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UniProtKB - Q00610 (CLH1_HUMAN)

Entry version 217 (29 Sep 2021)
Sequence version 5 (23 Jan 2007)
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Protein

Clathrin heavy chain 1

Gene

CLTC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582).

The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825).

Plays a role in early autophagosome formation (PubMed:20639872).

5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy, Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q00610

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-168275, Entry of Influenza Virion into Host Cell via Endocytosis
R-HSA-177504, Retrograde neurotrophin signalling
R-HSA-190873, Gap junction degradation
R-HSA-196025, Formation of annular gap junctions
R-HSA-2132295, MHC class II antigen presentation [Q00610-1]
R-HSA-3928665, EPH-ephrin mediated repulsion of cells
R-HSA-432720, Lysosome Vesicle Biogenesis [Q00610-1]
R-HSA-432722, Golgi Associated Vesicle Biogenesis [Q00610-1]
R-HSA-437239, Recycling pathway of L1
R-HSA-5099900, WNT5A-dependent internalization of FZD4
R-HSA-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
R-HSA-8866427, VLDLR internalisation and degradation
R-HSA-8964038, LDL clearance
R-HSA-9013420, RHOU GTPase cycle
R-HSA-9013424, RHOV GTPase cycle

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q00610

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q00610

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		Q00610, Curated

Transport Classification Database

More...TCDBi		8.A.137.1.1, the clathrin (clathrin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Clathrin heavy chain 12 Publications
Alternative name(s):
Clathrin heavy chain on chromosome 17
Short name:
CLH-17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLTC2 PublicationsImported
Synonyms:CLH17, CLTCL2, KIAA0034
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2092, CLTC

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		118955, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q00610

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000141367

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Coated pit, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, autosomal dominant 56 (MRD56)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080721554 – 556Missing in MRD56; unknown pathological significance. 1 Publication3
Natural variantiVAR_080722890P → L in MRD56. 1 PublicationCorresponds to variant dbSNP:rs1555606635EnsemblClinVar.1
Natural variantiVAR_0807231047L → P in MRD56; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1555607159EnsemblClinVar.1
Natural variantiVAR_0807241108W → R in MRD56; unknown pathological significance. 1 Publication1
Natural variantiVAR_0807251199 – 1675Missing in MRD56. 1 PublicationAdd BLAST477
Natural variantiVAR_0807261207Missing in MRD56; unknown pathological significance. 1 Publication1
Natural variantiVAR_0807271555 – 1675Missing in MRD56. 1 PublicationAdd BLAST121
Natural variantiVAR_0807281556 – 1675Missing in MRD56. 1 PublicationAdd BLAST120

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi65P → N: Disrupts spindle localization. 1 Publication1
Mutagenesisi67S → G: Disrupts spindle localization. 1 Publication1
Mutagenesisi87T → A: Disrupts spindle localization. 1 Publication1
Mutagenesisi89Q → A: Disrupts spindle localization. 1 Publication1
Mutagenesisi96K → E: Disrupts spindle localization. 1 Publication1
Mutagenesisi98K → E: Disrupts spindle localization. 1 Publication1
Mutagenesisi444R → E: Disrupts spindle localization; when associated with E-445, E-500 E-506 and E-507. 1 Publication1
Mutagenesisi445K → E: Disrupts spindle localization; when associated with E-444, E-500, E-506 and E-507. 1 Publication1
Mutagenesisi480 – 484LRANV → ERGQC: Disrupts spindle localization and interaction with TACC3. 1 Publication5
Mutagenesisi481R → E: Disrupts spindle localization; when associated with E-487, E-500, E-506 and E-507. 1 Publication1
Mutagenesisi487K → E: Disrupts spindle localization; when associated with E-481, E-500, E-506 and E-507. 1 Publication1
Mutagenesisi500K → E: Disrupts spindle localization; when associated with E-444, E-445, E-506 and E-507. 1 Publication1
Mutagenesisi500K → E: Disrupts spindle localization; when associated with E-481, E-487, E-506 and E-507. 1 Publication1
Mutagenesisi506K → E: Disrupts spindle localization; when associated with E-444, E-445, E-500 and E-507. 1 Publication1
Mutagenesisi506K → E: Disrupts spindle localization; when associated with E-481, E-487, E-500 and E-507. 1 Publication1
Mutagenesisi507K → E: Disrupts spindle localization; when associated with E-444, E-445, E-500 and E-506. 1 Publication1
Mutagenesisi507K → E: Disrupts spindle localization; when associated with E-481, E-487, E-500 and E-506. 1 Publication1

