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Protein

Norrin

Gene

NDP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • frizzled binding Source: BHF-UCL
  • growth factor activity Source: ProtInc
  • protein homodimerization activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processSensory transduction, Vision, Wnt signaling pathway

Enzyme and pathway databases

SIGNORiQ00604

Names & Taxonomyi

Protein namesi
Recommended name:
Norrin
Alternative name(s):
Norrie disease protein
X-linked exudative vitreoretinopathy 2 protein
Gene namesi
Name:NDP
Synonyms:EVR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000124479.8
HGNCiHGNC:7678 NDP
MIMi300658 gene
neXtProtiNX_Q00604

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Norrie disease (ND)28 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRecessive disorder characterized by very early childhood blindness due to degenerative and proliferative changes of the neuroretina. Approximately 50% of patients show some form of progressive mental disorder, often with psychotic features, and about one-third of patients develop sensorineural deafness in the second decade. In addition, some patients have more complex phenotypes, including growth failure and seizure.
See also OMIM:310600
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00547813L → R in ND. 1 PublicationCorresponds to variant dbSNP:rs104894879EnsemblClinVar.1
Natural variantiVAR_01604816L → P in ND. 1 Publication1
Natural variantiVAR_00547939C → R in ND. 2 Publications1
Natural variantiVAR_06400143H → Q in ND. 1 Publication1
Natural variantiVAR_06400243H → R in ND. 1 Publication1
Natural variantiVAR_00548244Y → C in ND. 2 PublicationsCorresponds to variant dbSNP:rs104894870EnsemblClinVar.1
Natural variantiVAR_06400345V → E in ND. 1 PublicationCorresponds to variant dbSNP:rs137852221EnsemblClinVar.1
Natural variantiVAR_06400445V → M in ND. 1 Publication1
Natural variantiVAR_06400655C → R in ND. 1 Publication1
Natural variantiVAR_00548460V → E in ND; reduction of protein amount in the extracellular matrix. 2 PublicationsCorresponds to variant dbSNP:rs104894869EnsemblClinVar.1
Natural variantiVAR_00548561L → F in ND. 2 PublicationsCorresponds to variant dbSNP:rs104894880EnsemblClinVar.1
Natural variantiVAR_00548661L → P in ND. 1 Publication1
Natural variantiVAR_00548763A → D in ND. 1 Publication1
Natural variantiVAR_00549065C → W in ND. 1 Publication1
Natural variantiVAR_00548865C → Y in ND. 2 Publications1
Natural variantiVAR_06400867G → E in ND. 1 Publication1
Natural variantiVAR_06400967G → R in ND. 1 Publication1
Natural variantiVAR_00548969C → S in ND. 1 PublicationCorresponds to variant dbSNP:rs104894872EnsemblClinVar.1
Natural variantiVAR_00549174R → C in ND. 3 PublicationsCorresponds to variant dbSNP:rs727504031EnsemblClinVar.1
Natural variantiVAR_00549275S → C in ND. 1 PublicationCorresponds to variant dbSNP:rs104894868EnsemblClinVar.1
Natural variantiVAR_01604975S → P in ND. 1 Publication1
Natural variantiVAR_06401089F → L in ND. 1 PublicationCorresponds to variant dbSNP:rs1057520333Ensembl.1
Natural variantiVAR_06401190R → C in ND. 1 PublicationCorresponds to variant dbSNP:rs1057518793Ensembl.1
Natural variantiVAR_00549490R → P in ND. 1 PublicationCorresponds to variant dbSNP:rs104894867EnsemblClinVar.1
Natural variantiVAR_06401292S → P in ND. 1 Publication1
Natural variantiVAR_00549594 – 96HCC → QCGL in ND. 3
Natural variantiVAR_06401395C → F in ND. 1 Publication1
Natural variantiVAR_06401495C → R in ND. 1 Publication1
Natural variantiVAR_00927596C → W in ND. 1 PublicationCorresponds to variant dbSNP:rs104894877EnsemblClinVar.1
Natural variantiVAR_00549696C → Y in ND. 3 PublicationsCorresponds to variant dbSNP:rs104894871EnsemblClinVar.1
Natural variantiVAR_06401597R → P in ND. 1 Publication1
Natural variantiVAR_06401698P → L in ND. 1 Publication1
Natural variantiVAR_005497101S → F in ND. 1 PublicationCorresponds to variant dbSNP:rs104894883EnsemblClinVar.1
Natural variantiVAR_064018104K → N in ND. 1 Publication1
Natural variantiVAR_005498104K → Q in ND. 1 Publication1
Natural variantiVAR_016050105A → T in ND. 1 PublicationCorresponds to variant dbSNP:rs104894875EnsemblClinVar.1
Natural variantiVAR_016051110C → G in ND. 1 PublicationCorresponds to variant dbSNP:rs104894876EnsemblClinVar.1
Natural variantiVAR_064020110C → R in ND. 1 Publication1
Natural variantiVAR_064021112G → E in ND. 1 Publication1
Natural variantiVAR_064023118A → D in ND. 1 Publication1
Natural variantiVAR_005503121 – 123Missing in ND. 1 Publication3
Natural variantiVAR_005504123I → N in ND. 1 Publication1
Natural variantiVAR_064025126C → S in ND. 1 Publication1
Natural variantiVAR_064026128C → R in ND. 1 Publication1
Vitreoretinopathy, exudative 2 (EVR2)7 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by scarring, retinal detachment and blindness. Clinical features can be highly variable, even within the same family. Patients with mild forms of the disease are asymptomatic, and their only disease related abnormality is an arc of avascular retina in the extreme temporal periphery.
See also OMIM:305390
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06399818I → K in EVR2; the patient presented significant phenotypic heterogeneity between the two eyes. 1 Publication1
Natural variantiVAR_00548041R → K in EVR2. 1 Publication1
Natural variantiVAR_00548142H → R in EVR2. 2 PublicationsCorresponds to variant dbSNP:rs104894874EnsemblClinVar.1
Natural variantiVAR_06400554K → N in EVR2. 1 Publication1
Natural variantiVAR_06400761L → I in EVR2. 1 Publication1
Natural variantiVAR_064017103L → V in EVR2. 1 Publication1
Natural variantiVAR_064022115R → L in EVR2. 1 Publication1
Natural variantiVAR_005499120Y → C in EVR2. 1 Publication1
Natural variantiVAR_005500121R → G in EVR2. 1
Natural variantiVAR_064024121R → L in EVR2. 1 PublicationCorresponds to variant dbSNP:rs137852220EnsemblClinVar.1
Natural variantiVAR_005505124L → F in EVR2. 1 PublicationCorresponds to variant dbSNP:rs28933684EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi95C → A: Impairs oligomerization. 1 Publication1

