Apolipoprotein A-I

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• amyloid-beta binding Source: MGI
• apolipoprotein A-I receptor binding Source: MGI
• apolipoprotein receptor binding Source: MGI
• chemorepellent activity Source: MGI
• cholesterol binding Source: MGI
• cholesterol transfer activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain."
    Hirsch-Reinshagen V., Zhou S., Burgess B.L., Bernier L., McIsaac S.A., Chan J.Y., Tansley G.H., Cohn J.S., Hayden M.R., Wellington C.L.
    J Biol Chem 279:41197-41207(2004) [PubMed] [Europe PMC] [Abstract]
• enzyme binding Source: MGI
• heat shock protein binding Source: MGI
• high-density lipoprotein particle binding Source: MGIInferred from direct assayⁱ
  • "Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distribution."
    Reschly E.J., Sorci-Thomas M.G., Davidson W.S., Meredith S.C., Reardon C.A., Getz G.S.
    J Biol Chem 277:9645-9654(2002) [PubMed] [Europe PMC] [Abstract]
  • "Influence of apoA-I and apoE on the formation of serum amyloid A-containing lipoproteins in vivo and in vitro."
    Cabana V.G., Feng N., Reardon C.A., Lukens J., Webb N.R., de Beer F.C., Getz G.S.
    J Lipid Res 45:317-325(2004) [PubMed] [Europe PMC] [Abstract]
• high-density lipoprotein particle receptor binding Source: MGI
• identical protein binding Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distribution."
    Reschly E.J., Sorci-Thomas M.G., Davidson W.S., Meredith S.C., Reardon C.A., Getz G.S.
    J Biol Chem 277:9645-9654(2002) [PubMed] [Europe PMC] [Abstract]
  • "Structural and functional properties of human and mouse apolipoprotein A-I."
    Gong E.L., Tan C.S., Shoukry M.I., Rubin E.M., Nichols A.V.
    Biochim Biophys Acta 1213:335-342(1994) [PubMed] [Europe PMC] [Abstract]
• lipase inhibitor activity Source: MGI
• lipid binding Source: MGIInferred from direct assayⁱ
  • "Structural and functional properties of human and mouse apolipoprotein A-I."
    Gong E.L., Tan C.S., Shoukry M.I., Rubin E.M., Nichols A.V.
    Biochim Biophys Acta 1213:335-342(1994) [PubMed] [Europe PMC] [Abstract]
• lipid transporter activity Source: MGIInferred from direct assayⁱ
  • "Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distribution."
    Reschly E.J., Sorci-Thomas M.G., Davidson W.S., Meredith S.C., Reardon C.A., Getz G.S.
    J Biol Chem 277:9645-9654(2002) [PubMed] [Europe PMC] [Abstract]
• lipoprotein particle binding Source: MGIInferred from direct assayⁱ
  • "Structural and functional properties of human and mouse apolipoprotein A-I."
    Gong E.L., Tan C.S., Shoukry M.I., Rubin E.M., Nichols A.V.
    Biochim Biophys Acta 1213:335-342(1994) [PubMed] [Europe PMC] [Abstract]
• phosphatidylcholine binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• phosphatidylcholine-sterol O-acyltransferase activator activity Source: MGI
• phospholipid binding Source: MGI
• protein homodimerization activity Source: UniProtKB
• signaling receptor binding Source: MGI