Keywords - Diseasei

Disease variant, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		1213

MalaCards human disease database

More...MalaCardsi		CLTC
MIMi617854, phenotype

Open Targets

More...OpenTargetsi		ENSG00000141367

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		178469, Autosomal dominant non-syndromic intellectual disability
178342, Inflammatory myofibroblastic tumor
319308, MiT family translocation renal cell carcinoma
442835, Non-specific early-onset epileptic encephalopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26618

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q00610, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3108634

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CLTC

Domain mapping of disease mutations (DMDM)

More...DMDMi		1705916

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources2 Publications
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002057782 – 1675Clathrin heavy chain 1Add BLAST1674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei67PhosphoserineCombined sources1
Modified residuei105PhosphothreonineBy similarity1
Modified residuei184PhosphotyrosineBy similarity1
Modified residuei394PhosphothreonineCombined sources1
Modified residuei634PhosphotyrosineCombined sources1
Modified residuei737N6-succinyllysineBy similarity1
Modified residuei856N6-acetyllysineCombined sources1
Modified residuei899PhosphotyrosineBy similarity1
Modified residuei1167PhosphoserineBy similarity1
Modified residuei1206PhosphotyrosineBy similarity1
Modified residuei1229PhosphoserineCombined sources1
Modified residuei1441N6-acetyllysine; alternateCombined sources1
Modified residuei1441N6-succinyllysine; alternateBy similarity1
Modified residuei1477PhosphotyrosineCombined sources1
Modified residuei1487PhosphotyrosineBy similarity1
Modified residuei1494PhosphoserineCombined sources1
Modified residuei1501N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-182
CPTAC-183

Encyclopedia of Proteome Dynamics

More...EPDi		Q00610

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q00610

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q00610

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q00610

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q00610

PeptideAtlas

More...PeptideAtlasi		Q00610

PRoteomics IDEntifications database

More...PRIDEi		Q00610

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57862 [Q00610-1]
57863 [Q00610-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q00610, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q00610

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q00610

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q00610

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q00610

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000141367, Expressed in dorsolateral prefrontal cortex and 252 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q00610, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q00610, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000141367, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat (PubMed:16968737). In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium.

Interacts with HIP1 (PubMed:11532990).

Interacts with DENND1A, DENND1B and DENND1C (By similarity). May interact with OCRL (By similarity).

Interacts with ERBB2 (PubMed:16314522).

Interacts with FKBP6 (PubMed:18529014).

Interacts with CKAP5 and TACC3 forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; the complex implicates clathrin triskelions; TACC3 and CLTC are proposed to form a composite microtubule interaction surface (PubMed:21297582).

Interacts with ATG16L1 (via N-terminus) (PubMed:20639872).

Interacts with RFTN1; the interaction occurs in response to pathogens (PubMed:27022195, PubMed:21266579).

Interacts with USP2 isoform 4 (PubMed:26756164).

By similarity9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107623, 450 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q00610

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q00610

Protein interaction database and analysis system

More...IntActi		Q00610, 233 interactors

Molecular INTeraction database

More...MINTi		Q00610

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000479606

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q00610

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q00610, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11675
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q00610

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q00610

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati537 – 683CHCR 1PROSITE-ProRule annotation1 PublicationAdd BLAST147
Repeati686 – 828CHCR 2PROSITE-ProRule annotation1 PublicationAdd BLAST143
Repeati833 – 972CHCR 3PROSITE-ProRule annotation1 PublicationAdd BLAST140
Repeati979 – 1124CHCR 4PROSITE-ProRule annotation1 PublicationAdd BLAST146
Repeati1128 – 1269CHCR 5PROSITE-ProRule annotation1 PublicationAdd BLAST142
Repeati1274 – 1420CHCR 6PROSITE-ProRule annotation1 PublicationAdd BLAST147
Repeati1423 – 1566CHCR 7PROSITE-ProRule annotation1 PublicationAdd BLAST144