Keywords - Diseasei

Deafness, Disease mutation

Organism-specific databases

DisGeNETi4693
GeneReviewsiNDP
MalaCardsiNDP
MIMi305390 phenotype
310600 phenotype
OpenTargetsiENSG00000124479
Orphaneti190 Coats disease
891 Familial exudative vitreoretinopathy
649 Norrie disease
91495 Persistent hyperplastic primary vitreous
90050 Retinopathy of prematurity
PharmGKBiPA31481

Polymorphism and mutation databases

BioMutaiNDP
DMDMi548342

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000002179425 – 133NorrinAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 961 Publication
Disulfide bondi55 ↔ 1101 Publication
Disulfide bondi65 ↔ 1261 Publication
Disulfide bondi69 ↔ 1281 Publication
Disulfide bondi93Interchain (with C-95)1 Publication
Disulfide bondi95Interchain (with C-93)1 Publication
Disulfide bondi131Interchain1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ00604
PeptideAtlasiQ00604
PRIDEiQ00604
ProteomicsDBi57861

PTM databases

iPTMnetiQ00604
PhosphoSitePlusiQ00604

Expressioni

Tissue specificityi

Expressed in the outer nuclear, inner nuclear and ganglion cell layers of the retina, and in fetal and adult brain.1 Publication

