.
See also OMIM:615577
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_074035865D → G in CVID10; unknown pathological significance; de novo mutation. 1 PublicationCorresponds to variant dbSNP:rs727502787EnsemblClinVar.1
Natural variantiVAR_074036867A → V in CVID10; unknown pathological significance; de novo mutation. 1 PublicationCorresponds to variant dbSNP:rs727502788EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi247 – 249YLL → AAA: Two-fold reduction in heterodimerization with RelA. 1 Publication3
Mutagenesisi399P → A: No change in cleavage rate or products. 1 Publication1
Mutagenesisi404G → A: No change in cleavage rate or products. 1 Publication1
Mutagenesisi405A → P: No change in cleavage rate or products. 1 Publication1
Mutagenesisi406Q → N: No change in cleavage rate or products. 1 Publication1
Mutagenesisi713S → G: Loss of phosphorylation; when associated with A-715 and A-717. 1 Publication1
Mutagenesisi715S → A: Loss of phosphorylation; when associated with G-713 and A-717. 1 Publication1
Mutagenesisi717S → A: Loss of phosphorylation; when associated with G-713 and A-715. 1 Publication1
Mutagenesisi866S → A: Decrease in MAP3K14-induced phosphorylation; no inducible processing occurs; when associated with A-869. 1 Publication1
Mutagenesisi870S → A: Decrease in MAP3K14-induced phosphorylation; no inducible processing occurs; when associated with A-865. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei490 – 491Breakpoint for translocation to form NFKB2-IGHA1 oncogene2

Keywords - Diseasei

Disease mutation, Proto-oncogene

Organism-specific databases

DisGeNETi4791
MalaCardsiNFKB2
MIMi615577 phenotype
OpenTargetsiENSG00000077150
Orphaneti1572 Common variable immunodeficiency
PharmGKBiPA31600

Chemistry databases

ChEMBLiCHEMBL3003
DrugBankiDB00945 Acetylsalicylic acid
DB05487 CC-8490
DB01296 Glucosamine
DB05212 HE3286
DB05767 HMPL-004
DB05464 NOX-700
DB05451 P54
DB05471 SGN-30

Polymorphism and mutation databases

DMDMi116242678

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000303211 – 900Nuclear factor NF-kappa-B p100 subunitAdd BLAST900
ChainiPRO_00000303221 – 454Nuclear factor NF-kappa-B p52 subunitAdd BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphoserineCombined sources1
Modified residuei161PhosphoserineCombined sources1
Modified residuei429PhosphothreonineCombined sources1
Modified residuei713Phosphoserine1 Publication1
Modified residuei715Phosphoserine1 Publication1
Modified residuei717Phosphoserine1 Publication1
Modified residuei812PhosphoserineCombined sources1
Cross-linki855Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei866Phosphoserine; by MAP3K141 Publication1
Modified residuei870Phosphoserine; by MAP3K141 Publication1

Post-translational modificationi

While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p52 making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing.
Subsequent to MAP3K14-dependent serine phosphorylation, p100 polyubiquitination occurs then triggering its proteasome-dependent processing.3 Publications
Constitutive processing is tightly suppressed by its C-terminal processing inhibitory domain, named PID, which contains the death domain.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei454 – 455Cleavage (when cotranslationally processed)2

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ00653
MaxQBiQ00653
PaxDbiQ00653
PeptideAtlasiQ00653
PRIDEiQ00653
ProteomicsDBi57866
57867 [Q00653-3]
57868 [Q00653-4]

PTM databases

CarbonylDBiQ00653
iPTMnetiQ00653
PhosphoSitePlusiQ00653
SwissPalmiQ00653

Miscellaneous databases

PMAP-CutDBiQ00653

Expressioni

Gene expression databases

BgeeiENSG00000077150 Expressed in 170 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_NFKB2
ExpressionAtlasiQ00653 baseline and differential
GenevisibleiQ00653 HS