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 479Globular terminal domainAdd BLAST478
Regioni24 – 67WD40-like repeat 1Add BLAST44
Regioni68 – 107WD40-like repeat 2Add BLAST40
Regioni108 – 149WD40-like repeat 3Add BLAST42
Regioni150 – 195WD40-like repeat 4Add BLAST46
Regioni196 – 257WD40-like repeat 5Add BLAST62
Regioni258 – 301WD40-like repeat 6Add BLAST44
Regioni302 – 330WD40-like repeat 7Add BLAST29
Regioni449 – 465Binding site for the uncoating ATPase, involved in lattice disassemblySequence analysisAdd BLAST17
Regioni457 – 507Involved in spindle localization and interaction with TACC31 PublicationAdd BLAST51
Regioni480 – 523Flexible linkerAdd BLAST44
Regioni524 – 1675Heavy chain armAdd BLAST1152
Regioni524 – 634Distal segmentAdd BLAST111
Regioni639 – 1675Proximal segmentAdd BLAST1037
Regioni1213 – 1522Involved in binding clathrin light chainBy similarityAdd BLAST310
Regioni1550 – 1675TrimerizationBy similarityAdd BLAST126

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal seven-bladed beta-propeller is formed by WD40-like repeats, and projects inward from the polyhedral outer clathrin coat. It constitutes a major protein-protein interaction node.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the clathrin heavy chain family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0985, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183166

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002136_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q00610

Database of Orthologous Groups

More...OrthoDBi		17940at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q00610

TreeFam database of animal gene trees

More...TreeFami		TF300059

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.10, 4 hits
2.130.10.110, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00662