Gene expression databases

BgeeiENSG00000124479 Expressed in 133 organ(s), highest expression level in decidua
CleanExiHS_NDP
GenevisibleiQ00604 HS

Organism-specific databases

HPAiHPA003095

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Component of a complex, at least composed of TSPAN12, FZD4, LRP5/6 and norrin (NDP). Binds FZD4 with high affinity. Interacts with LRP6 (via Beta-propellers 1 and 2).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
FZD4Q9ULV14EBI-2466352,EBI-2466380

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110773, 27 interactors
IntActiQ00604, 4 interactors
STRINGi9606.ENSP00000367301

Structurei

Secondary structure

1133
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ00604
SMRiQ00604
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 132CTCKPROSITE-ProRule annotationAdd BLAST94

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IR8E Eukaryota
ENOG4111RWI LUCA
GeneTreeiENSGT00390000004304
HOGENOMiHOG000030892
HOVERGENiHBG004945
InParanoidiQ00604
OMAiKQPFRST
OrthoDBiEOG091G0TKF
PhylomeDBiQ00604

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR003064 Norrie_dis
PANTHERiPTHR28611 PTHR28611, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
PRINTSiPR01304 NORRIEDSEASE
SMARTiView protein in SMART
SM00041 CT, 1 hit
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00604-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKHVLAASF SMLSLLVIMG DTDSKTDSSF IMDSDPRRCM RHHYVDSISH
60 70 80 90 100
PLYKCSSKMV LLARCEGHCS QASRSEPLVS FSTVLKQPFR SSCHCCRPQT
110 120 130
SKLKALRLRC SGGMRLTATY RYILSCHCEE CNS
Length:133
Mass (Da):15,044
Last modified:June 1, 1994 - v1
Checksum:iD219E8B7F957286A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00547813L → R in ND. 1 PublicationCorresponds to variant dbSNP:rs104894879EnsemblClinVar.1
Natural variantiVAR_01604816L → P in ND. 1 Publication1
Natural variantiVAR_06399818I → K in EVR2; the patient presented significant phenotypic heterogeneity between the two eyes. 1 Publication1
Natural variantiVAR_03413723D → E. Corresponds to variant dbSNP:rs5952410EnsemblClinVar.1
Natural variantiVAR_06399938R → C in ND and EVR2. 2 Publications1
Natural variantiVAR_00547939C → R in ND. 2 Publications1
Natural variantiVAR_00548041R → K in EVR2. 1 Publication1
Natural variantiVAR_06400041R → S in persistent fetal vasculature syndrome. 1 Publication1
Natural variantiVAR_00548142H → R in EVR2. 2 PublicationsCorresponds to variant dbSNP:rs104894874EnsemblClinVar.1
Natural variantiVAR_06400143H → Q in ND. 1 Publication1
Natural variantiVAR_06400243H → R in ND. 1 Publication1
Natural variantiVAR_00548244Y → C in ND. 2 PublicationsCorresponds to variant dbSNP:rs104894870EnsemblClinVar.1
Natural variantiVAR_06400345V → E in ND. 1 PublicationCorresponds to variant dbSNP:rs137852221EnsemblClinVar.1
Natural variantiVAR_06400445V → M in ND. 1 Publication1
Natural variantiVAR_06400554K → N in EVR2. 1 Publication1
Natural variantiVAR_06400655C → R in ND. 1 Publication1
Natural variantiVAR_00548358K → N in ND and EVR2. 2 Publications1
Natural variantiVAR_00548460V → E in ND; reduction of protein amount in the extracellular matrix. 2 PublicationsCorresponds to variant dbSNP:rs104894869EnsemblClinVar.1
Natural variantiVAR_00548561L → F in ND. 2 PublicationsCorresponds to variant dbSNP:rs104894880EnsemblClinVar.1
Natural variantiVAR_06400761L → I in EVR2. 1 Publication1
Natural variantiVAR_00548661L → P in ND. 1 Publication1
