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UniProtKB - Q00653 (NFKB2_HUMAN)

Entry version 242 (07 Oct 2020)
Sequence version 4 (17 Oct 2006)
Previous versions | rss
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Protein

Nuclear factor NF-kappa-B p100 subunit

Gene

NFKB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q00653

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1810476, RIP-mediated NFkB activation via ZBP1
R-HSA-3134963, DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-HSA-3214841, PKMTs methylate histone lysines
R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-448706, Interleukin-1 processing
R-HSA-4755510, SUMOylation of immune response proteins
R-HSA-5603029, IkBA variant leads to EDA-ID
R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5676590, NIK-->noncanonical NF-kB signaling
R-HSA-844456, The NLRP3 inflammasome
R-HSA-933542, TRAF6 mediated NF-kB activation
R-HSA-9660826, Purinergic signaling in leishmaniasis infection

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q00653

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear factor NF-kappa-B p100 subunit
Alternative name(s):
DNA-binding factor KBF2
H2TF1
Lymphocyte translocation chromosome 10 protein
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
Oncogene Lyt-10
Short name:
Lyt10
Cleaved into the following chain:
Nuclear factor NF-kappa-B p52 subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NFKB2
Synonyms:LYT10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000077150.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:7795, NFKB2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		164012, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q00653

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving NFKB2 is found in a case of B-cell non Hodgkin lymphoma (B-NHL). Translocation t(10;14)(q24;q32) with IGHA1. The resulting oncogene is also called Lyt-10C alpha variant.
A chromosomal aberration involving NFKB2 is found in a cutaneous T-cell leukemia (C-TCL) cell line. This rearrangement produces the p80HT gene which codes for a truncated 80 kDa protein (p80HT).
In B-cell leukemia (B-CLL) cell line, LB40 and EB308, can be found after heterogeneous chromosomal aberrations, such as internal deletions.
Immunodeficiency, common variable, 10 (CVID10)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency characterized by childhood-onset of recurrent infections, hypogammaglobulinemia, and decreased numbers of memory and marginal zone B-cells. Some patients may develop autoimmune features and have circulating autoantibodies. An unusual feature is central adrenal insufficiency.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_074035865D → G in CVID10; unknown pathological significance; de novo mutation. 1 PublicationCorresponds to variant dbSNP:rs727502787EnsemblClinVar.1
Natural variantiVAR_074036867A → V in CVID10; unknown pathological significance; de novo mutation. 1 PublicationCorresponds to variant dbSNP:rs727502788EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi247 – 249YLL → AAA: Two-fold reduction in heterodimerization with RelA. 1 Publication3
Mutagenesisi399P → A: No change in cleavage rate or products. 1 Publication1
Mutagenesisi404G → A: No change in cleavage rate or products. 1 Publication1
Mutagenesisi405A → P: No change in cleavage rate or products. 1 Publication1
Mutagenesisi406Q → N: No change in cleavage rate or products. 1 Publication1
Mutagenesisi713S → G: Loss of phosphorylation; when associated with A-715 and A-717. 1 Publication1
Mutagenesisi715S → A: Loss of phosphorylation; when associated with G-713 and A-717. 1 Publication1
Mutagenesisi717S → A: Loss of phosphorylation; when associated with G-713 and A-715. 1 Publication1
Mutagenesisi866S → A: Decrease in MAP3K14-induced phosphorylation; no inducible processing occurs; when associated with A-869. 1 Publication1
Mutagenesisi870S → A: Decrease in MAP3K14-induced phosphorylation; no inducible processing occurs; when associated with A-865. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei490 – 491Breakpoint for translocation to form NFKB2-IGHA1 oncogene2

Keywords - Diseasei

Disease mutation, Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		4791

MalaCards human disease database

More...MalaCardsi		NFKB2
MIMi615577, phenotype

Open Targets

More...OpenTargetsi		ENSG00000077150

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		1572, Common variable immunodeficiency
293978, Deficiency in anterior pituitary function-variable immunodeficiency syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31600