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR000547, Clathrin_H-chain/VPS_repeat
IPR015348, Clathrin_H-chain_linker_core
IPR016025, Clathrin_H-chain_N
IPR022365, Clathrin_H-chain_propeller_rpt
IPR016341, Clathrin_heavy_chain
IPR011990, TPR-like_helical_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00637, Clathrin, 7 hits
PF09268, Clathrin-link, 1 hit
PF01394, Clathrin_propel, 5 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002290, Clathrin_H_chain, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00299, CLH, 7 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 6 hits
SSF50989, SSF50989, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50236, CHCR, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q00610-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQILPIRFQ EHLQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV 
        60         70         80         90        100
VIIDMNDPSN PIRRPISADS AIMNPASKVI ALKAGKTLQI FNIEMKSKMK 
       110        120        130        140        150
AHTMTDDVTF WKWISLNTVA LVTDNAVYHW SMEGESQPVK MFDRHSSLAG 
       160        170        180        190        200
CQIINYRTDA KQKWLLLTGI SAQQNRVVGA MQLYSVDRKV SQPIEGHAAS 
       210        220        230        240        250
FAQFKMEGNA EESTLFCFAV RGQAGGKLHI IEVGTPPTGN QPFPKKAVDV 
       260        270        280        290        300
FFPPEAQNDF PVAMQISEKH DVVFLITKYG YIHLYDLETG TCIYMNRISG 
       310        320        330        340        350
ETIFVTAPHE ATAGIIGVNR KGQVLSVCVE EENIIPYITN VLQNPDLALR 
       360        370        380        390        400
MAVRNNLAGA EELFARKFNA LFAQGNYSEA AKVAANAPKG ILRTPDTIRR 
       410        420        430        440        450
FQSVPAQPGQ TSPLLQYFGI LLDQGQLNKY ESLELCRPVL QQGRKQLLEK 
       460        470        480        490        500
WLKEDKLECS EELGDLVKSV DPTLALSVYL RANVPNKVIQ CFAETGQVQK 
       510        520        530        540        550
IVLYAKKVGY TPDWIFLLRN VMRISPDQGQ QFAQMLVQDE EPLADITQIV 
       560        570        580        590        600
DVFMEYNLIQ QCTAFLLDAL KNNRPSEGPL QTRLLEMNLM HAPQVADAIL 
       610        620        630        640        650
GNQMFTHYDR AHIAQLCEKA GLLQRALEHF TDLYDIKRAV VHTHLLNPEW 
       660        670        680        690        700
LVNYFGSLSV EDSLECLRAM LSANIRQNLQ ICVQVASKYH EQLSTQSLIE 
       710        720        730        740        750
LFESFKSFEG LFYFLGSIVN FSQDPDVHFK YIQAACKTGQ IKEVERICRE 
       760        770        780        790        800
SNCYDPERVK NFLKEAKLTD QLPLIIVCDR FDFVHDLVLY LYRNNLQKYI 
       810        820        830        840        850
EIYVQKVNPS RLPVVIGGLL DVDCSEDVIK NLILVVRGQF STDELVAEVE 
       860        870        880        890        900
KRNRLKLLLP WLEARIHEGC EEPATHNALA KIYIDSNNNP ERFLRENPYY 
       910        920        930        940        950
DSRVVGKYCE KRDPHLACVA YERGQCDLEL INVCNENSLF KSLSRYLVRR 
       960        970        980        990       1000
KDPELWGSVL LESNPYRRPL IDQVVQTALS ETQDPEEVSV TVKAFMTADL 
      1010       1020       1030       1040       1050
PNELIELLEK IVLDNSVFSE HRNLQNLLIL TAIKADRTRV MEYINRLDNY 
      1060       1070       1080       1090       1100
DAPDIANIAI SNELFEEAFA IFRKFDVNTS AVQVLIEHIG NLDRAYEFAE 
      1110       1120       1130       1140       1150
RCNEPAVWSQ LAKAQLQKGM VKEAIDSYIK ADDPSSYMEV VQAANTSGNW 
      1160       1170       1180       1190       1200
EELVKYLQMA RKKARESYVE TELIFALAKT NRLAELEEFI NGPNNAHIQQ 
      1210       1220       1230       1240       1250
VGDRCYDEKM YDAAKLLYNN VSNFGRLAST LVHLGEYQAA VDGARKANST 
      1260       1270       1280       1290       1300
RTWKEVCFAC VDGKEFRLAQ MCGLHIVVHA DELEELINYY QDRGYFEELI 
      1310       1320       1330       1340       1350
TMLEAALGLE RAHMGMFTEL AILYSKFKPQ KMREHLELFW SRVNIPKVLR 
      1360       1370       1380       1390       1400
AAEQAHLWAE LVFLYDKYEE YDNAIITMMN HPTDAWKEGQ FKDIITKVAN 
      1410       1420       1430       1440       1450
VELYYRAIQF YLEFKPLLLN DLLMVLSPRL DHTRAVNYFS KVKQLPLVKP 
      1460       1470       1480       1490       1500
YLRSVQNHNN KSVNESLNNL FITEEDYQAL RTSIDAYDNF DNISLAQRLE 
      1510       1520       1530       1540       1550
KHELIEFRRI AAYLFKGNNR WKQSVELCKK DSLYKDAMQY ASESKDTELA 
      1560       1570       1580       1590       1600
EELLQWFLQE EKRECFGACL FTCYDLLRPD VVLETAWRHN IMDFAMPYFI 
      1610       1620       1630       1640       1650
QVMKEYLTKV DKLDASESLR KEEEQATETQ PIVYGQPQLM LTAGPSVAVP 
      1660       1670 
PQAPFGYGYT APPYGQPQPG FGYSM
Length:1,675
Mass (Da):191,615
Last modified:January 23, 2007 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C4F2D54950079E2
GO
Isoform 2 (identifier: Q00610-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1636-1639: QPQL → NLSL
     1640-1675: Missing.