Natural variantiVAR_00548763A → D in ND. 1 Publication1
Natural variantiVAR_00549065C → W in ND. 1 Publication1
Natural variantiVAR_00548865C → Y in ND. 2 Publications1
Natural variantiVAR_06400867G → E in ND. 1 Publication1
Natural variantiVAR_06400967G → R in ND. 1 Publication1
Natural variantiVAR_00548969C → S in ND. 1 PublicationCorresponds to variant dbSNP:rs104894872EnsemblClinVar.1
Natural variantiVAR_00549174R → C in ND. 3 PublicationsCorresponds to variant dbSNP:rs727504031EnsemblClinVar.1
Natural variantiVAR_00549275S → C in ND. 1 PublicationCorresponds to variant dbSNP:rs104894868EnsemblClinVar.1
Natural variantiVAR_01604975S → P in ND. 1 Publication1
Natural variantiVAR_06401089F → L in ND. 1 PublicationCorresponds to variant dbSNP:rs1057520333Ensembl.1
Natural variantiVAR_06401190R → C in ND. 1 PublicationCorresponds to variant dbSNP:rs1057518793Ensembl.1
Natural variantiVAR_00549490R → P in ND. 1 PublicationCorresponds to variant dbSNP:rs104894867EnsemblClinVar.1
Natural variantiVAR_06401292S → P in ND. 1 Publication1
Natural variantiVAR_00549594 – 96HCC → QCGL in ND. 3
Natural variantiVAR_06401395C → F in ND. 1 Publication1
Natural variantiVAR_06401495C → R in ND. 1 Publication1
Natural variantiVAR_00927596C → W in ND. 1 PublicationCorresponds to variant dbSNP:rs104894877EnsemblClinVar.1
Natural variantiVAR_00549696C → Y in ND. 3 PublicationsCorresponds to variant dbSNP:rs104894871EnsemblClinVar.1
Natural variantiVAR_06401597R → P in ND. 1 Publication1
Natural variantiVAR_06401698P → L in ND. 1 Publication1
Natural variantiVAR_005497101S → F in ND. 1 PublicationCorresponds to variant dbSNP:rs104894883EnsemblClinVar.1
Natural variantiVAR_064017103L → V in EVR2. 1 Publication1
Natural variantiVAR_064018104K → N in ND. 1 Publication1
Natural variantiVAR_005498104K → Q in ND. 1 Publication1
Natural variantiVAR_016050105A → T in ND. 1 PublicationCorresponds to variant dbSNP:rs104894875EnsemblClinVar.1
Natural variantiVAR_064019108L → P in retinopathy of prematurity. 1 Publication1
Natural variantiVAR_016051110C → G in ND. 1 PublicationCorresponds to variant dbSNP:rs104894876EnsemblClinVar.1
Natural variantiVAR_064020110C → R in ND. 1 Publication1
Natural variantiVAR_064021112G → E in ND. 1 Publication1
Natural variantiVAR_064022115R → L in EVR2. 1 Publication1
Natural variantiVAR_064023118A → D in ND. 1 Publication1
Natural variantiVAR_005499120Y → C in EVR2. 1 Publication1
Natural variantiVAR_005503121 – 123Missing in ND. 1 Publication3
Natural variantiVAR_005500121R → G in EVR2. 1
Natural variantiVAR_064024121R → L in EVR2. 1 PublicationCorresponds to variant dbSNP:rs137852220EnsemblClinVar.1
Natural variantiVAR_005501121R → Q in EVR2 and ND; reduced amount of protein in the extracellular matrix. 4 Publications1
Natural variantiVAR_005502121R → W in ND and EVR2. 2 PublicationsCorresponds to variant dbSNP:rs104894878EnsemblClinVar.1
Natural variantiVAR_005504123I → N in ND. 1 Publication1
Natural variantiVAR_005505124L → F in EVR2. 1 PublicationCorresponds to variant dbSNP:rs28933684EnsemblClinVar.1
Natural variantiVAR_064025126C → S in ND. 1 Publication1
Natural variantiVAR_064026128C → R in ND. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65724 mRNA Translation: CAA46639.1
X65882 mRNA Translation: CAA46713.1
AL034370 Genomic DNA No translation available.
AK313409 mRNA Translation: BAG36203.1
BC029901 mRNA Translation: AAH29901.1
CCDSiCCDS14262.1
PIRiA57005
RefSeqiNP_000257.1, NM_000266.3
UniGeneiHs.522615

