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UniProtKB - Q00649 (HSPB1_CHICK)
Protein
Heat shock protein beta-1
Gene
HSPB1
Organism
Gallus gallus (Chicken)
Status
Functioni
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization.
1 PublicationGO - Molecular functioni
- identical protein binding Source: UniProtKB
- protein folding chaperone Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- protein kinase C binding Source: AgBase
- protein kinase C inhibitor activity Source: AgBase
GO - Biological processi
- barbed-end actin filament capping Source: AgBase
- chaperone-mediated protein folding Source: UniProtKB
- negative regulation of actin filament polymerization Source: AgBase
- negative regulation of apoptotic signaling pathway Source: AgBase
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: AgBase
- negative regulation of protein kinase activity Source: AgBase
- negative regulation of protein serine/threonine kinase activity Source: AgBase
- positive regulation of interleukin-1 beta production Source: AgBase
- positive regulation of tumor necrosis factor production Source: AgBase
- regulation of I-kappaB kinase/NF-kappaB signaling Source: AgBase
- response to heat Source: AgBase
Keywordsi
Molecular function | Actin capping, Chaperone |
Biological process | Stress response |
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock protein beta-1Short name: HspB1 Alternative name(s): 25 kDa IAP Actin polymerization inhibitor Heat shock 25 kDa protein Short name: HSP 25 Heat shock 27 kDa protein Short name: HSP 27 |
Gene namesi | Name:HSPB1 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
- spindle Source: UniProtKB-SubCell
Mitochondrion
- mitochondrion Source: AgBase
Nucleus
- nucleus Source: AgBase
Plasma Membrane
- plasma membrane Source: AgBase
Other locations
- contractile fiber Source: AgBase
- cytoplasm Source: AgBase
- intracellular anatomical structure Source: AgBase
- Z disc Source: AgBase
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000125931 | 1 – 193 | Heat shock protein beta-1Add BLAST | 193 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 15 | PhosphoserineBy similarity | 1 | |
Modified residuei | 80 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinPTM databases
iPTMneti | Q00649 |
Expressioni
Tissue specificityi
Smooth, cardiac and skeletal muscle, hardly detectable in fibroblasts or focal contacts.
Interactioni
Subunit structurei
Homooligomer. Homodimer; becomes monomeric upon activation. Heterooligomer.
By similarityGO - Molecular functioni
- identical protein binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- protein kinase C binding Source: AgBase
Protein-protein interaction databases
BioGRIDi | 676487, 1 interactor |
IntActi | Q00649, 1 interactor |
STRINGi | 9031.ENSGALP00000039447 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 74 – 182 | sHSPPROSITE-ProRule annotationAdd BLAST | 109 |
Sequence similaritiesi
Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG3591, Eukaryota |
InParanoidi | Q00649 |
OrthoDBi | 1187096at2759 |
PhylomeDBi | Q00649 |
Family and domain databases
CDDi | cd06475, ACD_HspB1_like, 1 hit |
Gene3Di | 2.60.40.790, 1 hit |
InterProi | View protein in InterPro IPR002068, A-crystallin/Hsp20_dom IPR037876, ACD_HspB1 IPR001436, Alpha-crystallin/sHSP_animal IPR008978, HSP20-like_chaperone |
PANTHERi | PTHR45640, PTHR45640, 1 hit |
Pfami | View protein in Pfam PF00011, HSP20, 1 hit |
PRINTSi | PR00299, ACRYSTALLIN |
SUPFAMi | SSF49764, SSF49764, 1 hit |
PROSITEi | View protein in PROSITE PS01031, SHSP, 1 hit |
i Sequence
Sequence statusi: Complete.
Q00649-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAERRVPFTF LTSPSWEPFR DWYHGSRLFD QSFGMPHIPE DWYKWPSGSA
60 70 80 90 100
WPGYFRLLPS ESALLPAPGS PYGRALSELS SGISEIRQSA DSWKVTLDVN
110 120 130 140 150
HFAPEELVVK TKDNIVEITG KHEEKQDEHG FISRCFTRKY TLPPGVEATA
160 170 180 190
VRSSLSPDGM LTVEAPLPKP AIQSSEITIP VTVEAKKEEP AKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59541 mRNA Translation: CAA42114.1 |
PIRi | A39644 |
RefSeqi | NP_990621.1, NM_205290.1 |
Genome annotation databases
GeneIDi | 396227 |
KEGGi | gga:396227 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59541 mRNA Translation: CAA42114.1 |
PIRi | A39644 |
RefSeqi | NP_990621.1, NM_205290.1 |
3D structure databases
SMRi | Q00649 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 676487, 1 interactor |
IntActi | Q00649, 1 interactor |
STRINGi | 9031.ENSGALP00000039447 |
PTM databases
iPTMneti | Q00649 |
Genome annotation databases
GeneIDi | 396227 |
KEGGi | gga:396227 |
Organism-specific databases
CTDi | 3315 |
Phylogenomic databases
eggNOGi | KOG3591, Eukaryota |
InParanoidi | Q00649 |
OrthoDBi | 1187096at2759 |
PhylomeDBi | Q00649 |
Miscellaneous databases
PROi | PR:Q00649 |
Family and domain databases
CDDi | cd06475, ACD_HspB1_like, 1 hit |
Gene3Di | 2.60.40.790, 1 hit |
InterProi | View protein in InterPro IPR002068, A-crystallin/Hsp20_dom IPR037876, ACD_HspB1 IPR001436, Alpha-crystallin/sHSP_animal IPR008978, HSP20-like_chaperone |
PANTHERi | PTHR45640, PTHR45640, 1 hit |
Pfami | View protein in Pfam PF00011, HSP20, 1 hit |
PRINTSi | PR00299, ACRYSTALLIN |
SUPFAMi | SSF49764, SSF49764, 1 hit |
PROSITEi | View protein in PROSITE PS01031, SHSP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HSPB1_CHICK | |
Accessioni | Q00649Primary (citable) accession number: Q00649 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | April 7, 2021 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families