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q00653, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3003

Drug and drug target database

More...DrugBanki		DB05767, Andrographolide
DB05487, Custirsen
DB00843, Donepezil
DB13961, Fish oil
DB01296, Glucosamine
DB13751, Glycyrrhizic acid
DB05212, HE3286
DB05559, NF-kappaB Decoy
DB05464, NOX-700
DB05451, P54
DB14059, SC-236
DB05471, SGN-30

DrugCentral

More...DrugCentrali		Q00653

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NFKB2

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242678

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000303211 – 900Nuclear factor NF-kappa-B p100 subunitAdd BLAST900
ChainiPRO_00000303221 – 454Nuclear factor NF-kappa-B p52 subunitAdd BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei23PhosphoserineCombined sources1
Modified residuei161PhosphoserineCombined sources1
Modified residuei429PhosphothreonineCombined sources1
Modified residuei713Phosphoserine1 Publication1
Modified residuei715Phosphoserine1 Publication1
Modified residuei717Phosphoserine1 Publication1
Modified residuei812PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki855Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei866Phosphoserine; by MAP3K141 Publication1
Modified residuei870Phosphoserine; by MAP3K141 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p52 making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing.
Subsequent to MAP3K14-dependent serine phosphorylation, p100 polyubiquitination occurs then triggering its proteasome-dependent processing.3 Publications
Constitutive processing is tightly suppressed by its C-terminal processing inhibitory domain, named PID, which contains the death domain.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei454 – 455Cleavage (when cotranslationally processed)2

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-721

Encyclopedia of Proteome Dynamics

More...EPDi		Q00653

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q00653

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q00653

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q00653

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q00653

PeptideAtlas

More...PeptideAtlasi		Q00653

PRoteomics IDEntifications database

More...PRIDEi		Q00653

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57866 [Q00653-1]
57867 [Q00653-3]
57868 [Q00653-4]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q00653

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q00653

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q00653

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q00653

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000077150, Expressed in left lobe of thyroid gland and 186 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q00653, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q00653, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000077150, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the NF-kappa-B RelB-p52 complex. Homodimer; component of the NF-kappa-B p52-p52 complex.

Component of the NF-kappa-B p65-p52 complex.

Component of the NF-kappa-B p52-c-Rel complex. NFKB2/p52 interacts with NFKBIE.

Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Directly interacts with MEN1.

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110858, 69 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q00653

Database of interacting proteins

More...DIPi		DIP-24239N
DIP-27535N

Protein interaction database and analysis system

More...IntActi		Q00653, 45 interactors

Molecular INTeraction database

More...MINTi		Q00653

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000358983

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q00653, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1900
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q00653

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q00653

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 343RHDPROSITE-ProRule annotationAdd BLAST306
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati487 – 519ANK 1Add BLAST33
Repeati526 – 555ANK 2Add BLAST30
Repeati559 – 591ANK 3Add BLAST33
Repeati599 – 628ANK 4Add BLAST30
Repeati633 – 663ANK 5Add BLAST31
Repeati667 – 696ANK 6Add BLAST30
Repeati729 – 758ANK 7Add BLAST30
Domaini764 – 851DeathAdd BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni346 – 377GRRAdd BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi337 – 341Nuclear localization signalSequence analysis5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi350 – 400Gly-richAdd BLAST51

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminus of p100 might be involved in cytoplasmic retention, inhibition of DNA-binding by p52 homodimers, and/or transcription activation.By similarity
The glycine-rich region (GRR) appears to be a critical element in the generation of p52.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0504, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160968

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004343_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q00653

KEGG Orthology (KO)

More...KOi		K04469

Identification of Orthologs from Complete Genome Data

More...OMAi		IPEYDDF

Database of Orthologous Groups

More...OrthoDBi		916931at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q00653