Genome annotation databases

EnsembliENST00000378062; ENSP00000367301; ENSG00000124479
ENST00000642620; ENSP00000495972; ENSG00000124479
ENST00000647044; ENSP00000495811; ENSG00000124479
GeneIDi4693
KEGGihsa:4693
UCSCiuc004dga.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Mutations of the NDP gene

Retina International's Scientific Newsletter

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65724 mRNA Translation: CAA46639.1
X65882 mRNA Translation: CAA46713.1
AL034370 Genomic DNA No translation available.
AK313409 mRNA Translation: BAG36203.1
BC029901 mRNA Translation: AAH29901.1
CCDSiCCDS14262.1
PIRiA57005
RefSeqiNP_000257.1, NM_000266.3
UniGeneiHs.522615

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MY2X-ray2.40A30-133[»]
5BPUX-ray2.40A/B/C/D/E/F25-133[»]
5BQ8X-ray2.00A/B/C/D25-133[»]
5BQBX-ray2.30A/B/C/D25-133[»]
5BQCX-ray3.00A25-133[»]
5BQEX-ray2.30A/B25-133[»]
5CL1X-ray3.80A/B31-133[»]
ProteinModelPortaliQ00604
SMRiQ00604
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110773, 27 interactors
IntActiQ00604, 4 interactors
STRINGi9606.ENSP00000367301

PTM databases

iPTMnetiQ00604
PhosphoSitePlusiQ00604

Polymorphism and mutation databases

BioMutaiNDP
DMDMi548342

Proteomic databases

PaxDbiQ00604
PeptideAtlasiQ00604
PRIDEiQ00604
ProteomicsDBi57861

Protocols and materials databases

DNASUi4693
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378062; ENSP00000367301; ENSG00000124479
ENST00000642620; ENSP00000495972; ENSG00000124479
ENST00000647044; ENSP00000495811; ENSG00000124479
GeneIDi4693
KEGGihsa:4693
UCSCiuc004dga.5 human

Organism-specific databases

CTDi4693
DisGeNETi4693
EuPathDBiHostDB:ENSG00000124479.8
GeneCardsiNDP
GeneReviewsiNDP
HGNCiHGNC:7678 NDP
HPAiHPA003095
MalaCardsiNDP
MIMi300658 gene
305390 phenotype
310600 phenotype
neXtProtiNX_Q00604
OpenTargetsiENSG00000124479
Orphaneti190 Coats disease
891 Familial exudative vitreoretinopathy
649 Norrie disease
91495 Persistent hyperplastic primary vitreous
90050 Retinopathy of prematurity
PharmGKBiPA31481
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR8E Eukaryota
ENOG4111RWI LUCA
GeneTreeiENSGT00390000004304
HOGENOMiHOG000030892
HOVERGENiHBG004945
InParanoidiQ00604
OMAiKQPFRST
OrthoDBiEOG091G0TKF
PhylomeDBiQ00604

Enzyme and pathway databases

SIGNORiQ00604

Miscellaneous databases

ChiTaRSiNDP human
GeneWikiiNorrin
GenomeRNAii4693
PROiPR:Q00604
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124479 Expressed in 133 organ(s), highest expression level in decidua
CleanExiHS_NDP
GenevisibleiQ00604 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR003064 Norrie_dis
PANTHERiPTHR28611 PTHR28611, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
PRINTSiPR01304 NORRIEDSEASE
SMARTiView protein in SMART
SM00041 CT, 1 hit
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNDP_HUMAN
AccessioniPrimary (citable) accession number: Q00604
Secondary accession number(s): B2R8K6, Q5JYH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 12, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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