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Protein

T-lymphocyte activation antigen CD80

Gene

Cd80

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-1257604 PIP3 activates AKT signaling
R-MMU-389356 CD28 co-stimulation
R-MMU-389357 CD28 dependent PI3K/Akt signaling
R-MMU-389359 CD28 dependent Vav1 pathway
R-MMU-389513 CTLA4 inhibitory signaling
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
T-lymphocyte activation antigen CD80
Alternative name(s):
Activation B7-1 antigen
Short name:
B7
CD_antigen: CD80
Gene namesi
Name:Cd80
Synonyms:B7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:101775 Cd80

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini38 – 246ExtracellularSequence analysisAdd BLAST209
Transmembranei247 – 268HelicalSequence analysisAdd BLAST22
Topological domaini269 – 306CytoplasmicSequence analysisAdd BLAST38

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Add BLAST37
ChainiPRO_000001454838 – 306T-lymphocyte activation antigen CD80Add BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 119PROSITE-ProRule annotation
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi149N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi155N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi165 ↔ 219PROSITE-ProRule annotation
Glycosylationi189N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi210N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi214N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ00609
PRIDEiQ00609

PTM databases

iPTMnetiQ00609
PhosphoSitePlusiQ00609
SwissPalmiQ00609

Expressioni

Tissue specificityi

Expressed on activated B-cells, gamma interferon stimulated monocytes and non-circulating B-cell malignancies.

Developmental stagei

Expressed between 4 and 12 hours post-activation. Protein was detected at cell surface at 24 hours and it's expression was maximal from 48 to 72 hours post-activation.

Gene expression databases

BgeeiENSMUSG00000075122 Expressed in 65 organ(s), highest expression level in fibroblast
CleanExiMM_CD80
ExpressionAtlasiQ00609 baseline and differential
GenevisibleiQ00609 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Cd274Q9EP735EBI-5258929,EBI-5258879

Protein-protein interaction databases

IntActiQ00609, 1 interactor
STRINGi10090.ENSMUSP00000097404

Structurei

Secondary structure

1306
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ00609
SMRiQ00609
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 135Ig-like V-typeAdd BLAST98
Domaini148 – 229Ig-like C2-typeAdd BLAST82

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni227 – 246Ig-hinge-likeSequence analysisAdd BLAST20

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3XE Eukaryota
ENOG411154Z LUCA
GeneTreeiENSGT00720000108819
HOGENOMiHOG000036959
HOVERGENiHBG000261
InParanoidiQ00609
KOiK05412
OMAiVRIYWQK
OrthoDBiEOG091G0QRI
PhylomeDBiQ00609
TreeFamiTF351094

Family and domain databases

CDDicd16083 IgC_CD80, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR037676 CD80_IgC
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q00609-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MACNCQLMQD TPLLKFPCPR LILLFVLLIR LSQVSSDVDE QLSKSVKDKV
60 70 80 90 100
LLPCRYNSPH EDESEDRIYW QKHDKVVLSV IAGKLKVWPE YKNRTLYDNT
110 120 130 140 150
TYSLIILGLV LSDRGTYSCV VQKKERGTYE VKHLALVKLS IKADFSTPNI
160 170 180 190 200
TESGNPSADT KRITCFASGG FPKPRFSWLE NGRELPGINT TISQDPESEL
210 220 230 240 250
YTISSQLDFN TTRNHTIKCL IKYGDAHVSE DFTWEKPPED PPDSKNTLVL
260 270 280 290 300
FGAGFGAVIT VVVIVVIIKC FCKHRSCFRR NEASRETNNS LTFGPEEALA

EQTVFL
Length:306
Mass (Da):34,590
Last modified:February 1, 1994 - v1
Checksum:i1DBADE0931B84C62
GO
Isoform 2 (identifier: Q00609-2) [UniParc]FASTAAdd to basket
Also known as: MB7-2

The sequence of this isoform differs from the canonical sequence as follows:
     144-237: Missing.

Show »
Length:212
Mass (Da):24,051
Checksum:iE51455E62260ED75
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012552144 – 237Missing in isoform 2. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60958 mRNA Translation: CAA43291.1
L12589
, L12585, L12586, L12587, L12588 Genomic DNA Translation: AAA37240.1 Sequence problems.
D16220 mRNA Translation: BAA03748.1
CCDSiCCDS28168.1 [Q00609-1]
PIRiI49503
RefSeqiNP_033985.3, NM_009855.2 [Q00609-1]
UniGeneiMm.89474

Genome annotation databases

EnsembliENSMUST00000099816; ENSMUSP00000097404; ENSMUSG00000075122 [Q00609-1]
GeneIDi12519
KEGGimmu:12519
UCSCiuc007zez.2 mouse [Q00609-1]
uc012afo.1 mouse [Q00609-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCD80_MOUSE
AccessioniPrimary (citable) accession number: Q00609
Secondary accession number(s): Q61332
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 12, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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