TreeFam database of animal gene trees

More...TreeFami		TF325632

Family and domain databases

Conserved Domains Database

More...CDDi		cd01177, IPT_NFkappaB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 1 hit
2.60.40.10, 1 hit
2.60.40.340, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR033926, IPT_NFkappaB
IPR000451, NFkB/Dor
IPR008967, p53-like_TF_DNA-bd
IPR030492, RHD_CS
IPR032397, RHD_dimer
IPR011539, RHD_DNA_bind_dom
IPR037059, RHD_DNA_bind_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR24169, PTHR24169, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796, Ank_2, 2 hits
PF00531, Death, 1 hit
PF16179, RHD_dimer, 1 hit
PF00554, RHD_DNA_bind, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01415, ANKYRIN
PR00057, NFKBTNSCPFCT

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 6 hits
SM00005, DEATH, 1 hit
SM00429, IPT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 1 hit
SSF49417, SSF49417, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS01204, REL_1, 1 hit
PS50254, REL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q00653-1) [UniParc]FASTAAdd to basket
Also known as: p100

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESCYNPGLD GIIEYDDFKL NSSIVEPKEP APETADGPYL VIVEQPKQRG 
        60         70         80         90        100
FRFRYGCEGP SHGGLPGASS EKGRKTYPTV KICNYEGPAK IEVDLVTHSD 
       110        120        130        140        150
PPRAHAHSLV GKQCSELGIC AVSVGPKDMT AQFNNLGVLH VTKKNMMGTM 
       160        170        180        190        200
IQKLQRQRLR SRPQGLTEAE QRELEQEAKE LKKVMDLSIV RLRFSAFLRA 
       210        220        230        240        250
SDGSFSLPLK PVISQPIHDS KSPGASNLKI SRMDKTAGSV RGGDEVYLLC 
       260        270        280        290        300
DKVQKDDIEV RFYEDDENGW QAFGDFSPTD VHKQYAIVFR TPPYHKMKIE 
       310        320        330        340        350
RPVTVFLQLK RKRGGDVSDS KQFTYYPLVE DKEEVQRKRR KALPTFSQPF 
       360        370        380        390        400
GGGSHMGGGS GGAAGGYGGA GGGGSLGFFP SSLAYSPYQS GAGPMGCYPG 
       410        420        430        440        450
GGGGAQMAAT VPSRDSGEEA AEPSAPSRTP QCEPQAPEML QRAREYNARL 
       460        470        480        490        500
FGLAQRSARA LLDYGVTADA RALLAGQRHL LTAQDENGDT PLHLAIIHGQ 
       510        520        530        540        550
TSVIEQIVYV IHHAQDLGVV NLTNHLHQTP LHLAVITGQT SVVSFLLRVG 
       560        570        580        590        600
ADPALLDRHG DSAMHLALRA GAGAPELLRA LLQSGAPAVP QLLHMPDFEG 
       610        620        630        640        650
LYPVHLAVRA RSPECLDLLV DSGAEVEATE RQGGRTALHL ATEMEELGLV 
       660        670        680        690        700
THLVTKLRAN VNARTFAGNT PLHLAAGLGY PTLTRLLLKA GADIHAENEE 
       710        720        730        740        750
PLCPLPSPPT SDSDSDSEGP EKDTRSSFRG HTPLDLTCST KVKTLLLNAA 
       760        770        780        790        800
QNTMEPPLTP PSPAGPGLSL GDTALQNLEQ LLDGPEAQGS WAELAERLGL 
       810        820        830        840        850
RSLVDTYRQT TSPSGSLLRS YELAGGDLAG LLEALSDMGL EEGVRLLRGP 
       860        870        880        890        900
ETRDKLPSTA EVKEDSAYGS QSVEQEAEKL GPPPEPPGGL CHGHPQPQVH
Length:900
Mass (Da):96,749
Last modified:October 17, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6BAD7038834783CA
GO
Isoform 3 (identifier: Q00653-3) [UniParc]FASTAAdd to basket
Also known as: p49

The sequence of this isoform differs from the canonical sequence as follows:
     374-428: GSLGFFPSSL...EAAEPSAPSR → EGVLMEGGVK...RSSRPAWPTA
     429-900: Missing.