GO - Biological processⁱ

• adrenal gland development Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production."
    Plump A.S., Erickson S.K., Weng W., Partin J.S., Breslow J.L., Williams D.L.
    J Clin Invest 97:2660-2671(1996) [PubMed] [Europe PMC] [Abstract]
• animal organ regeneration Source: MGI
• blood vessel endothelial cell migration Source: MGIInferred from mutant phenotypeⁱ
  • "High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I."
    Seetharam D., Mineo C., Gormley A.K., Gibson L.L., Vongpatanasin W., Chambliss K.L., Hahner L.D., Cummings M.L., Kitchens R.L., Marcel Y.L., Rader D.J., Shaul P.W.
    Circ Res 98:63-72(2006) [PubMed] [Europe PMC] [Abstract]
• cholesterol biosynthetic process Source: MGIInferred from mutant phenotypeⁱ
  • "Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production."
    Plump A.S., Erickson S.K., Weng W., Partin J.S., Breslow J.L., Williams D.L.
    J Clin Invest 97:2660-2671(1996) [PubMed] [Europe PMC] [Abstract]
• cholesterol efflux Source: MGIInferred from direct assayⁱ
  • "Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distribution."
    Reschly E.J., Sorci-Thomas M.G., Davidson W.S., Meredith S.C., Reardon C.A., Getz G.S.
    J Biol Chem 277:9645-9654(2002) [PubMed] [Europe PMC] [Abstract]
  • "Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-I."
    Martinez L.O., Agerholm-Larsen B., Wang N., Chen W., Tall A.R.
    J Biol Chem 278:37368-37374(2003) [PubMed] [Europe PMC] [Abstract]
  • "Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain."
    Hirsch-Reinshagen V., Zhou S., Burgess B.L., Bernier L., McIsaac S.A., Chan J.Y., Tansley G.H., Cohn J.S., Hayden M.R., Wellington C.L.
    J Biol Chem 279:41197-41207(2004) [PubMed] [Europe PMC] [Abstract]
  • "ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes."
    Plump A.S., Azrolan N., Odaka H., Wu L., Jiang X., Tall A., Eisenberg S., Breslow J.L.
    J Lipid Res 38:1033-1047(1997) [PubMed] [Europe PMC] [Abstract]
• cholesterol homeostasis Source: MGI
• cholesterol import Source: MGI
• cholesterol metabolic process Source: MGIInferred from mutant phenotypeⁱ
  • "SAA-only HDL formed during the acute phase response in apoA-I+/+ and apoA-I-/- mice."
    Cabana V.G., Reardon C.A., Wei B., Lukens J.R., Getz G.S.
    J Lipid Res 40:1090-1103(1999) [PubMed] [Europe PMC] [Abstract]
  • "ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-beta pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis."
    Fagan A.M., Christopher E., Taylor J.W., Parsadanian M., Spinner M., Watson M., Fryer J.D., Wahrle S., Bales K.R., Paul S.M., Holtzman D.M.
    Am J Pathol 165:1413-1422(2004) [PubMed] [Europe PMC] [Abstract]
  • "Inflammation and skin cholesterol in LDLr-/-, apoA-I-/- mice: link between cholesterol homeostasis and self-tolerance?"
    Zabalawi M., Bharadwaj M., Horton H., Cline M., Willingham M., Thomas M.J., Sorci-Thomas M.G.
    J Lipid Res 48:52-65(2007) [PubMed] [Europe PMC] [Abstract]
  • "Effect of apolipoprotein A-I deficiency on lecithin:cholesterol acyltransferase activation in mouse plasma."
    Parks J.S., Li H., Gebre A.K., Smith T.L., Maeda N.
    J Lipid Res 36:349-355(1995) [PubMed] [Europe PMC] [Abstract]
  • "HDL deficiency in genetically engineered mice requires elevated LDL to accelerate atherogenesis."
    Hughes S.D., Verstuyft J., Rubin E.M.
    Arterioscler Thromb Vasc Biol 17:1725-1729(1997) [PubMed] [Europe PMC] [Abstract]
  • "The acute phase response in apolipoprotein A-1 knockout mice: apolipoprotein serum amyloid A and lipid distribution in plasma high density lipoproteins."
    Hajri T., Elliott-Bryant R., Sipe J.D., Liang J.S., Hayes K.C., Cathcart E.S.
    Biochim Biophys Acta 1394:209-218(1998) [PubMed] [Europe PMC] [Abstract]
• cholesterol transport Source: MGIInferred from direct assayⁱ
  • "Adenoviral vector-mediated overexpression of serum amyloid A in apoA-I-deficient mice."
    Webb N.R., de Beer M.C., van der Westhuyzen D.R., Kindy M.S., Banka C.L., Tsukamoto K., Rader D.L., de Beer F.C.
    J Lipid Res 38:1583-1590(1997) [PubMed] [Europe PMC] [Abstract]
• endothelial cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I."
    Seetharam D., Mineo C., Gormley A.K., Gibson L.L., Vongpatanasin W., Chambliss K.L., Hahner L.D., Cummings M.L., Kitchens R.L., Marcel Y.L., Rader D.J., Shaul P.W.
    Circ Res 98:63-72(2006) [PubMed] [Europe PMC] [Abstract]
• glucocorticoid metabolic process Source: MGIInferred from mutant phenotypeⁱ
  • "Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production."
    Plump A.S., Erickson S.K., Weng W., Partin J.S., Breslow J.L., Williams D.L.
    J Clin Invest 97:2660-2671(1996) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor signaling pathway Source: MGI
• high-density lipoprotein particle assembly Source: MGI
• high-density lipoprotein particle remodeling Source: MGI
• integrin-mediated signaling pathway Source: MGI
• lipid storage Source: MGIInferred from mutant phenotypeⁱ
  • "Apolipoprotein A-I is required for cholesteryl ester accumulation in steroidogenic cells and for normal adrenal steroid production."
    Plump A.S., Erickson S.K., Weng W., Partin J.S., Breslow J.L., Williams D.L.
    J Clin Invest 97:2660-2671(1996) [PubMed] [Europe PMC] [Abstract]
• lipoprotein biosynthetic process Source: MGIInferred from mutant phenotypeⁱ