Show »
Length:1,639
Mass (Da):187,890
Checksum:i9CE5237A31C9B0C6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WVQ6A0A087WVQ6_HUMAN
Clathrin heavy chain
CLTC hCG_1818599
1,679Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS13J3KS13_HUMAN
Clathrin heavy chain 1
CLTC
612Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJJ5K7EJJ5_HUMAN
Clathrin heavy chain 1
CLTC
222Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSQ2J3KSQ2_HUMAN
Clathrin heavy chain 1
CLTC
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QL20J3QL20_HUMAN
Clathrin heavy chain 1
CLTC
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRF5J3KRF5_HUMAN
Clathrin heavy chain 1
CLTC
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTN1J3KTN1_HUMAN
Clathrin heavy chain 1
CLTC
24Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA04801 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti560Q → R in CAA39363 (PubMed:1765375).Curated1
Sequence conflicti817G → V in CAA39363 (PubMed:1765375).Curated1
Sequence conflicti923R → H in CAE45761 (PubMed:17974005).Curated1
Sequence conflicti1563R → G in CAE45761 (PubMed:17974005).Curated1
Sequence conflicti1652Q → R in CAE45761 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080721554 – 556Missing in MRD56; unknown pathological significance. 1 Publication3
Natural variantiVAR_080722890P → L in MRD56. 1 PublicationCorresponds to variant dbSNP:rs1555606635EnsemblClinVar.1
Natural variantiVAR_0807231047L → P in MRD56; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1555607159EnsemblClinVar.1
Natural variantiVAR_0807241108W → R in MRD56; unknown pathological significance. 1 Publication1
Natural variantiVAR_0807251199 – 1675Missing in MRD56. 1 PublicationAdd BLAST477
Natural variantiVAR_0807261207Missing in MRD56; unknown pathological significance. 1 Publication1
Natural variantiVAR_0807271555 – 1675Missing in MRD56. 1 PublicationAdd BLAST121
Natural variantiVAR_0807281556 – 1675Missing in MRD56. 1 PublicationAdd BLAST120

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0115701636 – 1639QPQL → NLSL in isoform 2. 1 Publication4
Alternative sequenceiVSP_0115711640 – 1675Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D21260 mRNA Translation: BAA04801.2 Different initiation.
BX640615 mRNA Translation: CAE45761.1
CH471109 Genomic DNA Translation: EAW94396.1
CH471109 Genomic DNA Translation: EAW94399.1
BC051800 mRNA Translation: AAH51800.1
BC054489 mRNA Translation: AAH54489.1
X55878 mRNA Translation: CAA39363.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32696.1 [Q00610-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A40573

NCBI Reference Sequences

More...RefSeqi		NP_004850.1, NM_004859.3 [Q00610-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000269122; ENSP00000269122; ENSG00000141367 [Q00610-1]
ENST00000393043; ENSP00000376763; ENSG00000141367 [Q00610-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1213

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1213

UCSC genome browser

More...UCSCi		uc002ixp.4, human [Q00610-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Wikipedia

Clathrin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21260 mRNA Translation: BAA04801.2 Different initiation.
BX640615 mRNA Translation: CAE45761.1
CH471109 Genomic DNA Translation: EAW94396.1
CH471109 Genomic DNA Translation: EAW94399.1
BC051800 mRNA Translation: AAH51800.1
BC054489 mRNA Translation: AAH54489.1
X55878 mRNA Translation: CAA39363.1
CCDSiCCDS32696.1 [Q00610-1]
PIRiA40573
RefSeqiNP_004850.1, NM_004859.3 [Q00610-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XZGX-ray1.70A1-364[»]
4G55X-ray1.69A1-364[»]
6E4LX-ray1.60A1-364[»]
6QNNX-ray2.03A1-364[»]
6QNPX-ray2.70A/B/C/D1-364[»]
SMRiQ00610
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107623, 450 interactors
CORUMiQ00610
ELMiQ00610
IntActiQ00610, 233 interactors
MINTiQ00610
STRINGi9606.ENSP00000479606

Chemistry databases

BindingDBiQ00610
ChEMBLiCHEMBL3108634

Protein family/group databases

MoonDBiQ00610, Curated
TCDBi8.A.137.1.1, the clathrin (clathrin) family

PTM databases

GlyGeniQ00610, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ00610
MetOSiteiQ00610
PhosphoSitePlusiQ00610
SwissPalmiQ00610