Show »
Length:428
Mass (Da):47,021
Checksum:iE4D38A8635501807
GO
Isoform 4 (identifier: Q00653-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     860-860: Missing.

Show »
Length:899
Mass (Da):96,678
Checksum:iB3753FF15B7BDF57
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZX1M0QZX1_HUMAN
Nuclear factor NF-kappa-B p100 subu...
NFKB2
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA43715 differs from that shown. Reason: Frameshift.Curated
The sequence CAA43716 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti144K → E in AAB21124 (PubMed:1531086).Curated1
Sequence conflicti213I → T in CAA43715 (PubMed:1876189).Curated1
Sequence conflicti213I → T in CAA43716 (PubMed:1876189).Curated1
Sequence conflicti213I → T in AAA68171 (PubMed:7969113).Curated1
Sequence conflicti396G → R in CAA43715 (PubMed:1876189).Curated1
Sequence conflicti433 – 434EP → DA in AAB21124 (PubMed:1531086).Curated2
Sequence conflicti459R → K AA sequence (PubMed:8360178).Curated1
Sequence conflicti465G → C in CAA43715 (PubMed:1876189).Curated1
Sequence conflicti470A → R in CAA43715 (PubMed:1876189).Curated1
Sequence conflicti470A → R in AAB21124 (PubMed:1531086).Curated1
Sequence conflicti741K → L in CAA43715 (PubMed:1876189).Curated1
Sequence conflicti860A → T in AAB21124 (PubMed:1531086).Curated1
Sequence conflicti876E → K in AAB21124 (PubMed:1531086).Curated1
Sequence conflicti891C → S in CAA43715 (PubMed:1876189).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02222314E → K1 PublicationCorresponds to variant dbSNP:rs45581936EnsemblClinVar.1
Natural variantiVAR_022224351G → R1 PublicationCorresponds to variant dbSNP:rs45580031Ensembl.1
Natural variantiVAR_051781392A → G. Corresponds to variant dbSNP:rs11574848Ensembl.1
Natural variantiVAR_022225452G → R1 PublicationCorresponds to variant dbSNP:rs45471103Ensembl.1
Natural variantiVAR_018452618 – 900Missing in truncated form EB308. Add BLAST283
Natural variantiVAR_006909667 – 669AGN → SAS in truncated form p80HT. 3
Natural variantiVAR_006910670 – 900Missing in truncated form p80HT. Add BLAST231
Natural variantiVAR_018453703 – 900Missing in truncated form LB40. Add BLAST198
Natural variantiVAR_074035865D → G in CVID10; unknown pathological significance; de novo mutation. 1 PublicationCorresponds to variant dbSNP:rs727502787EnsemblClinVar.1
Natural variantiVAR_074036867A → V in CVID10; unknown pathological significance; de novo mutation. 1 PublicationCorresponds to variant dbSNP:rs727502788EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040082374 – 428GSLGF…SAPSR → EGVLMEGGVKVREAVEEKNL GEAGRGLHACNPALWEAKAG RLPEIRSSRPAWPTA in isoform 3. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_040083429 – 900Missing in isoform 3. 1 PublicationAdd BLAST472
Alternative sequenceiVSP_040084860Missing in isoform 4. 4 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X61498 mRNA Translation: CAA43715.1 Frameshift.
X61499 mRNA Translation: CAA43716.1 Frameshift.
S76638 mRNA Translation: AAB21124.1
U09609 mRNA Translation: AAA21462.2
BT009769 mRNA Translation: AAP88771.1
AK292654 mRNA Translation: BAF85343.1
AY865619 Genomic DNA Translation: AAW56071.1
AL121928 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49700.1
CH471066 Genomic DNA Translation: EAW49701.1
CH471066 Genomic DNA Translation: EAW49702.1
CH471066 Genomic DNA Translation: EAW49704.1
CH471066 Genomic DNA Translation: EAW49706.1
BC002844 mRNA Translation: AAH02844.1
U20816 Genomic DNA Translation: AAA68171.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41564.1 [Q00653-1]
CCDS41565.1 [Q00653-4]