Organism-specific databases

HPAiCAB022098
HPA008422
HPA023900

Interactioni

Subunit structurei

Component of the NF-kappa-B RelB-p52 complex. Homodimer; component of the NF-kappa-B p52-p52 complex. Component of the NF-kappa-B p65-p52 complex. Component of the NF-kappa-B p52-c-Rel complex. NFKB2/p52 interacts with NFKBIE. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Directly interacts with MEN1.6 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi110858, 53 interactors
CORUMiQ00653
DIPiDIP-24239N
DIP-27535N
IntActiQ00653, 36 interactors
MINTiQ00653
STRINGi9606.ENSP00000358983

Structurei

Secondary structure

1900
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ00653
SMRiQ00653
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ00653

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 343RHDPROSITE-ProRule annotationAdd BLAST306
Repeati487 – 519ANK 1Add BLAST33
Repeati526 – 555ANK 2Add BLAST30
Repeati559 – 591ANK 3Add BLAST33
Repeati599 – 628ANK 4Add BLAST30
Repeati633 – 663ANK 5Add BLAST31
Repeati667 – 696ANK 6Add BLAST30
Repeati729 – 758ANK 7Add BLAST30
Domaini764 – 851DeathAdd BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni346 – 377GRRAdd BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi337 – 341Nuclear localization signalSequence analysis5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi350 – 400Gly-richAdd BLAST51

Domaini

The C-terminus of p100 might be involved in cytoplasmic retention, inhibition of DNA-binding by p52 homodimers, and/or transcription activation.By similarity
The glycine-rich region (GRR) appears to be a critical element in the generation of p52.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00500000044765
HOGENOMiHOG000004822
HOVERGENiHBG052613
InParanoidiQ00653
KOiK04469
OMAiFRGHTPL
OrthoDBiEOG091G03PF
PhylomeDBiQ00653
TreeFamiTF325632

Family and domain databases

CDDicd00204 ANK, 2 hits
cd01177 IPT_NFkappaB, 1 hit
Gene3Di1.25.40.20, 1 hit
2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR033926 IPT_NFkappaB
IPR000451 NFkB/Dor
IPR008967 p53-like_TF_DNA-bd
IPR030492 RHD_CS
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf
PANTHERiPTHR24169 PTHR24169, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF00531 Death, 1 hit
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit
PRINTSiPR01415 ANKYRIN
PR00057 NFKBTNSCPFCT
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00005 DEATH, 1 hit
SM00429 IPT, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 1 hit
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS01204 REL_1, 1 hit
PS50254 REL_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q00653-1) [UniParc]FASTAAdd to basket
Also known as: p100

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESCYNPGLD GIIEYDDFKL NSSIVEPKEP APETADGPYL VIVEQPKQRG 
        60         70         80         90        100
FRFRYGCEGP SHGGLPGASS EKGRKTYPTV KICNYEGPAK IEVDLVTHSD 
       110        120        130        140        150
PPRAHAHSLV GKQCSELGIC AVSVGPKDMT AQFNNLGVLH VTKKNMMGTM 
       160        170        180        190        200
IQKLQRQRLR SRPQGLTEAE QRELEQEAKE LKKVMDLSIV RLRFSAFLRA 
       210        220        230        240        250
SDGSFSLPLK PVISQPIHDS KSPGASNLKI SRMDKTAGSV RGGDEVYLLC 
       260        270        280        290        300
DKVQKDDIEV RFYEDDENGW QAFGDFSPTD VHKQYAIVFR TPPYHKMKIE 
       310        320        330        340        350
RPVTVFLQLK RKRGGDVSDS KQFTYYPLVE DKEEVQRKRR KALPTFSQPF 
       360        370        380        390        400
GGGSHMGGGS GGAAGGYGGA GGGGSLGFFP SSLAYSPYQS GAGPMGCYPG 
       410        420        430        440        450
GGGGAQMAAT VPSRDSGEEA AEPSAPSRTP QCEPQAPEML QRAREYNARL 
       460        470        480        490        500
FGLAQRSARA LLDYGVTADA RALLAGQRHL LTAQDENGDT PLHLAIIHGQ 
       510        520        530        540        550
TSVIEQIVYV IHHAQDLGVV NLTNHLHQTP LHLAVITGQT SVVSFLLRVG 
       560        570        580        590        600
ADPALLDRHG DSAMHLALRA GAGAPELLRA LLQSGAPAVP QLLHMPDFEG 
       610        620        630        640        650
LYPVHLAVRA RSPECLDLLV DSGAEVEATE RQGGRTALHL ATEMEELGLV 
       660        670        680        690        700
THLVTKLRAN VNARTFAGNT PLHLAAGLGY PTLTRLLLKA GADIHAENEE 
       710        720        730        740        750
PLCPLPSPPT SDSDSDSEGP EKDTRSSFRG HTPLDLTCST KVKTLLLNAA 
       760        770        780        790        800
QNTMEPPLTP PSPAGPGLSL GDTALQNLEQ LLDGPEAQGS WAELAERLGL 
       810        820        830        840        850
RSLVDTYRQT TSPSGSLLRS YELAGGDLAG LLEALSDMGL EEGVRLLRGP 
       860        870        880        890        900
ETRDKLPSTA EVKEDSAYGS QSVEQEAEKL GPPPEPPGGL CHGHPQPQVH
Length:900
Mass (Da):96,749
Last modified:October 17, 2006 - v4
Checksum:i6BAD7038834783CA
GO
Isoform 3 (identifier: Q00653-3) [UniParc]FASTAAdd to basket
Also known as: p49