Genetic variation databases

BioMutaiCLTC
DMDMi1705916

Proteomic databases

CPTACiCPTAC-182
CPTAC-183
EPDiQ00610
jPOSTiQ00610
MassIVEiQ00610
MaxQBiQ00610
PaxDbiQ00610
PeptideAtlasiQ00610
PRIDEiQ00610
ProteomicsDBi57862 [Q00610-1]
57863 [Q00610-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q00610, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4164, 493 antibodies

The DNASU plasmid repository

More...DNASUi		1213

Genome annotation databases

EnsembliENST00000269122; ENSP00000269122; ENSG00000141367 [Q00610-1]
ENST00000393043; ENSP00000376763; ENSG00000141367 [Q00610-2]
GeneIDi1213
KEGGihsa:1213
UCSCiuc002ixp.4, human [Q00610-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1213
DisGeNETi1213

GeneCards: human genes, protein and diseases

More...GeneCardsi		CLTC
HGNCiHGNC:2092, CLTC
HPAiENSG00000141367, Low tissue specificity
MalaCardsiCLTC
MIMi118955, gene
617854, phenotype
neXtProtiNX_Q00610
OpenTargetsiENSG00000141367
Orphaneti178469, Autosomal dominant non-syndromic intellectual disability
178342, Inflammatory myofibroblastic tumor
319308, MiT family translocation renal cell carcinoma
442835, Non-specific early-onset epileptic encephalopathy
PharmGKBiPA26618
VEuPathDBiHostDB:ENSG00000141367

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0985, Eukaryota
GeneTreeiENSGT00950000183166
HOGENOMiCLU_002136_0_0_1
InParanoidiQ00610
OrthoDBi17940at2759
PhylomeDBiQ00610
TreeFamiTF300059

Enzyme and pathway databases

PathwayCommonsiQ00610
ReactomeiR-HSA-168275, Entry of Influenza Virion into Host Cell via Endocytosis
R-HSA-177504, Retrograde neurotrophin signalling
R-HSA-190873, Gap junction degradation
R-HSA-196025, Formation of annular gap junctions
R-HSA-2132295, MHC class II antigen presentation [Q00610-1]
R-HSA-3928665, EPH-ephrin mediated repulsion of cells
R-HSA-432720, Lysosome Vesicle Biogenesis [Q00610-1]
R-HSA-432722, Golgi Associated Vesicle Biogenesis [Q00610-1]
R-HSA-437239, Recycling pathway of L1
R-HSA-5099900, WNT5A-dependent internalization of FZD4
R-HSA-5140745, WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
R-HSA-8866427, VLDLR internalisation and degradation
R-HSA-8964038, LDL clearance
R-HSA-9013420, RHOU GTPase cycle
R-HSA-9013424, RHOV GTPase cycle
SignaLinkiQ00610
SIGNORiQ00610

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1213, 636 hits in 1028 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CLTC, human
EvolutionaryTraceiQ00610

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CLTC

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1213
PharosiQ00610, Tbio

Protein Ontology

More...PROi		PR:Q00610
RNActiQ00610, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000141367, Expressed in dorsolateral prefrontal cortex and 252 other tissues
ExpressionAtlasiQ00610, baseline and differential
GenevisibleiQ00610, HS

Family and domain databases

Gene3Di1.25.40.10, 4 hits
2.130.10.110, 1 hit
IDEALiIID00662
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR000547, Clathrin_H-chain/VPS_repeat
IPR015348, Clathrin_H-chain_linker_core
IPR016025, Clathrin_H-chain_N
IPR022365, Clathrin_H-chain_propeller_rpt
IPR016341, Clathrin_heavy_chain
IPR011990, TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF00637, Clathrin, 7 hits
PF09268, Clathrin-link, 1 hit
PF01394, Clathrin_propel, 5 hits
PIRSFiPIRSF002290, Clathrin_H_chain, 1 hit
SMARTiView protein in SMART
SM00299, CLH, 7 hits
SUPFAMiSSF48371, SSF48371, 6 hits
SSF50989, SSF50989, 1 hit
PROSITEiView protein in PROSITE
PS50236, CHCR, 7 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLH1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q00610
Secondary accession number(s): D3DU00, Q6N0A0, Q86TF2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: September 29, 2021
This is version 217 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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