Protein sequence database of the Protein Information Resource

More...PIRi		A42024
A57034
I38609
S17233

NCBI Reference Sequences

More...RefSeqi		NP_001070962.1, NM_001077494.3 [Q00653-1]
NP_001248332.1, NM_001261403.2 [Q00653-4]
NP_001275653.1, NM_001288724.1 [Q00653-4]
NP_001309863.1, NM_001322934.1 [Q00653-1]
NP_001309864.1, NM_001322935.1
NP_002493.3, NM_002502.5 [Q00653-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000189444; ENSP00000189444; ENSG00000077150 [Q00653-4]
ENST00000369966; ENSP00000358983; ENSG00000077150 [Q00653-1]
ENST00000428099; ENSP00000410256; ENSG00000077150 [Q00653-4]
ENST00000652277; ENSP00000498308; ENSG00000077150 [Q00653-4]
ENST00000661543; ENSP00000499294; ENSG00000077150 [Q00653-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4791

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4791

UCSC genome browser

More...UCSCi		uc001kva.4, human [Q00653-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61498 mRNA Translation: CAA43715.1 Frameshift.
X61499 mRNA Translation: CAA43716.1 Frameshift.
S76638 mRNA Translation: AAB21124.1
U09609 mRNA Translation: AAA21462.2
BT009769 mRNA Translation: AAP88771.1
AK292654 mRNA Translation: BAF85343.1
AY865619 Genomic DNA Translation: AAW56071.1
AL121928 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49700.1
CH471066 Genomic DNA Translation: EAW49701.1
CH471066 Genomic DNA Translation: EAW49702.1
CH471066 Genomic DNA Translation: EAW49704.1
CH471066 Genomic DNA Translation: EAW49706.1
BC002844 mRNA Translation: AAH02844.1
U20816 Genomic DNA Translation: AAA68171.1
CCDSiCCDS41564.1 [Q00653-1]
CCDS41565.1 [Q00653-4]
PIRiA42024
A57034
I38609
S17233
RefSeqiNP_001070962.1, NM_001077494.3 [Q00653-1]
NP_001248332.1, NM_001261403.2 [Q00653-4]
NP_001275653.1, NM_001288724.1 [Q00653-4]
NP_001309863.1, NM_001322934.1 [Q00653-1]
NP_001309864.1, NM_001322935.1
NP_002493.3, NM_002502.5 [Q00653-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A3QX-ray2.10A/B37-327[»]
2D96NMR-A766-859[»]
3DO7X-ray3.05B37-329[»]
4OT9X-ray3.35A407-765[»]
5ZMCX-ray2.99A35-329[»]
SMRiQ00653
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110858, 69 interactors
CORUMiQ00653
DIPiDIP-24239N
DIP-27535N
IntActiQ00653, 45 interactors
MINTiQ00653
STRINGi9606.ENSP00000358983

Chemistry databases

ChEMBLiCHEMBL3003
DrugBankiDB05767, Andrographolide
DB05487, Custirsen
DB00843, Donepezil
DB13961, Fish oil
DB01296, Glucosamine
DB13751, Glycyrrhizic acid
DB05212, HE3286
DB05559, NF-kappaB Decoy
DB05464, NOX-700
DB05451, P54
DB14059, SC-236
DB05471, SGN-30
DrugCentraliQ00653

PTM databases

CarbonylDBiQ00653
iPTMnetiQ00653
PhosphoSitePlusiQ00653
SwissPalmiQ00653

Polymorphism and mutation databases

BioMutaiNFKB2
DMDMi116242678

Proteomic databases

CPTACiCPTAC-721
EPDiQ00653
jPOSTiQ00653
MassIVEiQ00653
MaxQBiQ00653
PaxDbiQ00653
PeptideAtlasiQ00653
PRIDEiQ00653
ProteomicsDBi57866 [Q00653-1]
57867 [Q00653-3]
57868 [Q00653-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q00653, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1322, 953 antibodies