  • "Point mutations in apolipoprotein A-I mimic the phenotype observed in patients with classical lecithin:cholesterol acyltransferase deficiency."
    Chroni A., Duka A., Kan H.Y., Liu T., Zannis V.I.
    Biochemistry 44:14353-14366(2005) [PubMed] [Europe PMC] [Abstract]
• lipoprotein metabolic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative chemotaxis Source: MGI
• negative regulation of cell adhesion molecule production Source: MGI
• negative regulation of cytokine production involved in immune response Source: MGI
• negative regulation of heterotypic cell-cell adhesion Source: MGI
• negative regulation of hydrolase activity Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I."
    Gruen M.L., Plummer M.R., Zhang W., Posey K.A., Linton M.F., Fazio S., Hasty A.H.
    J Lipid Res 46:2007-2014(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of inflammatory response Source: MGI
• negative regulation of interleukin-1 beta production Source: MGI
• negative regulation of lipase activity Source: MGI
• negative regulation of response to cytokine stimulus Source: MGI
• negative regulation of tumor necrosis factor-mediated signaling pathway Source: MGI
• negative regulation of very-low-density lipoprotein particle remodeling Source: MGI
• peptidyl-methionine modification Source: UniProtKB
• phosphatidylcholine biosynthetic process Source: MGI
• phosphatidylcholine metabolic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• phospholipid efflux Source: MGI
• phospholipid homeostasis Source: MGI
• phospholipid metabolic process Source: MGIInferred from mutant phenotypeⁱ
  • "The acute phase response in apolipoprotein A-1 knockout mice: apolipoprotein serum amyloid A and lipid distribution in plasma high density lipoproteins."
    Hajri T., Elliott-Bryant R., Sipe J.D., Liang J.S., Hayes K.C., Cathcart E.S.
    Biochim Biophys Acta 1394:209-218(1998) [PubMed] [Europe PMC] [Abstract]
• phospholipid transport Source: MGI
• positive regulation of cholesterol efflux Source: UniProtKB
• positive regulation of cholesterol esterification Source: MGI
• positive regulation of fatty acid biosynthetic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of hydrolase activity Source: MGI
• positive regulation of lipid biosynthetic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of lipoprotein lipase activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of phagocytosis Source: UniProtKB
• positive regulation of phospholipid efflux Source: UniProtKB
• positive regulation of Rho protein signal transduction Source: MGI
• positive regulation of stress fiber assembly Source: MGI
• positive regulation of substrate adhesion-dependent cell spreading Source: MGI
• positive regulation of triglyceride catabolic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein oxidation Source: UniProtKB
• protein stabilization Source: UniProtKB
• regulation of Cdc42 protein signal transduction Source: MGI
• regulation of intestinal cholesterol absorption Source: MGIInferred from direct assayⁱ
  • "ApoA1 reduces free cholesterol accumulation in atherosclerotic lesions of ApoE-deficient mice transplanted with ApoE-expressing macrophages."
    Boisvert W.A., Black A.S., Curtiss L.K.
    Arterioscler Thromb Vasc Biol 19:525-530(1999) [PubMed] [Europe PMC] [Abstract]
• regulation of protein phosphorylation Source: MGIInferred from direct assayⁱ
  • "Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-I."
    Martinez L.O., Agerholm-Larsen B., Wang N., Chen W., Tall A.R.
    J Biol Chem 278:37368-37374(2003) [PubMed] [Europe PMC] [Abstract]
• reverse cholesterol transport Source: MGI
• triglyceride homeostasis Source: MGI
• very-low-density lipoprotein particle remodeling Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• vitamin transport Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• apolipoprotein A-I receptor binding Source: MGI
• apolipoprotein receptor binding Source: MGI
• chemorepellent activity Source: MGI
• enzyme binding Source: MGI
• heat shock protein binding Source: MGI
• high-density lipoprotein particle receptor binding Source: MGI
• identical protein binding Source: MGIInferred from physical interactionⁱ
  • "Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distribution."
    Reschly E.J., Sorci-Thomas M.G., Davidson W.S., Meredith S.C., Reardon C.A., Getz G.S.
    J Biol Chem 277:9645-9654(2002) [PubMed] [Europe PMC] [Abstract]
  • "Structural and functional properties of human and mouse apolipoprotein A-I."
    Gong E.L., Tan C.S., Shoukry M.I., Rubin E.M., Nichols A.V.
    Biochim Biophys Acta 1213:335-342(1994) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: UniProtKB
• signaling receptor binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MKAVVLAVAL VFLTGSQAWH VWQQDEPQSQ WDKVKDFANV YVDAVKDSGR 
        60         70         80         90        100
DYVSQFESSS LGQQLNLNLL ENWDTLGSTV SQLQERLGPL TRDFWDNLEK 
       110        120        130        140        150
ETDWVRQEMN KDLEEVKQKV QPYLDEFQKK WKEDVELYRQ KVAPLGAELQ 
       160        170        180        190        200
ESARQKLQEL QGRLSPVAEE FRDRMRTHVD SLRTQLAPHS EQMRESLAQR 
       210        220        230        240        250
LAELKSNPTL NEYHTRAKTH LKTLGEKARP ALEDLRHSLM PMLETLKTQV 
       260 
QSVIDKASET LTAQ                                        

Experimental Info

<p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryⁱ

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families