The sequence of this isoform differs from the canonical sequence as follows:
     374-428: GSLGFFPSSL...EAAEPSAPSR → EGVLMEGGVK...RSSRPAWPTA
     429-900: Missing.

Note: PubMed:1876189 (CAA43716.1) sequence(s) differ(s) from that shown due to frameshifts in positions 407, 414.
Show »
Length:428
Mass (Da):47,021
Checksum:iE4D38A8635501807
GO
Isoform 4 (identifier: Q00653-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     860-860: Missing.

Show »
Length:899
Mass (Da):96,678
Checksum:iB3753FF15B7BDF57
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R119M0R119_HUMAN
Nuclear factor NF-kappa-B p100 subu...
NFKB2
68Annotation score:
M0QZX1M0QZX1_HUMAN
Nuclear factor NF-kappa-B p100 subu...
NFKB2
22Annotation score:

Sequence cautioni

The sequence CAA43715 differs from that shown. Reason: Frameshift at positions 456, 458, 470 and 900.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144K → E in AAB21124 (PubMed:1531086).Curated1
Sequence conflicti213I → T in CAA43715 (PubMed:1876189).Curated1
Sequence conflicti213I → T in CAA43716 (PubMed:1876189).Curated1
Sequence conflicti213I → T in AAA68171 (PubMed:7969113).Curated1
Sequence conflicti396G → R in CAA43715 (PubMed:1876189).Curated1
Sequence conflicti433 – 434EP → DA in AAB21124 (PubMed:1531086).Curated2
Sequence conflicti459R → K AA sequence (PubMed:8360178).Curated1
Sequence conflicti465G → C in CAA43715 (PubMed:1876189).Curated1
Sequence conflicti470A → R in CAA43715 (PubMed:1876189).Curated1
Sequence conflicti470A → R in AAB21124 (PubMed:1531086).Curated1
Sequence conflicti741K → L in CAA43715 (PubMed:1876189).Curated1
Sequence conflicti860A → T in AAB21124 (PubMed:1531086).Curated1
Sequence conflicti876E → K in AAB21124 (PubMed:1531086).Curated1
Sequence conflicti891C → S in CAA43715 (PubMed:1876189).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02222314E → K1 PublicationCorresponds to variant dbSNP:rs45581936EnsemblClinVar.1
Natural variantiVAR_022224351G → R1 PublicationCorresponds to variant dbSNP:rs45580031Ensembl.1
Natural variantiVAR_051781392A → G. Corresponds to variant dbSNP:rs11574848Ensembl.1
Natural variantiVAR_022225452G → R1 PublicationCorresponds to variant dbSNP:rs45471103Ensembl.1
Natural variantiVAR_018452618 – 900Missing in truncated form EB308. Add BLAST283
Natural variantiVAR_006909667 – 669AGN → SAS in truncated form p80HT. 3
Natural variantiVAR_006910670 – 900Missing in truncated form p80HT. Add BLAST231
Natural variantiVAR_018453703 – 900Missing in truncated form LB40. Add BLAST198
Natural variantiVAR_074035865D → G in CVID10; unknown pathological significance; de novo mutation. 1 PublicationCorresponds to variant dbSNP:rs727502787EnsemblClinVar.1
Natural variantiVAR_074036867A → V in CVID10; unknown pathological significance; de novo mutation. 1 PublicationCorresponds to variant dbSNP:rs727502788EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040082374 – 428GSLGF…SAPSR → EGVLMEGGVKVREAVEEKNL GEAGRGLHACNPALWEAKAG RLPEIRSSRPAWPTA in isoform 3. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_040083429 – 900Missing in isoform 3. 1 PublicationAdd BLAST472