The CPTC Antibody Portal

More...CPTCi		Q00653, 1 antibody

The DNASU plasmid repository

More...DNASUi		4791

Genome annotation databases

EnsembliENST00000189444; ENSP00000189444; ENSG00000077150 [Q00653-4]
ENST00000369966; ENSP00000358983; ENSG00000077150 [Q00653-1]
ENST00000428099; ENSP00000410256; ENSG00000077150 [Q00653-4]
ENST00000652277; ENSP00000498308; ENSG00000077150 [Q00653-4]
ENST00000661543; ENSP00000499294; ENSG00000077150 [Q00653-1]
GeneIDi4791
KEGGihsa:4791
UCSCiuc001kva.4, human [Q00653-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4791
DisGeNETi4791
EuPathDBiHostDB:ENSG00000077150.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		NFKB2
HGNCiHGNC:7795, NFKB2
HPAiENSG00000077150, Low tissue specificity
MalaCardsiNFKB2
MIMi164012, gene
615577, phenotype
neXtProtiNX_Q00653
OpenTargetsiENSG00000077150
Orphaneti1572, Common variable immunodeficiency
293978, Deficiency in anterior pituitary function-variable immunodeficiency syndrome
PharmGKBiPA31600

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0504, Eukaryota
GeneTreeiENSGT00940000160968
HOGENOMiCLU_004343_1_1_1
InParanoidiQ00653
KOiK04469
OMAiIPEYDDF
OrthoDBi916931at2759
PhylomeDBiQ00653
TreeFamiTF325632

Enzyme and pathway databases

PathwayCommonsiQ00653
ReactomeiR-HSA-1810476, RIP-mediated NFkB activation via ZBP1
R-HSA-3134963, DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-HSA-3214841, PKMTs methylate histone lysines
R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-448706, Interleukin-1 processing
R-HSA-4755510, SUMOylation of immune response proteins
R-HSA-5603029, IkBA variant leads to EDA-ID
R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5676590, NIK-->noncanonical NF-kB signaling
R-HSA-844456, The NLRP3 inflammasome
R-HSA-933542, TRAF6 mediated NF-kB activation
R-HSA-9660826, Purinergic signaling in leishmaniasis infection
SIGNORiQ00653

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4791, 25 hits in 897 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NFKB2, human
EvolutionaryTraceiQ00653

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NFKB2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4791
PharosiQ00653, Tchem

Protein Ontology

More...PROi		PR:Q00653
RNActiQ00653, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000077150, Expressed in left lobe of thyroid gland and 186 other tissues
ExpressionAtlasiQ00653, baseline and differential
GenevisibleiQ00653, HS

Family and domain databases

CDDicd01177, IPT_NFkappaB, 1 hit
Gene3Di1.25.40.20, 1 hit
2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR033926, IPT_NFkappaB
IPR000451, NFkB/Dor
IPR008967, p53-like_TF_DNA-bd
IPR030492, RHD_CS
IPR032397, RHD_dimer
IPR011539, RHD_DNA_bind_dom
IPR037059, RHD_DNA_bind_dom_sf
PANTHERiPTHR24169, PTHR24169, 1 hit
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF00531, Death, 1 hit
PF16179, RHD_dimer, 1 hit
PF00554, RHD_DNA_bind, 1 hit
PRINTSiPR01415, ANKYRIN
PR00057, NFKBTNSCPFCT
SMARTiView protein in SMART
SM00248, ANK, 6 hits
SM00005, DEATH, 1 hit
SM00429, IPT, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 1 hit
SSF49417, SSF49417, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 5 hits
PS01204, REL_1, 1 hit
PS50254, REL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFKB2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q00653
Secondary accession number(s): A8K9D9
, D3DR83, Q04860, Q9BU75, Q9H471, Q9H472
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 17, 2006
Last modified: October 7, 2020
This is version 242 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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