Alternative sequenceiVSP_040084860Missing in isoform 4. 4 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61498 mRNA Translation: CAA43715.1 Frameshift.
X61499 mRNA Translation: CAA43716.1 Frameshift.
S76638 mRNA Translation: AAB21124.1
U09609 mRNA Translation: AAA21462.2
BT009769 mRNA Translation: AAP88771.1
AK292654 mRNA Translation: BAF85343.1
AY865619 Genomic DNA Translation: AAW56071.1
AL121928 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49700.1
CH471066 Genomic DNA Translation: EAW49701.1
CH471066 Genomic DNA Translation: EAW49702.1
CH471066 Genomic DNA Translation: EAW49704.1
CH471066 Genomic DNA Translation: EAW49706.1
BC002844 mRNA Translation: AAH02844.1
U20816 Genomic DNA Translation: AAA68171.1
CCDSiCCDS41564.1 [Q00653-1]
CCDS41565.1 [Q00653-4]
PIRiA42024
A57034
I38609
S17233
RefSeqiNP_001070962.1, NM_001077494.3 [Q00653-1]
NP_001248332.1, NM_001261403.2 [Q00653-4]
NP_001275653.1, NM_001288724.1 [Q00653-4]
NP_001309863.1, NM_001322934.1 [Q00653-1]
NP_001309864.1, NM_001322935.1
NP_002493.3, NM_002502.5 [Q00653-4]
UniGeneiHs.73090

Genome annotation databases

EnsembliENST00000189444; ENSP00000189444; ENSG00000077150 [Q00653-4]
ENST00000369966; ENSP00000358983; ENSG00000077150 [Q00653-1]
ENST00000428099; ENSP00000410256; ENSG00000077150 [Q00653-4]
GeneIDi4791
KEGGihsa:4791
UCSCiuc001kva.4 human [Q00653-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61498 mRNA Translation: CAA43715.1 Frameshift.
X61499 mRNA Translation: CAA43716.1 Frameshift.
S76638 mRNA Translation: AAB21124.1
U09609 mRNA Translation: AAA21462.2
BT009769 mRNA Translation: AAP88771.1
AK292654 mRNA Translation: BAF85343.1
AY865619 Genomic DNA Translation: AAW56071.1
AL121928 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49700.1
CH471066 Genomic DNA Translation: EAW49701.1
CH471066 Genomic DNA Translation: EAW49702.1
CH471066 Genomic DNA Translation: EAW49704.1
CH471066 Genomic DNA Translation: EAW49706.1
BC002844 mRNA Translation: AAH02844.1
U20816 Genomic DNA Translation: AAA68171.1
CCDSiCCDS41564.1 [Q00653-1]
CCDS41565.1 [Q00653-4]
PIRiA42024
A57034
I38609
S17233
RefSeqiNP_001070962.1, NM_001077494.3 [Q00653-1]
NP_001248332.1, NM_001261403.2 [Q00653-4]
NP_001275653.1, NM_001288724.1 [Q00653-4]
NP_001309863.1, NM_001322934.1 [Q00653-1]
NP_001309864.1, NM_001322935.1
NP_002493.3, NM_002502.5 [Q00653-4]
UniGeneiHs.73090

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A3QX-ray2.10A/B37-327[»]
2D96NMR-A766-859[»]
3DO7X-ray3.05B37-329[»]
4OT9X-ray3.35A407-765[»]
ProteinModelPortaliQ00653
SMRiQ00653
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110858, 53 interactors
CORUMiQ00653
DIPiDIP-24239N
DIP-27535N
IntActiQ00653, 36 interactors
MINTiQ00653
STRINGi9606.ENSP00000358983

Chemistry databases

ChEMBLiCHEMBL3003
DrugBankiDB00945 Acetylsalicylic acid
DB05487 CC-8490
DB01296 Glucosamine
DB05212 HE3286
DB05767 HMPL-004
DB05464 NOX-700
DB05451 P54
DB05471 SGN-30

PTM databases

CarbonylDBiQ00653
iPTMnetiQ00653
PhosphoSitePlusiQ00653
SwissPalmiQ00653

Polymorphism and mutation databases

DMDMi116242678

Proteomic databases

EPDiQ00653
MaxQBiQ00653
PaxDbiQ00653
PeptideAtlasiQ00653
PRIDEiQ00653
ProteomicsDBi57866
57867 [Q00653-3]
57868 [Q00653-4]

Protocols and materials databases

DNASUi4791
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000189444; ENSP00000189444; ENSG00000077150 [Q00653-4]
ENST00000369966; ENSP00000358983; ENSG00000077150 [Q00653-1]
ENST00000428099; ENSP00000410256; ENSG00000077150 [Q00653-4]
GeneIDi4791
KEGGihsa:4791
UCSCiuc001kva.4 human [Q00653-1]

Organism-specific databases

CTDi4791
DisGeNETi4791
EuPathDBiHostDB:ENSG00000077150.17
GeneCardsiNFKB2
HGNCiHGNC:7795 NFKB2
HPAiCAB022098
HPA008422
HPA023900
MalaCardsiNFKB2
MIMi164012 gene
615577 phenotype
neXtProtiNX_Q00653
OpenTargetsiENSG00000077150
Orphaneti1572 Common variable immunodeficiency
PharmGKBiPA31600
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00500000044765
HOGENOMiHOG000004822
HOVERGENiHBG052613
InParanoidiQ00653
KOiK04469
OMAiFRGHTPL
OrthoDBiEOG091G03PF
PhylomeDBiQ00653
TreeFamiTF325632

Enzyme and pathway databases

ReactomeiR-HSA-1810476 RIP-mediated NFkB activation via ZBP1
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-448706 Interleukin-1 processing
R-HSA-4755510 SUMOylation of immune response proteins
R-HSA-5603029 IkBA variant leads to EDA-ID
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-844456 The NLRP3 inflammasome
R-HSA-933542 TRAF6 mediated NF-kB activation
SIGNORiQ00653

Miscellaneous databases

ChiTaRSiNFKB2 human
EvolutionaryTraceiQ00653
GeneWikiiNFKB2
GenomeRNAii4791
PMAP-CutDBiQ00653
PROiPR:Q00653
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000077150 Expressed in 170 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_NFKB2
ExpressionAtlasiQ00653 baseline and differential
GenevisibleiQ00653 HS

Family and domain databases

CDDicd00204 ANK, 2 hits
cd01177 IPT_NFkappaB, 1 hit
Gene3Di1.25.40.20, 1 hit
2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR033926 IPT_NFkappaB
IPR000451 NFkB/Dor
IPR008967 p53-like_TF_DNA-bd
IPR030492 RHD_CS
IPR032397 RHD_dimer
IPR011539 RHD_DNA_bind_dom
IPR037059 RHD_DNA_bind_dom_sf
PANTHERiPTHR24169 PTHR24169, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF00531 Death, 1 hit
PF16179 RHD_dimer, 1 hit
PF00554 RHD_DNA_bind, 1 hit
PRINTSiPR01415 ANKYRIN
PR00057 NFKBTNSCPFCT
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00005 DEATH, 1 hit
SM00429 IPT, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF48403 SSF48403, 1 hit
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS01204 REL_1, 1 hit
PS50254 REL_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNFKB2_HUMAN
AccessioniPrimary (citable) accession number: Q00653
Secondary accession number(s): A8K9D9
, D3DR83, Q04860, Q9BU75, Q9H471, Q9H472
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 17, 2006
Last modified: September 12, 2018
This is version 225 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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